检索结果-南通市图书馆

Genetic Predisposition for Type 2 Diabetes Mellitus in a Cameroonian Population: Contribution of rs4731702 (C/T) Polymorphism of Krüppel-Like Factor 14 Gene

引用

Open Journal of Genetics 2021年第2期11卷 9-22页

作者： Magellan Guewo-Fokeng Eugene Sobngwi barbara atogho-tiedeu Eric Lontchi-Yimagou Jean-Paul Chedjou Jean-Claude Mbanya Wilfred F. Mbacham Department of Biochemistry Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon The Biotechnology Centre University of Yaoundé I Nkolbisson Yaoundé Cameroon Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of Biochemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon

Introduction: Krüppel Like Factor 14 (KLF14) gene has recently been identified as a master gene for multiple metabolic phenotypes. The aim of the research study was to investigate the relationship between KLF14 rs4731702 (C/T) gene polymorphism with Type 2 Diabetes Mellitus (T2DM) in a Cameroonian population. Patients and Methods: This case-control study was conducted in 85 patients with T2DM and 95 healthy normoglycemic controls. All were nonrelated, of Cameroonian origin, and were adults aged 24 years old and above. Demographic, clinical and biological data were collected, and biochemical explorations were performed using enzymatic colorimetric methods. The genotyping of KLF14 rs4731702 (CT) gene polymorphism was done by the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism. Results: In comparing the Cameroonian population that consisted of 85 patients with T2DM and 95 healthy controls, the minor or risk allele of the rs4731702 (C/T) polymorphism of the KLF14 gene was T (63.53% diabetic patients vs. 26.32% healthy controls, OR = 4.877 and p Conclusion: This study has demonstrated for the first time the relationship between the KLF14 rs4731702 (C/T) gene polymorphism and T2DM in this Cameroonian population. This gene polymorphism could be a promising target for personalized medicine through the development of clinical genetic testing.

关键词： Genetic Krüppel-Like Factor 14 Gene Type 2 Diabetes Mellitus Cameroon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

引用

Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antioxidant properties of cell wall polysaccharides of Stevia rebaudiana leaves

引用

Journal of Coastal Life Medicine 2014年第12期 962-969页

作者： Mediesse Kengne Francine Woguia Alice Louise Fogue Souopgui Pythagore atogho-tiedeu barbara Simo Gustave Thaddée Boudjeko Laboratory of Phytoprotection and Valorization of Plants Resources Biotechnology Centre-NkolbissonPo.Box 3851MessaYaoundeCameroon Department of Biochemistry Faculty of ScienceUniversity of Yaounde IPo.Box 812 YaoundeCameroon Department of Biochemistry Faculty of ScienceUniversity of DschangPo.Box 67 DschangCameroon Laboratory for Metabolic and Molecular Medicine Biotechnology Centre-NkolbissonPo.Box 3851MessaYaoundeCameroon

Objective:To examine the total phenolic and protein contents,and the antioxidant activities of cell wall polysaccharide fractions of Stevia rebaudiana ***:Three different polysaccharide-enriched fractions,namely FPE(extract with 50 mmol/L ethylene diamine tetra acetic acid),FPK(extract with 0.05 mol/L KOH)and FH(extract with 4 mol/L KOH)were extracted from Stevia rebaudiana *** antioxidant activity of these fractions was evaluated based on their ability to scavenge DPPH(1,1-diphenyl-2-picryl hydrazyl)free radical,to reduce ferric power,to chelate ferrous ion and to protect human ***:The results indicated that protein content was found to be higher in FPK polysaccharide enriched fraction(47.48μg per mg of FPK).Furthermore,the phenolic compound analysis according to the Folin-Ciocalteu method was higher in FPK(17.71μg ferulic acid).The DPPH maximal inhibition percentage of the three polysaccharide-enriched fractions at 400μg/mL was 27.66%,59.90%and 23.21%respectively for FPE,FPK and *** the polysaccharide fractions exhibited a ferric reducing power except the FH *** three fractions also exhibited lipid peroxidation inhibition,and they completely reverted the DNA damage induced by H_(2)O_(2)/FeCl_(2).FPK showed the strongest scavenging activity against the DPPH radical,the best chelating ability and lipid peroxidation ***:Stevia cell wall polysaccharide fractions are potent protective agents against oxidative *** analysis revealed major differences in the antioxidant activity in the three polysaccharides ***,the 0.05 mol/L KOH pectin fraction(FPK)showed better antioxidant activity.

