检索结果-南通市图书馆

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

引用

Acta Pharmaceutica Sinica B 2023年第2期13卷 722-738页

作者： Dan Wang Bochuan Deng Lu Cheng Jieru Li Jiao zhang Xiang zhang Xiaomin Guo Tiantian Yan Xin Yue Yingying An bangzhi Zhang Wenle Yang Junqiu Xie Rui Wang Institute of Materia Medica and Research Unit of Peptide Science Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China

Pulmonary fibrosis(PF)is a pathological change caused by repeated injuries and repair dysfunction of the alveolar epithelium.Our previous study revealed that the residues Asn3 and Asn4 of peptide DR8(DHNNPQIR-NH_(2))could be modified to improve stability and antifibrotic activity,and the unnatural hydrophobic amino acids a-(4-pentenyl)-Ala and D-Ala were considered in this study.DR3penA(DHa-(4-pentenyl)-ANPQIR-NH_(2))was verified to have a longer half-life in serum and to significantly inhibit oxidative damage,epithelial-mesenchymal transition(EMT)and fibrogenesis in vitro and in vivo.Moreover,DR3penA has a dosage advantage over pirfenidone through the conversion of drug bioavailability under different routes of administration.A mechanistic study revealed that DR3penA increased the expression of aquaporin 5(AQP5)by inhibiting the upregulation of miR-23b-5p and the mitogen-activated protein kinase(MAPK)pathway,indicating that DR3penA may alleviate PF by regulating MAPK/miR-23b-5p/AQP5.Safety evaluation showed that DR3penA is a peptide drug without obvious toxicity or acute side effects and has significantly improved safety compared to DR8.Thus,our findings suggest that DR3penA,as a novel and low-toxic peptide,has the potential to be a leading compound for PF therapy,which provides a foundation for the development of peptide drugs for fibrosis-related diseases.

关键词： Peptide Structure modification Pulmonary fibrosis miR-23b-5p AQP5

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and anisotropic thermophysical properties of SiC honeycomb/Al-Mg-Si composite via spontaneous infiltration

引用

Progress in Natural Science:Materials International 2019年第2期29卷 177-183页

作者： Zhejian zhang Zhongqi Shi Biguo Yang bangzhi Ge Xiaoyu zhang Yajie Guo State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Engineering Research Center of Transportation Materials of Ministry of Education School of Materials Science and Engineering Chang'an University

The SiC honeycomb/Al-Mg-Si composite with interpenetrated microstructure was prepared by spontaneous infiltration of Al-8 wt%Mg-7 wt%Si alloy into directional porous SiC honeycomb served as reinforcement. The microstructure and anisotropic thermophysical properties of this composite were also examined. The results showed that the initial microstructure of the SiC honeycomb can be retained and the as-prepared SiC honeycomb/Al-Mg-Si composite exhibited significantly anisotropic characteristics. Meanwhile, the alloying treatment on the Al matrix can avoid the generation of Al;C;and promote the wettability between Al and SiC.Particularly,the directional porous SiC honeycomb with such a low ceramic content（19 vol.%） made it possible for the composite to have a higher thermal conductivity(138.3 W/（m?K）) in the axial direction and a lower coefficient of thermal expansion(11.40 × 10;/K) in the radial direction.The influences of the SiC honeycomb reinforcement on the anisotropic thermophysical properties were also studied by the theoretical models in comparing with the experimental results.

关键词： SiC honeycomb Al-Mg-Si alloy Spontaneous infiltration Anisotropy Thermophysical properties

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Conjugation with Acridines Turns Nuclear Localization Sequence into Highly Active Antimicrobial Peptide

引用

Engineering 2015年第4期1卷 500-505页

作者： Wei zhang Xiaoli Yang Jingjing Song Xin Zheng Jianbo Chen Panpan Ma bangzhi Zhang Rui Wang Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Institute of Biochemistry and Molecular Biology School of Life Sciences Lanzhou University

The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Ac r_3-NLS, by conjugating hydrophobic acridines to the N-terminus of a nuclear localization sequence(NLS), a short cationic peptide. To further improve the antimicrobial activity of our agent, dimeric(Acr_3-NLS)_2 was simultaneously synthesized by joining two monomeric Acr_3-NLS together via a disulfide linker. Our results show that Acr_3-NLS and especially(Acr_3-NLS)_2 display signifi cant antimicrobial activity against gramnegative and gram-positive bacteria compared to that of the NLS. Subsequently, the results derived from the study on the mechanism of action demonstrate that Acr_3-NLS and(Acr_3-NLS)_2 can kill bacteria by membrane disruption and DNA binding. The double targets—cell membrane and intracellular DNA—will reduce the risk of bacteria developing resistance to Acr_3-NLS and(Acr_3-NLS)_2. Overall, this study provides a novel strategy to design highly eff ective antimicrobial agents with a dual mode of action for infection treatment.

