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BABAR measurement of baryon time-like form factors via initial state radiation

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Chinese Physics C 2010年第6期34卷 860-862页

作者： R.baldini Ferroli Enrico Fermi Center INFN Laboratori Nazionali di Frascati

BABAR has measured with unprecedented accuracy the e^＋e^- → pp and e^＋e^- →∧∧ cross sections by means of the initial state radiation technique, which has the advantages of good efficiency, good energy resolution and full angular acceptance, even exactly at threshold. A peculiar feature of these cross sections is their non-vanishing values at threshold. In the case of charged baryons, this phenomenon is expected according to the Coulomb interaction between the outgoing baryon and antibaryon. Once this Coulomb enhancement factor is taken into account, the striking result is achieved that the proton form factor at threshold is ｜GP（4Mp^2）｜ = 1, that is what is expected for pointlike fermion pairs, in spite of the proton structure. However a Coulomb enhancement factor is not expected for neutral fermions, likely in contradiction with the BABAR data. Qualitatively this behaviour is consistent with Coulomb interactions at the valence quark level.

关键词： baryon form factor Initial state radiation BABAR

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Palladium-Catalyzed Carbonylation of Multifunctionalized Substituted Alkynes to Quinolinone Derivatives under Mild Conditions

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Chinese Journal of Chemistry 2023年第23期41卷 3223-3228页

作者： Aleksandr Voronov Francesco Pancrazzi Ana Maria Constantin Raimondo Maggi Raffaella Mancuso Bartolo Gabriele Diego Olivieri Carla Carfagna Alessandro Casnati Francesco Rispoli Laura baldini Nicola Della Ca Department of Chemistry Life Sciences and Environmental Sustainability (SCVSA)University of ParmaParco Area delle Scienze17/A43124 Parma (PR)Italy Center for Energy and Environment (CIDEA) University of ParmaParco Area delle Scienze 181/A43124 Parma (PR)Italy Laboratory of Industrial and Synthetic Organic Chemistry (LISOC) Department of Chemistry and Chemical TechnologiesUniversity of CalabriaVia P.Bucci 12/C87036 Arcavacata di RendeCosenza (CS)Italy Department of Biomolecular Sciences University of Urbino “Carlo Bo”Piazza Rinascimento 661029 Urbino (PU)Italy Department of Industrial Chemistry “T.Montanari” University of BolognaViale Risorgimento 440136 Bologna (BO)Italy

A highly selective palladium-catalyzed carbonylation of 2-alkynylanilines bearing an amide moiety to condensed six-membered heterocyclic structures has been developed under mild conditions(room temperature and atmospheric pressure of CO).The carbonylative protocol is also compatible with CO surrogates,such as benzene-1,3,5-triyl triformate(TFBen)or the newly developed calix[6]arenes functionalized with six formate groups(CLX[6]CO),which are both capable to release CO in situ.A series of tricyclic fused heterocycles containing the important oxazino-quinolinone scaffold have been selectively obtained(only the 6-endo-dig cyclization mode has been observed)in good to excellent yields(up to 99%).

关键词： Pd-catalysis Carbonylation Alkynes CO surrogates 6-endo-dig Calixarenes C1 building blocks Domino reactions

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中子的内部结构:来自BESIII的研究

Science Bulletin 2022年第6期67卷 557-560页

作者： Simone Pacetti Rinaldo baldini Ferroli Andrea Bianconi Egle Tomasi-Gustafsson Dipartimento di Fisica e Geologia and INFN Sezione di Perugia1-06123 PerugiaItaly Laboratori Nazionali di Frascati dell'INFN 1-00044 FrascatiItaly Dipartimento di Ingegneria dell'Informazione Brescia1-25133 BresciaItaly INFN Sezione di Pavia1-27100 PaviaItaly DPhN IRFUCEAUniversitéParis-Saclay1-91191 Gif-sur-Yvette CedexFrance

The BESⅢCollaboration has recently published a new precise measurement of the time-like neutron form factor(FF)[1].In the light of the remarkable accuracy and of the wideness of the explored kinematical range,these data represent an unprecedented tool for highlighting and studying specific features of the neutron *** a few years ago,the only available data were those obtained by the FENICE experiment at Frascati,in the’90s[2].

