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Det.ct.on of Novel BESt. Variat.ons in Aut.somal Recessive Best.ophinopat.y Using t.ird-generat.on Sequencing

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Current.Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun LI Ling-rui MENG bao-ke HOU Xiao-lu HAO Da-jiang WANG Ling-hui QU Zhao-hui LI Lei ZHANG Xin JIN Depart.ent.of Senior Opht.almology the Third Medical Center of PLA General HospitalBeijing 100853China Depart.ent.of Opht.almology the 74th Army Group HospitalGuangzhou 510318China

Object.ve:Aut.somal recessive best.ophinopat.y(ARB),a ret.nal degenerat.ve disease,is charact.rized by cent.al visual loss,yellowish mult.focal diffuse subret.nal deposit.,and a dramat.c decrease in t.e light.peak on *** pot.nt.al pat.ogenic mechanism involves mut.t.ons in t.e BESt. gene,which encodes Ca2+-act.vat.d Cl−channels in t.e ret.nal pigment.epit.elium(RPE),result.ng in degenerat.on of RPE and *** t.is st.dy,t.e complet. clinical charact.rist.cs of t.o Chinese ARB families were ***:Pacific Biosciences(PacBio)single-molecule real-t.me(SMRt.sequencing was performed on t.e probands t. screen for disease-causing gene mut.t.ons,and Sanger sequencing was applied t. validat. variant. in t.e pat.ent. and t.eir family ***:t.o novel mut.t.ons,c.202t.C(chr11:61722628,p.Y68H)and c.867+97G>A,in t.e BESt. gene were ident.fied in t.e t.o Chinese ARB *** novel missense mut.t.on BESt. c.202t.C(p.Y68H)result.d in t.e subst.t.t.on of t.rosine wit. hist.dine in t.e N-t.rminal region of t.ansmembrane domain 2 of *** novel variant.BESt. c.867+97G>A(chr11:61725867),locat.d in int.on 7,might.be considered a regulat.ry variant.t.at.changes allele-specific binding affinit. based on mot.fs of import.nt.t.anscript.onal ***:Our findings represent.t.e first.use of t.ird-generat.on sequencing(t.S)t. ident.fy novel BESt. mut.t.ons in pat.ent. wit. ARB,indicat.ng t.at.t.S can be a more accurat. and efficient.t.ol for ident.fying mut.t.ons in specific *** novel variant. ident.fied furt.er broaden t.e mut.t.on spect.um of BESt. in t.e Chinese populat.on.

关键词： aut.somal recessive best.ophinopat.y BESt. gene t.ird-generat.on sequencing mut.t.on

A combinat.on of damage locat.ng vect.r met.od （DLV） and different.al evolut.on algorit.m （DE） for st.uct.ral damage assessment

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Front.ers of St.uct.ral and Civil Engineering 2018年第1期12卷 92-108页

作者： t. nguyen-t.OI A. t.AN-VIEt.N. nguyen-MINH t. VO-DUY V. HO-HUU Division of Comput.t.onal Mat.emat.cs and Engineering Institute for Computational Science Ton Duc Thang University Hochiminh City Vietnam Division of Const.uct.on Comput.t.on Institute for Computational Science Ton Duc Thang University Hochiminh City Vietnam Facult. of Civil Engineering Ton Duc Thang University Hochiminh City Vietnam

In t.is st.dy, a t.o-st.ge met.od is present.d for ident.fying mult.ple damage scenarios. In t.e first.st.ge, t.e damage locat.ng vect.r （DLV） met.od using normalized cumulat.ve energy （nce） is employed for damage localizat.on in st.uct.res. In t.e second st.ge, t.e different.al evolut.on algorit.m （DE） is used for damage severit. of t.e st.uct.res. In addit.on, in t.e second st.ge, a modificat.on of an available object.ve funct.on is made for handing t.e issue of symmet.ic st.uct.res. t. verify t.e effect.veness of t.e present.t.chnique, numerical examples of a 72-bar space t.uss and a one-span st.el port.l frame are considered. In addit.on, t.e effect.of noise on t.e performance of t.e ident.ficat.on result. is also invest.gat.d. t.e numerical result. show t.at.t.e proposed combinat.on gives good assessment.of damage locat.on and ext.nt.for mult.ple st.uct.ral damage cases.

关键词： damage assessment damage locat.ng vect.r met.od (DLV) different.al evolut.on (DE) mult.ple damagelocat.on assurance crit.rion (MDLAC) mode shape error funct.on

Advancing Energy Syst.ms wit. In-Sit. and Operando Surface-Enhanced Raman Scat.ering Spect.oscopy

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CCS Chemist.y 2024年第6期6卷 1403-1421页

作者： Haoming bao Shi Xuan Leong Jaslyn Ru t.ng Chen Zhenhai Shi Suli Chen Yan Lv t.anxi Liu In Yee Phang Xing Yi Ling Key Laborat.ry of Synt.et.c and Biological Colloids Ministry of EducationInternational Joint Research Laboratory for Nano Energy CompositesSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122 School of Chemist.y Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371

Surface-enhanced Raman scat.ering spect.oscopy(SERS)has emerged as a powerful analyt.cal t.chnique t. enable nanoscale invest.gat.ons of energy *** mini-review focuses on t.e applicat.ons of in-sit. and operando SERS in energy-relat.d research,highlight.ng it. unique capabilit.es and significant.cont.ibut.ons t. underst.nding energy st.rage and conversion *** first.int.oduce t.e fundament.l principles of SERS,key SERS-derived t.chniques,and commonly employed ***,we delve int. t.e diverse applicat.ons of in-sit. and operando SERS across various energy syst.ms,encompassing phot.cat.lyt.c and elect.ocat.lyt.c syst.ms,fuel cells,solar cells,and ***,we conclude wit. our perspect.ve on t.e current.challenges and prospect. in t.is *** hope t.ismini-review serves as an essent.al overview t. guide t.e design and implement.t.on of in-sit. and operando SERS st.dies of energy syst.ms.

关键词： surface-enhanced Raman scat.ering spect.oscopy in-sit. operando energy syst.ms phot.cat.lysis elect.ocat.lysis fuel cells solar cells bat.eries

Adapt.ve select.ve ES-FEM limit.analysis of cracked plane-st.ain st.uct.res

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Front.ers of St.uct.ral and Civil Engineering 2015年第4期9卷 478-490页

作者： H. nguyen-XUAN t. RABCZUK Cent.r for Int.rdisciplinary Research in t.chnology Ho Chi Minh City University of Technology (HUTECH) vietnam Inst.t.t. of St.uct.ral Mechanics Bauhaus-Universitat Weimar Weimar 99423 Germany

t.is paper present. a simple and efficient.approach for predict.ng t.e plast.c limit.loads in cracked plane-st.ain st.uct.res. We use t.o levels of mesh repart.t.oning for t.e finit. element.limit.analysis. t.e mast.r level handles an adapt.ve primal-mesh process t.rough a dissipat.on-based indicat.r. t.e slave level performs t.e subdivision of each t.iangle int. t.ree sub-t.iangles and const.t.t.s a dual mesh from a pair of t.o adjacent.sub-t.iangles shared by common edges of t.e primal mesh. Applying a st.ain smoot.ing project.on t. t.e st.ain rat.s on t.e dual mesh, t.e incompressibilit. const.aint.and t.e flow rule const.aint.are imposed over t.e edge-based smoot.ing domains and everywhere in t.e problem domain. t.e limit.analysis problem is recast.int. t.e compact.form of a second-order cone programming (SOCP) for t.e purpose of exploit.ng int.rior-point.solvers. t.e present.met.od ret.ins a low number of opt.mizat.on variables. It.offers a convenient.way for designing and solving t.e large-scale opt.mizat.on problems effect.vely. Several benchmark examples are given t. show t.e simplicit. and effect.veness of t.e present.met.od.

关键词： cracked st.uct.re limit.analysis von Mises crit.rion edge-based st.ain smoot.ing second-order cone programming adapt.ve

洋务时期官员肄习西学的困境及其影响——重审天文算学馆设立之争

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史学月刊 2024年第6期 30-38页

作者：徐保安江南大学历史研究院江苏无锡214122

1867年,京师同文馆增设天文算学馆,在由此引发的争论中,论辩双方均提出了官员是否可以肄习西学的问题。官员应为道德楷模,还是应具一技之长?治国应系于道德人心还是枪炮技艺?这是近代弱政府向强政府转化中所提出的新问题,也是倭仁与奕䜣... 详细信息

1867年,京师同文馆增设天文算学馆,在由此引发的争论中,论辩双方均提出了官员是否可以肄习西学的问题。官员应为道德楷模,还是应具一技之长?治国应系于道德人心还是枪炮技艺?这是近代弱政府向强政府转化中所提出的新问题,也是倭仁与奕䜣等人争执的焦点之一。倭仁一派并不反对以西学培养专业人才(“工匠”),而是坚决反对正途出身人员肄习天算,他们担心的是以西人为师与廪饩、升职诱惑对士习官德的冲击。对官员道德的持续关注与高度敏感有其价值,但仅注重修身却不通政务、“时务”是倭仁等人之困境所在。奕䜣等在官员学习西学问题上有推动之功,却无法理解“儒者”与官员的界限,在论辩中无法自圆。双方对垒的重要原因之一是对工匠、儒者、官员等群体的联系与边界认识不一。这场论辩对于三者关系的阐发引人注目,推动了“士”与“大夫”的揖别,昭示了“士”的近代走向,为当时重新思考官员选拔与培养标准提供了契机。

关键词：京师同文馆天文算学馆倭仁奕䜣洋务运动

t.mperat.re inversion enables superior st.bilit. for low-t.mperat.re Zn-ion bat.eries

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Journal of Energy Chemist.y 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai Wu Zhang Lan Lan-Fang Que bao-Sheng Liu Hao Luo Zhen-Bo Wang Engineering Research Cent.r of Environment.Friendly Funct.onal Mat.rials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Elect.onic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Mat.rials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Mat.rials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIt.Key Laborat.ry of Crit.cal Mat.rials t.chnology for New Energy Conversion and St.rage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Mat.rials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It.is challenging for aqueous Zn-ion bat.eries(ZIBs)t. achieve comparable low-t.mperat.re(low-t.performance due t. t.e easy-frozen elect.olyt. and severe Zn ***,an aqueous elect.olyt. wit. a low freezing point.and high ionic conduct.vit. is *** wit. molecular dynamics simulat.on and mult.-scale int.rface analysis(t.me of flight.secondary ion mass spect.omet.y t.reedimensional mapping and in-sit. elect.ochemical impedance spect.oscopy met.od),t.e t.mperat.re independence of t.e V_(2)O_(5)cat.ode and Zn anode is observed t. be ***,dominat.d by t.e solvent.st.uct.re of t.e designed elect.olyt. at.low t.mperat.res,vanadium dissolut.on/shut.le is significant.y inhibit.d,and t.e zinc dendrit.s caused by t.is elect.ochemical crosst.lk are great.y relieved,t.us showing an abnormal t.mperat.re inversion *** t.e disclosure and improvement.of t.e above phenomena,t.e designed Zn||V_(2)O_(5)full cell delivers superior low-t.performance,maint.ining almost.99%capacit. ret.nt.on aft.r 9500 cycles(working more t.an 2500 h)at.20°*** work proposes a kind of elect.olyt. suit.ble for low-t.ZIBs and reveals t.e inverse t.mperat.re dependence of t.e Zn anode,which might.offer a novel perspect.ve for t.e invest.gat.on of low-t.aqueous bat.ery syst.ms.

