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Chinese Physics Letters 2015年第12期32卷 30-34页

作者： barbara Betz Miklos Gyulassy Institut for Theoretische Physik Johann Wolfgang Goethe-Universitat Frankfurt am Main 60438 Germany Department of Physics Columbia University New York 10027 USA Institute of Particle Physics Central China Normal University Wuhan 430079

We compare the jet-path length and beam-energy dependence of the pion nuclear modification factor and a patton-jet nuclear modification factor at RHIC and LHC, and contrast the predictions based on a linear pQCD and a highly non-linear hybrid AdS holographic model of jet-energy loss. It is found that both models require a reduction of the jet-medium coupling from RHIC to LHC to account for the measured pion nuclear modification factor. In the case of the parton-jet nuclear modification factor, however, which serves as a lower bound for the LO jet nuclear modification factor of reconstructed jets, the extracted data can be characterized without a reduced jet-medium coupling at LHC energies. It is concluded that when the reconstructed jets are sensitive to both quarks and gluons and thus provide more information than the pion nuclear modification factor, their information regarding the jet-medium coupling is limited due to the superposition with NLO and medium effects. Hence, a detailed description of the underlying physics requires both the leading hadron and the reconstructed jet nuclear modification factor. Unfortunately, the results for both the pion and the parton-jet nuclear modification factor are insensitive to the jet-path dependence of the models considered.

关键词： LHC Sensitivity of Pion versus Parton-Jet Nuclear Modification Factors to the Path-Length Dependence of Jet-Energy Loss at RHIC and LHC

Factors associated with intensification of antihypertensive drug therapy in patients with poorly controlled hypertension

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Journal of Geriatric Cardiology 2019年第1期16卷 19-26页

作者： Olga Siga barbara Wizner barbara Gryglewska Jolanta Walczewska Tomasz Grodzicki Department of Internal Medicine and Gerontology Jagiellonian University Medical College

Objective To assess antihypertensive management of older patients with poor blood pressure(BP)*** Physicians,voluntary participating in the study,included six consecutive hypertensive patients during routine *** had to have been previously recognized and averaged office BP was>140 and/or>90 mmHg in spite of>6 weeks of antihypertensive *** physicians completed a questionnaire on patients'history of cardiovascular(CV)risk factors,comorbidities,home BP monitoring,anthropometric data and the *** Mean age of the 6462 patients was 61 years,7%were>80 years,51%were ***士SD office BP values were 158士13/92土10 *** most commonly prescribed antihypertensive drugs were:diuretics(67%),ACE inhibitors(64%),calcium channel blockers(58%)and卩-blockers(54%),and their use increased with *** monotherapy or dual therapy,43%of the patients and 40%had their latest treatment modification within six *** BP monitoring was a factor that accelerated the modification of the *** patients had to have less chance on faster modification of antihypertensive therapy in spite of presence of diabetes and higher systolic *** Our study suggests that a large number of outpatients with poor BP control receive suboptimal antihypertensive therapy,especially in primary *** older patients,higher BP values in the office settings are more frequently accepted by physicians even in case of higher CV *** home BP monitoring hastens the decision to intensify of antihypertensive treatment.

关键词： Antihypertensive therapy Comorbidities Modification of therapy Older patients Uncontrolled hypertension

Rare horizontal transmission does not hide long-term inheritance of SINE highly conserved domains in the metazoan evolution

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Current Zoology 2016年第6期62卷 667-674页

作者： Andrea LUCHETTI barbara MANTOVANI Dipartimento di Scienze Biologiche Geologiche e Ambientali--Universit~ di Bologna Via Selmi 3 Bologna 40126Italy

Transposable elements （TEs） are self-replicating, mobile DNA sequences which constitute a significant fraction of eukaryotic genomes. They are generally considered selfish DNA, as their replication and random insertion may have deleterious effects on genome functionalities, although some beneficial effects and evolutionary potential have been recognized. Short interspersed elements （SINEs） are non-autonomous TEs with a modular structure： a small RNA-related head, a body, and a long interspersed element-related tail. Despite their high turnover rate and de novo emergence, the body may retain highly conserved domains （HCDs） shared among divergent SINE families： in metazoans, at least nine HCD-SINEs have been recognized. Data mining on public molecular databases allowed the retrieval of 16 new HCD-SINE families from cnidarian, molluscs, arthropods, and vertebrates. Tracking the ancestry of HCDs on the metazoan phylogeny revealed that some of them date back to the Radiata-Bilateria split. Moreover, phylogenetic and age versus divergence analyses of the most ancient HCDs suggested that long-term vertical inheritance is the rule, with few horizontal transfer events. We suggest that the evolutionary conservation of HCDs may be linked to their potential to serve as recombination hotspots. This indirectly affects host genomes by maintaining active and diverse SINE lineages, whose insertions may impact （either positively or negatively） on the evolution of the genome.

