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Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： Wei-wei Jia Hua-wei Lin Min-guang yang Ya-ling Dai yan-yi Ding Wen-shan Xu Si-nuo {2. Ya-jun Cao Sheng-xiang Liang Zhi-fu {2. cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina The Institute of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina National-Local Joint engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina Traditional Chinese Medicine Rehabilitation Research Center of state Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

Objective Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer’s disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the specific mechanism involved remains to be ***,this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial *** The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKα1-subunit conditional knockout(AMPKα1-cKO)were used for *** evaluate the effects of EA treatment on cognitive function,the T-maze and Morris water maze were *** addition,chemical exchange saturation transfer,thioflavin staining,transmission electron microscopy,mitochondrial membrane potential,and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 *** Both APP/PS1 mice and AMPKα1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory *** of the AMPK/peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)pathway increased pathological amyloid-β(Aβ)deposition and aggravated the dysfunction in mitochondrial *** addition,EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1αpathway,specifically by reducing pathological Aβdeposition,normalizing energy metabolism,protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins,and downregulating the expression of fission ***,the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by AMPKα1 *** The regulation of hippocampal mitochondrial dynamics and reduction in Aβdeposition via the AMPK/PGC-1αpathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo wang Xin Zheng yan Huang Bei-Ling Li yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-bao Zheng Hua-Dong yan Guo-Hong Deng Liang Qiao yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang yan Xiong cong-cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-yan Liu Wei Yuan Xue Mei Jing Li Tao Li Rong-Jiong Zheng Xin-Yi Zhou Jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina state key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(2..2.)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 2.9(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(2..8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(2.2.535)for type-C ACLF,36.0%(36/100)for type-B ACLF,2..0%(58/2.5)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/2.9)for LC-A,and 1.2.(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

基于代谢组学研究中药固肠止泻丸治疗小鼠溃疡性结肠炎的机制

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中国新药杂志 2024年第11期33卷 1144-1154页

作者：范安琪侯宝龙朱洁梁艳妮王征陕西中药资源产业化省部共建协同创新中心/秦药特色资源研究开发国家重点实验室(培育)/陕西省创新药物研究中心/陕西中医药大学咸阳712083

目的:固肠止泻丸为溃疡性结肠炎患者的临床专家推荐用药。课题组前期研究发现固肠止泻丸对结肠炎的临床效果与肠道微生物密切相关,但固肠止泻丸在治疗溃疡性结肠炎方面的作用机制仍不明确。方法:采用2.5%葡聚糖硫酸钠建立溃疡性结肠炎... 详细信息

目的:固肠止泻丸为溃疡性结肠炎患者的临床专家推荐用药。课题组前期研究发现固肠止泻丸对结肠炎的临床效果与肠道微生物密切相关,但固肠止泻丸在治疗溃疡性结肠炎方面的作用机制仍不明确。方法:采用2.5%葡聚糖硫酸钠建立溃疡性结肠炎小鼠模型,探讨固肠止泻丸对溃疡性结肠组织病理变化、疾病活动指数、炎症细胞因子的影响。同时采用液相色谱串联质谱技术检测小鼠血清样本中代谢物水平,并结合主成分分析和正交偏最小二乘法判别分析筛选出差异代谢物,采用MetaboAnalyst 5.0确定与差异代谢物有关的代谢通路。结果:固肠止泻丸降低小鼠疾病活动指数评分,改善结肠组织形态,降低小鼠血清中的肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β含量,升高白细胞介素-4、白细胞介素-10含量。代谢组学结果显示,与固肠止泻丸调控相关的潜在差异代谢物共18个,主要涉及甘油磷脂代谢、不饱和脂肪酸的合成、亚麻酸代谢、α-亚麻酸代谢、嘌呤代谢。结论:固肠止泻丸对溃疡性结肠炎有一定的防治作用,其机制可能与调节甘油磷脂代谢、不饱和脂肪酸的合成、亚麻酸代谢、α-亚麻酸代谢、嘌呤代谢有关。