关键词： BESⅢ precise

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The Cruelty of Love

新美术 2022年第3期 2-2页

作者： Baccio baldini

Use of programmed cell death protein ligand 1 assay to predict the outcomes of non-small cell lung cancer patients treated with immune checkpoint inhibitors

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World Journal of Clinical Oncology 2017年第4期8卷 320-328页

作者： Carmelo Tibaldi Alice Lunghi Editta baldini Division of Oncology Department of OncologyS. Luca Hospital

The recent discovery of immune checkpoints inhibitors, especially anti-programmed cell death protein 1(PD-1)and anti-programmed cell death protein ligand 1(PD-L1) monoclonal antibodies, has opened new scenarios in the management of non-small cell lung cancer(NSCLC) and this new class of drugs has achieved a rapid development in the treatment of this disease. However, considering the costs of these drugs and the fact that only a subset of patients experience long-term disease control, the identification of predictive biomarkers for the selection of candidates suitable for treatment has become a priority. The research focused mainly on the expression of the PD-L1 receptor on both tumor cells and/or immune infiltrates determined by immunohistochemistry(IHC). However, different checkpoint inhibitors were tested, different IHC assays were used, different targets were considered(tumor cells, immune infiltrates or both) and different expression thresholds were employed in clinical trials. In some trials the assay was used prospectively to select the patients, while in other trials it was evaluated retrospectively. Some confusion emerges, which makes it difficult to easily compare the literature data and to translate them in practice management. This mini-review shows the possibilities and pitfalls of the PD-L1 expression to predict the activity and efficacy of anti PD1/PD-L1 monoclonal antibodies in the treatment of NSCLC.

关键词： Predictive biomarkers Immunotherapy Checkpoint inhibitors Programmed cell death protein ligand 1 Non-small cell lung cancer

Is hyperhomocysteinemia relevant in patients with celiac disease?

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World Journal of Gastroenterology 2011年第24期17卷 2941-2944页

作者： Giovanni Casella Gabrio Bassotti Vincenzo Villanacci Camillo Di Bella Fabio Pagni Gian Luigi Corti Giuseppe Sabatino Mara Piatti Vittorio baldini Division of Internal Medicine Desio General Hospital Gastroenterology and Hepatology Section Department of Clinical and Experimental MedicineOspedale Santa Maria della Misericordia 2nd Pathology Section Spedali Civili Pathology Unit Desio General Hospital Endoscopy Unit Division of SurgeryDesio General Hospital Laboratory Medicine Unit Desio General Hospital

AIM:To investigate whether this might be related to the presence of ***:Hyperhomocysteinemia was evident in 32 patients(19.3%),although most of them had moderate levels(mean value 25 mcg/ml;range 15-30).Only one patient had a history of myocardial infarction(heterozygosis for N5-N10-metil tetrahydrofolate reductase mutation).CONCLUSION:The systematic assessment of hyperhomocysteinemia seems,at present,unjustified in CD patients.

关键词：高同型半胱氨酸血症患者腹腔疾病平均年龄心肌梗死基因突变四氢叶酸

Self-efficacy for managing hypertension and comorbid conditions

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World Journal of Hypertension 2019年第3期9卷 30-41页

作者： Mi Jung Lee Sergio Romero HuanGuang Jia Craig A Velozo Ann L Gruber-baldini Lisa M Shulman Department of Occupational Therapy University of FloridaGainesvilleFL 32610United States NF/SG VHS Center of Innovation on Disability and Rehabilitation Research-GNVGainesvilleFL 32601United States Division of Occupational Therapy Medical University of South CarolinaCharlestonSC 29425United States Department of Epidemiology and Public Health University of Maryland School of MedicineBaltimoreMD 21201United States Department of Neurology University of Maryland School of MedicineBaltimoreMD 21201United States

BACKGROUND Self-efficacy is defined an individual’s belief in completing necessary actions to achieve the desired *** individuals with hypertension and other chronic conditions,self-efficacy has been an essential factor to predict adherence to treatment *** To examine self-efficacy for managing chronic conditions in individuals with *** A total of 1087 individuals with chronic conditions in two groups(hypertension and non-hypertension groups)were selected in this *** two groups’selfefficacy for managing chronic conditions were investigated using the five domains of patient reported outcomes measurement information system selfefficacy for managing chronic conditions measures(PROMIS-SE);daily activities,emotions,medication and treatment,social interactions,and ***,the relationships between self-efficacy and other health-related outcomes for the hypertension group were examined using structural equation *** Among 1087 participants,437 reported having *** hypertension and non-hypertension groups were statistically different in self-efficacy for managing daily activities[F(1,598)=5.63,P<0.05].Structural equation modeling indicated that for individuals with hypertension,two domains of PROMIS-SE(managing daily activities and emotions)significantly predict global physical health(P<0.001 and P<0.01 sequentially),and one domain(managing emotions)significantly predicts mental health(P<0.001).Hypertension patients’general quality of life was significantly predicted by global physical health(P<0.001)and mental health(P<0.001).CONCLUSION The hypertension group reported deficits in self-efficacy in managing daily activities as compared to the non-hypertension *** this hypertension group,self-efficacy functioned as an indirect predictor of general quality of life,mediated by global physical and mental health.

