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Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis

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World Journal of Gastroenterology 2013年第26期19卷 4200-4208页

作者： Xin-Hong He Wen-Tao Li Ya-Jia gu bao-Feng Yang Hui-Wen Deng Yi-Hua Yu Wei-jun Peng Department of Radiology Fudan University Shanghai Cancer Center Shanghai Key Laboratory of Functional Magnetic Resonance Imaging Physics Department East China Normal University

AIM: To investigate the metabolic profiles of xenograft pancreatic cancer before and after radiotherapy by high-resolution magic angle spinning proton magnetic resonance spectroscopy (HRMAS 1H NMR) combined with principal components analysis (PCA) and evaluate the radiotherapeutic effect. METHODS: The nude mouse xenograft model of human pancreatic cancer was established by injecting human pancreatic cancer cell SW1990 subcutaneously into the nude mice. When the tumors volume reached 800 mm3 , the mice received various radiation doses. Two weeks later, tumor tissue sections were prepared for running the NMR measurements. 1H NMR and PCA were used to determine the changes in the metabolic profiles of tumor tissues after radiotherapy. Metabolic profiles of normal pancreas, pancreatic tumor tissues, and radiationtreated pancreatic tumor tissues were compared. RESULTS: Compared with 1H NMR spectra of the normal nude mouse pancreas, the levels of choline, taurine, alanine, isoleucine, leucine, valine, lactate, and glutamic acid of the pancreatic cancer group were increased, whereas an opposite trend for phosphocholine, glycerophosphocholine, and betaine was observed. The ratio of phosphocholine to creatine, and glycerophosphocholine to creatine showed noticeable decrease in the pancreatic cancer group. After further evaluation of the tissue metabolic profile after treatment with three different radiation doses, no significant change in metabolites was observed in the 1H NMR spectra, while the inhibition of tumor growth was in proportion to the radiation doses. However, PCA results showed that the levels of choline and betaine were decreased with the increased radiation dose, and conversely, the level of acetic acid was dramatically increased. CONCLUSION: The combined methods were demonstrated to have the potential for allowing early diagnosis and assessment of pancreatic cancer response to radiotherapy.

关键词： High-resolution magic angle spinning proton magnetic resonance spectroscopy Principal components analysis Pancreatic cancer Radiotherapy

Abandonment and Recovery Operation of Steel Lazy-Wave Riser in Deepwater by Controlled Vessel and Cable Velocity Rate

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China Ocean Engineering 2023年第1期37卷 29-41页

作者： gu Ji-jun HUANG jun GAO Lei CHEN Lei-lei JIA Ji-chuan WANG Shu-jiang College of Mechanical and Transportation Engineering China University of Petroleum-BeijingBeijing 102249China CNOOC Research Institute Beijing 100028China

Evaluation of abandonment and recovery operation of steel lazy-wave riser in deepwater is presented in this *** calculation procedure includes two single continuous SLWR and cable segments, which are coupled together to form the overall mathematical model. Then the equilibrium equations of SLWR and cable are established based on minimum total potential energy principle. The coupled equations are discretized by the finite difference method and solved by Newton-Raphson technique in an iterative manner. The present method is validated by well-established commercial code OrcaFlex. Recovery methods by considering different ratios of vessel’s moving velocity to cable’s recovery velocity are evaluated to optimize the abandonment and recovery operation. In order to keep the tension more stable during the recovery process, the rate ratio before leaving the seabed is increased, and the rate ratio after leaving the seabed is reduced.

关键词： steel lazy-wave riser abandonment recovery

Evaluating and Improving Linear Regression Based Profiling:On the Selection of Its Regularization

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Journal of Computer Science & Technology 2020年第5期35卷 1175-1197页

作者： Xiang-jun Lu Chi Zhang Da-Wu gu jun-Rong Liu Qian Peng Hai-Feng Zhang School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China ZhiXun Crypto Testing and Evaluation Technology Co.Ltd. Shanghai 200240China Department of Microelectronics and Nanoelectronics Tsinghua UniversityBeijing 100084China Beijing Smartchip Microelectronics Technology Co. Ltd.Beijing 100082China

Side-channel attacks(SCAs)play an important role in the security evaluation of cryptographic *** a form of SCAs,profiled differential power analysis(DPA)is among the most powerful and efficient by taking advantage of a profiling phase that learns features from a controlled *** regression(LR)based profiling,a special profiling method proposed by Schindler et al.,could be extended to generic-emulating DPA(differential power analysis)by on-the-fly *** formal extension was proposed by Whitnall et *** SLR-based ***,to improve SLR-based method,Wang et *** a method based on ridge ***,the constant format of L-2 penalty still limits the performance of *** this paper,we generalize the ridge-based method and propose a new strategy of using variable *** then analyze from a theoretical point of view why we should not use constant penalty format for all *** speaking,our work reveals the underlying mechanism of how different formats affect the profiling process in the context of side ***,by selecting a proper regularization,we could push the limits of LR-based ***,we conduct simulation-based and practical experiments to confirm our ***,the results of our practical experiments show that the proper formats of regularization are different among real devices.

