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Antibiotic resistant Esherichia coli strains from seafood and its susceptibility to seaweed extracts

Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 977-981页

作者： Subramanian Kumaran balaraman deivasiganiani Kumarappan Alagappan Mannikam Sakthivel Rajamani Karthikeyan Faculty of Marine Sciences Annamalai UniversityParangipettaiTamil NaduIndia

Objective:To determine the prevalence and antibiotic resistance of Escherichia coli(E. coli),in seafood obtained from Cuddalore and Parangipettai fish landing ***,to identify the susceptibility of *** against predominant seaweeds red alga Kappaphycus alvarezii(***) and brown alga Padina boergessenii(***) extracts as sulfated polysaccharides and polyphenols ***:A total of 48 samples(Two stations Cuddalore and Parangipettai,Tamil Nadu,India).Sampling area are fish landing centre where fishes caught from sea and estuary,seafood processing plants(packing and ice packed fishes) and local fish markets(fish samples).After isolation totally 80 strains were analyzed for its antimicrobial resistance and sensitivity against commercially 10 *** ampicillin resistant *** CE21 was identified through molecular techniques as I6S rDNA sequencing. Two seaweeds *** and *** were screened lor antibacterial activity against 12 antibiotic resistant *** ***:Totally 48 swabbed samples from two different fish handling area were characterized for total bacterial and *** ***,the *** strains were isolated from fish local market and seafood processing plants before and after packaging *** that maximum 56.25%strains were resistant to ampicillin and the minimum 2.5%strains were resistant to ***,the *** CE21 was identified through molecular techniques ***(GenBank accession number GU065251),The MIC value for polyphenol extract was slightly less than sulfated *** strain isolated from Parangipettai was considerably increased MIC value that ***: The polyphenol and sulfated polysaccharides showed promising inhibitory response against all antimicrobial resistant *** strains and in particular the inhibitory response of ampicillin resistant ***.

关键词： Antibiotic resistant E.coli Antibacterial activity Seaweed extract Seafood

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Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells

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Cancer Communications 2024年第3期44卷 448-452页

作者： Donghai Xiong Zheng Yin Mofei Huang Yian Wang Micael Hardy balaraman Kalyanaraman Stephen T Wong Ming You Center for Cancer Prevention Houston Methodist Neal Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Department of Systems Medicine and Bioengineering Houston Methodist Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Aix Marseille Univ Centre Nationaldela Recherche Scientifique(CNRS)Institut de Chimie Radicalaire(ICR)UnitéMixte de Recherche(UMR)7273MarseilleFrance Department of Biophysics Medical College of WisconsinMilwaukeeWisconsinUSA

Dear Editor,Atovaquone(ATO),a mitochondrial inhibitor,has anti-cancer effects[1].Based on ATO,we developed mitochondria-targeted atovaquone(Mito-ATO)that had even stronger anti-tumor efficacy than ATO[2].We syn-thesized Mito-ATO by attaching the bulky triphenylphos-phonium(TPP)group to ATO via a ten-carbon alkyl chain(Supplementary file of methods;Supplementary Figure S1).

关键词： metabolism immunity targeted

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Tomato lycopene attenuates myocardial infarction induced by isoproterenol:Electrocardiographic,biochemical and anti-apoptotic study

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Asian Pacific Journal of Tropical Biomedicine 2012年第5期2卷 345-351页

作者： Aman Upaganlawar Vaibhav Patel balaraman R Pharmacy Department Faculty of Technology and EngineeringThe Maharaja Sayajirao University of Baroda

Objective:To assess the protective effects of lycopene on electrocardiographic,hemodynamic, biochemical and apoptotic changes in isoproterenol induced myocardial ***: Myocardial infarction was induced in rats by subcutaneous injection of isoproterenol(200 mg/kg) for two consecutive days at an interval of 24 *** were treated with lycopene(10 mg/kg/day, p.o.) for a period of 30 days and isoproterenol(ISO) was injected on the 29th and 30th *** the end of experiment *** the 31st day electrocardiographic,hemodynamic,biochemical and apoptotic changes were monitored from control and experimental ***:ISO injected ruts showed a significant alteration in electrocardiograph pattern and hemodynamic changes(i.e. systolic,diastolic and mean arterial pressure).It also showed significant increase in C-reactive protein,myeloperoxidase,nitrite levels and Caspase-3 protease *** addition,it also exhibited alteration in the levels of electrolytes(Na^+,K^+ and Ca^(2+),vitamin E,uric acid and serum *** electrophoresis of ISO injected rats showed increase in DNA *** tetrazolium chloride staining of the heart section shows increase area of infarction in ISO injected ***-co-treatment with lycopene significantly prevented the ISO induced ullerution in ECC, haemodynamic,biochemical and apoptotic ***:The present result shows that treatment of lycopene in ISO injected rats significantly attenuates induced myocardial infarction.

关键词： Myocardial infarction Lycopene Isoproterenol Apoptosis Antioxidants Necrosis

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Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells

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Chinese Journal of Integrative Medicine 2021年第9期27卷 680-687页

作者： Ashok Mari Gopikrishnan Mani Sirpu Natesh Nagabhishek Gopaiakrishnan balaraman Nirmala Subramanian Fathima Bushra Mirza Jagan Sundaram Devaki Thiruvengadam Department of Biochemistry University of MadrasGuindy CampusChennai(600025)India Cancer Biology Lab Department of Nanoscience and NanotechnologySathyabama Institute of Science and TechnologyChennai(600119)India VRR Institute of Biomedical Science KattupakkamChennai(600056)India

