检索结果-南通市图书馆

Neur.l regeneration research 2025年第10期20卷 2921-2922页

作者： Ori bar Avi Eran Perlson Department of Physiology and Pharmacology Faculty of Medical&Health ScienceTel-Aviv UniversityTel-AvivIsrael Sagol School of Neuroscience Tel-Aviv UniversityTel-AvivIsrael

Neurons are highly polarized cells with axons reaching over a meter.long in adult *** survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotempor.l signaling and metabolic events,which need to be carried out at the right place,time,and *** mechanisms include axonal transport,local synthesis,and liquid-liquid phase *** and malfunctions in these processes are corr.lated to neurodegenerative diseases such as amyotrophic later.l sclerosis(AlS).

关键词： synthesis local aggregation

Heterogeneity of mature oligodendrocytes in the centr.l nervous system

在线全文

学校读者我要写书评

暂无评论

Neur.l regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.groh Moein Yaqubi Qiao-ling Cui Jo Anne Stratton g.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neur.logy Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the centr.l nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human centr.l nervous system that are highly transcriptomically diverse and vary with centr.l nervous system *** and disease r.lated mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from tempor.lly confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,centr.l nervous system region,age,and disease,

关键词： aging centr.l nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natur.l history neuroglia oligodendroglia single-cell gene expression analysis

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

在线全文

学校读者我要写书评

暂无评论

Neur.l regeneration research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Ker.l lászlógál Sylvia Nürnberger barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripher.l nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and centr.l necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intr.luminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripher.l nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

retention and redistribution of biological legacies generate resource sinks in silvopastor.l systems of Arid Chaco forests

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2019年第1期8卷 344-359页

作者： laura Cavallero Marcela ledesma Dardo r.lópez Carlos A.Carranza Centro Científico Tecnológico(CCT)CONICET Córdoba CórdobaArgentina Estación Forestal INTA-Villa Dolores(EEA Manfredi) CórdobaArgentina

Background:Forests are used for multiple purposes worldwide,which often include timber harvest,firewood extraction and livestock *** excessive pressure on multipurpose systems may decrease soil cover,promoting soil erosion and causing the loss of other resources,as litter and *** forestry practices can help to decrease or mitigate resource loss in the managed ***,retaining and redistributing biological legacies(***,branches,woody debris)at strategic locations can create sediment,litter,and seed-sinks in the silvopastor.l *** addition,grazing management could increase or,even,decrease the success of this *** this study,we assessed the effect of branch barriers and grazing management on resource run-off/runon processes in silvopastor.l systems of Arid Chaco(Córdoba,Argentina).To do this,a 2-ha area was divided in two paddocks that were randomly assigned to different grazing managements:winter *** *** randomly selected 22 water run-off paths in each paddock,and in the half of them,we build elongated branch *** each run-off path(with and without branch barriers),we recorded the amount of accumulated and lost sediment(during the rainy season),litter biomass,germinable seed bank,richness and cover of plant species,and richness and density of seedlings and saplings of woody ***:Branch barriers promoted sediment accumulation during the first and the second year of the study,depending on grazing *** tempor.l and spatial scale of the effect of the branch barriers also depended on grazing *** barriers also trapped litter and seeds,which may have increased the richness and density of seedlings and saplings of woody ***:By intercepting the dominant flow of erosive agents,branch barriers trapped sediment,litter,and propagules of different species.A greater amount of sediment and litter would have improved microsite quality,favouring seed germination an

关键词： Branch barriers Ecosystem degradation Multipurpose forests Soil erosion Winter grazing

Combustion characteristics of low-quality lignite for different bed material sphericities in a circulating fluidized bed boiler:A numerical study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第7期90卷 364-382页

作者： barış gür.l gülşah Karaca Dolgun Osman İpek Ali Keçebaş Department of Mechanical Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy Systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals sever.l key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this r.lationship in the case of glI-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions gener.lly decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with Ilgın lignite showcasing low NO_(x) but high SO_(2) emissions,underscoring the intricate inter.lay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions contr.l,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and SO_(2)emissions Energy production efficiency

Addition of collagen type I in agarose created a dose-dependent effect on matrix production in engineered cartilage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

regenerative Biomaterials 2022年第1期9卷 704-709页

作者： gabriel r.lópez-Marcial Keerthana Elango grace D.O’Connell Department of Mechanical Engineering University of California-Berkeley6141 Etcheverry HallBerkeley CA 94720USA Department of Orthopaedic Surgery University of California-San Francisco500 Parnassus Ave MU-320WSan Francisco CA 94143USA

Extracellular-matrix composition impacts mechanical performance in native and engineered *** studies showed collagen typeⅠ-agarose blends increased cell-matrix interactions and extracellular matrix ***,long-term impacts on protein production and mechanical properties of engineered cartilage are *** objective was to characterize the effect of collagen type I on the matrix production of chondrocytes embedded in agarose *** hypothesized that the addition of collagen would improve longterm mechanical properties and matrix production(*** and glycosaminoglycans)through increased *** hydrogels(2%w/v)were mixed with varying concentrations of collagen typeⅠ(0,2 and 5 mg/ml).Juvenile bovine chondrocytes were added to the hydrogels to assess matrix production over 4 weeks through biochemical assays,and mechanical properties were assessed through unconfined *** observed a dose-dependent effect on cell bioactivity,where 2 mg/ml of collagen improved bioactivity,but 5 mg/ml had a negative impact on *** resulted in a higher modulus for scaffolds supplemented with lower collagen concentration as compared to the higher collagen concentration,but not when compared to the *** conclusion,the addition of collagen to agarose constructs provided a dose-dependent impact on improving glycosaminoglycan production but did not improve collagen production or compressive mechanics.

关键词： hydrogel tissue engineering composition agarose-collagen matrix mechanics

Stepping up after spinal cord injury:negotiating an obstacle during walking

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neur.l regeneration research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in sever.l structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter.limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntar.ly modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical contr.l of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Coarse to Fine: The r.le of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive review

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size contr.l is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primar.ly hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

An SPH Framework for Earthquake-Induced liquefaction Hazard Assessment of geotechnical Structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the lower San Fernando *** agreement for.liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications r.lated to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotempor.l dementia and amyotrophic later.l sclerosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neur.l regeneration research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotempor.l dementia and amyotrophic later.l sclerosis:Frontotempor.l dementia(F T D)and amyo t rophic later.l sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and tempor.l lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis