检索结果-南通市图书馆

Targeting mitochondrial transcription factor A sensitizes pancreatic cancer cell to gemcitabine

在线全文

学校读者我要写书评

暂无评论

国际肝胆胰疾病杂志:英文版 2023年第5期22卷 519-527页

作者： Wei wang Chun-Fan Jiang Hai-Sen Yin shan Gao bao-Ping Yu Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastroenterology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Department of Pathology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China

Background:The survival of pancreatic cancer cells,particularly cancer stem cells which are responsible for tumor relapse,depends on mitochondrial *** transcription factor A(TFAM)is critical for the regulation of mitochondrial DNA and thus mitochondrial ***,the possible involvement of TFAM in pancreatic cancer is ***:Human samples were obtained from pancreatic cancers and their adjacent tissues;human pancreatic cell lines were cultured in RPMI1640 *** expressions in pancreatic tissues and cultured cells were determined using immunohistochemistry,ELISA,and reverse transcription polymerase chain reaction(RT-PCR).The effect of TFAM on cell growth,migration,colony formation and apoptosis were *** biogenesis in pancreatic cancer and normal cells were ***:The majority of pancreatic cancer tissues exhibited higher TFAM expression compared to the adjacent ***,TFAM mRNA and protein levels were higher in pancreatic cancer cell lines than in immortalized normal pancreatic epithelial *** was no difference on TFAM level between gemcitabine-sensitive and resistant pancreatic cancer *** analysis demonstrated that TFAM overexpression activated pancreatic normal and tumor cells whereas TFAM inhibition effectively inhibited the growth of pancreatic cancer *** inhibition enhanced gemcitabine’s cytotoxicity and suppressed growth,anchorage-independent colony formation and survival of gemcitabine-resistant pancreatic cancer *** studies showed that TFAM inhibition resulted in remarkable mitochondrial dysfunction and energy crisis followed by oxidative *** basal mitochondrial biogenesis level correlated well with TFAM level in pancreatic cancer ***:TFAM played essential roles in pancreatic cancer via regulating mitochondrial functions which highlighted the therapeutic value of inhibiting TFAM to overcome gemcitabine resist

关键词： TFAM Mitochondrial respiration and biogenesis Pancreatic cancer Gemcitabine

Exploiting push-pull strategy to combat the tea green leafhopper based on volatiles of Lavandula angustifolia and Flemingia macrophylla

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2020年第1期19卷 193-203页

作者： HAN shan-jie wang Meng-xin wang Yan-su wang Yun-gang CUI Lin HAN bao-yu Zhejiang Provincial Key Laboratory of Biometrology and Inspection&Quarantine College of Life SciencesChina Jiliang UniversityHangzhou 310018P.R.China Tea Research Institute Yunnan Academy of Agricultural SciencesMenghai 666201P.R.China

Thirteen volatile compounds were identified from Flemingia macrophylla plants. Eight major components significantly attracted the tea green leafhoppers, Empoasca flavescens F. Based on their relative abundances, following synthetic blends were made for field experiments: 1) eight-component-attractant blend included Z-3-hexen-1-ol, Z-3-hexenyl acetate, Z-ocimene, Me SA, Z-3-hexenyl butyrate, dodecane, hexadecane and nonanal at 10, 10, 1, 11, 2, 6, 2 and 4 mg mL^-1 in n-hexane, respectively;2) four-component-attractant blend #1 contained hexadecane, Z-3-hexenyl acetate, Z-3-hexen-1-ol and nonanal at 2, 10, 10 and 4 mg mL^-1 in n-hexane, respectively;3) four-component-attractant blend #2 contained hexadecane, Z-3-hexenyl acetate, Z-3-hexen-1-ol and Me SA at 2, 10, 10 and 11 mg mL^-1 in n-hexane, respectively. Thymol and 1-methoxy-4-methyl-2-(1-methylethyl)-benzene, identified from Lavandula angustifolia aeration samples, significantly repelled the leafhopper as strong repellents when tested alone or in combination at 10 mg mL^-1. For field bioassays, each attractant lure was attached to a bud green sticky board hung from a bamboo stick at above tea plant level for catching the leafhoppers, whereas the repellent dispenser was tied to a tea branch inside tea clump for pushing the leafhoppers away from tea clumps. The results showed that the eight-component-attractant blend caught similar numbers of the leafhopper as did the four-component-attractant blend #1 at about 53–79 leafhoppers/trap/day, which were significantly higher than those on the hexane-control bud green sticky boards. Average leafhopper catches from un-baited sticky boards were about 51–73 leafhoppers/trap/day when pushed by the repellents placed inside tea plants, with the two-component-repellent blend being more effective than their single components. When the two-component-repellent blend was further tested with the three attractant blends in a push-pull fashion, average trap catches ranged from 62 to 9