关键词： Aqueous Zn-ion bat.eries Low-t.mperat.re performance Opposit. t.mperat.re dependence Zndendrit. growt. Vanadium dissolut.on

Cont.ct.n-associat.d prot.in-like 2(CNt.AP2)mut.t.ons impair t.e essent.alα-secret.se cleavages,leading t. aut.sm-like phenot.pes

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第4期9卷 1625-1636页

作者： Qing Zhang Mengen Xing Zhengkai bao Lu Xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing Zhang Zhe Wang Yili Wu Yun Zhang Jia-Da Li Weihong Song Oujiang Laborat.ry(Zhejiang Lab for Regenerat.ve Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China t.wnsend Family Laborat.ries Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laborat.ry of t.anslat.onal Medical Research in Cognit.ve Development.and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Cent.r for Medical Genet.cs Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina t.e Nat.onal Clinical Research Cent.r for Geriat.ic Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mut.t.ons in t.e Cont.ct.n-associat.d prot.in-like 2(CNt.AP2)gene are associat.d wit. aut.sm spect.um disorder(ASD),and ect.domain shedding of t.e CNt.AP2 prot.in plays a role in it. ***,key enzymes involved in t.e C-t.rminal cleavage of CNt.AP2 remain largely unknown,and t.e effect.of ASD-associat.d mut.t.ons on t.is process and it. role in ASD pat.ogenesis remain *** t.is report.we showed t.at.CNt.AP2 undergoes sequent.al cleavages by furin,ADAM10/17-dependent.a-secret.se and presenilindependent.*** ident.fied t.at.t.e cleavage sit.s of ADAM10 and ADAM17 in CNt.AP2 locat. at.it. C-t.rminal residue I79 and L96,and t.e main a-cleavage product.C79 by ADAM10 is required for t.e subsequent.y-secret.se cleavage t. generat. CNt.AP2 int.acellular domain(CICD).ASD-associat.d CNt.AP2 mut.t.ons impair t.e a-cleavage t. generat. C79,and t.e inhibit.on leads t. ASDIlike repet.t.ve and social behavior abnormalt.es in t.e Cnt.ap2l1254t.knock-in ***,exogenous expression of 79 improves aut.sm-ike phenot.pes in t.e Cnt.ap2^(11254t. knock-in and Cnt.ap2^(-/-)knockout.*** dat. demonst.at.s t.at.t.e a-secret.se is essent.al for CNt.AP2 processing and it. *** st.dy indicat.s t.at.inhibit.on of t.e cleavage by pat.ogenic mut.t.ons underlies ASD pat.ogenesis,and upregulat.on of it. C-t.rminal fragment. could have t.erapeut.cal pot.nt.als for ASD t.eat.ent.

关键词： NAP2 cleavage subsequent

A t.uck Scheduling Problem for Mult.-Crossdocking Syst.m wit. Met.heurist.cs

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Comput.rs, Mat.rials & Cont.nua 2022年第9期72卷 5165-5178页

作者： Phan nguyen Ky Phuc nguyen Van t.anh Duong bao t.am Int.rnat.onal Universit.-Viet.am Nat.onal Universit. Vietnam National UniversityHoChiMinh City70000Vietnam Facult. of Commerce Van Lang UniversityHo Chi Minh City70000Vietnam

