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p21 and p27 immunoexpression in gastric well differentiated endocrine tumors(ECL-cell carcinoids)

World Journal of Gastroenterology 2006年第39期12卷 6280-6284页

作者： Basak Doganavsargil banu Sarsik Fatma Secil Kirdok Ahmet Musoglu Muge Tuncyurek Department of Pathology Ege University Faculty of Medicine Izmir Turkey Department of Gastroenterology Ege University Faculty of Medicine Izmir Turkey

AIM： To investigate the expression of cyclin-dependent kinase inhibitors p21 and p27 in gastric well differentiated endocrine tumors （GWDET）（ECLocell carcinoids）.METHODS： The expressions of p21 and p27 were examined immunhistochemically in endoscopic biopsy specimens from 16 patients matching the diagnostic criteria of GWDET. Percentage of positive nuclear staining either weak or strong was noted. The association of immunoexpressions with age, gender, tumor localization, multifocality and accompanying chronic atrophic gastritis, neuroendocrine cell hyperplasia （NEH）, neuroendocrine dysplasia （NED）, intestinal metaplasia （IM）, Ki-67 proliferation index and clinical outcome were also ***： All cases expressed p27 with a mean expression score of 43.6%, while 31.3% of the cases showed any p21 expression, p21 and p27 immunoexpressions were significantly correlated with each other （P 〈 0.01）, and the p21-expressing group had higher p27 expression scores （68% vs 22%）. p21 and p27 expressions were lower in women, in non-atrophic mucosa and cases whose tumors were located somewhere other than fundus without submucosal extension. On contrary, p21 and p27 expressions were higher in males and the patients with submucosal extension and atrophic gastritis. Cases presenting lower p27 scores had solitary tumors showing neither NEH-NED nor IM. Despite, cases with lower p21 expression presented multifocal tumors accompanied by NEH-NED. However, no correlation of p21 and p27 expressions was found with age and Ki-67 ***： p27 is widely expressed in GWDETs, while p21 expression is sparse and observed in two thirds of the cases. Loss of p21 and p27 expressions may be correlated with different carcinoid tumor subtypes; however,more studies are needed to assess the role of these prospective markers in gastrointestinal endocrine tumors.

关键词： p21^waf1 p27^kip1 Cyclin-dependent kinase inhibitors Gastrointestinal carcinoids Well differentiated endocrine tumors Stomach

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A case of solid pseudopapillary tumor of the pancreas

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World Journal of Gastroenterology 2006年第38期12卷 6239-6243页

作者： Ozan Karatag Gulden Yenice Huseyin Ozkurt Muzaffer Basak Can Basaran banu Yilmaz Department of Radiology Sisli Etfal Education and Research Hospital Istanbul Turkey Department of Surgery Sisli Etfal Education and Research Hospital Istanbul Turkey Department of Pathology Sisli Etfal Education and Research Hospital Istanbul Turkey

We present ultrasound, computed tomography and magnetic resonance imaging findings in a case with pancreatic solid pseudopapillary tumor and their correlations with histopathology. Ultrasound revealed a hypoechogenic mass, and computed tomography revealed a hypodense mass at the pancreatic head minimally enhanced after intravenous contrast agent administration. Magnetic resonance imaging showed a hypointense mass on unenhanced Tl-weighted images including a hyperintense focus representing the hemorrhage. The lesion was hyperintense on T2- weighted images. On the postcontrast images the lesion showed peripheral thin contrast enhancement in arterial phase and enhanced slightly diffusely in venous and equilibrium phases. The patient underwent elective resection of the mass and pancreatoduodenectomy with jejunostomy tube placement. A final diagnosis of solid pseudopapillary tumor was made histoPathologically. Solid pseudopapillary tumor is a rare pancreatic tumor. It is important to make the diagnosis preoperatively because with an adequate surgical resection the prognosis is good. A multimodalitary approach, especially magnetic resonance imaging can suggest the diagnosis without the need for biopsy.

关键词： Pancreas Solid pseudopapillary tumor Magnetic resonance imaging Computed tomography Ultrasound

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Effect of Fiber Diameter and Air Gap on Acoustic Performance of Nanofibrous Membrane

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Journal of Chemistry and Chemical Engineering 2015年第1期9卷 45-50页

作者： Merve Ktiqukali Ozttirk banu Nergis Cevza Candan Klara Kalinova Department of Textile Engineering Istanbul Technical University lstanbu134437 Turkey Centre for Nanomaterials Technical University of Liberec Liberec 46117 Czech Republic

The absorption of sound in the low frequency range is problematic with fibrous materials made up of coarser fibers. In that case, highly efficient sound absorption materials from much finer fibers must be developed. Although studies on the acoustic properties of conventional textile materials started in the nineties, analysis of the acoustic properties of the electrospun nanofibrous membranes is a novel subject. Nanofibrous membranes can improve acoustic insulation products by increasing the sound absorption coefficient, reducing material thickness, and decreasing material weight offering a competitive advantage. The purpose of this study is to analyze the effect of fiber diameter on the acoustic behavior of nanofibrous membranes.