关键词：固肠止泻丸溃疡性结肠炎代谢组学液相色谱串联质谱

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山区铁路隧道工程资源环境影响效应评估研究

铁道科学与工程学报 2024年第4期21卷 1613-1623页

作者：闫林君陈慧鑫鲍学英王起才李亚娟兰州交通大学土木工程学院甘肃兰州730070

山区地质复杂、环境敏感、生态脆弱,致使铁路隧道建设难度大,且在资源节约、环境保护等方面面临较高要求。绿色设计作为绿色建设的先行环节,对减少隧道建设对资源环境的扰动作用,达到资源节约、环境友好的目的起关键引领作用。为定量评... 详细信息

山区地质复杂、环境敏感、生态脆弱,致使铁路隧道建设难度大,且在资源节约、环境保护等方面面临较高要求。绿色设计作为绿色建设的先行环节,对减少隧道建设对资源环境的扰动作用,达到资源节约、环境友好的目的起关键引领作用。为定量评估山区铁路隧道工程的资源环境影响效应、衡量隧道设计的绿色程度,提出一种山区铁路隧道工程资源环境影响效应分析方法。首先,基于“驱动力-状态-响应”模型(Driving force-state-Response,DSR),以隧道设计参数为驱动力指标、资源环境状况为状态指标、隧道设计措施为响应指标,构建山区铁路隧道工程资源环境影响效应评估指标体系,并建立各指标分级标准;其次,运用一种具有自学习自调整能力的支持向量回归模型(Support Vector Regression,SVR)对隧道工程的资源环境影响效应进行评估;再次,以驱动力指标和响应指标为分析对象,运用考虑指标间关联关系及叠加效应的敏感性分析法,甄别对隧道工程资源环境影响效应优化具有重要影响的隧道设计因素;最后,以某山区铁路隧道工程为例,得到该隧道工程的资源环境影响效应值为4.7157,对应等级为较好,表明该隧道工程绿色设计水平较好,资源集约节约利用较合理、环境保护力度较大,可为其他类似工况隧道工程的绿色设计提供借鉴。此外,分析结果显示,注浆加固效果是导致该隧道工程资源环境影响效应变化最敏感的因素,其次为清污分流比例,可着重从这2.方面进行优化设计,以实现隧道工程资源环境影响效应的进一步优化。研究结果验证了本文研究方法的适用性和可操作性,可为山区铁路隧道工程资源环境影响效应评估及明确隧道工程优化设计方向提供科学依据。

关键词：山区铁路隧道工程资源环境影响效应 “驱动力-状态-响应”模型支持向量回归模型敏感性分析

Enhancing Clinical Efficacy through the Gut Microbiota: A New Field of Traditional Chinese Medicine

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engineering 2019年第4期5卷 40-49页

作者： yan-Meng Lu Jiao-Jiao Xie cong-Gao Peng {2.-Hong wang Kai-Cen wang Lan-Juan Li state key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003 China

Traditional Chinese medicines (TCMs) have a long history of playing a vital role in disease prevention, symptom alleviation, and health improvement. However, their complex ingredients and as-yetunknown mechanisms restrict their application. With increasing evidence indicating that the gut microbiota is important in host health and may be associated with the therapeutic activity of TCM components, it may now be possible to assess the effects of TCMs from the perspective of the gut microbiota. The gut microbiota functions within four major physiological pathways as follows: It participates in host metabolism, forms global immunity, maintains homeostasis of the gastrointestinal tract, and affects brain function and host behavior. This article reviews the reported correlations between TCMs and certain diseases, such as chronic liver disease, ulcerative colitis, obesity, and type 2.diabetes, and elucidates the underlying mechanisms, with a focus on changes in the gut microbiota. In future, further studies are required with more advanced experimental design in order to reveal the interactions between TCMs and the gut microbiota, and provide new insight into and guidance for TCM-based drug discovery.