关键词： Hypertension Self-efficacy Self-management Chronic conditions

Ionized jet deposition of antimicrobial and stem cell friendly silver-substituted tricalcium phosphate nanocoatings on titanium alloy

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Bioactive Materials 2021年第8期6卷 2629-2642页

作者： Gabriela Graziani Katia Barbaro Inna V.Fadeeva Daniele Ghezzi Marco Fosca Enrico Sassoni Gianluca Vadalà Martina Cappelletti Francesco Valle Nicola baldini Julietta V.Rau IRCSS Istituto Ortopedico Rizzoli Laboratory of NanoBiotechnologyvia di Barbiano 1/1040136BolognaItaly Istituto Zooprofilattico Sperimentale Lazio e Toscana“M.Aleandri” Via Appia Nuova 1411-00178RomeItaly A.A.Baikov Institute of Metallurgy and Materials Science Russian Academy of SciencesLeninsky prospect 49119334MoscowRussia Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere100-00133RomeItaly University of Bologna Department of CivilChemicalEnvironmental and Materials Engineeringvia Terracini 2840131BolognaItaly UniversitàCampus Bio-Medico di Roma Research Unit of Orthopaedic SurgeryFaculty of Medicine and SurgeryVia Alvaro del Portillo 2100128RomeItaly University of Bologna Department of Pharmacy and Biotechnologyvia Irnerio 4240126BolognaItaly Institute of Nanostructured Materials National Research Council(ISMN-CNR)Via Piero Gobetti10140129BolognaItaly IRCSS Istituto Ortopedico Rizzoli BST Biomedical Science and Technologies Labvia di Barbiano 1/1040136BolognaItaly University of Bologna Department of Biomedical and Neuromotor SciencesVia Massarenti940128BolognaItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8build.2119991MoscowRussia

Orthopedic infections pose severe societal and economic burden and interfere with the capability of the implanted devices to integrate in the host bone,thus significantly increasing implants failure *** address infection and promote integration,here nanostructured antibacterial and bioactive thin films are proposed,obtained,for the first time,by Ionized Jet Deposition(IJD)of silver-substituted tricalcium phosphate(Ag-TCP)targets on *** morphology,composition and mechanical properties are characterized and proof-of-concept of biocompatibility is *** efficacy is investigated against four Gram positive and Gram negative bacterial strains and against *** fungus,by investigating the modifications in planktonic bacterial growth in the absence and presence of ***,for all bacterial strains,the capability of the film to inhibit bacterial adhesion is also *** indicate that IJD permits a fine control over films composition and morphology and deposition of films with suitable mechanical *** studies show a good efficacy against Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis and against fungus Candida albicans,with evidences of efficacy against planktonic growth and significant reduction of bacterial cell *** cytotoxic effects are evidenced for equine adipose tissue derived mesenchymal stem cells(ADMSCs),as no reductions are caused to cells viability and no interference is assessed in cells differentiation towards osteogenic lineage,in the presence of ***,thanks to nanostructuration and biomimetic composition,tricalcium phosphate(TCP)coatings favor cells viability,also when *** findings show that silver-substituted nanostructured coatings are promising for orthopedic implant applications.

关键词： Tricalcium phosphate Silver Nanostructured coatings Antibacterial coatings Orthopedics Antibacterial ceramics

A New Volumetric Parameter for a Comparative Finite-Element Analysis of a Six- or Four-Implant Mandibular Total-Arch Rehabilitation

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Open Journal of Stomatology 2016年第1期6卷 12-21页

作者： Alfredo Natali Enrico Bertocchi Andrea baldini Giuseppe Antonio Mulas Matteo Martinolli Bortolini Sergio DDS Teacher at the PhD “Enzo Ferrari” in Industrial and Environmental Engineering University of Modena and Reggio Emilia Modena Italy Department of Engineering “Enzo Ferrari” University of Modena and Reggio Emilia Modena Italy Tecnopolo di Mirandola Science and Technology Park for Medicine Mirandola Italy School of High Mechanics and Automotive Design & Technology Department of Mechanical and Civil Engineering University of Modena and Reggio Emilia Modena Italy Department of Surgery Medicine Dentistry and Morphologic Science with Interests in Transplant Oncologic and Regenerative Medicine University of Modena and Reggio Emilia Modena Italy

In a full-arch implant rehabilitation ad modum Branemark, the distribution of stress and strain in mandibular bone is influenced by the type, number and position of implants used. In particular, the biomechanical behaviour of the bone structure after complete osseointegration depends on the load transferred to the bone by each fixture. In this study, a finite-element analysis of two models was performed. Models of an all-on-four configuration and a six-implant configuration were compared in a worst-case scenario. A new V parameter is presented to aid the quantitative and comparative analysis of the all-on-four and six-implant configurations. The influence of orthotropy was also investigated, and a geometric change in the all-on-four configuration is presented.

关键词： Finite-Element Analysis Oral Implants All-on-Four Configuration Six-Implant Configuration Bone Mechanics Comparative Analysis