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Enhancing Clinical Efficacy through the Gut Microbiota: A New Field of Traditional Chinese Medicine

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engineering 2019年第4期5卷 40-49页

作者： yan-Meng Lu Jiao-Jiao Xie cong-Gao {2. {3.-Hong wang Kai-Cen wang Lan-Juan Li state Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003 China

Traditional Chinese medicines (TCMs) have a long history of playing a vital role in disease prevention, symptom alleviation, and health improvement. However, their complex ingredients and as-yetunknown mechanisms restrict their application. With increasing evidence indicating that the gut microbiota is important in host health and may be associated with the therapeutic activity of TCM components, it may now be possible to assess the effects of TCMs from the perspective of the gut microbiota. The gut microbiota functions within four major physiological pathways as follows: It participates in host metabolism, forms global immunity, maintains homeostasis of the gastrointestinal tract, and affects brain function and host behavior. This article reviews the reported correlations between TCMs and certain diseases, such as chronic liver disease, ulcerative colitis, obesity, and type 2.diabetes, and elucidates the underlying mechanisms, with a focus on changes in the gut microbiota. In future, further studies are required with more advanced experimental design in order to reveal the interactions between TCMs and the gut microbiota, and provide new insight into and guidance for TCM-based drug discovery.

关键词： Traditional Chinese medicines Gut microbiome Fatty liver disease Ulcerative colitis Obesity Diabetes

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封丘县典型农田土壤质量与时空变化特征

生态与农村环境学报 2024年第3期40卷 408-417页

作者：谢越马东豪王擎运赵炳梓朱安宁张丛志张佳宝李晓鹏安徽农业大学资源与环境学院安徽合肥230036 土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 江苏南京210008

黄淮海平原作为我国重要的粮食产区,系统全面地评价该区域典型潮土的质量变化,对指导农业生产具有重要意义。以典型潮土分布的封丘县作为研究区,选取1984、2.03.2.11年的17项土壤指标,基于土壤参与生态过程中作物生产、碳固存、持水净... 详细信息

黄淮海平原作为我国重要的粮食产区,系统全面地评价该区域典型潮土的质量变化,对指导农业生产具有重要意义。以典型潮土分布的封丘县作为研究区,选取1984、2.03.2.11年的17项土壤指标,基于土壤参与生态过程中作物生产、碳固存、持水净化和养分运移等功能,构建土壤综合质量评价系统,采用主成分分析结合逼近理想点排序法(TOPSIS)计算各功能得分及土壤质量综合指数,通过GIS空间插值描述封丘县2.年内潮土耕作区土壤质量和功能的时空变化特征。结果表明:(1)封丘县土壤全氮、全磷、碱解氮、有效磷、速效钾和有机质含量及阳离子交换量、饱和导水率和孔隙度均呈现不同程度的提升趋势;全钾含量、pH、容重、田间持水量和有效含水量则呈逐年降低趋势;(2.封丘县土壤作物生产、碳固存和养分运移功能得分均有所提升,增长率分别为9.2.%、9.68%和7.3.%,持水净化功能得分则降低4.17%;(3.封丘县土壤质量综合指数提升较为明显,1984年全县耕地土壤质量综合指数均≤2.0,2.03.综合指数>2.0的耕地面积占全县总面积的8.44%,2.11年提升至2..05%。整体而言,封丘县该时期的耕地保护和利用模式基本是有效的,封丘县耕地整体质量不断向好的方向发展,相关结果可以为黄淮海地区耕地资源可持续利用提供参考。

关键词：土壤质量评价体系土壤功能黄淮海平原 TOPSIS法 GIS

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan {2. Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 3. GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 3. MW per beam,it can achieve a luminosity of 5×10^(3.)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13.ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,{3.5)and the Conceptual Design Report(CDR,{3.8),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.3.s.

关键词： initiated exceeding precise

Effects of greenness on preterm birth: A national longitudinal study of 3.7 million singleton births

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The Innovation 2022年第3期3卷 57-63页

作者： Lina Zhang Shuyan Shi Shenpeng Wu Ying yang Jihong Xu Ya Zhang Qiaomei {3. Haiping Shen Yiping Zhang Donghai yan Zuoqi peng cong Liu Weidong {3. Yixuan Jiang Su Shi Renjie Chen Haidong Kan Yuan He Xia Meng Xu Ma School of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China National Research Institute for Family Planning Beijing 100081China National Human Genetic resources Center Beijing 101199China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaBeijing 100088China Children’s Hospital of Fudan university National Center for Children’s HealthShanghai 201102China Peking Union Medical College Beijing 100730China Chinese Academy of Medical Sciences Beijing 100730China

Exposure to greenness may lead to a wide range of beneficial health ***,the effects of greenness on preterm birth(PTB)are inconsistent,and limited studies have focused on the subcategories of PTB.A total of 3.751,672.singleton births from a national birth cohort in china's Mainland were included in this *** was estimated using the satellitebased Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index with 500-m and 1,000-m buffers around participants’*** subcategories of PTB(2.-3. weeks)included extremely PTB(EPTB,2.-2. weeks).

