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Individual having a parent with early-onset gastric cancer may need screening at younger age

World Journal of Gastroenterology 2015年第15期21卷 4592-4598页

作者： Hee-Won Kwak Il Ju Choi Chan Gyoo Kim Jong Yeul Lee Soo-Jeong Cho bang wool eom Hong Man Yoon Jungnam Joo Keun Won Ryu Young-Woo Kim Center for Gastric Cancer National Cancer Center Biometric Research Branch National Cancer Center

AIM: To evaluate whether individuals with gastric cancer(GC) are diagnosed earlier if they have firstdegree relatives with ***: A total of 4282 patients diagnosed with GC at National Cancer Center Hospital from 2002 to 2012 were enrolled in this retrospective study. We classified the patients according to presence or absence of first-degree family history of GC and compared age at diagnosis and clinicopathologic characteristics. In addition, we further classified patients according to specific family member with GC(father, mother, sibling, or offspring) and compared age at GC diagnosis among these patient groups. Baseline characteristics were obtained from a prospectively collected database. Information about the family member's age at GC diagnosis was obtained by ***: A total of 924 patients(21.6%) had a firstdegree family history of GC. The mean age at GC diagnosis in patients having paternal history of GC was 54.4 ± 10.4 years and was significantly younger than in those without a first-degree family history(58.1 ± 12.0 years, P < 0.001). However, this finding was not observed in patients who had an affected mother(57.2 ± 10.0 years) or sibling(62.2 ± 9.8 years). Among patients with family member having early-onset GC(< 50 years old), mean age at diagnosis was 47.7 ± 10.3 years for those with an affected father, 48.6 ± 10.4 years for those with an affected mother, and 57.4 ± 11.5 years for those with an affected sibling. Thus, patients with a parent diagnosed before 50 years of age developed GC 10.4 or 9.5 years earlier than individuals without a family history of GC(both P <0.001).CONCLUSION: Early-onset GC before age of 50 was associated with parental history of early-onset of GC. Individual having such family history need to start screening earlier.

关键词： Gastric cancer Family history Family member Age at diagnosis Screening

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National validation of laparoscopic approach for locally advanced gastric cancer:Comparison of a randomized controlled trial and real-world practice results

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Chinese Journal of Cancer Research 2024年第6期36卷 742-751页

作者： bang wool eom Mira Han Hong Man Yoon Woo Jin Hyung Han-Kwang Yang Young-Kyu Park Hyuk-Joon Lee Ji Yeong An Wook Kim Hyoung-Il Kim Hyung-Ho Kim Seung Wan Ryu Hoon Hur Min-Chan Kim Seong-Ho Kong Gyu Seok Cho Jin-Jo Kim Do Joong Park Young-Woo Kim Jong Won Kim Joo-Ho Lee Sang-Uk Han Keun Won Ryu the information committee of the Korean Gastric Cancer Association Center of Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Medical Research Collaborating Center Seoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoul 07061Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Department of Surgery Seoul National University HospitalSeoul 03080Republic of Korea Department of Surgery Chonnam National University College of MedicineHwasun 58128Republic of Korea Department of Surgery Sungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Cheju Halla General HospitalCheju 63127Republic of Korea Department of Surgery Chung-Ang University Gwangmyeong HospitalGwangmyeong 14353Republic of Korea Department of Surgery Keimyung University Dongsan Medical CenterDaegu 42601Republic of Korea Department of Surgery Ajou University School of MedicineSuwon 16499Republic of Korea Department of Surgery Dong-A University HospitalBusan 49201Republic of Korea Department of Surgery Soonchunhyang University Bucheon HospitalBucheon 14584Republic of Korea Department of Surgery Incheon St Mary’s Hospitalthe Catholic University of KoreaIncheon 21431Republic of Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620Republic of Korea Department of Surgery Chung-Ang University HospitalSeoul 06973Republic of Korea Department of Surgery Ewha Womans University Mokdong HospitalSeoul 07985Republic of Korea 不详

Objective:The laparoscopic approach for locally advanced gastric cancer has recently been adopted based on the results of several randomized controlled trials(RCTs).However,findings from RCTs have not been examined at the national *** study aimed to investigate the external validity of the Korean Laparoscopic Gastrointestinal Surgery Study-02(KLASS-02)trial involving 13 tertiary hospitals,using data from the Korean Gastric Cancer Association(KGCA)-led nationwide survey involving 68 tertiary or general ***:Data on patients who underwent laparoscopic or open distal gastrectomy for pathological stageⅠB-ⅢC gastric cancer under the same conditions were collected from the KLASS-02 trial and the KGCA nationwide survey *** outcomes were assessed for each dataset and multivariable analyses were performed to examine the effect of the laparoscopic approach on surgical ***:The laparoscopic group had a lower overall complication rate than the open group in both KLASS-02and KGCA datasets(16.1%vs.23.5%for the KLASS-02 and 12.6%vs.19.6%for the KGCA).Moreover,the laparoscopic group had fewer wound problems,and fewer gradeⅡ,Ⅲa,andⅣcomplications than the open group in the KGCA data(0.8%vs.3.4%,5.8%vs.10.4%,2.3%vs.3.7%,and 0.5%vs.1.4%,respectively),which were not observed in the KLASS-02 *** analyses revealed that the laparoscopic approach was not associated with overall complications,but reduced wound problems and more harvested lymph nodes in the KGCA survey data(adjusted odds ratios,0.19 for wound problems,adjustedβcoefficient 4.39 for number of harvested lymph nodes),which were not shown in the KLASS-02 ***:The safety and feasibility of the laparoscopic approach for locally advanced gastric cancer were validated at a national *** laparoscopic approach for locally advanced gastric cancer can be implemented in the Republic of Korea.

关键词： Advanced gastric cancer laparoscopy complication trial national survey

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