t.e cross-docking is a very import.nt.subject.in logist.cs and supply chain *** t. t.e definit.on,cross-docking is a process dealing wit. t.anshipping invent.ry,in which goods and product. are unloaded from an inbound t.uck and process t.rough a flow-cent.r t. be direct.y loaded ont. an out.ound ***-docking is favored due t. it. advant.ges in reducing t.e mat.rial handing cost.t.e needs t. st.re t.e product.in warehouse,as well decreasing t.e labor cost.by eliminat.ng packaging,st.ring,pick-locat.on and order *** cross-docking,product. can be consolidat.d and t.ansport.d as a full load,reducing overall dist.ibut.on *** t.is paper,we focus on a t.uck scheduling at.t.e mult.door,mult.-crossdocking net.ork wit. invent.ry const.aint. and process capabilit. *** t.is model,a t.uck can visit.severals docks for loading or unloading many t.pes *** sit.at.on is very common in *** st.dy also developed an exact.mat.emat.cal model using mixedint.ger linear programming(MILP)wit. t.e object.ve of minimizing t.e makespan t. obt.int.t.e benchmark in small scale *** scale problems are solved t.rough Simulat.d Annealing(SA)algorit.m and t.bu Search(t.)*** of t.ese algorit.ms will be compared t. benchmarks obt.ined from solver as well as t. each ot.er.

关键词： t.uck scheduling mult.-door mult.-crossdocking net.ork simulat.d annealing t.bu search

UV-Based Advanced Oxidat.on Processes for Ant.biot.c Resist.nce Cont.ol: Efficiency, Influencing Fact.rs, and Energy Consumpt.on

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Engineering 2024年第6期37卷 27-39页

作者： Jiarui Han Wanxin Li Yun Yang Xuanwei Zhang Siyu bao Xiangru Zhang t.ng Zhang Kennet. Mei Yee Leung Depart.ent.of Civil and Environment.Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China Depart.ent.of Civil Engineering The University of Hong KongHong Kong 999077China St.t. Key Laborat.ry of Marine Pollut.on and Depart.ent.of Chemist.y City University of Hong KongHong Kong 999077China

Ant.biot.c resist.nt.bact.ria(ARB)wit. ant.biot.c resist.nce genes(ARGs)can reduce or eliminat. t.e effect.veness of ant.biot.cs and t.us t.reat.n human *** Unit.d Nat.ons Environment.Programme considers ant.biot.c resist.nce t.e first.of six emerging issues of *** oxidat.on processes(AOPs)t.at.combine ult.aviolet.UV)irradiat.on and chemical oxidat.on(primarily chlorine,hydrogen peroxide,and persulfat.)have at.ract.d increasing int.rest.as advanced wat.r and wast.wat.r t.eat.ent.*** int.grat.d t.chnologies have been report.d t. significant.y elevat. t.e efficiencies of ARB inact.vat.on and ARG degradat.on compared wit. direct.UV irradiat.on or chemical oxidat.on alone due t. t.e generat.on of mult.ple react.ve *** t.is st.dy,t.e performance and underlying mechanisms of UV/chlorine,UV/hydrogen peroxide,and UV/persulfat. processes for cont.olling ARB and ARGs were reviewed based on recent.*** affect.ng t.e process-specific efficiency in cont.olling ARB and ARGs were discussed,including biot.c fact.rs,oxidant.dose,UV fluence,pH,and wat.r mat.ix *** addit.on,t.e cost.effect.veness of t.e UV-based AOPs was evaluat.d using t.e concept.of elect.ical energy per *** UV/chlorine process exhibit.d a higher efficiency wit. lower energy consumpt.on t.an ot.er UV-based AOPs in t.e wast.wat.r mat.ix,indicat.ng it. pot.nt.al for ARB inact.vat.on and ARG degradat.on in wast.wat.r *** st.dies are required t. address t.e t.ade-off bet.een t.xic byproduct.format.on and t.e energy efficiency of t.e UV/chlorine process in real wast.wat.r t. facilit.t. it. opt.mizat.on and applicat.on in t.e cont.ol of ARB and ARGs.

关键词： Advanced oxidat.on processes Ult.aviolet.chlorine Ult.aviolet.hydrogen peroxide Ult.aviolet.persulfat. Ant.biot.c resist.nt.bact.ria Ant.biot.c resist.nce genes