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Nasopharyngeal carcinoma in Indonesia:epidemiology,incidence,signs,and symptoms at presentation

Chinese Journal of Cancer 2012年第4期31卷 185-196页

作者： Marlinda Adham Antonius N.Kurniawan Arina Ika Muhtadi Averdi Roezin bambang Hermani Soehartati Gondhowiardjo I Bing Tan Jaap M.Middeldorp Department of Otorhinolaryngology Department of Anatomy Pathology Department of Radiotherapy Faculty of MedicineUniversity of IndonesiaDr.Cipto Mangunkusumo HospitalJakartaIndonesia Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute Department of Pathology VU University Medical CenterAmsterdamNetherlands

Among all head and neck (H&N) cancers,nasopharyngeal carcinoma (NPC) represents a distinct entity regarding epidemiology,clinical presentation,biological markers,carcinogenic risk factors,and prognostic *** is endemic in certain regions of the world,especially in Southeast Asia,and has a poor *** Indonesia,the recorded mean prevalence is 6.2/100 000,with 13 000 yearly new NPC cases,but otherwise little is documented on NPC in ***,we report on a group of 1121 NPC patients diagnosed and treated at *** Mangunkusumo Hospital,Jakarta,Indonesia between 1996 and *** studied NPC incidence among all H&N cancer cases (n=6000) observed in that period,focusing on age and gender distribution,the ethnic background of patients,and the disease *** also analyzed most prevalent signs and symptoms and staging of NPC patients at first *** this study population,NPC was the most frequent H&N cancer (28.4%),with a male-to-female ratio of 2.4,and was endemic in the Javanese ***,NPC appeared to affect patients at a relatively young age (20% juvenile cases) without a bimodal age ***,NPC initiated in the fossa of Rosenmuller and spreaded intracranially or locally as a mass in the ***,NPC developed at the submucosal level spreading outside the anatomic limits of the *** presentation,NPC associated with hearing problems,serous otitis media,tinnitus,nasal obstruction,anosmia,bleeding,difficulty in swallowing and dysphonia,and even eye symptoms with diplopia and *** initial diagnosis is difficult to make because early signs and symptoms of NPC are not specific to the ***-age Epstein-Barr virus (EBV) infection combined with frequent exposure to environmental carcinogenic co-factors is suggested to cause NPC *** NPC is the most frequent histological type and is closely associated with *** of the EBV-encoded latent membrane protein

关键词：早期症状鼻咽癌发病率 Epstein-Barr病毒全国人民代表大会体征流行病学印尼

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Analysis of Forkhead Box Protein-3 (Foxp3) in Allergic Rhinitis Patients

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第4期7卷 228-236页

作者： bambang Suprayogi Resi Utomo Mochammad Hatta Sutji Pratiwi Muhammad Nasrum Massi Lina Marlina Erica Gilda Minawati Simanjuntak Department of Ear Nose and Throat Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia Molecular Biology and Immunology Laboratory for Infection Diseases Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Ear Nose and Throat Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Microbiology Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Anesthesiology Faculty of Medicine Indonesia Christian University of Jakarta Jakarta Indonesia

Background: A new concept in understanding allergic diseases is regulatory T cells (Tregs), which control the immune reaction caused by Th2 cytokine production. Forkhead Box Protein 3 (FoxP3) is a marker that has a critical role in the development and function of Tregs. Some studies found differences in FoxP3 level and in Tregs capacity to control immune reactions in allergic diseases. The aim of this study was to investigate FoxP3 level in Allergic rhinitis (AR) patients compared to atopic and healthy/normal persons in Jakarta. Methodology: This study used observation to analyze the level of FoxP3 in AR, atopic and healthy/normal persons, and used ELISA to measure the FoxP3 level. Results: The study had sixty participants divided into three groups: 21 in the Normal group, 16 in the Atopic group, and 23 in the AR group. The mean FoxP3 levels were 0.81 ± 0.35 in the normal group, 3.42 ± 0.15 in the atopic group, and 3.40 ± 0.13 in the AR group. Statistical analysis with Mann-Whitney tests indicated significant differences, with AR and atopic groups having higher FoxP3 levels than the normal group, (p = 0.001), and no statistically significant differences between the AR and atopic groups, (p = 0.92). Conclusion: Our study results suggested that FoxP3 was active in the control of inflammatory processes due to allergies, and decrease level of FoxP3 indicated severe AR, but suggested another mechanism caused differences in the clinical phenotypes of AR and atopic patients, despite them having equally high levels of FoxP3.