关键词： Etectrospun nanofibrous membrane acoustic characteristic fiber diameter.

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Chong-Chet Anterior Scoring Technique for the Correction of Prominent Ears: Results in 30 Patients

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Modern Plastic Surgery 2012年第2期2卷 39-42页

作者： Nazan Sivrioglu Saime Irkoren banu Aksoy Eray Copcu Department of Plastic and Reconstructive Surgery Adnan Menderes University Faculty of Medicine Aydin Turkey

A lot ofotoplasty techniques have been developed during the past years. However, there is no single perfect technique which is worldwide accepted. We present our assessment of a Chong-Chet anterior scoring technique for the correction of prominent ears which we applied in 30 patients between 2005 and 2010. This study is a report of creating a natural fold of cartilage using Chong-Chet anterior scoring technique by cartilage incision at the border between the antihelix and scapha, with medial scoring of the scapha and lateral scoring of the antihelix. Sutures were used to maintain the created fold. There were no major complications at the 1-year follow-up evaluation. None of the patients developed a recurrence, or retro protrusion of the helix which required a second operation for correction. The procedure is a simple surgical technique. The reconstructed ear shows reliable results in stability, size and normal convolutions. Furthermore, sharp cartilaginous ridges and hidden helix are avoided.

关键词： Chong-Chet Anterior Scoring Prominent Ear

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Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 74-90页

作者： Ayşe N Erbakan Müzeyyen Arslan Bahadır FatoşN Kaya Büşra Güleç MiraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel banu Mesçi Aytekin Oğuz Department of Internal Medicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Department of Family Medicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic *** To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic *** This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 *** were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as *** analysis focused on the success rates of good glycemic control and the associated factors within each *** The study showed significant improvements in HbA1c levels in all *** most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored ***

关键词： Type 2 diabetes mellitus Glycated hemoglobin Glycemic control Patient-centered care Diabetes management glycemic background

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The Number of Lymph Nodes and Relationship with Presence of Thyroiditis and Thymic Tissue in the Central Neck Dissection Materials for Thyroid Papillary Carcinoma: Pathologic Analysis

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International Journal of Clinical Medicine 2016年第9期7卷 566-576页

作者： banu Bilezikçi Seyfettin Ilgan Serdar Özbaş Savaş Koçak Departments of Pathology Guven Hospital Ankara Turkey Departments of Nuclear Medicine Guven Hospital Ankara Turkey Departments of Endocrine Surgery Guven Hospital Ankara Turkey

Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determine the number of the lymph nodes in the CLND and the relationship to presence of chronic lymphocytic thyroiditis (CLT) and thymic tissue (TT). Methods: Total thyroidectomy and CLND materials from 153 patients with PTC were included in this study. Two histopathologic features (presence of CLT and TT) were evaluated for their value in adequacy of CLND. Results: Histopathologic examination revealed CLT and TT in CLND materials in 70 (46%) and 63 (41%) patients, respectively. Total number of lymph nodes in CLND materials was significantly higher in CLT (+) and TT (+) groups (p Conclusions: Our study demonstrates that presence of CLT in thyroid gland has been associated with higher number of central lymph nodes mainly due to increased number of benign hyperplastic lymph nodes. It may be possible to conclude that upper limit of lymph nodes for satisfactory CLND would be higher to correctly evaluate central lymph node status in existing staging systems if specimens have CLT. Results of this study also show that the presence of TT in surgical materials may represent the adequacy of CLND.

关键词： Thyroid Papillary Carcinoma Central Lymph Node Dissection Thyroiditis Thymus

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Gabapentin for the treatment of behavioral and psychological symptoms of dementia

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Advances in Alzheimer's Disease 2012年第2期1卷 13-16页

作者： Rajesh R. Tampi banu Ozkan Deena Williamson Department of Psychiatry University of Maryland Baltimore USA Department of Psychiatry Yale University School of Medicine New Haven USA Saint Francis Hospital and Medical Center Hartford USA

Objective: To examine the efficacy of gabapentin for the treatment of behavioral and psychological symptoms of dementia (BPSD). Design: A retrospective chart review. Settings: Tertiary care geriatric psychiatry inpatient unit. Participants: 230 patients with BPSD. Measurements: The socio-demographic information, type of behaviors, co-morbid psychiatric and medical diagnoses, daily doses of medications and side-effects were recorded. Results: Of the 230 patients, 22 were treated with gabapentin. Twenty of these patients were on a combination of gabapentin and an antipsychotic medication while two patients were treated with gabapentin monotherapy. Eighteen of the 20 patients in the combination group tolerated the treatments with little or no side effects as did the two patients in the monotherapy group. Conclusions: Gabapentin may be a safe option for the treatment of BPSD in combination with antipsychotic medications. Gabapentin may also be effective as monotherapy in certain patients with BPSD.