关键词： push-pull strategy attractants repellents Flemingia macrophylla tea green leafhopper tea plantation

Surface and Volume Symmetry Energy Coefficients of a Neutron-Rich Nucleus

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2012年第9期29卷 32-35页

作者： MA Chun-wang YANG Ju-bao YU Mian PU Jie wang shan-shan WEI Hui-Ling Department of Physics Henan Normal UniversityXinxiang 453007 Department of Life Sciences and Technology Xinxiang Medical UniversityXinxiang 453003 Department of Nuclear Physics Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800

Using an isobaric method,the symmetry-energy coefficient(asym)of a neutron-rich nucleus is obtained from experimental binding *** shell effects are shown in a^(*)_(sym)/A≡4asym/A of nuclei.A(sub)magic neutron magic number N=40 is suggested in a very neutron-rich nucleus,and a^(*)_(sym)/A of a nucleus is found to decrease when its mass *** a^(*)_(sym)/A of a very neutron-rich nucleus with large mass *** volume-symmetry coefficients(b_(v))and surface-symmetry coefficients(b_(s))of a neutron-rich nucleus are extracted from a sym*/A by a correlation a^(*)_(sym)/A=bv/A-b s/A^(4/3).It is found that bv and bs decrease when the nucleus becomes more neutron-rich,and tend to saturate in the very neutron-rich nucleus.A linear correlation between b v and bs is obtained in nuclei with different neutron-excess I,and bv of I>7 nuclei is found to coincide with the results of infinite nuclear matter a sym=32±4 MeV,and bs/bv of the nucleus is found to coincide with the results of the finite-range liquid-drop model results.

关键词： symmetry infinite coincide

A scheme to realize time-bin entanglement between two photons that never interacted

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2008年第1期51卷 38-44页

作者： LU shan bao XiaoHui YANG Tao Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

We propose a scheme of entangling two photons from two separated *** proposal which is inspired by the time-bin entanglement developed recently,provides a novel alternative for revealing contradiction between quantum ... 详细信息

关键词： quantum nonlocality time-bin entanglement linear optics

在线全文

学校读者我要写书评

暂无评论

基于亚稳态液膜空化的长程疏水力作用机制

物理学报 2024年第3期73卷 225-235页

作者：包西程邢耀文张凡凡张德轲刘秦杉杨海昌桂夏辉中国矿业大学炼焦煤资源绿色开发全国重点实验室徐州221116 中国矿业大学化工学院徐州221116 中国矿业大学国家煤加工与洁净化工程技术研究中心徐州221116 郑州大学关键金属河南实验室郑州450000

疏水力作为胶体物理化学及生物大分子体系中重要作用力,具有典型的多尺度作用程特征,其中亚稳态液膜空化气泡桥接诱发长程疏水力和固液界面水分子重排熵效应诱导短程疏水力假说占据着当前学术主流,但仍缺少系统理论研究.为进一步阐明基... 详细信息

