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New insights into gibberellin signaling in regulating flowering in Arabidopsis

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Journal of Integrative Plant Biology 2020年第1期62卷 118-131页

作者： shengjie bao Changmei Hua Lisha shen Hao Yu Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Temasek Life Sciences Laboratory National University of SingaporeSingapore 117604Singapore

In angiosperms,floral transition is a key developmental transition from the vegetative to reproductive growth,and requires precise regulation to maximize the reproductive success.A complex regulatory network governs this transition through integrating flowering pathways in response to multiple exogenous and endogenous *** are essential for proper plant developmental regulation and have been extensively studied for their involvement in the floral *** various phytohormones,gibberellin(GA)plays a major role in affecting flowering in the model plant Arabidopsis *** GA pathway interact with other flowering genetic pathways and phytohormone signaling pathways through either DELLA proteins or mediating GA *** this review,we summarize the recent advances in understanding the mechanisms of DELLA-mediated GA pathway in flowering time control in Arabidopsis,and discuss its possible link with other phytohormone pathways during the floral transition.

关键词： Arabidopsis integrating flowering

Evolution of genes and genomes: an emerging paradigm in life science

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Science China(Life Sciences) 2019年第4期62卷 435-436页

作者： Manyuan long Bairong shen Department of Ecology & Evolution The University of Chicago Institutes for Systems Genetics West China Hospital Sichuan University

Traditional molecular biology,defined in a broad sense to include most of life science research that focuses on single or a few genes to understand their functions and application values to medicine and agriculture,ha... 详细信息

关键词： broad life research

Feedback of Efficient Shock Acceleration on Magnetic-field Structure Inside Young Type Ia Supernova Remnants

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Research in Astronomy and Astrophysics 2024年第6期24卷 234-244页

作者： Jun-Yu shen Bi-Wen bao Li Zhang Department of Astronomy Key Laboratory of Astroparticle Physics of Yunnan ProvinceYunnan UniversityKunming 650091China Key Laboratory of Statistical Modeling and Data Analysis of Yunnan Province Yunnan UniversityKunming 650091China

Using an effective adiabatic index γ_(eff) to mimic the feedback of efficient shock acceleration,we simulate the temporal evolution of a young type Ia supernova remnant (SNR) with two different background magnetic field(BMF) topologies:a uniform and a turbulent *** density distribution and magnetic-field characteristics of our benchmark SNR are studied with two-dimensional cylindrical magnetohydrodynamic *** γ_(eff)is considered,we find that:(1) the two-shock structure shrinks and the downstream magnetic-field orientation is dominated by the Rayleigh–Taylor instability structures;(2) there exists more quasi-radial magnetic fields inside the shocked region;and (3) inside the intershock region,both the quasi-radial magnetic energy density and the total magnetic energy density are enhanced:in the radial direction,with γ_(eff)=1.1,they are amplified about 10–26 times more than those with γ_(eff)=5/*** in the angular direction,the total magnetic energy densities could be amplified about 350 times more than those with γ_(eff)=5/3,and there are more grid cells within the intershock region where the magnetic energy density is amplified by a factor greater than 100.

关键词： methods:numerical ISM:magnetic fields ISM:supernova remnants magnetohydrodynamics(MHD)

Thirty years of research on driving behavior active intervention:A bibliometric overview

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第5期10卷 721-742页

作者： Miaomiao Yang Qiong bao Yongjun shen Qikai Qu School of Transportation Southeast UniversityNanjing 211189China

