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基于智能计算噬菌体的细菌宿主范围预测

微生物学报 2024年第2期64卷 344-363页

作者：王博宇杨孜孜 sun Fengzhu 王颖厦门大学自动化系福建厦门361000 厦门大学国家健康医疗大数据厦门研究院福建厦门361000 美国南加州大学量化与计算生物系加利福尼亚州洛杉矶CA900894 厦门市大数据智能分析与决策重点实验室福建厦门361000

针对噬菌体的细菌宿主范围预测对于深入理解噬菌体及将其作为抗生素替代用于生物疗法具有重要意义。传统生物实验方法确定噬菌体的细菌宿主范围受到极有限的噬菌体可培养性和严苛的培养条件限制,而高通量测序技术所提供的海量基因组或... 详细信息

针对噬菌体的细菌宿主范围预测对于深入理解噬菌体及将其作为抗生素替代用于生物疗法具有重要意义。传统生物实验方法确定噬菌体的细菌宿主范围受到极有限的噬菌体可培养性和严苛的培养条件限制,而高通量测序技术所提供的海量基因组或宏基因组序列提供了噬菌体及细菌重要的序列信息,因此智能计算为预测噬菌体的细菌宿主范围提供了可行方法。本文从智能计算的角度对噬菌体的细菌宿主范围预测研究进行系统梳理,从噬菌体感染细菌的过程入手,描述配对预测模型所依赖的特征及其生物合理性,归纳宿主范围预测的智能模型、建模原理及预测策略,总结建模训练和评估所依赖的参考数据集与真实数据及评价指标。本文特别注意挖掘和分析各信息手段、模型、方法其背后的生物合理性及其依赖的生物机理。本综述期望推动基于智能算法的噬菌体的细菌宿主范围预测研究发展,并探索将生物先验结合人工智能实现噬菌体侵袭细菌宿主的本质机理推断,同时也为基于噬菌体的临床应用提供参考与借鉴。

关键词：微生物组噬菌体-宿主相互作用预测模型智能算法机器学习神经网络

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 224-231页

作者： Guo-Fu Liang Sheng Chao Zhou sun Ke-Jing Zhu Qian Chen Lei Jia Yu-Lin Niu Department of Organ Transplantation School of Clinical MedicineGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Kidney transplantation is the best option for patients with end-stage renal ***,the need for lifelong immunosuppression results in renal transplant recipients being susceptible to various *** equi(***)is a rare opportunistic pathogen in humans,and there are limited reports of infection with *** in post-renal transplant recipients and no uniform standard of *** article reports on the diagnosis and treatment of a renal transplant recipient infected with *** 21 mo postoperatively and summarizes the charac-teristics of infection with *** after renal transplantation,along with a detailed review of the ***,we present the case of a 25-year-old man who was infected with *** 21 mo after renal *** the clinical features at the time of presentation were not specific,chest computed tomography(CT)showed a large volume of pus in the right thoracic cavity and right middle lung atelectasis,and fiberoptic bronchoscopy showed an endobronchial mass in the right middle and lower lobe *** culture and metagenomic next-generation sequen-cing sequencing of the pus were suggestive of *** *** immunosup-pressive drugs were immediately suspended and intravenous vancomycin and azithromycin were administered,along with adequate drainage of the *** endobronchial mass was then *** the patient’s clinical symptoms and chest CT presentation resolved,he was switched to intravenous ciprofloxacin and azithromycin,followed by oral ciprofloxacin and *** patient was re-hospitalized 2 wk after discharge for recurrence of *** *** recovered after another round of adequate abscess drainage and intravenous ciprofloxacin and *** Infection with *** in renal transplant recipients is rare and complex,and the clinical presentation lacks *** antibiotic therapy is required,and adequate abscess drainage and s

关键词： Kidney transplantation Rhodococcus equi Pleural empyema Pulmonary atelectasis Immunosuppression Case report

Sequence-controlled dynamic covalent units enable decoupling of mechanical and self-healing performance of polymers

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Science China Chemistry 2024年

作者： Luzhi Zhang Hongfei Huang Lijie sun Xiaopeng Ma Hui Tan Zhengwei You Respiratory Department Shenzhen Children's Hospital Affiliated to Shantou University Medical College State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsShanghai Key Laboratory of Lightweight CompositeShanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua University Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China

Sequence regulation provides an effective approach to controlling the properties of polymer ***,this approach remains an open question in the field of dynamic polymers,which emerge as more and more important new generation ***,we systematically investigate the effect of sequence control of dynamic covalent units in tuning the properties of *** sequence-controlled poly(oxime-urethanes) are *** dynamic oxime-urethane groups are relatively dispersed (SCP-1) or concentrated (SCP-2) distributed in their molecular *** sequence control strategy provides an efficient way to decouple the mechanical and self-healing performance of polymers,which is one of the most pressing challenges in the *** relatively dispersed oxime-urethane groups in SCP-1 not only facilitate the reorganization of the dynamic covalent bonds but also increase the probability of the reformation of hydrogen *** reversible dissociation/reassociation of dynamic bonds is conducive to dissipating energy to enhance mechanical performance and promote self-healing *** a result,SCP-1 exhibits much faster self-healing than SCP-2,and its tensile strength is nearly twice that of *** addition,energy dissipation capacity and degradation behavior also show significant sequence ***,this work reveals a new molecular structure-property relationship and provides a powerful strategy to construct high-performance polymers.