关键词： Allergic Rhinitis Atopic Regulator T Cells FoxP3 ELISA

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The Analysis of the Effective Systemic Lidocaine Dosage on the Expression of HMGB1 mRNA on Mice with Sterile Musculoskeletal Injury

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Open Journal of Anesthesiology 2017年第2期7卷 35-41页

作者： Robert Hotman Sirait Mochammad Hatta Muhammad Ramli Tigor Peniel Simanjuntak bambang Suprayogi Andi Asadul Islam Syafrie Kamsul Arief Department of Anesthesiology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Molecular Biology and Immunology Laboratory Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Anesthesiology Faculty of Medicine University of Hasanuddin Makassar Indonesia Department of Obstetric and Gynecology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Department of Otorhinolaryngology Faculty of Medicine Christian University of Indonesia Jakarta Indonesia Department of Surgery Faculty of Medicine University of Hasanuddin Makassar Indonesia

A severe injury can trigger an inflammation response and excessive response can cause multiple organ failure. HMGB1 is an early inflammation mediator in sterile injury and a late inflammation mediator in infection. It is an important mediator in severe sepsis and always associated with the severity of organ failure. Previous studies showed that the administration of systemic lidocaine could inhibit the expression of HMGB1 on septic mice with musculoskeletal injury. Nine male adult Balb/c mice were grouped by simple random sampling method into three groups of intravenous lidocaine injection dosages: 2 mg/kg, 3 mg/kg, 4 mg/kg. Musculoskeletal injury was done by breaking the left femoral bone in a close manner. Peripheral blood sampling was done 4 hours after injury and 2 hours after lidocaine therap. To evaluate the expression level of HMGB1 mRNA, RT-PCR was used. The result of our study showed that intravenous lidoaine administration on the 3 groups could decrease the level of HMGB1. In conclusion, lidocaine hold an important role in clinical diseases by inhibiting HMGB1.

关键词： High Mobility Group Box 1 Lidocaine Musculoskeletal Injury

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Critical Concentration of Zinc for Increasing Production and Quality of Mangosteen Fruit in West Sumatera, Indonesia

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Phyton-International Journal of Experimental Botany 2024年第11期93卷 2767-2786页

作者： Martias Dewi Fatria Adha Fatmah Siregar Raden Heru Praptana Antonius Kasno Muhammad Prama Yufdy Riska Ni Luh Putu Indriyani Affandi Tri Budiyanti Sri Hadiati Ellina Mansyah Irwan Muas Jumjunidang Mizu Istianto Djoko Mulyono Intan Gilang Cempaka Triyani Dewi Agus Supriyo bambang Nuryanto West Sumatera Mangosteen Association Department of PlantationFood Crops and Horticulture West SumateraPadang25157Indonesia Indonesian Agency for Agricultural Instrument Standardization Jakarta12540Indonesia Research Center for Food Crops National Research and Innovation AgencyBogor16911Indonesia Research Center for Horticulture National Research and Innovation AgencyBogor16915Indonesia

West Sumatera is one of the largest mangosteen production centers in *** the 2019 harvest season,there were variations in fruit production and quality which indicated symptoms of zinc(Zn)deﬁ*** study evaluates the status of Zn for increasing the production and quality of mangosteen fruit Ratu Kamang *** study was conducting using the observation method in Lima Puluh Kota,West Sumatera from January to December *** study used ten mangosteen trees aged 23 years in three locations selected *** observed included soil properties,leaf nutrients,number of fruits;fruit,rind,aril and seed weights,percentage of fruit scars(FS)and percentage of fruit contaminated with yellow sap(YSC).The relationship between Zn concentration in leaves and fruit production and quality was analyzed using Pearson’s correlation and regression *** results showed that Zn played a role in increasing the production and quality of man-gosteen fruit at certain concentration ranges in the *** concentrations of 23.45–30.00 mg/kg play a role in increasing production,while Zn concentrations of 26.29–30.29 mg/kg play a role in increasing *** lowest incidence of FS and YSC was found in trees with Zn concentration in the leaves between 30.00–32.00 mg/*** concentration in the leaves of 30.00 mg/kg was the critical concentration in increasing the production and quality of mangosteen fruit under local cultivation *** has an antagonistic relationship to iron(Fe)and cop-per(Cu)in leaf tissue.

