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Surf4,cargo trafficking,lipid metabolism,and therapeutic implications

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Journal of Molecular Cell Biology 2022年第9期14卷 3-13页

作者： Yishi Shen hong-Mei gu Shucun Qin Da-Wei Zhang Group on the Molecular and Cell Biology of Lipids and Department of Pediatrics Faculty of Medicine and DentistryUniversity of AlbertaEdmonton ABT6R2G3Canada Institute of Atherosclerosis in Shandong First Medical University(Shandong Academy of Medical Sciences) Taian 271016China

Surfeit 4 is a polytopic transmembrane protein that primarily resides in the endoplasmic reticulum(ER)*** is ubiquitously expressed and functions as a cargo receptor,mediating cargo transport from the ER to the Golgi apparatus via the canonical coat protein complex Il(CoPll)-coated vesicles or specific *** also participates in ER-Golgi protein trafficking through a tubular ***,it facilitates retrograde transportation of cargos from the Golgi apparatus to the ER through Coplcoated ***4 can selectively mediate export of diverse cargos,such as PCSK9 very low-density lipoprotein(VLDL),progranulin,α1-antitrypsin,STING,proinsulin,and *** has been implicated in facilitating VLDL secretion,promoting cell proliferation and migration,and increasing replication of positive-strand RNA ***,Surf4 plays a crucial role in various physiological and pathophysiological processes and emerges as a promising therapeutic ***,the molecular mechanisms by which Surf4 selectively sorts diverse cargos for ER-Golgi protein trafficking remain ***,we summarize the most recent advances in Surf4,focusing on its role in lipid metabolism.

关键词： VLDL secretion cargo receptor PCSK9 lipid metabolism atherosclerosis trafficking

Vitamin A regulates intramuscular adipose tissue and muscle development:promoting high-quality beef production

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1138-1147页

作者： Dong Qiao Peng Stephen B.Smith hong gu Lee Department of Animal Science and Technology Sanghuh College of Life SciencesKonkuk UniversitySeoul 05029South Korea Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA

During growth in cattle,the development of intramuscular adipose tissue and muscle is dependent upon cell hyperplasia(increased number of adipocytes)and hypertrophy(increased size of adipocytes).Based on the results of previous studies,other adipose tissue depots(e.g.,perirenal and subcutaneous)develop from the fetal stage primarily as brown adipose *** hyperplastic stage of intramuscular adipose is considered to develop from late pregnancy,but there is no evidence indicating that intramuscular adipose tissue develops initially as brown adipose *** growth of intramuscular adipose continues well into postweaning and is dependent on the timing of the transition to grain-based diets;thereafter,the late-stage development of intramuscular adipose tissue is dominated by *** muscle development,hyperplasia of myoblasts lasts from early(following development of somites in the embryo)to middle pregnancy,after which growth of muscle is the result of hypertrophy of *** A is a fat-soluble compound that is required for the normal immunologic function,vision,cellular proliferation,and *** we review the roles of vitamin A in intramuscular adipose tissue and muscle development in *** A regulates both hyperplasia and hypertrophy in in vitro *** A supplementation at the early stage and restriction at fattening stage generate opposite effects in the beef *** vitamin A supplementation and restriction strategy increase intramuscular adipose tissue development(i.e.,marbling or intramuscular fat)in some in vivo ***,hyperplasia and hypertrophy of myoblasts/myotubes were affected by vitamin A treatment in in vitro ***,some studies reported an interaction between the alcohol dehydrogenase-1C(ADH1C)genotype and vitamin A feed restriction for the development of marbling and/or intramuscular adipose tissue,which was dependent on the timing and level of vitamin A

关键词： Adipose tissue Cattle Intramuscular adipose tissue Muscle development Vitamin A

A simple Pb-doping to achieve bonding evolution, VSn and resonant level shifting for regulating thermoelectric transport behavior of SnTe

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Journal of Materials Science & Technology 2023年第20期151卷 66-72页

作者： Xu-Ye Xin Jun Ma hong-Quan Liu Yi-Jie gu Yan-Fang Wang hong-Zhi Cui College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China School of Mechanical-electronic and Vehicle Engineering Weifang UniversityWeifang 261061China School of Materials Science and Engineering China University of Petroleum HuadongQingdao 266580China