关键词： horizontal transfer Metazoan genome retrotransposons selfish DNA SINEs highly conserved domain vertica inheritance.

Plasma Membrane Protein Ubiquitylation and Degradation as Determinants of Positional Growth in Plants

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Journal of Integrative Plant Biology 2013年第9期55卷 809-823页

作者： barbara Korbei Christian Luschnig Department of Applied Genetics and Cell Biology University of Natural Resources and Life SciencesVienna (BOKU)Muthgasse 181190 Vienna Austria

Being sessile organisms, plants evolved an unparalleled plasticity in their post-embryonic development, allowing them to adapt and fine-tune their vital parameters to an ever-changing environment. Cross-talk between plants and their environment requires tight regulation of information exchange at the plasma membrane （PM）. Plasma membrane proteins mediate such communication, by sensing variations in nutrient availability, external cues as well as by controlled solute transport across the membrane border. Localiza-tion and steady-state levels are essential for PM protein function and ongoing research identified cis- and trans-acting determinants, involved in control of plant PM protein localization and turnover. In this overview, we summarize recent progress in our understanding of plant PM protein sorting and degradation via ubiquitylation, a post-translational and reversible modification of proteins. We highlight characterized components of the machinery involved in sorting of ubiquitylated PM proteins and discuss consequences of protein ubiquitylation on fate of selected PM proteins. Specifically, we focus on the role of ubiquitylation and PM protein degradation in the regulation of polar auxin transport （PAT）. We combine this regulatory circuit with further aspects of PM protein sorting control, to address the interplay of events that might control PAT and polarized growth in higher plants.

关键词： Arabidopsis auxin PIN protein protein degradation ubiquitin.

Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre McNamara Trinity Academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland Department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

Cr(Ⅵ) reduction capability of humic acid extracted from the organic component of municipal solid waste

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Journal of Environmental Sciences 2013年第3期25卷 487-494页

作者： barbara Scaglia Fulvia Tambone Fabrizio Adani Gruppo Ricicla Dipartimento di Science Agrarie e Ambientali:ProduzioneTerritorioAgroenergiaUniversità degli Studi di Milano

The capacity of humic acid extracted from organic waste （HAw） to reduce Cr（Ⅵ） was tested at pH 2.5,4 and 6 and compared with coal-derived humic acid （HAc）.HAw was more effective than HAc in reducing Cr（Ⅵ）.The kinetics of Cr（Ⅵ） reductions depended strongly on *** calculation of the apparent rate coefficients indicated that HAw was more efficient at reducing Cr（Ⅵ） than HAc,but was also more efficient than HAs from soil and *** reduction capability of HAs depends on the type of functional groups （i.e.,thiols and phenols） present,rather than the free *** was more efficient at reducing Cr（Ⅵ） than HAc because more reactive phenols were present,i.e.,methoxy-and methyl-phenols.

关键词： hexavalent chromium humic acid reduction kinetic organic fraction municipal solid waste phenol molecules

A natural neighbour method based on Fraeijs de Veubeke variational principle for materially non-linear problems

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Acta Mechanica Sinica 2009年第1期25卷 83-93页

作者： Xiang Li Serge Cescotto barbara Rossi Dalian University of Technology 116023 Dalian China ArGEnCo Department University of Liege Liege Belgium

The natural neighbour method can be considered as one of many variants of the meshless methods. In the present paper, a new approach based on the Fraeijs de Veubeke （FdV） functional, which is initially developed for linear elasticity, is extended to the case of geometrically linear but materially non-linear solids. The new approach provides an original treatment to two classical problems： the numerical evaluation of the integrals over the domain A and the enforcement of boundary conditions of the type ui = hi on Su. In the absence of body forces （Fi = 0）, it will be shown that the calculation of integrals of the type fA .dA can be avoided and that boundary conditions of the type ui = hi on Su can be imposed in the average sense in general and exactly if hi is linear between two contour nodes, which is obviously the case for tTi = O.

关键词： Natural neighbour method Meshless methodFraeijs de Veubeke variational principle Discretization Voronoi cell

Odorants could elicit repair processes in melanized neuronal and skin cells

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Neural Regeneration Research 2017年第9期12卷 1401-1404页

作者： barbara Pavan Alessandro Dalpiaz Department of Life Sciences and Biotechnology University of Ferrara Department of Chemistry and Pharmaceutical Sciences University of Ferrara

The expression of ectopic olfactory receptors （ORs） in melanized cells, such as the human brain nigrostri- atal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin melanogenesis, whereas OR expression in the dopaminergic neurons, characterized by accumulation of pigment neuromelanin, is downregulated in Parkinson＇s disease. Furthermore, the correlation between the pigmentation process and the dopamine pathway through ct-synuclein expression is also highlighted. Purposely, these ORs are suggested as therapeutic target for neurodegenerative diseases related to the pig- mentation disorders. Based on this evidence, a possible way of turning odorants into drugs, acting on three specific olfactory receptors, OR51E2, OR2AT4 and VN1R1, is thus introduced. Various odorous molecules are shown to interact with these ORs and their therapeutic potential against melanogenic and neurodegen- erative dysfunctions, including melanoma and Parkinson＇s disease, is suggested. Finally, a direct functional link between olfactory and endocrine systems in human brain through VNIR1 is proposed, helping to counteract female susceptibility to Parkinson＇s disease in quiescent life.

关键词： OR51E2 OR2AT4 VN1R1 melanoma Parkinson's disease β-ionone sandalore hedione

What is attractive rural landscape?Differences in the social and expert assessment of the changes in the rural landscape of the Carpathian region in Poland with regard to the need of its protection

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Journal of Mountain Science 2023年第2期20卷 501-515页

作者： Agata GAJDEK barbara KRUPA Anna NOWAK Department of Landscape Architecture Institute of Agricultural SciencesEnvironmental Protection and DevelopmentCollege of Natural SciencesUniversity of Rzeszowul.Ćwiklińskiej 2PL-35-601 RzeszówPoland

Contemporary villages of the mountain region are subject to uncontrolled structural and spatial transformations,which cause deformation of centuries-old spatial systems of high cultural and natural *** aim of the study is to confront the opinions of the inhabitants and experts regarding the condition of the cultural landscape of the villages in south-eastern *** area belongs to the Carpathian region of Central *** historical and economic conditions of the studied region,related to the functioning in the post-war period,and then its breakdown and the development of the free market economy,constitute an interesting background for the proposed *** communities still remembering the period of difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,many difficulties related to the period of systemic transformations,are currently experiencing a relative prosperity,which is also expressed in a completely new,previously unknown way of managing the *** implemented in villages are associated by the inhabitants with the improvement of the standards and quality of *** assess them rather *** expert assessment of these landscape transformations indicates their negative dimension and the risk of losing timeless *** discrepancy in the assessment of experts and local residents creates difficulties in the protection of the rural ***,high-quality visual landscape features among rural residents is necessary from the point of view of its multi-faceted and effective *** initiatives and actions in the field of industry policy should play a significant role in this respect by consolidating the images of a harmonious landscape in the public awareness.

关键词： Polish village Landscape attractiveness Cultural landscape Spatial systems

Circadian regulation of Limulus visual functions:A role for octopamine and cAMP

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Current Zoology 2010年第5期56卷 518-536页

作者： Jasbir S.DALAL barbara-Anne BATTELLE Whitney Laboratory for Marine Bioscience and the Departments of Neuroscience and Biology University of Florida Department of Internal Medicine and Division of Human Nutrition and Metabolic Diseases University of Texas Southwestern Medical Center

The purpose of this contribution is to review our current understanding of the source and biochemistry of the circadian efferent input to the eyes of the American horseshoe crab Limuluspolyphemus and the impact of this input on the structure, physiology and biochemistry of Limulus eyes. Special emphasis is given to the role of the biogenic amine octopamine and bio- chemical cascades it activates in the eyes. In addition to reviewing published data, we present new data showing that octopamine elevates cAMP levels in Limulus lateral eyes, and we partially characterize the pharmacology of the receptors involved in this response. We also present new data showing that octopamine regulates gene expression in Limulus lateral eyes by activating a cAMP cascade

关键词： Horseshoe crab Circadian rhythms Oetopamine Photoreceptors Substance P Arrestin