关键词： mainland birth inconsistent

The primary dolostone in the Meso-Neoproterozoic:Cases study on platforms in china

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Journal of Palaeogeography 2022年第2期11卷 151-172页

作者： Zhi-Dong bao Han-Cheng Ji Yuan wang Zong-Feng Li Ting Liang Bo Niu Ming-{2.g Wei Kai Lu {2.-Qing Shi Hua Zhang Pu Wan Zhuo-Lun Li Zhi-Bo {2.g Rui Liu Can-Xing Liu Xu-Lin Zhong Xiao-Qi Guo peng-Fei Xiang Zhong-Xian Cai Shui-Chang Zhang china university of Petroleum(Beijing) Beijing 102249China state Key Laboratory of Petroleum resources and Prospecting Ministry of EducationBeijing 102249China china university of Geosciences(Wuhan) Wuhan 430074China Petro china Research Institute of Petroleum Exploration and Development Beijing 100083China

Meso-Neoproterozoic dolostone is abnormally well-developed in the platform areas in china,detailly,in the Mesoproterozoic Calymmian Wumishan Formation of North china Basin,Neoproterozoic Ediacaran Qigbulak Formation of Tarim Basin,and the Neoproterozoic Ediacaran Dengying Formation of Sichuan *** outcrops and drilling cores from these basins show that these dolostones are mostly thick-bedded to massive,with mud-sized to silt-sized crystalline dolostone reaching 86%-97%of the total dolostone *** dolostones basically suffered no secondary metasomatism,regardless of containing microorganisms(such as algae and bacteria)or *** analyses of sedimentary palaeogeographic features indicate that:(1)the Meso-Neoproterozoic dolostone nearly covered the entire area basins,and was widely deposited in supratidal to intertidal zones,as well as in open platform environments;(2.the dolostone was subdivided according to the crystalline size,with the distribution controlled by geomorphology,i.e.,the pure mud-sized crystalline dolostone developing in depression areas,whereas the grainy mud-sized crystalline dolostone or the mound stromatolitic mud-sized crystalline dolostone developing in uplift areas;(3.deep-{2. basins developed between the carbonate platforms,and the seismic profiles show that these basins were formed by syngenetic deep faults in the Meso-Neoproterozoic *** syngenetic faults increased Mg^(2.)concentration in the sea{2. by injecting rich-Mg2.-bearing hydrothermal fluids into the carbonate *** analyses of geochemical and paleoclimatic indexes reveal that there is no obvious difference in carbon and oxygen isotope ratios between dolostones having different textures,with the ratios similar to those of the global sea{2. of the Meso-Neoproterozoic,indicating that the silt-sized crystalline dolostone has the same sedimentary origin as the mud-sized crystalline dolostone,i.e.,the former is from authigenic recrystallization of the

关键词： Thick-bedded to massive dolostone C-O isotopes Meso-Neoproterozoic Tarim basin Sichuan basin North china Basin

Lifetime measurement for the 2.+1 state in^106Cd

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Chinese Physics C 2020年第9期44卷 76-82页

作者： Jian Zhong Ying-Jun Ma Xiao-Guang Wu bao-Ji Zhu cong-Bo Li Guang-Sheng Li Yun Zheng Qi-Ming Chen Chuang-Ye He Li-Tao Deng Wen-Kui Zhou Ke-{2. Ma Dong {2.g Hao Guo Jia-Qi wang Xian Guang Ji Sun Hui-Bin Sun Shi-peng Hu Lin Gan Hai-Ge Zhao Qi Luo Zheng-Xin Wu College of Physics and Optoelectronic engineering Shenzhen UniversityShenzhen 518060China china Institute of Atomic Energy Beijing 102413China College of Physics Jilin UniversityChangchun 621010China

The lifetime of the 2.+1 state in ^106Cd populated via the ^94Zr(^16O,4n)^106Cd reaction has been measured with the Recoil Distance Doppler Shift technique in combination with the Differential Decay Curve *** subtracting the contamination in the data,the mean lifetime of the I^π=2.+163. keV state was determined as 9.9(12.*** B(E2.value calculated in this study is in good agreement with the experimental systematics and was compared to the shell model calculations.

关键词： lifetime measurement the Differential Decay Curve Method experimental systematics

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乌江梯级水库碳氮耦合的生物地球化学循环

上海大学学报（自然科学版） 2015年第3期21卷 294-300页

作者：王宝利刘丛强汪福顺刘小龙彭希赵颜创中国科学院地球化学研究所环境地球化学国家重点实验室贵阳550002 上海大学环境与化学工程学院上海200444 天津师范大学天津市水资源与水环境重点实验室天津300387

以乌江梯级水库及相关河段为研究对象,对溶解CO_2.NO_3.-含量的时空变化特征进行了研究.溶解CO_2.均值为(113.6±105.7)μmol·L^(-1),变化为1.6~93..6μmol·L^(-1);NO_3.-平均值为(163.0±104.9)μmol·L^(-1),变化为0.4~63.0}0μmol·L^(-1).水库采样点溶解CO_2.NO_3.-的含量以及振幅均小于相应河流采样点.由于来源及影响因素不同,河流采样点CO_2.NO_3.-不存在显著性相关.筑坝建库后,水库浮游植物生物作用增强,成为影响物质循环的重要因素.光合作用和呼吸作用将C和N的生物地球化学循环耦合在一起,致使水库CO_2.NO_3.-表现出显著性相关.研究结果表明,梯级水电开发显著改变了原始河流C和N的生物地球化学循环特征.