关键词：核定位序列抗菌肽吖啶高活性 DNA结合细菌耐药性共轭 NLS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of linker amino acids on the potency and selectivity of dimeric antimicrobial peptides

引用

Chinese Chemical Letters 2018年第7期29卷 1163-1166页

作者： Ming Kai Wei zhang Huan Xie Liwei Liu Sujie Huang Xiao Li Zhengzheng zhang Yuyang Liu bangzhi Zhang Jingjing Song Rui Wang School of Life Sciences Lanzhou University Lanzhou 730000 China Laboratory of Preclinical Study for New Drugs of Cansu Province School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China

Dimerization is an effective strategy for designing antimicrobial peptides that combine the advantages of different native peptides. In this study, we explored the effects of different linker amino acids, including leucine, proline and aminocaproic acid, on the anticancer, antimicrobial and hemolytic activities of the heteromeric antimicrobial peptides AM-1, AM-2, and AM-3. Proline and aminocaproic acid are ideal linkers for increasing the potency and selectivity of heteromeric antimicrobial peptides. The results of MD simulations provided a rationalization for this observation. Both AM-2, which had a proline linker,and AM-3, which had an aminocaproic acid linker, adopted a compact conformation in water and a bent conformation in membranes. This change in the flexible structures of AM-2 and AM-3 could have resulted in decreased binding of these peptides to zwitterionic lipid bilayers and increased damage to mixed lipid bilayers containing acidic phospholipids. In short, these findings obtained via assessing the effects of linker amino acids will contribute to the design of ideal heteromeric antimicrobial peptides with high selectivity and potency.

关键词： Linker amino acid Flexibility Heteromeric antimicrobial peptides Potency and selectivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis

引用

Acta Pharmaceutica Sinica B 2021年第1期11卷 100-111页

作者： Zhibin Yan Dan Wang Chunmei An Hongjiao Xu Qian Zhao Ying Shi Nazi Song Bochuan Deng Xiaomin Guo Jing Rao Lu Cheng bangzhi Zhang Lingyun Mou Wenle Yang Xianxing Jiang Junqiu Xie Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

The antimicrobial peptide APKGVQGPNG(named YD),a natural peptide originating from Bacillus amyloliquefaciens CBSYD1,exhibited excellent antibacterial and antioxidant properties in vitro.These characteristics are closely related to inflammatory responses which is the central trigger for liverfibrosis.However,the therapeutic effects of YD against hepatic fibrosis and the underlying mechanisms are rarely studied.In this study,we show that YD improved liver function and inhibited the progression of liver fibrosis by measuring the serum transaminase activity and the expression of a-smooth muscle actin and collagen I in carbon tetrachloride-induced mice.Then we found that YD inhibited the level of miR-155,which plays an important role in inflammation and liver fibrosis.Bioinformatics analysis and luciferase reporter assay indicate that Casp12 is a new target of miR-155.We demonstrate that YD signifi-cantly decreases the contents of inflammatory cytokines and suppresses the NF-k B signaling pathway.Further studies show that transfection of the miR-155 mimic in RAW264.7 cells partially reversed the YD-mediated CASP12 upregulation,the downregulated levels of inflammatory cytokines,and the inactivation of the NF-k B pathways.Collectively,our study indicates that YD reduces inflammation throughthe mi R-155 e Casp12 e NF-k B axis during liver fibrosis and provides a promising therapeutic candidate for hepatic fibrosis.

关键词： Liver fibrosis Inflammation Antimicrobial peptide MiR-155 CASP12

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

推动校园篮球课程建设对培育青少年篮球人口素质的思考

引用

当代体育科技 2021年第10期11卷 178-181页

作者：沃酉鸣郑贺源吴邦智张湘君周美微李春贵张聪刘义峰哈尔滨体育学院黑龙江哈尔滨150008

青少年篮球人口的培育对于新时代背景下我国篮球事业的蓬勃发展至关主要,该文通过文献资料法、逻辑分析法对当前校园篮球课程建设中的现状进行分析,研究表明,校园篮球课程建设中应明确育人与素质教育为总的指导思想,同时提升各学段课程... 详细信息

青少年篮球人口的培育对于新时代背景下我国篮球事业的蓬勃发展至关主要,该文通过文献资料法、逻辑分析法对当前校园篮球课程建设中的现状进行分析,研究表明,校园篮球课程建设中应明确育人与素质教育为总的指导思想,同时提升各学段课程的衔接性,进而树立青少年体育观念的培养,以及延伸篮球课程建设中的文化与意志品质教育,最终形成具备培育新时代社会主义青少年高素质篮球人口的课程建设标准。

关键词：青少年篮球人口素质教育篮球课程建设

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于注意力机制组合模型的燃煤-煤气混合燃烧电厂NO_(x)排放预测

引用

热力发电 2023年第8期52卷 137-145页

作者：钱虹张俊徐邦智上海电力大学自动化工程学院上海200090 上海市电站自动化技术重点实验室上海200072

针对当前燃煤-煤气锅炉煤气掺烧量不确定情况下对NO_(x)排放量预测不够准确的问题,提出一种基于注意力机制组合在线预测模型。首先,通过最大信息系数法与皮尔逊相关系数法相结合确定模型的特征变量;其次,对线性相关特征变量采用滑动时... 详细信息