The intensification of energy crises and environmental pollution inspire researchers’attention to environment-friendly SnTe thermoelectric *** this work,we achieved a lower lattice thermal conductivity and optimized the power factor via the synergistic optimization of bonding characteristic,VSn,and resonant level for the SnTe system,***-introduction produces weak bonding strength,mass fluctuation,and stress distortion,which result in lower thermal *** lowest lattice thermal conductivity achieves 0.66 W m^(–1) K^(–1) at 773 *** introduced VSn relieves loss of electrical conductivity caused by Pb-introduction,and it also makes the bigger g(E)and up-shift of resonance *** VSn,enhanced g(E),and resonant level make electrical conductivity and Seebeck coefficient enhance ***,the further optimization of thermal and electronic transport performance contributes to a higher ZT value of∼0.86 at 773 K in the Sn_(0.685)Pb_(0.285)In_(0.015)Te_(0.7)Se_(0.3) *** strategy of bonding characteristic,VSn,and resonant level synergistic engineering will be widely applicable to various TE systems for achieving better thermoelectric performance.

关键词： SnTe-based material Low thermal conductivity Projected crystal orbital hamiltonian populations VSn Resonant level

A Trade-off between Propagation Length and Light Confinement in Cylindrical Metal-Dielectric Waveguides

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Chinese Physics Letters 2011年第5期28卷 222-225页

作者： SUN bao-Qing gu Ying HU Xiao-Yong GONG Qi-Huang State Key Laboratory for Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871

We theoretically investigate the hybrid plasmonic modes of cylindrical nanocables with gold nanocore and two dielectric nanolayers(SiO2 and BN).By solving a complete set of Maxwell's equations,the propagation constants and effective radii depending on geometrical parameters are numerically *** declining a trade-off between propagation length and light confinement,high quality hybrid modes which can travel a long range of 120-200λwith a subwavelength effective radius are obtained at the optical *** modes in one-dimensional cylindrical waveguides should have potential applications in nanoscale optical device designs.

关键词： optical cylindrical propagation

Awakening the oxygen evolution activity of MoS_(2) by oxophilic-metal induced surface reorganization engineering

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Journal of Energy Chemistry 2021年第11期30卷 546-551,I0013页

作者： Xueqin Mu Yang Zhu Xiangyao gu Shipeng Dai Qixin Mao Lintao bao Wenxuan Li Suli Liu Jianchun bao Shichun Mu Jiangsu Key Laboratory of Biofunctional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023JiangsuChina Key Laboratory of Advanced Functional Materials of Nanjing Nanjing Xiaozhuang UniversityNanjing 211171JiangsuChina State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Foshan Xianhu Laboratory of the Advanced Energy Science and Technology guangdong Laboratory Xianhu hydrogen ValleyFoshan 528200GuangdongChina

Although molybdenum disulfide (MoS_(2))-based materials are generally known as active electrocatalysts for the hydrogen evolution reaction (HER), the inert performance for the oxygen evolution reaction (OER) seriously limits their wide applications in alkaline electrolyzers due to there exists too strong metal-sulfur (M−S) bond in MoS_(2). Herein, by means of surface reorganization engineering of bimetal Al, Co-doped MoS_(2) (devoted as AlCo_(3)-MoS_(2)) through in situ substituting partial oxidation, we successfully significantly activate the OER activity of MoS_(2), which affords a considerably low overpotential of 323 mV at −30 mA cm^(−2), far lower than those of MoS_(2), Al-MoS_(2) and Co-MoS_(2) catalysts. Essentially, the AlCo_(3)-MoS_(2) substrate produces lots of M−O (M=Al, Co and Mo) species with oxygen vacancies, which trigger the surface self-reconstruction of pre-catalysts and simultaneously boost the electrocatalytic OER activity. Moreover, benefiting from the moderate M−O species formed on the surface, the redistribution of surface electron states is induced, thus optimizing the adsorption of OH* and OOH* intermediates on metal oxyhydroxides and awakening the OER activity of MoS_(2).

关键词： Surface reorganization engineering Porous nanosheets Oxygen evolution reaction MoS_(2) Oxophilic-metal

Morphological evolution of CdS films prepared by chemical bath deposition

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Rare Metals 2013年第4期32卷 380-389页

作者： Xing-Yu Peng hong-Wei gu Teng Zhang Fei Qu Fa-Zhu Ding hong-Yan Wang Key Laboratory of Applied Superconductivity Institute of Electrical Engineering Chinese Academy of Sciences

In this article, the growth process of chemical bath deposited CdS films was systematically investigated. The structural, optical, and morphological properties were investigated by X-ray diffraction （XRD）, transmission electron microscope （TEM）, UV-Vis spectrophotometer, scanning electron microscope （SEM）, respectively. CdS nanocubes with size of less than 500 nm and nanocrystal-lites with diameter of less than 5 nm forming in reaction solution are observed. According to the TEM results and the SEM morphological evolution of CdS films, a crystal-lite-by-crystallite growth mechanism is proposed to eluci-date the growth process of chemical bath deposited CdS films based on the present growth mechanism.

