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现代生物技术在蒙药创新发展中的应用探讨

中国民族医药杂志 2024年第1期30卷 59-64页

作者：宫宝泉单迎春黄丽艳内蒙古民族大学附属医院内蒙古通辽028050

目的:对现代生物技术在蒙药发展中的适宜性和可操作性进行探讨,为蒙药的创新发展提供新的思路和方法。方法:查阅国内外文献,对中药学研究领域获得成功的较经典、前沿现代生物技术进行系统分析。结果:蒙药虽与中药有所不同,但在中药学发... 详细信息

目的:对现代生物技术在蒙药发展中的适宜性和可操作性进行探讨,为蒙药的创新发展提供新的思路和方法。方法:查阅国内外文献,对中药学研究领域获得成功的较经典、前沿现代生物技术进行系统分析。结果:蒙药虽与中药有所不同,但在中药学发展中适用的分子生物学技术同样适用于蒙药材的药用植株培养、分类鉴定、质量控制、品种鉴定、品质改良、毒副作用研究、剂型改革、加工贮存等领域。结论:现代生物学技术在蒙药创新发展中具有广阔的应用前景。

关键词：现代生物技术蒙药创新发展应用探讨

基于主要药效成分统计的两面针最佳采收期与合理药用部位研究

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中国中药杂志 2024年第11期49卷 2889-2896页

作者：蒙兰花马庆贡保草姚英刘信丹马志国曹晖张英吴孟华暨南大学岭南传统中药研究中心/国家中药现代化工程技术研究中心岭南资源分中心/广东省中医药信息化重点实验室广东广州510632 华润三九医药股份有限公司广东深圳518110 佛山科学技术学院广东佛山528051

通过分析不同生长年限、不同采收月份、不同部位的两面针栽培品主要药效成分含量的变化规律,并与野生品比较,确定两面针的最佳采收期和合理药用部位。采用高效液相色谱法(HPLC),色谱柱为Kinetex C_(18)(4.6 mm×100 mm,2.6μm),流动相为... 详细信息

通过分析不同生长年限、不同采收月份、不同部位的两面针栽培品主要药效成分含量的变化规律,并与野生品比较,确定两面针的最佳采收期和合理药用部位。采用高效液相色谱法(HPLC),色谱柱为Kinetex C_(18)(4.6 mm×100 mm,2.6μm),流动相为0.2%三乙胺的0.3%磷酸水溶液-乙腈(80∶20),流速1.0 m L·min^(-1),检测波长273 nm,柱温30℃,以主要药效成分氯化两面针碱和白屈菜红碱为指标,对两面针样品进行含量测定。结果表明野生与栽培两面针根的主要药效成分含量无显著性差异,栽培两面针根与根+茎无显著性差异;由层次聚类分析(HCA)与主成分分析(PCA)结果说明两面针根与茎能明显区分,但无法区分野生与栽培品,与显著性分析结果一致;1~6年两面针根的氯化两面针碱和白屈菜红碱质量分数之和为0.114%~0.256%,茎0.030%~0.133%,主要药效成分含量与生长年限呈正相关;4个季节采样均无显著性差异,说明采收季节对两面针主要药效成分含量无影响;3个种植基地的两面针(不含枝)以干燥品计算氯化两面针碱和白屈菜红碱含量之和,云浮为0.308%±0.123%,茂名为0.192%±0.025%,南宁为0.197%±0.052%,3个种植基地均≥0.15%,即移栽2年6个月以上的两面针同时以根(含须根、主根和地下茎)和茎(地上茎)入药可满足要求。综上,两面针栽培品可以作为两面针野生品的合理替代,为实现两面针资源的可持续开发与应用提供保障;根与茎均可作为两面针的药用部位,建议《中国药典》两面针的药用部位修订为干燥根和茎,全年均可采挖。为保障有效成分含量及临床有效性,建议采收移栽3年以上的两面针根和茎入药。

关键词：两面针氯化两面针碱白屈菜红碱含量测定茎

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杂物电梯轿厢入口和层门锁紧与闭合的检验要点和注意事项

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中国特种设备安全 2024年第7期40卷 52-55,61页

作者：袁长福刘旭王进龚豹徐亚东成都市特种设备检验检测研究院(成都市特种设备应急处置中心) 成都610036

针对杂物电梯中存在的轿厢入口和层门锁紧与闭合方面的问题,本文结合不同时期杂物电梯的制造规范和检验规则的要求,提出了在现行制造标准和检验规则的要求下,如何正确地进行杂物电梯轿厢入口和层门锁紧与闭合的检验,同时提出相关注意事... 详细信息

针对杂物电梯中存在的轿厢入口和层门锁紧与闭合方面的问题,本文结合不同时期杂物电梯的制造规范和检验规则的要求,提出了在现行制造标准和检验规则的要求下,如何正确地进行杂物电梯轿厢入口和层门锁紧与闭合的检验,同时提出相关注意事项,让检验人员在检验过程中及时发现不满足要求的轿厢入口和层门锁紧与闭合装置,更好地保障杂物电梯使用人员的安全。