疏水力作为胶体物理化学及生物大分子体系中重要作用力,具有典型的多尺度作用程特征,其中亚稳态液膜空化气泡桥接诱发长程疏水力和固液界面水分子重排熵效应诱导短程疏水力假说占据着当前学术主流,但仍缺少系统理论研究.为进一步阐明基于亚稳态液膜空化的长程疏水力作用机制,借助原子力显微镜(AFM)及分子动力学模拟对全氟辛基三氯硅烷疏水化颗粒与表面间长程疏水力进行了系统研究.AFM力测试结果表明:长程疏水力作用程随接近次数增加而逐渐增大并逐渐趋于稳定,第十次接触时进针曲线跳入黏附距离达到502.01 nm,退针曲线中观察到了预示空化气泡毛细桥断裂的台阶.此外,发现经典毛细力数学模型可以较好地拟合进针曲线,通过计算得到毛细桥体积约为0.30μm^(3),从理论角度直接验证了亚稳态液膜空化气泡毛细桥的存在.进一步借助GROM ACS(GROningen M A chine for Chemical Simulations)大尺度牵引分子动力学模拟从分子尺度探索疏水颗粒分离过程中空化气泡毛细桥产生、演化过程与力学行为的内在关联机制,结果表明:疏水颗粒从基板表面跳出分离瞬间,产生的局部压降吸引氮气分子向液膜内部扩散从而形成空化气泡毛细桥,同时,在毛细桥断裂时刻在计算弹簧势力曲线中观察到了力跳跃行为.最后研究了溶液气体含量对长程疏水力的影响规律,发现气体分子含量和空化气泡毛细桥体积增长速率与毛细桥拉伸断裂长度呈现正相关关系,进一步表明了长程疏水力的气体浓度依赖效应.基于亚稳态液膜空化的长程疏水力作用机制的揭示有助于进一步完善胶体物理化学及生物大分子间相互作用理论体系,同时对调控实际矿物浮选过程具有重要指导意义.

关键词：长程疏水力原子力显微镜空化毛细力分子动力学模拟

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

垂直循环停车设备导向系统的设计

建筑机械 2024年第7期 204-209页

作者：刘宝军周正山上海振华重工(集团)股份有限公司上海200125

垂直循环停车设备具有集约化利用土地、布置灵活等优势,且成本相对低廉,但市场接受度并不高,究其原因,主要是设备使用时噪音较大,震动厉害,用户体验感不好。为了降低噪音,增强稳定性,提高用户体验感与舒适度,文章介绍了垂直循环停车设... 详细信息

垂直循环停车设备具有集约化利用土地、布置灵活等优势,且成本相对低廉,但市场接受度并不高,究其原因,主要是设备使用时噪音较大,震动厉害,用户体验感不好。为了降低噪音,增强稳定性,提高用户体验感与舒适度,文章介绍了垂直循环停车设备的运动原理,对吊篮轨迹进行分析,对运行稳定性相关因素进行研究,尤其是重点分析了吊篮过渡段的运动特征,提出了导向系统设计的主要注意点以及优化建议,并通过实际案例进行了验证。结果表明,本设计方法对设备导向系统的改善明显,噪音较小,稳定性好,不影响周边居民正常生活。

关键词：垂直循环停车设备导向系统链传动多边形效应

维普期刊数据库博看期刊

Analyses of Magnetic Force Images of Submicron Magnetic Mn-Ga Particles

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1999年第5期16卷 333-335页

作者： LI Dan HAN bao-shan State key Laboratory of Magnetism Institute of PhysicsChinese Academy of SciencesBeijing 100080

The sample was prepared by implanting Mn^(+) ions at energy of 80keV and Mn^(+) ions of dose of 2×1017/cm^(2) directly into the semi-insulating(100)GaAs wafer,followed by rapid annealing at 830℃ for *** using magnetic force microscopy,both the topographic and magnetic force images of the submicron particles in the surface layer of the sample were *** formation of the magnetic particles is more complex,corresponding to more types of magnetic force image *** simulation was carried out by integrating the interactions between the tip and the particles,which can be used to judge the magnetization direction of particles more ***,the simulation has confirmed that all submicron magnetic particles are single crystals with a single *** fact,the simulated patterns of the single-domain particles are the“elemental”magnetic force patterns for magnetic materials,hence their acquirement and collection are the basis of the analysis and explanation of magnetic force images.