关键词： Behavioral and Psychological Symptoms of Dementia Neuropsychiatric Symptoms of Dementia Anticonvulsants Gabapentin

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Clinical Research on Efficacy of Cassia Twig Tuckahoe Capsule and Mifepristone Combined with Laparoscopic Surgery for the Treatment of Endometriosis

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International Journal of Clinical Medicine 2017年第7期8卷 463-471页

作者： Hasina banu Pasupati Rajoria Hui Li Wenhui Ju Hua Liu Gynecology and Obstetric Department Jingzhou Central Hospital Affiliated to Yangtze University Medical College Jingzhou China

Objective: To compare the clinical efficacy of Cassia Twig Tuckahoe capsule (Chinese Medicine) and Mifepristone combined with laparoscopic surgery for the treatment of endometriosis. Designs: Prospective cohort study. Setting: Gynecology and Obstetrics Department, Jingzhou Central Hospital, affiliated to Yangtze University. Methods: We selected 67 patients suspected with endometriosis and divided randomly into 2 groups on patient choice. Outcome Measures: Treatment efficacy, side effects, recurrence rate and pregnancy rate. Results: Comparing the effect of treatment between the two groups, the success rate was almost same (P > 0.5). However, the disappearance of pain was faster in Cassia twig Tuckahoe group (P Conclusion: After analysis of the result, Cassia twig Tuckahoe capsule combined with Laparoscopy is superior to the Mifepristone combined with Laparoscopy. Cassia twig Tuckahoe capsule is a very propitious medicine for treating endometriosis for long term benefits.

关键词： Cassia Twig Tuckahoe Capsule Chocolate Cyst Endometriosis Laparoscopy Mifepristone

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Synthesis of Crystalline Ag Nanoparticles (AgNPs) from Microorganisms

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Materials Sciences and Applications 2010年第1期1卷 1-7页

作者： Seema Sharma naheed Ahmad Anuradha Prakash Vidya Nand Singh Ashok Kumar Ghosh Bodh Raj Mehta 不详

Bacteria obtained from the isolates of the biodiversity of riverine coast of Ganga identified as Bacillus Koriensis, when challenged with silver nitrate solution accumulated silver nanoparticles on the surface of its cell wall. These nanoparticles showed an absorption peak at 438 nm in UV-visible spectrum corresponding to the plasmon resonance of AgNPs. The transmission electron micrographs of nanoparticles in aqueous solution showed the production of reasonably monodisperse AgNPs (average particle size: 9.92 ±1.311 nm) by the bacteria. X-ray diffraction spectrum of the nanoparticles confirmed the formation of metallic silver.

关键词： Crystal Structure Nanostructures Metal AgNPs

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Treatment of Multiple Sclerosis

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Neuroscience & Medicine 2016年第2期7卷 74-82页

作者： M. Nadeem O. Mufti I. Ahsan R. naheed S. M. Faheem Muhammad Nadeem MBBS SUNY Buffalo NY USA Owais Mufti MD SUNY Buffalo NY USA Irfan Ahsan MD Abington Memorial Hospital Abington PA USA Rabia naheed MBBS Fatima Memorial Hospital Lahore Pakistan Sheikh Muhammad Faheem MBBS University of IOWA Hospital Iowa City IA USA

Background: A new method of immune-based therapies has been made and applied on multiple sclerosis patients in last decades. Some of these treatments have a high efficacy and reasonable side effects. In slowing disease progression, present treatments have significant limitations, but often associated with significant adverse effects of immunosuppression, with having a bit low capability to counter the disability. Methods: This is a review meta-analysis of treatment of multiple sclerosis. Results: Thus a valuable aim for multiple sclerosis clinical research is to introduce more effective therapies. Conclusion: It is absolutely necessary to increase the individualized therapy planes development in respect to make better planes to disease-modifying treatments.

关键词： Immune Sequestration Multiple Sclerosis Non-Specific Immune Modulation Lymphocyte-Targeted Therapy

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