To better understand the research focus and development direction in the field of driving behavior active intervention,thereby laying a scientific foundation for further research,we used the combination of topic words and keywords to retrieve relevant articles from the Core Collection Database of Web of Science(WOS).A total of 578 articles published from1992 to 2022 were finally ***,the time distribution characteristics,country distribution,institution distribution and main source journal distribution of published articles were ***,by using the Cite Space and VOSviewer software,cited reference co-citation analysis,keyword co-occurrence analysis and burst detection analysis were carried out respectively to visually explore the knowledge base,research topic,research frontier and development trend of this *** results indicate that the USA,Australia and China are the three most active countries in the studies of driving behavior active *** Analysis&Prevention,Transportation Research Part F:Traffic Psychology and Behavior,and Journal of Safety Research are widely selected journals for publications related to this *** research frontiers in the field of driving behavior active intervention focus on:“traffic safety and crashes analysis,as well as enforcement intervention”,“driving risk and education for young drivers”,“information provision and driving behavior”,“workload and situation awareness for automated driving”.It is worth noting that in recent years,“warning system”,“time”,“work load”have become research hotspots in this *** sum up,by a bibliometric overview of research on driving behavior active intervention over the past thirty years,this paper clarifies the development skeleton of this research field,determines its hot topics and research progress,and provides a reference for the follow-up exploratory scientific research in this field.

关键词： Driving behavior Active intervention Bibliometric analysis Mapping knowledge domain Visualization

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao Liang Shu-Peng Liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng shen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,P<0.001].Additionally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,P<0.001).Multivariate and univariate analyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,P<0.001)were significant risk factors for GPs,while pepsinogen I was identified as a protective *** PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen shen Liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

long TIME ASYMPTOTIC BEHAVIOR OF SOLUTIONS OF EXPLICIT DIFFERENCE SCHEME FOR SEMILINEAR PARABOLIC EQUATIONS

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Journal of Computational Mathematics 2002年第5期20卷 543-550页

作者： Hui Feng long-jun shen Department of Mathematics Wuhan UniversityWuhan 430072China Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics P.O.Box 8009Beijing 100088China

Presents a study that investigated the asymptotic behavior of discrete solutions in comparison to the case of continuous solutions. Numerical representation of the problem; Details on the solution of explicit differen... 详细信息

关键词： asymptotic behavior explicit difference scheme semilinear prarbolic equations

Chincona Alkaloid-Catalyzed Enantioselective Trifluoromethylthiolation of Oxindoles

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Chinese Journal of Chemistry 2014年第8期32卷 678-680页

作者： Tao Yang Qilong shen long Lu Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

An organocatalytic asymmetric trifluoromethylthiolation of 3-aryl or 3-alkyloxindoles employing a trifluoromethyl-substituted thioperoxide as the electrophilic trifluoromethylthiolating reagent was *** occurred in goo... 详细信息

关键词： organocatalytic fluorine trifluoromethylthio asymmetric oxindole

Innovative Strategies for Overall Water Splitting Using Nanostructured Transition Metal Electrocatalysts

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Electrochemical Energy Reviews 2022年第4期5卷 286-315页

作者： Asad Ali Fei long Pei Kang shen Collaborative Innovation Center of Sustainable Energy Materials Guangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Processing for Non-Ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004PR China Guilin University of Technology Guilin 541004China

Electrochemical water splitting is regarded as the most auspicious technology for renewable sources,transport,and storage of hydrogen ***,noble Pt metal and noble-metal oxides(IrO_(2)and RuO_(2))are recognized as state-of-the-art electrocatalysts for both the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),*** for earth-abundant electrocatalysts for the HER and OER with remarkable performance and high stability to replace precious metals plays a significant role in the commercial application of electrochemical water *** this review,recent advancements in nanostructured transition metal electrocatalysts are assessed through the selected examples of nitrides,carbides,phosphides,sulfides,borides,layered double hydroxides,and *** breakthroughs in nanostructured transition metal electrocatalysts are discussed in terms of their mechanisms,controllable production,structural design,and innovative strategies for boosting their *** instance,most nanostructured transition metal electrocatalysts for overall water splitting(OWS)only function well in neutral and alkaline ***,current research challenges and future perspectives for increasing the performance of nanostructured transition metals for OWS are proposed.

关键词： Hydrogen evolution reaction(HER) Oxygen evolution reaction(OER) Overall water splitting(OWS) Transition metal electrocatalyst Innovative strategies Basic electrochemistry