关键词： magnetic integrating hence

Phosphorus sorption capacities in a headstream landscape—The pond chain structure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2006年第5期18卷 1004-1011页

作者： FU Qiang YIN Cheng-qing shan bao-qing State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Understanding phosphorus sorption phenomena in different wetland sediments is important in controlling the P output in headstream watersheds. The pond chain structure （PCS） is widespread in the headstream agricultural watersheds in the southeast of China. Phosphorus sorption characteristics were determined for pond surface sediments （0-12 cm） along a pond chain structure in Liuchahe watershed of Chaohu Lake. Results showed that P sorption capacities （expressed by P sorption index （PSI）） varied both with the landscape position of the ponds and sediment depth. From foothill ponds to riverside ponds the P sorption capacities indicated a significant gradient variability. The higher elevation ponds showed greater sorption capacities, and with the pond elevation decline, P sorption capacities gradually decreased. Some physico-chemical properties, such as pH, oxalate-extractable Fe （Feox）, organic matter （TOC） and Mehlich l-extractable Ca, Mg of pond sediments also indicated significant gradient variability from high elevation ponds to low elevation ponds. Feox was the sediment parameters most highly positively correlated with PSI and was the key factor in controlling P sorption capacity in the pond chain structure （r=0.92, p〈0.001）. Long-term hydrologic and sediment inputs can affect the distribution of sediment constituents and further affect the P sorption capacity. Making the best of the spatial difference of sorption capacities of ponds in watersheds to control nonpoint source P pollutant is necessary.

关键词： pond sediment adsorption spatial variability nonpoint source

改良灵活拮抗剂方案对卵巢功能正常女性COH结局的影响

在线全文

学校读者我要写书评

暂无评论

国际生殖健康/计划生育杂志 2024年第3期43卷 185-189页

作者：王冬雪包莉莉刘珊杨波中国人民解放军联勤保障部队第九八〇医院妇产科生殖中心

目的：分析改良灵活促性腺激素释放激素拮抗剂（gonadotropin releasing hormone antagonist,GnRH-ant）方案对卵巢功能正常女性体外受精/卵胞质内单精子注射-胚胎移植（in vitro fertilization/intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET）妊娠结局的影响。方法：回顾性分析2020年1—12月卵巢功能正常的不孕患者行IVF/ICSI-ET助孕的124个周期的临床资料，根据扳机日黄体生成素（luteinizing hormone,LH）0.05）。改良组促性腺激素（gonadotropin,Gn）用量、Gn天数、GnRH-ant天数及GnRH-ant总量均低于固定组（均P0.05）。添加GnRH-ant日改良组的LH水平高于固定组（P0.05）。2组卵泡穿刺数、获卵数、MⅡ卵数、双原核（2PN）受精数、可利用胚胎数、优质胚胎数、移植胚胎数、获卵率、MⅡ卵率、2PN受精率、2PN卵裂率及优质胚胎率比较，差异均无统计学意义（均P>0.05）;2组无卵泡早排及卵巢过度刺激综合征发生。2组种植率、临床妊娠率、生化妊娠率、流产率及异位妊娠率比较差异无统计学意义（均P>0.05）。结论：两种GnRH-ant方案的临床结局无显著差异，在卫生经济方面改良灵活GnRH-ant方案具有明显的优越性，是卵巢储备功能正常的年轻患者较理想的COH方案。

关键词：改良灵活GnRH-ant方案促性腺素释放激素卵巢储备功能种植率妊娠率