关键词：杂物电梯门系统轿厢入口层门门锁检验要点

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服务器机箱底座下沉量Sag仿真与测试研究

机械研究与应用 2024年第3期37卷 41-44页

作者：龚宝龙张海龙郭峰路纪雷浪潮电子信息产业股份有限公司山东济南250101 广东浪潮智慧计算技术有限公司广东广州510623 高效能服务器与存储技术国家重点实验室山东济南250101

文章采用Abaqus仿真与批量测试的方法,对服务器机箱底座的下沉量进行深入研究分析。以2U通用机架服务器为例展开分析,通过进行仿真与实测对比,证明了仿真精度足够且演练了满载sag到空载sag的分析和管控过程。该研究提出了全新的空载sag... 详细信息

文章采用Abaqus仿真与批量测试的方法,对服务器机箱底座的下沉量进行深入研究分析。以2U通用机架服务器为例展开分析,通过进行仿真与实测对比,证明了仿真精度足够且演练了满载sag到空载sag的分析和管控过程。该研究提出了全新的空载sag管控理论,并根据满载建议值反推空载建议值,再由仿真计算出空满载差值,该方法有效提升了工厂端的sag管控,对服务器机箱的sag设计和生产有重要指导意义。

关键词：服务器机箱 sag仿真 sag测试

Effect of Mo and cold forging deformation on strength and ductility of cobalt-based alloy L605

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1811-1823页

作者： Zhong-lin Wang Zhi-hua gong Quan Li Han-sheng bao School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014017Inner MongoliaChina Institute of Special Steels Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

Mo element was added to cobalt-based alloy L605,and cold forging deformation was *** effects of the addition and cold forging deformation on the microstructure and mechanical properties of the alloy were studied by thermodynamic calculation,electron backscatter diffraction,transmission electron microscopy,and X-ray *** stacking fault energy(SFE)of the alloy decreased after the addition,and the formation of stacking faults and intersections were promoted to improve the strength and *** tensile strength of the alloy with Mo increased from 1190 to 1702 MPa after 24%cold deformation,producing significant work *** strengthening mechanism is strain-induced martensitic transformation(SIMT)and deformation *** alloy,combined with Mo and after 24%deformation,had both high strength and ductility in comparison with the original cobalt-based alloy *** is attributed to the lower SFE which caused the increase in stacking fault *** the tensile process,theε-hcp phase was easily generated at the stacking fault to reduce the stress concentration and increase the *** SIMT by adjusting the density of stacking faults can improve the mechanical properties of cobalt-based ***ε-hcp phase,the interaction between deformation twins and dislocations,and the interaction between e-hcp phases during cold forging deformation caused local stress concentration,lowering ductility and toughness.

关键词： Cobalt-based alloy-Stacking fault energy Strain-induced martensitic transformation Deformation twin Cold forging deformation

Dalbergia odorifera Essential Oil Protects against Myocardial Ischemia through Upregulating Nrf2 and Inhibiting Caspase Signaling Pathways in Isoproterenol-Induced Rats

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 338-347页

作者： Can-Hong Wang bao gong Hui Meng Yu-Lan Wu Xiang-Sheng Zhao Jian-He Wei Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College Ministry of Education and National Engineering Laboratory for Breeding of Endangered Medicinal Materials Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Dalbergia odorifera has long been used as a Chinese herbal medicine for the treatment of cardiovascular and cerebrovascular *** study aimed to determine the potential myocardial protective effect and possible mechanism of action of *** ife ra essential oil(DOEO).Materials and Methods:The essential oil of *** was extracted by *** cardioprotective effects of DOEO were examined by histopathological observation,myocardial enzyme detection,peroxidation,anti-oxidant level detection,and related protein *** compounds in the blood were identified by gas chromatography-mass ***:These results showed that DOEO had significant myocardial cell protection,with IC50 values ranging from 17.64 to 24.78μg/mL in *** to the myocardial ischemia group,the DOEO pretreatment groups had lower levels of myocardial injury,creatinine kinase,lactate dehydrogenase,alanine transaminase,aspartate transaminase,hydrogen peroxide,and nitric oxide,and higher levels of glutathione and superoxide *** addition,DOEO pretreatment significantly increased Na+-K+-ATPase and Ca2+-ATPase *** r,immunohistochemical e xperiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2(Nrf2)and heme oxygenase-1(HO-1)and reduced the expression of apoptotic caspases,including caspase 3 and caspase *** main components of the blood were transnerolidol and nerolidol ***,the study showed that DOEO displayed myocardial protection by upregulating the NF-E2-related nuclear factor-antioxidant response element(Nrf2-ARE)and caspase *** has a therapeutic effect on MI by inhibiting the oxidant and apoptotic ***:*** may be a potential candidate drug for treating myocardial ischemic injury.