关键词： Mangosteen fruit fertilizer management fruit grade production level of zinc

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Effect of the Austempering Process on Thin Wall Ductile Iron

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材料科学与工程（中英文A版） 2011年第2X期1卷 236-242页

作者： Johny Wahyuadi Soedarsono Tresna Priyana Soemardi bambang Suhamo Rianti Dewi Sulamet-Ariobimo Elwado Zulfikar Damanik Wahyu Dwi Haryono Department of Metallurgy and Materials Faculty of Engineering University of lndonesia Jakarta Indonesia State Polytechnic of Jakarta Jakarta Indonesia Department of Mechanical Engineering Faculty of Engineering University of lndonesia Jakarta Indonesia Mechanical Engineering Department Faculty of lndustrial Technology Trisakti University Jakarta Indonesia

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基于互联网的温室控制系统开发(摘选)

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农业工程 2014年第1期4卷 125-128页

作者： bambang Marhaenanto Peeyush Soni Vilas M. Salokhe 任抹学院农业工程系亚洲理工学院农业系统工程环境资源开发学院兰佳大学

该研究旨在设计一种基于互联网的温室控制系统,以便实现远程监测和控制。所设计的系统包括硬件(传感器、单片机、交换机、电脑、网络摄像头和执行器)和软件(采集和控制)。通过将执行器(风机、泵、喷雾器、机械遮光装置和可旋转摄像头)... 详细信息

该研究旨在设计一种基于互联网的温室控制系统,以便实现远程监测和控制。所设计的系统包括硬件(传感器、单片机、交换机、电脑、网络摄像头和执行器)和软件(采集和控制)。通过将执行器(风机、泵、喷雾器、机械遮光装置和可旋转摄像头)安装在试验温室并且连接到计算机互联网上对系统性能进行测试。在水培生菜等整个生长期内对其微气候参数进行监测,在3种操作模式(手动、自动和定时)下,对温度、湿度、光照和含水率进行控制。利用开关对风机、泵和喷雾器进行控制以确保微气候参数能保持在所需范围内。机械遮阴和摄头旋转采用伺服电机驱动,由PWM信号驱动进行控制。对3种模式下系统的性能进行评价和比较。结果表明,对温度、湿度、光照和含水率4个参数可以通过互联网Remote Desktop完成远程控制。监控单元提供的植物生长图片可作为制定控制决策的附加信息。

关键词：温室控制系统互联网微气候控制远程监测和控制

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Study Biocompatibility and Osteogenic Differentiation Potential of Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) with Gelatin Solvent

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Journal of Biomedical Science and Engineering 2015年第7期8卷 420-428页

作者： Nike Hendrijantini Utari Kresnoadi Sherman Salim bambang Agustono Endang Retnowati Iwan Syahrial Pungky Mulawardhana Manggala Pasca Wardhana Coen Pramono Fedik Abdul Rantam Department of Prosthodontic Faculty of Dental Medicine Airlangga University Surabaya Indonesia Department of Clinical Pathology Airlangga University & Dr. Soetomo General Hospital Surabaya Indonesia Department of Pathology Faculty of Veterinary Medicine Airlangga University Surabaya Indonesia Department of Obstetric & Gynecology Airlangga University & Dr. Soetomo General Hospital Airlangga University Surabaya Indonesia Department of Oral and Maxillofacial Surgery/Dental Hospital Faculty of Dental Medicine Airlangga University & Dental Hospital Surabaya Indonesia Laboratory of Stem Cell Institute of Tropical Disease Airlangga University Surabaya Indonesia Regenerative Medicine & Stem Cell Centre Airlangga University & Dr. Soetomo General Hospital Surabaya Indonesia

The human umbilical cord is a source of numerous Mesenchymal Stem Cells (MSCs), making it as a potential source of allogeneic multipotent cell for bone tissue engineering. The aims of this study were to find: 1) Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) phenotypic characterization, 2) The in-vitro osteogenic differentiation potential of hUCMSCs, 3) The cytotoxicity of gelatin solvent to hUCMSCs using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. As a result, through characterization of hUCMSCs, the majority of target cells expressed specific MSCs markers, Cellular Differentiation (CD)73, smaller number of subpopulation expressed CD90 with only minimal subpopulation expressed CD105 and all negative MSCs markers. Osteoblastic differentiation was found in a significantly high number of cells when in vitro osteogenic differentiation of hUCMSCs with Alizarin Red staining was done. Biocompatibility analysis using the MTT assay showed that gelatin solvent and Alpha modification of minimum essential medium Eagle (α-MEM) was non-toxic for hUCMSCs in vitro. The study concluded that hUCMSCs isolated from human umbilical cord was capable of undergoing in vitro osteogenesis, indicating its potential as allogeneic stem cells for clinical application in bone tissue engineering.

