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Suspected Resistance against Moxidectin in Sheep Strongylid Nematodes in Austria

Journal of Pharmacy and Pharmacology 2017年第3期5卷 109-117页

作者： Julia Schoiswohl barbara hinney Alexander Tichy Karl Bauer Anja Joachim Reinhild Krametter-Frotscher Department for Farm Animals and Veterinary Public Health University of Veterinary Medicine Vienna Vienna 1210 Austria Department of Pathobiology Institute of Parasitology University of Veterinary Medicine Vienna Vienna 1210 Austria Bioinformatics and Biostatistics Platform University of Veterinary Medicine Vienna Vienna 1210 Austria Animal Health Service Styria Graz 8010 Austria

Loss of efficacy due to resistance development against anthelmintics in livestock parasites is a growing concern worldwide. The aim of the present study was to determine the efficacy of moxidectin, a frequently-used macrocyclic lactone, against gastrointestinal nematodes of sheep in Austria. Individual faecal samples were collected from 243 adult sheep from 16 flocks in Styria and Salzburg before deworming and egg excretion （EPG （eggs per gram） of faeces） was determined using a modified McMaster technique. The animals were randomly assigned to a treatment group which received 0.2 mg/kg of body weight of moxidectin （Cydectin , Zoetis Schweiz GmbH, Zurich, Switzerland）, and an untreated control group. Fourteen days after deworming a FECRT （faecal egg count reduction test） for detection of anthelmintic resistance was performed. Before deworming, the infection rate for gastrointestinal strongylids was 94.7%, with EPG values of 0-5,800. The FECRT showed reduction rates between 93.08% and 99.78% and was sufficient in 15/16 flocks. The lower confidence interval was 70.0-100%. In 3/16 flocks this value was below the minimum for sufficient efficacy （70.0%, 79.0%, 85.0%）, and in two flocks the value （90,0%） was near the limit. These results indicated a （suspected） reduced efficacy of moxidectin in 5/16 examined flocks.

关键词： FECRT (faecal egg count reduction test) EPG (eggs per gram) faeces moxidectin anthelmintic resistance.

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Control of Canine Endoparasites,Especially Isospora spp.,with Procox^(■) in Naturally Infected Puppies:Parasitological,Bacteriological and Health Parameters

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Open Journal of Veterinary Medicine 2013年第2期3卷 121-130页

作者： barbara Anna Rauscher Sabine Schafer-Somi Monika Ehling-Schulz Karin Mostl Stefanie Handl barbara hinney Joachim Spergser Roland Schaper Anja Joachim Institute of Parasitology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Centre for Artificial Insemination and Embryo Transfer Department for Small Animals and HorsesUniversity of Veterinary Medicine ViennaViennaAustria Functional Microbiology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Virology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Animal Nutrition Department for Farm Animals and Veterinary Public HealthUniversity of Veterinary Medicine ViennaViennaAustria Clinical Microbiology and Infection Biology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Bayer Animal Health GmbH MonheimGermany

The effect of Procox? (Bayer, emodepside/toltrazuril suspension for dogs) against natural infections with Isospora spp. was investigated. Two groups were treated either with 0.5 ml suspension/kg of body weight (0.45 mg emodepside and 9 mg toltrazuril/kg of body weight) in the 3rd, 5th and 7th week of life (w.o.l.) (Procox? group;n = 28) or with a control anthelminthic (Dewormed Control group;n = 26). Animals were surveyed weekly from the 3rd w.o.l. by coproscopy and clinical examination. Faecal samples were examined microbiologically from the 4th to the 8th w.o.l. and faecal inflammatory markers canine calprotectin and canine S100A12 were measured in the 8th w.o.l. Specific antibody titres were evaluated in serum samples from five litters before and after vaccination against canine distemper virus and canine parvovirus 2. The prevalence of Isospora-positive animals increased to 67% in the Dewormed Control group (n = 15 puppies from four parasite-positive litters), while in the Procox? group (n = 15 puppies) it was less than 34% with significantly lower excretion (p ? was easily applied and effective;adverse effects did not occur. The level of seroconversion or titre increase upon vaccination was higher in parasite-free animals (91%) compared to Procox?-treated puppies (30%) and the Control animals (10%). Animals from parasite-free litters showed significantly different excretion patterns for haemolytic Escherichia coli and Clostridium perfringens, while there was no difference between Procox?-treated and Control animals. In some animals kept under poor hygienic conditions diarrhoea was noted in association with C. perfringens, E. coli or Salmonella. Concentrations of inflammatory markers in the faeces did not significantly differ between the Procox? and the Control group. Adequate control of parasitic and bacterial infections in suckling puppies requires both antiparasitic treatment and hygiene. Even when parasites do not cause overt effects treatment is recommended

关键词： Dog Emodepside Gut Health Isospora Toltrazuril Toxocara Vaccination

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