针对当前燃煤-煤气锅炉煤气掺烧量不确定情况下对NO_(x)排放量预测不够准确的问题,提出一种基于注意力机制组合在线预测模型。首先,通过最大信息系数法与皮尔逊相关系数法相结合确定模型的特征变量;其次,对线性相关特征变量采用滑动时间窗口在线构建向量自回归模型(VAR),实现多维时序线性相关变量输入下对NO_(x)排放量的预测,而对于非线性相关特征变量通过构建在线循环极限学习机(OR-ELM)模型在线学习非线性相关变量在时序上的关系对NO_(x)排放量进行预测;最后,采用注意力机制对2个预测模型进行动态赋权以实现趋势预测。采用实际运行数据对该模型验证,结果表明,所构建的VAR-OR-ELM组合在线预测模型能够准确预测10 min后的NO_(x)排放量变化趋势,并在不同负荷段对NO_(x)质量浓度进行准确预测;综合预测精度及预测时间,所构建的组合预测模型比其他单一预测模型的预测效果更好。

关键词：最大信息系数注意力机制组合预测在线学习 NO_(x)排放

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钴掺杂铜基复合材料的制备及其电催化析氧性能

引用

复合材料学报 2024年第4期41卷 1923-1933页

作者：张海成杨邦志张娇高鹏向万夏郭婷徐海涛陕西理工大学化学与环境科学学院陕西省催化基础与应用重点实验室汉中723001

铜基纳米材料在电催化方面受到广泛关注,但其存在催化活性低和稳定性差的问题,探索简单高效的策略解决上述问题具有重要的实际意义。本文在室温条件下,采用Co-MOF材料在CuCl_(2)溶液中水解刻蚀策略成功在泡沫镍基底上构筑了钴掺杂的碱... 详细信息

铜基纳米材料在电催化方面受到广泛关注,但其存在催化活性低和稳定性差的问题,探索简单高效的策略解决上述问题具有重要的实际意义。本文在室温条件下,采用Co-MOF材料在CuCl_(2)溶液中水解刻蚀策略成功在泡沫镍基底上构筑了钴掺杂的碱式氯化铜/氯化亚铜复合材料。通过改变Co-MOF在CuCl_(2)溶液中的水解刻蚀时间,从而调控物种和复合物的形貌结构。最优催化剂仅需238 mV的过电位便能够驱动100 mA·cm^(−2)的电流密度。经过50 h的稳定性测试,电流密度几乎没有下降,表明其具有良好的稳定性。优异的电催化析氧反应(OER)性能可归属于Co原子的掺杂优化了Cu原子周围电子环境,激活碱式氯化铜和氯化亚铜的催化活性及CuCl_(2)对泡沫镍的刻蚀增加了活性位点。本文为铜基电催化材料的制备和电催化OER活性增强提供了新的思路和策略。

关键词：金属有机框架材料铜基材料析氧反应掺杂协同作用电催化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

攀钢高炉炉役末期高产原因浅析

引用

四川冶金 2007年第3期29卷 1-3页

作者：张帮志攀钢新钢钒炼铁厂

攀钢3#高炉在炉役末期稳定、顺行、高产,利用系数突破2.6 t/m3.d。结合高炉生产中“四大制度”,分析了取得突破的原因及采取的措施,“发展中心气流,抑制边缘煤气流发展”及上下部调剂的有机配合是3#高炉取得良好技术经济指标的基础。

关键词：炉役末期大修冶炼高炉

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种基于小波分量变换的人脸图像光照归一化算法

引用

北华大学学报（自然科学版） 2017年第5期18卷 689-696页

作者：尹帮治张星明河源市广播电视大学广东河源517000 广东省智能制造与自动化工程技术研究中心广东河源517000 华南理工大学计算机科学与工程学院广东广州510006

基于小波变换原理,提出一种基于小波分量变换的人脸图像光照归一化算法.人脸图像经过二维离散小波变换(DWT),被分解成4个子分量(LL,HL,LH,HH).将低频分量(LL)进行对数变换和分段线性变换,对高频分量(LH,HL,HH)进行Gamma变换.对所有子分... 详细信息

基于小波变换原理,提出一种基于小波分量变换的人脸图像光照归一化算法.人脸图像经过二维离散小波变换(DWT),被分解成4个子分量(LL,HL,LH,HH).将低频分量(LL)进行对数变换和分段线性变换,对高频分量(LH,HL,HH)进行Gamma变换.对所有子分量进行小波逆变换,对经小波重构后的人脸图像进行中值滤波.分别在Yale B和CMU-PIE人脸数据库中对本文算法进行光照归一化有效性试验;对比本文算法与其他22种光照归一化算法的处理时间及处理效果;进行分段线性变换和伽马变换参数比较试验及人脸识别试验.结果表明:本文算法执行速度快,处理效果好,人脸识别率高,适用于不同光照条件的人脸识别系统.

关键词：小波变换光照对数域变换分段线性变换伽马变换

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：