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Decomposition of pre-existing Au–P clusters induced in situ a-Fe grains uniformization in Fe–P-based nanocrystalline alloys

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Rare Metals 2024年第10期43卷 5242-5255页

作者： Min-Hao Han Cheng sun Guo-Guo Xi Yang Meng Qiang Luo Xue-Qian Yu Wen-Feng Zhang Hao Liu Hong-Jie Xu Tao Zhang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang University Laboratory of Functional Fiber Materials Institute of Bast Fiber CropsChinese Academy of Agricultural Science School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast University Institute for Advanced Materials North China Electric Power University Center for Advanced Analysis and Computational Science Zhengzhou University

In Fe-based amorphous-/nanocrystalline ribbons,the uniformization and refinement of a-Fe grains are key aspects for optimizing their soft magnetic and mechanical ***,the Fe–P–C–B nanocrystalline alloy system was selected for *** produced as-spun ribbons with pre-existing nanocrystals through melt-quenching and then obtained a well-distributed a-Fe nanocrystalline structure through annealing below the first crystallization onset temperature （633 K）resulting in excellent magnetic properties (saturation magnetization of 1.65 T and coercivity of 1.6 A·m-1)ultra-wide annealing temperature window （from 613 to 733 K）,and extremely high annealing stability （up to 480 min at 633 K）.Furthermore,we propose a new in situ two-step mechanism for the uniformization of a-Fe nanocrystals,which is separately induced by the decomposition of the Au–P clusters and the pre-existing a-Fe nanocrystals during *** work underscores the crucial significance of micro-alloying via metastable clusters primarily influenced by metal-phosphide interactions in the process of refining a-Fe ***,i introduces a new principle for optimizing the comprehensive properties of Fe-based amorphous/nanocrystalline alloys.

关键词： Fe-based nanocrystalline alloys In-situ nano-crystallization Micro-alloying Soft magnetic property

Error Analysis of A New Higher Order Boundary Element Method for A Uniform Flow Passing Cylinders

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China Ocean Engineering 2023年第3期37卷 369-377页

作者： sun Shi-yan CUI Jie bao Chao-ming School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

A higher order boundary element method(HOBEM)is presented for inviscid flow passing cylinders in bounded or unbounded *** traditional boundary integral equation is established with respect to the velocity potential and its normal *** present work,a new integral equation is derived for the tangential *** boundary is discretized into higher order elements to ensure the continuity of slope at the element *** velocity potential is also expanded with higher order shape functions,in which the unknown coefficients involve the tangential *** expansion then ensures the continuities of the velocity and the slope of the boundary at element *** extensive comparison of the results for the analytical solution of cylinders,it is shown that the present HOBEM is much more accurate than the conventional BEM.

关键词： higher order boundary element method(HOBEM) error analysis integral equations for potential and velocity cylinders

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海军军事训练伤研究进展

解放军医院管理杂志 2017年第5期24卷 477-479页

作者：王新伟孙金海张宝陈礼潮孙欣然第二军医大学卫生勤务学系军队健康管理学教研室上海200433

对军事训练伤、骨骼肌肉损伤和骨骼肌肉疾患三个概念进行区分和鉴别,全面总结军事训练伤的危险因素(个体因素、体能素质和活动量、行为习惯、训练组织管理、环境心理等)和目前主要的干预策略(健康宣教、训练组织、心理辅导、医务督导和... 详细信息

对军事训练伤、骨骼肌肉损伤和骨骼肌肉疾患三个概念进行区分和鉴别,全面总结军事训练伤的危险因素(个体因素、体能素质和活动量、行为习惯、训练组织管理、环境心理等)和目前主要的干预策略(健康宣教、训练组织、心理辅导、医务督导和营养供给);提出未来军事训练伤的研究方向和重点:明确军事训练伤的概念,增强训练伤研究方法科学性,加强训练伤研究内容系统性,提升训练伤防治研究的内涵。

关键词：军事训练伤危险因素干预策略

马来酸酐接枝聚丙烯增强碳纤维织物聚丙烯复合材料界面的研究

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塑料工业 2021年第10期49卷 126-130页

作者：任毅景鹏展孙宝忠周剑锋朱姝胡益男余木火东华大学上海市高性能纤维复合材料省部共建协同创新中心民用航空复合材料东华大学协同创新中心上海201620 东华大学纺织学院上海201620 宁波信泰机械有限公司浙江宁波315800