关键词： side-channel attack(SCA) cryptography linear regression based profiling generic-emulating differential power analysis regularization

Integrative square-grid triboelectric nanogenerator as a vibrational energy harvester and impulsive force sensor

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Nano Research 2018年第2期11卷 1157-1164页

作者： Chuan He Weijun Zhu guang Qin gu Tao Jiang Liang Xu bao Dong Chen Chang bao Han Dichen Li Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST) Beijing China State Key Laboratory of Manufacturing Systems Engineering Xi’an Jiaotong University Xi’an China Collaborative Innovation Center of High-End Manufacturing Equipment Xi’an Jiaotong University Xi’an China University of Chinese Academy of Sciences Beijing China School of Materials Science and Engineering Georgia Institute of Technology Atlanta USA

A square-grid triboelectric nanogenerator （SG-TENG） is demonstrated for harvesting vibrational energy and sensing impulsive forces. Each square of the three-dimensional （3D）-printed square grid is filled with an aluminum （A1） ball. The grid structure allows the SG-TENG to harvest vibrational energy over a broad bandwidth and operate at different vibrational angles. The most striking feature of the SG-TENG is its ability of being scaled and integrated. After connecting two SG-TENGs in parallel, the open-circuit voltage and short-circuit current are significantly increased over the full vibrational frequency range. Being integrated with a table tennis racket, the SG-TENG can harvest the vibrational energy from hitting a ping pong ball using the racket, where a direct hit by the racket generates an average output voltage of 10,9 ~ 0.6 V and an average output current of 0.09 ± 0.02 boA. Moreover, the SG-TENG integrated into a focus mitt can be used in various combat sports, such as boxing and taekwondo, to monitor the frequency and magnitude of the punches or kicks from boxers and other practitioners. The collected data allow athletes to monitor their status and improve their performance skills. This work demonstrates the enormous potential of the SG-TENG in energy harvesting and sensing applications.

关键词： square grid triboelectric nanogenerator vibration sensor

Clinical characteristics of patients with Haff disease after eating crayfish

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World Journal of Emergency Medicine 2019年第3期10卷 156-159页

作者： Cai-jun Wu Hai-jiang Zhou Wei gu Department of Emergency Medicine Dongzhimen Hospital Institute of Sepsis Beijing University of Chinese Medicine Beijing 100700 China Department of Emergency Medicine Beijing Chao-yang Hospital Capital Medical University Beijing China Emergency Medicine Center Chuiyangliu Hospital Affi liated to Tsinghua University Beijing China

BACKGROUND: The study aimed to explore the clinical presentations, laboratory findings, treatments and prognosis of patients with Haff disease after eating crayfi sh. METHODS: Sixteen patients with Haff disease after eating crayfish were admitted to the Emergency Department of Beijing Chao-yang Hospital between june 2013 and August 2017. Clinical data was retrospectively analyzed. RESULTS: Alcohol consumption and exercise were found to be most commonly associated with the onset of rhabdomyolysis after consuming crayfi sh. Most patients were young adults and the symptoms mostly occurred within 24 hours of consumption of crayfi sh. Clinical symptoms included myalgia (100%), fatigue (87.5%), nausea (43.8%), dizziness (62.5%), chest distress (37.5%) and fever (18.8%). Also found after laboratory testing was elevations in the levels of creatine kinase (11,376±5,535 U/L), myoglobin (350±158 ng/mL), lactate dehydrogenase (6,539±3,180 U/L), alanine transaminase (174±71 U/L) and aspartate aminase (348±100 U/L). The incidence of renal dysfunction was low (6.25%), and all 16 patients had a good prognosis. CONCLUSION: Patients with Haff disease exhibited typical symptoms after consuming crayfish, and laboratory findings gave highly accurate diagnostic results. The development of rhabdomyolysis was considered to be associated with alcohol consumption and exercise, but further studies are needed to demonstrate its relationship with crayfi sh consumption. Compared with other causes of rhabdomyolysis, rhabdomyolysis after crayfi sh consumption has fewer complications and better prognosis.

