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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin yang Ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei hu Jing yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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Exfoliation of poly(ethylene glycol)-intercalated graphite oxide composite in water without sonication

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International Journal of Minerals,Metallurgy and Materials 2020年第6期27卷 840-845页

作者： yang hu Chun-bao Sun Jue Kou School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

A novel method for exfoliating graphite oxide(GrO)was implemented through the mass water absorption of a GrO–poly(ethylene glycol)(GrO–PEG)*** GrO–PEG composite was prepared by intercalating PEG into the lamellae of GrO,and the variation of the basal spacing was measured by X-ray diffraction *** yield of graphene was measured with an ultraviolet–visible spectrophotometer,and the properties of graphene oxide(GO)were characterized by atomic force microscopy,transmission electron microscopy(TEM),Raman spectrometry,and Fourier transform infrared *** intercalation time was found to improve the yield of GO,whereas increasing the PEG molecular weight had the opposite *** GO sheets produced from the intercalation–absorption–exfoliation process were found to be a four-layer *** and Raman analyses indicate that the graphitized structure and oxygen groups of GO were preserved during the exfoliation *** importantly,the results show that good-quality GO could be prepared via a mild method involving water absorption of a GrO–PEG composite.

关键词： graphene oxide poly(ethylene glycol) intercalation exfoliation

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu Zhang Aihua Yuan hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng hu Long yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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掺聚合物纤维面板混凝土的防裂抗冻性能

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土木工程与管理学报 2017年第2期34卷 60-63页

作者：戈雪良陆采荣梅国兴刘伟宝王珩杨虎南京水利科学研究院水文水资源与水利工程科学国家重点实验室江苏南京210029 南京水利科学研究院国家能源水电工程安全与环境技术研发中心江苏南京210029

严寒区面板混凝土的抗裂防冻性能对大坝的耐久性具有较大影响,本文采用平板法研究了不同聚丙烯腈纤维掺量对掺粉煤灰面板混凝土的早期抗裂性;采用冻融试验、气泡参数试验方法研究了掺聚丙烯腈纤维面板混凝土的质量损失、相对动弹性模量... 详细信息

严寒区面板混凝土的抗裂防冻性能对大坝的耐久性具有较大影响,本文采用平板法研究了不同聚丙烯腈纤维掺量对掺粉煤灰面板混凝土的早期抗裂性;采用冻融试验、气泡参数试验方法研究了掺聚丙烯腈纤维面板混凝土的质量损失、相对动弹性模量变化、气泡参数变化特征。研究结果表明:细短型聚丙烯腈纤维在面板混凝土内分布的平均间距约为5.98 mm,聚丙烯腈纤维的增强阻裂效果提高了面板混凝土的强度和早期抗裂性;掺入聚丙烯腈纤维后,面板混凝土的引气效果更好,且引入气泡的间距系数小于200μm,聚丙烯腈纤维弹性模量随温度降低而增大的特点,可以提高面板混凝土的抗冻性能。

关键词：面板混凝土聚丙烯腈纤维早期抗裂冻融气泡参数机理分析

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基于古代汉语实践思维的大棚温室无线控制系统

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农机化研究 2025年第4期47卷 218-223页

作者：罗杨胡士强宜宾学院四川宜宾644000 红河学院云南红河661100

为了实现对大棚温室内环境的实时监测和控制,提高农作物的生长质量和产量,将古代汉语实践思维注重实际应用和实践操作、强调“知行合一”的理念,应用到大棚温室无线控制系统的设计中,注重系统的实际应用,通过设计无线采集子模块、无线... 详细信息

为了实现对大棚温室内环境的实时监测和控制,提高农作物的生长质量和产量,将古代汉语实践思维注重实际应用和实践操作、强调“知行合一”的理念,应用到大棚温室无线控制系统的设计中,注重系统的实际应用,通过设计无线采集子模块、无线控制子模块、供电网络子模块和各个子电路,实现了整个系统。测试结果表明:系统采集温度的差值为±0.2℃,相对湿度差值为±2%RH,且与系统预设的温湿度值基本一致,准确性较高,符合设计需求。

关键词：大棚无线控制农作物古代汉语实验思维

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Electrokinetic and permeation characterization of hydrolyzed polyacrylonitrile (PAN) hollow fiber ultrafiltration membrane

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Science China Chemistry 2009年第5期52卷 683-689页

作者： bao WenXuan XU ZhenLiang yang hu Membrane Science and Engineering R&D Laboratory Chemical Engineering Research CenterEast China University of Science and TechnologyShanghai 200237China

PAN membrane and hydrolyzed PAN membranes with the same pore size were used to investigate the relationship between the electrokinetic property and permeation performance by streaming potential measurement and ion exchange technology. SEM and FT-IR/ATR spectra were employed to analyze the reaction and the presence of the amide groups. The thickness of the polyacrylic acid (PAA) layer on the membrane surface measured by ion-exchange titration technology increased with the reaction time, and that on membrane hydrolyzed for 50 min could reach 10.8 nm. Streaming potential measurement was used to study the influence of the carboxylic and nitrile group on the membrane surface on their separation property. Zeta potential measured in pure water had close relationship with the permeation property. This measurement also proved that there was a maximum zeta potential between zero and the concentration tested. For the ionization or dissociation of the carboxylic group on the membrane surface, treated membranes had a more flexible zeta potential range than that of the untreated membrane in the pH range of 3-9. They were all negative in pure water and 1 g·L-1 KCl solution, while the membranes hydrolyzed for 30 min and 50min had IEPs at pH 5.5 and 6.1 in 1 g·L-1 MgCl2 solution. Special inflection points of all the membranes were observed in AlCl3 solution for the positive colloid structure of Al(OH)3.

关键词： polyacrylonitrile (PAN) zeta potential ultrafiltration hollow fiber membrane

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语音情感识别在联合收割机疲劳驾驶预警中的研究——基于汉语语言音韵

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农机化研究 2025年第3期47卷 202-206页

作者：胡士强罗杨红河学院云南红河661100 宜宾学院四川宜宾644000

通过汉语语言音韵的语音情感识别实现联合收割机疲劳驾驶检测具有非侵入性、高效准确、实时性强、可普及性强和应用场景广泛等优点。因此,为了提高疲劳驾驶准确识别率,将梅尔频率倒谱系数和汉语语言音韵融合在一起,利用高斯混合模型和... 详细信息

通过汉语语言音韵的语音情感识别实现联合收割机疲劳驾驶检测具有非侵入性、高效准确、实时性强、可普及性强和应用场景广泛等优点。因此,为了提高疲劳驾驶准确识别率,将梅尔频率倒谱系数和汉语语言音韵融合在一起,利用高斯混合模型和极限学习机作为分类器进行语音疲劳检测。检测结果表明:该方法疲劳识别率很高,平均正确识别率达到了93.17%,具有较高的实用价值和推广价值。

关键词：汉语语言音韵情感识别联合收割机疲劳驾驶

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Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance Li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi Lian Kang hu Qiuju Li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range Li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and Li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range Li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： Li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)

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