关键词： Stevia rebaudiana Cell wall polysaccharides Fractions Antioxidant properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predominance of Plasmodium malariae-falciparum Co-Infection by Molecular Speciation in Bangolan, North West Region of Cameroon

引用

Journal of Life Sciences 2013年第6期7卷 599-606页

作者： Olivia Afa Achonduh Aristid Herve Ekollo Mbange atogho-tiedeu barbara Innocent Ali Mbulli Daniel Achinko Palmer Masumbe Netongo Wilfred Fon Mbacham The Bioteehnology Center University of Yaounde I Yaounde Center Region Cameroon

Although microscopy still remains the gold standard for the diagnosis of malaria, rapid diagnostic tests （RDTs） and PCR assays have been shown to be sensitive and specific. Very few comparative studies have been reported of the three diagnostic methods on the same samples in vulnerable groups. Microscopy, RDTs and PCR assays were used for detection and speciation of Plasmodium falciparum （P）＇）, Plasmodium malariae （Pm） and Plasmodium ovale （Po） in patients in a rice culture savanna ecotype. Fifty four children and 16 pregnant women presenting with a fever were recruited. Bloods collected was used for thin and thick smears, perform RDTs and spotted blood on filter paper for DNA extraction and performance of a PCR. Mean parasitaemia was 37,619.06 （＋ 33,599.04） p/pL and 7,512.5 （＋ 12,446.11） p/μL for children and pregnant women, respectively. A total of 87.14% were positive by microscopy, 85.71% by RDTs and 90% by PCR. Distribution of Plasmodium species as identified by PCR was 72.86% Pf/Pm, 11.43% Pf/Pm/Po and 5.43% Pm while 10% were negative. Cohen＇s Kappa value for PCR and RDTs was K = 0.75 （CI = 0.28-1.22） while PCR and microscopy was K = 0.64 （CI = 0.18-1.10）. Malaria infection in Bangolan was mostly due to mix infection predominantly P. falciparum/P, malariae.

关键词： Plasmodium sp. microscopy rapid diagnostic tests PCR children pregnant women.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

引用

Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

引用

Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Secured Transmission of ECG Signals: Numerical and Electronic Simulations

引用

Journal of Signal and Information Processing 2013年第2期4卷 158-169页

作者： Gutenbert Kenfack Alain tiedeu Laboratoire d’Electronique et de Traitement du Signal GRETMAT National Advanced School of Engineering University of Yaoundé I Yaoundé Cameroon

In many domains of science and technology, as the need for secured transmission of information has grown over the years, a variety of methods have been studied and devised to achieve this goal. In this paper, we present an information securing method using chaos encryption. Our proposal uses only one chaotic oscillator both for signal encryption and decryption for?avoiding the delicate synchronisation step. We carried out numerical and electronic simulations of the proposed circuit using electrocardiographic signals as input. Results obtained from both simulations were compared and exhibited a good agreement proving the suitability of our system for signal encryption and decryption.

关键词： Chaos Demultiplexer Decryption Electrocardiogram (ECG) Encryption Multiplexer Secure Communications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A power function model for simulating creep mechanical properties of salt rock

引用

Journal of Central South University 2020年第2期27卷 578-591页

作者： LI Huan Ngaha tiedeu WILLIAM Jaak DAEMEN ZHOU Jun MA Chang-kun State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China School of Civil and Environmental Engineering University of Chinese Academy of SciencesBeijing 100049China School of Resources and Environmental Sciences Chongqing UniversityChongqing 400044China Mackay School of Earth Sciences and Engineering University of NevadaRenoNVUSA

In this paper,a new micro-creep model of salt rock is proposed based on a linear parallel bonded model(LPBM)using the two-dimensional particle flow code(PFC2D).The power function weakening form is assumed to describe the variation of the parallel bonded diameter(PBD)over *** comparing with the parallel-bonded stress corrosion(PSC)model,a smaller stress fluctuation and smoother creep strain−time curves can be obtained by this power function model at the same stress *** validity and adaptability of the model to simulate creep deformation of salt rock are verified through comparing the laboratory creep test curves and the Burgers model fitting *** numerical results reveal that this model can be capable of capturing the creep deformation and damage behavior from the laboratory observations.

关键词： salt rock creep damage particle flow code power function model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chaos-Based Encryption of ECG Signals: Experimental Results

引用

Journal of Biomedical Science and Engineering 2014年第6期7卷 368-379页

作者： Gutenbert Kenfack Alain tiedeu LETS GRETMAT National Advanced School of Engineering University of Yaoundé I Yaoundé Cameroon

In this work, we suggest a system for chaos-based encryption of electrocardiographic signals. It uses simple electronics organized around a colpitts chaotic oscillator. The system has been designed, implemented and tested. The encrypted signal has been decrypted and compared to the original ECG signal. Experimental results were analysed and proved encouraging.

关键词： ECG Colpitts Oscillator Chaos Encryption Decryption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heterogeneous patterning of blood-brain barrier and adaptive myelination as renewing key in gray and white matter

引用

Neural Regeneration Research 2024年第3期19卷 481-482页

作者： barbara Pavan Department of Neuroscience and Rehabilitation University of Ferraravia L BorsariFerraraItalyCenter for Translational Neurophysiology of Speech and Communication(CTNSC)Italian Institute of Technology(IIT)via Fossato di MortaraFerraraItaly

Background:Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier(BBB),which interfaces between the brain parenchyma and the lumen of blood microvessels,and by the blood-cerebrospinal fluid barrier,which separates the cerebrospinal fluid from the blood vessels of the choroid plexus(Villabona-Rueda et al.,2019).Here,the focus will be on the BBB,the impairment of which is considered the earliest common denominator in neurovascular diseases.

关键词： homeostasis blood

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：