关键词：碳氮耦合浮游植物呼吸作用水电开发乌江

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磁性斯格明子的多场调控研究

物理学报 2018年第13期67卷 209-226页

作者：董博闻张静言彭丽聪何敏张颖赵云驰王超孙阳蔡建旺王文洪魏红祥沈保根姜勇王守国北京科技大学材料科学与工程学院材料物理与化学系北京100083 中国科学院物理研究所磁学国家重点实验室北京100190

斯格明子(skyrmion)的概念最早是由英国的粒子物理学家Tony Skyrme提出,它被用来描述粒子的一个状态,是一种拓扑孤立子.磁性斯格明子是一种具有拓扑行为的新型磁结构,其空间尺寸为纳米量级,空间距离从纳米到微米量级可调;其存在温度涵... 详细信息

斯格明子(skyrmion)的概念最早是由英国的粒子物理学家Tony Skyrme提出,它被用来描述粒子的一个状态,是一种拓扑孤立子.磁性斯格明子是一种具有拓扑行为的新型磁结构,其空间尺寸为纳米量级,空间距离从纳米到微米量级可调;其存在温度涵盖从低温、室温到高温的宽温区;其材料体系不仅包括早期发现的低温区B2.型中心对称破缺的铁磁体和螺旋磁有序的弱铁磁材料,也包括近期发现的室温及以上的中心对称六角结构磁性MnNiGa金属合金和磁性薄膜/多层膜体系.利用磁性斯格明子的拓扑磁结构可以实现类似于自旋阀或者磁性隧道结中的自旋转移矩效应,即外加电流可以驱动斯格明子,其临界电流密度比传统翻转磁性多层膜体系中磁矩的电流密度(一般为10~7A/cm^2.要低5个数量级,约为10~2./cm^2.该临界值远低于硅基半导体技术中沟道电流密度的上限,在未来的磁信息技术中具有广泛的应用前景.本综述简单介绍了磁性斯格明子的发展历程,归纳总结了磁性斯格明子的材料体系,介绍了观察磁性斯格明子的实验手段,重点介绍了多场(磁场、电流、温度场)调控作用下中心对称MnNiGa合金和Pt/Co/Ta磁性多层膜体系中磁性斯格明子的产生、消失以及外场调控演变等动态行为.

关键词：斯格明子拓扑磁性磁畴结构磁成像

Improved air quality and reduced burden of preterm birth in china:2.13.2.17

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Science Bulletin 2022年第9期67卷 879-882,M0003页

作者： Yixuan Jiang Yuan He Shenpeng Wu Renjie Chen Ying yang Jihong Xu Ya Zhang Qiaomei {2. Haiping Shen Yiping Zhang Donghai yan Zuoqi peng Xudong Dong Hongping Zhang Lifang Jiang Huichu Li Yixiang Zhu cong Liu Weidong {2. Xia Meng Tao Pei Ci Song Aaron Cohen Xu Ma Jing Cai Haidong Kan School of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China National Research Institute for Health and Family Planning Beijing 100081China National Human Genetic resources Center Beijing 101199China Peking Union Medical College Beijing 100730China Chinese Academy of Medical Sciences Beijing 100730China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaBeijing 100044China The Obstetrical Department of the First People’s Hospital of Yunnan Province The Affiliated Hospital of Kunming University of Science and TechnologyKunming 650500China Wenzhou People’s Hospital Wenzhou Maternal and Child Health Care HospitalThe Third Clinical Institute Affiliated to Wenzhou Medical UniversityWenzhou 305006China National Health Commission Key Laboratory of Birth Defects Prevention Henan Key Laboratory of Population Defects PreventionHenan Institute of Reproduction Health Science and TechnologyZhengzhou 450002China Department of Environmental Health Harvard T.H.Chan School of Public HealthBoston 02115USA state Key Laboratory of resources and Environmental Information System Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of resources and Environment University of Chinese Academy of SciencesBeijing 101408China Health Effects Institute Boston 02110USA Institute for Health Metrics and Evaluation University of WashingtonSeattle 98195USA Children’s Hospital of Fudan university National Center for Children’s HealthShanghai 201102China

Preterm birth(PTB)is a leading cause of perinatal mortality and morbidity worldwide[1].Since maternal and fetal health protection has been included in the United Nations Sustainable Development Goals,identification of modifiable risk factors for PTB is particularly *** Global Burden of Disease(GBD)Study 2.19 recognized fine particulate matter(PM2.5)pollution as a risk factor for decreased gestational age and low birth weight.

关键词： pollution 空气质量改善疾病负担