关键词： Traditional Chinese medicines Gut microbiome Fatty liver disease Ulcerative colitis Obesity Diabetes

怀洪新河蓄水性河段浮游植物功能群演替及水生态评价

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生态与农村环境学报 2024年第8期40卷 1059-1069页

作者：何利聪王东伟周彦锋陈永进南京农业大学无锡渔业学院江苏无锡214081 中国水产科学研究院淡水渔业研究中心/农业农村部淡水渔业和种质资源利用重点实验室江苏无锡214081

为探究怀洪新河蓄水性河段浮游植物功能群演替及水生态现状,于2.19—2.2.年在怀洪新河新浍河段开展8次季度调查。采用浮游植物功能群划分法和冗余分析(RDA)探究浮游植物功能群演替特征以及主要环境影响因子,采用综合营养状态指数、多样... 详细信息

为探究怀洪新河蓄水性河段浮游植物功能群演替及水生态现状,于2.19—2.2.年在怀洪新河新浍河段开展8次季度调查。采用浮游植物功能群划分法和冗余分析(RDA)探究浮游植物功能群演替特征以及主要环境影响因子,采用综合营养状态指数、多样性指数、河流生态健康指数(Q r)对水环境状况进行综合评价。结果显示,调查期间怀洪新河浮游植物共8门70属136种,绿藻门种类数量占比最高(52.2.%),蓝藻门(19.12.)与硅藻门次之(13.2.%)。浮游植物丰度季度均值变化范围为1.60×10^(6)~3.61×10^(7)L^(-1),平均为(8.99±3.84)×10^(6)L^(-1);生物量季度均值变化范围为0.59~6.07 mg·L^(-1),平均为(2.48±0.35)mg·L^(-1)。浮游植物优势种主要为尖尾蓝隐藻(Chroomonas acuta)、啮蚀隐藻(Cryptomonas erosa)、梅尼小环藻(Cryptocryptophyta acuminatum)和微囊藻(Microcystis)等。怀洪新河共划分出2.个功能群,其中优势功能群9个,2.19—2.2.年优势功能群季节演替特征为B、X2.Y(春季)→M、J、Y(夏季)→B、P、Y(秋季)→B、X2.Y(冬季)→B、X2.Y(春季)→J、S1、S2.Y(夏季)→B、P、J、Y(秋季)→B、E、Y(冬季),主要优势功能群B、Y指示怀洪新河水体为中至富营养静水状态。RDA结果显示,温度、氮磷营养盐和pH值是影响怀洪新河优势功能群演替的主要环境因子。Q_(r)指数指示怀洪新河新浍河段水质为“好-中等”,与综合营养状态指数评价结果相近。相较于多样性指数,Q_(r)指数更适用于怀洪新河蓄水河段水生态评价。

关键词：怀洪新河浮游植物功能群演替水生态评价

配方施肥对华北落叶松各器官非结构性碳水化合物特征的影响

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西北林学院学报 2024年第2期39卷 44-50页

作者：李帆于嘉俐贾忠奎郝国宝李岩王利东林木资源高效生产全国重点实验室北京林业大学森林培育与保护教育部重点实验室北京100083 宁夏回族自治区林业调查规划院宁夏银川750000 河北省塞罕坝机械林场河北围场068466

探究配方施肥对华北落叶松针叶、枝条和细根的非结构性碳水化合物(NSC)的影响,为华北落叶松高效施肥技术提供参考依据。以32.生华北落叶松为研究对象,采用N、P、K三因素三水平正交设计L 9(34),以不施肥为对照,研究配方施肥对华北落叶... 详细信息

探究配方施肥对华北落叶松针叶、枝条和细根的非结构性碳水化合物(NSC)的影响,为华北落叶松高效施肥技术提供参考依据。以32.生华北落叶松为研究对象,采用N、P、K三因素三水平正交设计L 9(34),以不施肥为对照,研究配方施肥对华北落叶松针叶、枝条和细根的NSC及组分(可溶性糖、淀粉)含量的影响,分析华北落叶松各器官NSC及组分含量的相关关系。结果表明,1)华北落叶松针叶、枝条和细根非结构性碳水化合物含量随月份呈显著变化,基本均在10月达到峰值,且3个器官中NSC均以可溶性糖为主。2.各施肥处理对针叶、枝条和细根的NSC及组分含量的表现不同,其中针叶和细根的NSC含量分别在处理T4和T8较CK平均增幅最大,为2..65%、2.%;而枝条的NSC含量和可溶性糖含量与CK的平均增幅相比表现为减少。3)相关性分析显示:针叶、枝条和细根的NSC含量与其可溶性糖含量和淀粉含量间均存在极显著正相关(P1);细根NSC含量与针叶和枝条的可溶性糖含量均存在显著负相关(P2.N 52..78 g·株^(-1)、P 162..58 g·株^(-1)、K 172.98 g·株^(-1))。施用适宜的N、P、K配方能有效改善华北落叶松针叶、枝条和细根的NSC及组分含量,且各器官在生长过程中存在相互平衡和动态调配的关系。