关键词： Human Umbilical Cord Mesenchymal Stem Cells Mesenchymal Stem Cells Phenotypic Characterization Osteogenic Differentiation Bone Tissue Engineering

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印度尼西亚竹子栽培与利用(英文)

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竹子研究汇刊 1997年第2期16卷 1-7页

作者： Subyakto and bambang Subiyanto(R&D Centre for Applied Physics—Indonesia Institute of Sciences Puspiptek Serpong 15310，Indonesia)Sandra A.Azis(Department of Agronomy，Bogor Agricultural University， Bogor，Indonesia)

竹子在印度尼西亚广为使用，尤其是在乡村，因为它生长快，易采伐，使用方便，性能好。本文“印度尼西亚竹子栽培与利用”报道了目前印尼竹子的栽培、加工及研究、开发方面的进展。在印尼，许多竹种的栽植历史已有好几百年。传统的繁殖... 详细信息

竹子在印度尼西亚广为使用，尤其是在乡村，因为它生长快，易采伐，使用方便，性能好。本文“印度尼西亚竹子栽培与利用”报道了目前印尼竹子的栽培、加工及研究、开发方面的进展。在印尼，许多竹种的栽植历史已有好几百年。传统的繁殖方法是用秆及鞭，而其它栽培繁殖方法尚处于试验阶段。可以这样说，印尼的竹子栽培研究尚处于早期的开拓时期。竹子在印尼有许多用途，如建筑材料，家具，墙，篮子，家庭器具，造纸，篱笆，手工艺品，农具，乐器及食品。目前，印尼竹子加工利用技术研究正处于全面的开发阶段。今后竹子作为工业用材的前景非常广阔，然而也存在一些问题。为提高竹子对乡村社会的贡献，促进竹子工业利用的发展，我们应该对竹子的生物学特性，营林，社会经济，新产品设计、开发，防蛀防霉，精加工等等进行更深入的研究。

关键词：竹栽培加工印尼

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医学专业本科留学生诊断教育探讨

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教育教学论坛 2019年第47期 41-43页

作者：夏小慧钱倩陈丽灵马元孙文逵陈红 bambang Gunawan Oetomo Jash Divyeshbhai Jagani 南京医科大学第一临床医学院诊断教研室江苏南京211166 南京医科大学附属脑科医院胸科院区江苏南京210029 南京医科大学第一附属医院呼吸与危重症医学科江苏南京210029

为探讨留学生的医学诊断学教育问题,该研究对南京医科大学100名在校留学生进行问卷调查,并进行统计分析。调查发现提高教学质量,加强教师英语培训,增加实践课时和学生动手机会等是改善学生诊断学习的重要方法。

关键词：本科留学生诊断教育评价探讨

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4种激光粒度仪对下蜀土湿法粒度测试的对比研究

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分析测试技术与仪器 2018年第2期24卷 65-76页

作者：贝佳鹏凌超豪贾玉连张智曹向明刘倩龙进江西师范大学地理与环境学院鄱阳湖湿地与流域研究教育部重点实验室江西南昌330022 中国科学院南京地理与湖泊研究所江苏南京210008

使用4种应用较为广泛的激光粒度仪(Mastersizer2000、Bettersize2000、Horiba LA950和LS13320)对粒度差异较小的下蜀土(土塘剖面)进行了测试,从而对比分析不同激光粒度仪对于下蜀土的粒度组成测试差异及其这种差异对研究结果可能产生的... 详细信息

使用4种应用较为广泛的激光粒度仪(Mastersizer2000、Bettersize2000、Horiba LA950和LS13320)对粒度差异较小的下蜀土(土塘剖面)进行了测试,从而对比分析不同激光粒度仪对于下蜀土的粒度组成测试差异及其这种差异对研究结果可能产生的影响.结果表明:对粉砂颗粒组分的分析,4种激光粒度分析仪分析结果的差异最小,而对砂和粘土颗粒组分分析的差异最大.就粒度频数曲线、概率累积曲线、粒度组分、C-M图、粒度参数散点图及粒度参数剖面垂向变化等统计参数与统计方式而言,4种仪器的测试结果均有一定的差异,其中,概率累积曲线、粒度参数散点图差异较大.粒度参数的剖面变化差异也较大,影响了对剖面的阶段性划分,这在一定程度上影响了研究结果,造成使用不同仪器,可能会得出不同的结果.

关键词：激光粒度仪湿法粒度分析粒度参数下蜀土

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