关键词： Haff disease Rhabdomyolysis Crayfish

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文明叙事:习近平文化思想的方法论审视

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 34-42页

作者：张明谷生秀南京大学马克思主义学院江苏南京210023

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基... 详细信息

文明是中国共产党百余年推进马克思主义中国化时代化的核心线索,文明叙事是中国共产党历史叙事的重要维度,也是习近平文化思想的重要方法论。习近平文化思想的深厚文明意蕴体现在四个方面:一是从历史纵深出发把握“走自己的路”的文明基因,即从中华5000多年文明的历史传承中把握中国道路的来龙去脉及其内在逻辑必然;二是以“第二个结合”为根本方法,重塑发展中华文明的使命担当,不断推动建设中华民族现代文明实现传统文明的现代新生;三是坚守文明超越理念,将新文明的建构与中国式现代化的现实实践相互关联,以中国式现代化创造人类文明新形态,打破西方以资本逻辑为核心的形而上学抽象文明观的历史困境;四是坚持文明交流互鉴,推动落实全球文明倡议,构建人类文明交往新范式。

关键词：习近平文化思想文明叙事 “走自己的路” “第二个结合” 文明交流互鉴

Effects of Pr on the structure and magnetic properties of FePt alloys

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Rare Metals 2007年第1期26卷 19-22页

作者： CHENG Gang gu Zhengfei ZGOU Huaiying CHENG jun YUAN Songliu Department of Physics Huazhong University of Science and Technology Wuhan 430074 China Department of Information Materials Science and Engineering Guilin University of Electronic Technology Guilin 541004 China

The effects of Pr on the structure and magnetic properties of PrxFe60.5-xPt39.5 alloys （x = 0, 0.5, 1.0, and 1.5） were investigated. X-ray diffraction data indicated that the phase transition temperature of FePt based alloys from disordered face-centered-cubic to ordered face-centered-tetragonal cubic decreases with the increase in Pr concentration. Pr plays the role of a grain refiner and it can enhance the exchange coupling between soft magnetic phase and hard magnetic phase. The results indicate that the replacement of Fe by Pr can significantly improve the remanence and coercivity of the Fe60.5Pt39.5 alloy. These results can be explained on the basis of phase transformation and microstructure. Both the remanence ratio and coercivity of the FePt based alloy as a function of the Pr content are increased by the optimum addition of 0.5 at.% Pr.

关键词： phase transformation exchange coupling anisotropy constant Fe-Pt based alloys

A Trade-off between Propagation Length and Light Confinement in Cylindrical Metal-Dielectric Waveguides

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Chinese Physics Letters 2011年第5期28卷 222-225页

作者： SUN bao-Qing gu Ying HU Xiao-Yong GONG Qi-Huang State Key Laboratory for Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871

We theoretically investigate the hybrid plasmonic modes of cylindrical nanocables with gold nanocore and two dielectric nanolayers(SiO2 and BN).By solving a complete set of Maxwell's equations,the propagation constants and effective radii depending on geometrical parameters are numerically *** declining a trade-off between propagation length and light confinement,high quality hybrid modes which can travel a long range of 120-200λwith a subwavelength effective radius are obtained at the optical *** modes in one-dimensional cylindrical waveguides should have potential applications in nanoscale optical device designs.

关键词： optical cylindrical propagation

Awakening the oxygen evolution activity of MoS_(2) by oxophilic-metal induced surface reorganization engineering

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Journal of Energy Chemistry 2021年第11期30卷 546-551,I0013页

作者： Xueqin Mu Yang Zhu Xiangyao gu Shipeng Dai Qixin Mao Lintao bao Wenxuan Li Suli Liu Jianchun bao Shichun Mu Jiangsu Key Laboratory of Biofunctional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023JiangsuChina Key Laboratory of Advanced Functional Materials of Nanjing Nanjing Xiaozhuang UniversityNanjing 211171JiangsuChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology guangdong Laboratory Xianhu hydrogen ValleyFoshan 528200GuangdongChina

Although molybdenum disulfide (MoS_(2))-based materials are generally known as active electrocatalysts for the hydrogen evolution reaction (HER), the inert performance for the oxygen evolution reaction (OER) seriously limits their wide applications in alkaline electrolyzers due to there exists too strong metal-sulfur (M−S) bond in MoS_(2). Herein, by means of surface reorganization engineering of bimetal Al, Co-doped MoS_(2) (devoted as AlCo_(3)-MoS_(2)) through in situ substituting partial oxidation, we successfully significantly activate the OER activity of MoS_(2), which affords a considerably low overpotential of 323 mV at −30 mA cm^(−2), far lower than those of MoS_(2), Al-MoS_(2) and Co-MoS_(2) catalysts. Essentially, the AlCo_(3)-MoS_(2) substrate produces lots of M−O (M=Al, Co and Mo) species with oxygen vacancies, which trigger the surface self-reconstruction of pre-catalysts and simultaneously boost the electrocatalytic OER activity. Moreover, benefiting from the moderate M−O species formed on the surface, the redistribution of surface electron states is induced, thus optimizing the adsorption of OH* and OOH* intermediates on metal oxyhydroxides and awakening the OER activity of MoS_(2).

关键词： Surface reorganization engineering Porous nanosheets Oxygen evolution reaction MoS_(2) Oxophilic-metal