关键词：配方施肥华北落叶松非结构性碳水化合物综合评价

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中药材种植中植物生长调节剂的使用现状和应对措施

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中国新药杂志 2024年第14期33卷 1429-1436页

作者：安晓静刘尚年郭皓李先恩王彦婷关敏郭宝林陈彩霞中国医学科学院北京协和医学院药用植物研究所/中草药物质基础与资源利用教育部重点实验室/濒危药材繁育国家工程实验室北京100193 天津中医药大学中药学院天津301617 成都中医药大学药学院西南特色中药资源国家重点实验室成都611137 河北农业大学农学院保定071000

植物生长调节剂(plant growth regulator,PGR)是一类具有植物激素活性的人工合成的化合物,能通过调控植物生长发育、形态建成及物质代谢等,提高中药材产量和抗逆性。随着中药材种植品种和面积的增加,PGR在中药材种植生产中应用愈加广泛... 详细信息

植物生长调节剂(plant growth regulator,PGR)是一类具有植物激素活性的人工合成的化合物,能通过调控植物生长发育、形态建成及物质代谢等,提高中药材产量和抗逆性。随着中药材种植品种和面积的增加,PGR在中药材种植生产中应用愈加广泛。由于种植户对PGR缺乏充分认识和科学系统了解,使用时存在为追求产量盲目增加PGR种类和用量,导致药材品质下降等盲目乱用现象。本文通过对中药材主产区PGR使用现状进行调研,并结合近年来相关研究的文献资料,对中药材生产中PGR应用现状进行归纳、总结,分析中药材生产中PGR存在的问题,并提出可行建议和应对措施,以期为中药材生产实践中PGR应用提供技术指导和理论依据。

关键词：中药材植物生长调节剂使用现状应对措施

Pseudomonas Cyclic Lipopeptide Medpeptin:Biosynthesis and Modulation of Plant Immunity

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engineering 2023年第9期28卷 153-165页

作者： Yi-Lin Gu Jun-Zhou Li yan Li Shen cong Jing {2. Yi-Nan Ma Hai-Lei Wei state key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern{2. Key Laboratory of Microbial Resources Collection and PreservationMinistry of Agriculture and Rural AffairsInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

The multifunctional secondary metabolites known as cyclic lipopeptides(CLPs),which are produced by a large variety of bacteria,have become a key category of plant immunity ***-CLPs(PsCLPs)are extremely diverse in structure and biological ***,an understanding of CLP-plant structure–function interactions currently remains ***,we identify medpeptin,a novel CLP from Pseudomonas mediterranea that consists of 2. amino *** is synthesized by a non-ribosomal peptide synthase(NRPS)gene cluster and regulated by a quorum-sensing *** research indicates that medpeptin does not exhibit antimicrobial activity;instead,it induces plant cell death immunity and confers resistance to bacterial *** transcriptome analysis and virus-induced gene silencing(VIGS)reveal a set of immune signaling candidates involved in medpeptin *** of a cell-wall leucine-rich repeat extensin protein(NbLRX3)or a receptor-like protein kinase(NbRLK2.)—but not BAK1 or SGT1—compromises medpeptin-triggered cell death and resistance to pathogen infection in Nicotiana *** findings point to a noncanonical mechanism of CLP sensing and suggest perspectives for the development of plant disease resistance.

关键词： Pseudomonas Cyclic lipopeptide Cell death Leucine-rich repeat extension(LRX) Medpeptin Receptor-like kinase(RLK)