关键词： CdS Chemical bath deposition Growthmechanism Crystallite-by-crystallite

Structure and Absorbability of a Nanometer Nonmetallic Polymer Thin Film Coating on Quartz Used in Piezoelectric Sensors

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Chinese Physics Letters 2013年第10期30卷 191-194页

作者： gu Yu LI Qiang TIAN Fang-Fang XU bao-Jun Department of Mechanics School of Civil EngineeringBeijing Jiaotong UniversityBeijing 100044

We present a new type of gas piezoelectric sensor taking quartz piezoelectric crystal as the basal material and nanometer nonmetallic polymer thin film coating as the *** coating,plated by vacuum electron beam dispersion(EBD)coating technology,is carried out by employing a nanometer nonmetallic polymer thin film that has properties of selecting and identifying characteristic *** experimental survey shows that EBD coating technology can produce a uniform thickness of the thin film coating,and the physical and chemical analyses show that the coating has a high performance of absorption using the method of infrared ***,the absorption and sensitivity performance of the thin film coating will change if other organic materials are added to the coated thin *** the measurement of the thin film coating,the feature of sensitivity to the change of humidity is *** on the above description,a new type of gas piezoelectric sensor is designed and manufactured reasonably,which provides a valid method to rapidly monitor and distinguish complex gases.

关键词： coating piezoelectric absorption

A space power system of free piston Stirling generator based on potassium heat pipe

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Frontiers in Energy 2020年第1期14卷 1-10页

作者： Mingqiang LIN Jian MOU Chunyun CHI guotong hong Panhe GE gu HU Key Laboratory of Space Energy Conversion Technology Technical Institute of Physics and ChemistryUniversity of Chinese Academy of SciencesBeijing 100049China China Institute of Atomic Energy China National Nuclear CorporationBeijing 100822China

The power system of a free piston Stirling generator(FPSG)based on potassium heat pipes has been developed in this *** to the advantages of long life,high reliability,and high overall thermal efficiency,the FPSG is a promising candidate for nuclear energy,especially in space *** this paper,the recent progress of FPSG based on nuclear reactor for space use was briefly reviewed.A novel FPSG weighted only 4.2 kg was designed,and one dimensional thermodynamic modeling of the FPSG using Sage software was performed to estimate its *** experiment results indicated that this FPSG could provide 142.4 W at a thermal-to-electric efficiency of nearly 17.4%.Besides,the power system integrated with four FPSGs and potassium heat pipes was performed and the single machine failure test was *** results show that this system could provide an electrical power of 300 W at an overall thermal efficiency of 7.3%.Thus,it is concluded that this power system is feasible and will have a great prospect for future applications.

关键词： free piston Stirling generator(FPSG) potassium heat pipe power system energy conversion

Growth mechanism of CdS film prepared by chemical bath deposition

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Rare Metals 2014年第3期33卷 324-329页

作者： Xing-Yu Peng hong-Wei gu Teng Zhang Fa-Zhu Ding Fei Qu hong-Yan Wang Key Laboratory of Applied Superconductivity Institute of Electrical Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences

In this paper, sodium citrate was adopted as a complexing agent and ammonia merely served as pH adjustor to investigate the growth mechanism of CdS film The growth rate, structural properties, surface morphology microstructure, and optical properties of CdS films were studied by profilometer, X-ray diffractometer（XRD）scanning electron microscopy（SEM）, transmission elec tron microscopy（TEM）, and spectrophotometer, respec tively. The SEM images show that CdS films prepared with higher ammonia concentration have lower nucleation density on substrate. SEM and EDS results show that the formation of Cd（OH）2is not required in the growth of CdS film. As the ammonia concentration increases, the sites tha previously adsorbed S2-are taken by OH-which leads to lower S2-density on substrate. CdS film forms through direct reaction of Cd2？with the S2-which are adsorbed on the substrate. Lower S2-density on the substrate results in the decrease of particle density on the substrate. The as deposited CdS films have relatively high-average trans mittance（＊80 %） in the wavelength range from 500 to1,000 nm which makes them suitable to be used in sola cell.

关键词： CdS Chemical bath deposition Ammoniaconcentration Growth mechanism