关键词： Anti-apoptosis Anti-oxidation Dalbergia odorifera essential oil Isoproterenol Myocardial ischemia

Finite Element Simulations of the Localized Failure and Fracture Propagation in Cohesive Materials with Friction

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 997-1015页

作者： Chengbao Hu Shilin gong Bin Chen Zhongling Zong Xingwang bao Xiaojian Ru Department of Civil Engineering Hangzhou City UniversityHangzhou310015China Zhejiang Engineering Research Center of Intelligent Urban Infrastructure Hangzhou310015China Key Laboratory of Safe Construction and Intelligent Maintenance for Urban Shield Tunnels of Zhejiang Province Hangzhou310015China School of Civil and Ocean Engineering Jiangsu Ocean UniversityLianyungang222005China Institute of Municipal Engineering Hangzhou Shangcheng District Municipal Engineering Group Co.Ltd.Hangzhou310016China

Strain localization frequently occurs in cohesive materials with friction(e.g.,composites,soils,rocks)and is widely recognized as a fundamental cause of progressive structural ***,achieving high-fidelity simulation for this issue,particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones,remains significantly *** response,this study introduces an integrated algorithmwithin the finite element framework,merging a coupled cohesive zone model(CZM)with the nonlinear augmented finite elementmethod(N-AFEM).The coupledCZMcomprehensively describes tension-compression and compressionshear failure behaviors in cohesive,frictional materials,while the N-AFEM allows nonlinear coupled intraelement discontinuities without necessitating extra nodes or nodal *** CZM validation using existing experimental data,this integrated algorithm was utilized to analyze soil slope failure mechanisms involving a specific tensile strength and to assess the impact of mechanical parameters(e.g.,tensile strength,weighting factor,modulus)in soils.

关键词： FEM analysis strong discontinuity nonlinear soil rupture cohesive zone model tension-compression-shear coupling

Organic-acid-assisted synthesis of a 3D lasagna-like Fe-N-doped CNTs-G framework： An efficient and stable electrocatalyst for oxygen reduction reactions

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Nano Research 2017年第4期10卷 1258-1267页

作者： Xiaobing bao Yutong gong Jiang Deng Shiping Wang Yong Wang Advanced Materials and Catalysis Group ZJU-NHU United R&D Center Center for Chemistry of High-Performance and Novel Materials Department of Chemistry Zhejiang University Hangzhou 310028 China

The scalable preparation of multi-functional three-dimensional （3D） carbon nanotubes and graphene （CNTs-G） hybrids via a well-controlled route is urgently required and challenging. Herein, an easily operated, oxalic acid-assisted method was developed for the in situ fabrication of a 3D lasagna-like Fe-N-doped CNTs-G framework （LMFC） from a precursor designed at the molecular level. The well-organized architecture of LMFC was constructed by multi-dimensionally interconnected graphene and CNTs which derived from porous graphene sheets, to form a fundamentally robust and hierarchical porous structure, as well as favorable conductive networks. The impressive oxygen reduction reaction （ORR） performances in both alkaline and acidic conditions helped confirm the significance of this technically favorable morphological structure. This product was also the subject of research for the exploration of decisive effects on the performance of ORR catalysts with reasonable control variables. The present work further advances the construction of novel 3D carbon architectures via practical and economic routes.

关键词： well-controlled oxalic acid robust three-dimensional (3D) lasagna-like framework impressive oxygen reduction reaction (ORR) performances

Recycling of spent lithium-ion batteries to resynthesize high-performance cathode materials for sodium-ion storage

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Tungsten 2024年第3期6卷 574-584页

作者： Hai-Qiang gong Xing-Yuan Wang Long Ye bao Zhang Xing Ou National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and Environment Central South University

The spent lithium-ion batteries recovery has been brought into focus widely for its environmental imperatives and potential profits from the metal components,such as lithium,cobalt,nickel and ***,the weaker pollution and fewer profits of LiMn2O4cathode dispel the enthusiasm and responsibility of industry ***,a simplified and efncient method to regenerate the sodium-ion cathode materials and separate Li from spent LiMn2O4materials for the profit improvement is *** detail,adjusting the parameters of carbothermal reduction process appropriately,the LiMn2O4spinel structure is destroyed within a short period time and transformed into simple metal *** anticipated,nearly 95 wt.%lithium can be obtained and recovered during the water leaching,while 99 wt.% of manganese can be extracted in acid *** that the leaching residue can return to the carbothermic reduction,leading to a closed-loop economic recycling *** regenerated Na0.67Ni0.3Mn0.7O2cathode displays excellent electrochemical performance with superior cycling stability(the initial capacity reaches 95.9 mAh·g-1,and the retention rate reached 98.3% after 100 cycles at 1 C).The delicate strategy of sodium-ion cathode material regenerated from spent LiMn2O4aims to realize lithium separation and material utilization of manganese simultaneously,providing the instructive suggestion to rise up the recycling profits of spent batteries.

关键词： Manganese Spent battery LiMn 2 O 4 cathode Recycling Regenerated Na 0.67 Ni 0.3 Mn 0.7 O 2 Sodium-ion storage