研究了马来酸酐接枝聚丙烯(MAPP)偶联剂对碳纤维织物(CFF)增强聚丙烯(PP)复合材料力学性能的影响以及CFF与基体的界面相互作用。采用模压成型工艺制备了一系列不同MAPP含量的CFF/PP复合材料层合板。扫描电镜观察断裂形貌发现,随着MAPP... 详细信息

研究了马来酸酐接枝聚丙烯(MAPP)偶联剂对碳纤维织物(CFF)增强聚丙烯(PP)复合材料力学性能的影响以及CFF与基体的界面相互作用。采用模压成型工艺制备了一系列不同MAPP含量的CFF/PP复合材料层合板。扫描电镜观察断裂形貌发现,随着MAPP的加入,断口拔出的CFF中PP基体覆盖较多,CFF/PP界面脱黏较少。随着MAPP添加量的增加,界面黏结力得到改善。复合材料的弯曲强度、弯曲模量、拉伸强度、拉伸模量、冲击强度和层间剪切强度均显著提高2~10倍。当MAPP质量分数超过10%~15%后,力学性能趋于平稳然后下降。

关键词：碳纤维织物力学性能马来酸酐接枝聚丙烯界面相互作用

无溶剂聚焦微波提取/气-质联机分析肉豆蔻挥发油

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食品科学 2007年第9期28卷 484-487页

作者：郑福平孙宝国谢建春刘玉平杜丹丹北京工商大学化学与环境工程学院北京100037

采用无溶剂聚集微波提取法从肉豆蔻种仁中提取肉豆蔻挥发油,提取率8.23%。对所得挥发油进行气-质联机分析,用计算机质谱库检索结合气相色谱保留指数二维定性方法,共鉴定出42种挥发性成分,总相对含量为98.62%,主要成分为香桧烯(23.93%)... 详细信息

采用无溶剂聚集微波提取法从肉豆蔻种仁中提取肉豆蔻挥发油,提取率8.23%。对所得挥发油进行气-质联机分析,用计算机质谱库检索结合气相色谱保留指数二维定性方法,共鉴定出42种挥发性成分,总相对含量为98.62%,主要成分为香桧烯(23.93%)、肉豆蔻醚(11.60%)、α-蒎烯(9.52%)、β-蒎烯(8.95%)、4-松油醇(5.27%)、柠檬烯(4.47%)、榄香脂素(4.03%)、对伞花烃(3.38%)和黄樟油素(3.16%)等。

关键词：无溶剂聚焦微波提取肉豆蔻油挥发性成分保留指数

CGRP经鼻用药促进蛛网膜下腔出血后脑血供和VEGF表达

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中国药理学通报 2009年第12期25卷 1571-1574页

作者：孙保亮申发平曹明志杨明峰袁慧张颜波谢方民山东省高校脑微循环重点实验室、泰山医学院附属医院神经内科山东泰安271000 大庆油田总医院集团龙南医院黑龙江大庆163001 济宁医学院附属湖西医院神经外科山东菏泽274300 泰山医学院附属医院神经外科山东泰安271000

目的探讨经鼻给予降钙素基因相关肽(CGRP)对蛛网膜下腔出血(SAH)后脑血供和血管内皮生长因子(VEGF)表达的影响。方法将Wistar大鼠随机分入正常对照组、SAH组、经鼻生理盐水(NS)+SAH、经鼻CGRP+SAH组。用枕大池两次注入自体动脉血法制作... 详细信息

目的探讨经鼻给予降钙素基因相关肽(CGRP)对蛛网膜下腔出血(SAH)后脑血供和血管内皮生长因子(VEGF)表达的影响。方法将Wistar大鼠随机分入正常对照组、SAH组、经鼻生理盐水(NS)+SAH、经鼻CGRP+SAH组。用枕大池两次注入自体动脉血法制作SAH模型,CGRP和NS经鼻腔给予。用激光多普勒血流计检测皮层局部脑血流量(rCBF)动态变化;于第2次枕大池注血后3d,将大鼠处死取脑制作冰冻切片,用免疫荧光结合激光共聚焦显微镜检测大脑皮层VEGF蛋白表达。结果解剖学观察表明SAH模型制作成功。SAH组和经鼻NS+SAH组大鼠大脑皮层rCBF持续下降,经鼻CGRP+SAH组大脑皮层rCBF下降的程度较轻。第2次枕大池注血后3d,SAH组和经鼻NS+SAH组大鼠大脑皮层VEGF蛋白表达增多,经鼻CGRP+SAH组大鼠大脑皮层VEGF蛋白表达进一步增强。结论CGRP经鼻用药可缓解SAH脑血供下降,并促进血管新生。

关键词：降钙素基因相关肽经鼻给药蛛网膜下腔出血脑血管痉挛脑血供血管内皮生长因子血管新生