Objective:To examine the role of carvacrol in modulating PI3 K/AKT signaling involved in human breast cancer pathogenesis using in vitro experimental model MCF-7 ***:MTT and lactate dehydrogenase assays were performed with cells treated with different doses of carvacrol(0–250μmol/L)at different time points(24 and 48 h).The nuclear morphology was assessed in MCF-7 cells with propidium iodide(PI)and acridine orange/ethidium bromide(AO/EB)staining and analyzed by fluorescence *** like cell cycle arrest and apoptosis were observed by flow cytometric analysis and expressions of p-Rb,cyclin D1,cyclin-dependent kinase 4(CDK4),CDK6,Bax,Bcl-2,PI3 K/p-AKT were analyzed by ***:Carvacrol significantly reduced cell viability with the half maximal inhibitory concentration value of 200μmol/L at 24 and 48 h(P<0.05).importantly,there was a significant increase in the accumulation of the G0/G1 phase upon treatment with carvacrol in MCF-7 cells(P<0.05 or P<0.01).A remarkable decrease in protein expressions of p-Rb,cyclin D1,CDK4 and CDK6 denoted cell cycle arrest(P<0.05 or P<0.01).In addition,carvacrol treatment significantly inhibited PI3 K/p-AKT protein expressions leading to induction of apoptosis mediated by decreased Bcl2 and increased Bax protein ***,Annexin V/PI staining by FACS analysis,dual staining by AO/EB and PI staining studies suggested induction of apoptosis by carvacrol through PI3 K/Akt signaling pathway in MCF-7 ***:Carvacrol significantly inhibited the breast cancer MCF-7 cell proliferation and induced apoptosis via suppressing PI3/AKT signaling pathway.

关键词： carvacrol breast cancer proliferation apoptosis PI3K/AKT signaling pathway

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Antibacterial potential of sponge endosymbiont marine Enterobacter sp at Kavaratti Island,Lakshadweep archipelago

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 142-146页

作者： Mohan Gopi Subramanian Kumaran Thipparamalai Thangappanpillai Ajith Kumar balaraman Deivasigamani Kumarappan Alagappan Srinivasan Guru Prasad CAS in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai- 608 502Tamil NaduIndia CMLRE Field Research Station Agatti IslandLakshadweep- 682 553India

Objective:To isolate antibacterial potential of sponge endosymbiotic bacteria from marine sponges at Lakshadweep *** to identify the potent bacteria by 16s rDNA sequencing and determine the antibacterial activity against clinical pathogens by ***: Sponge samples was collected from sub-tidal habitats at Kavaratti Island and *** endosymbiotic bacteria were isolated and selected potential bacteria which show antibacterial activity in preliminary screening against clinical pathogens Staphylococcus aureus(***), Escherichia coli(***),Salmonella typhi(***),Klebsiella pneumoniea(***) and Streptococcus *** disc diffusion *** crude extracts of potential bacteria LB3 was tested against clinical pathogens by *** LB3 strain was identified by 16s rDNA sequencing, 1111 bp was submitted in NCBI(HQ589912) and constructed phylogenetic ***:Sponge sample was identified as Dysidea granulosa(***) and potential bacteria LB3 identified as Enterobacter sp *** screening of sponge isolates against clinical pathogens,LB3 strain was selected as potential producer of secondary metabolites and crude extract was implies on MIC of LB3 have confirmed with lowest concentration of 5.0 mg/mL in broth medium influence of crude extract on growth inhibitory activity after 5 h of incubation period and completed the inhibitory activity at 15 ***:The present study concluded that phylogenetic analysis of endosymbiotic bacteria Enterobacter sp from sponge *** of Lakshadweep islands showed significant antibacterial activity against clinical bacterial pathogens.

关键词： Lakshadweep Sponge 16s rDNA Clinical pathogens

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Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

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Genes & Diseases 2016年第1期3卷 82-87页

作者： Baozhong Zhao Lei Qiang Joy Joseph balaraman Kalyanaraman Benoit Viollet Yu-Ying He Department of Medicine Section of DermatologyUniversity of ChicagoChicagoILUSA Free Radical Research Center Medical College of WisconsinMilwaukeeWIUSA INSERM U567 CNRS UMR8104Department of EndocrinologyMetabolism and CancerInstitut CochinUniversite´Paris 575014 ParisFrance

Autophagy is a cellular self-eating process essential for stress response and maintainingtissue homeostasis by lysosomal degradation of unwanted or damaged proteins and ***, we show that cells with defective mitochondria induce autophagy to promotecell survival through activating the AMPK pathway. Loss of mitochondrial complex III proteincytochrome b activates the AMPK signaling and induced autophagy. Inhibiting mitochondria energeticsby mitochondria-targeted agents activates the AMPK signaling and induced *** inhibition of AMPK inhibits autophagy induction in cells with defective mitochondria,while genetic inhibition of autophagy has no effect on AMPK activation. Mitochondria dysfunctionhas no effect of DNA repair of UV-induced DNA damage. However, mitochondria dysfunctionsensitizes cells to apoptosis induced by UV radiation. Genetic inhibition of autophagy orAMPK sensitized cells to apoptosis in cells with defective mitochondria. Our results demonstratethat AMPK and autophagy senses mitochondria dysfunction and serves as a mechanismfor survival. Our findings may provide new insights into the interplay between mitochondriafunction and autophagy process in maintaining tissue homeostasis, and suggest that this interactionmay play important roles in diseases such as cancer and neurodegeneration.

关键词： AMPK Apoptosis Autophagy DNA repair Mitochondria Ultraviolet radiation UV

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Extracts of passion fruit peel and seed of Passiflora edulis(Passifloraceae) attenuate oxidative stress in diabetic rats

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Chinese Journal of Natural Medicines 2015年第9期13卷 680-686页

作者： Salanee Kandandapani Ashok K.balaraman Haja N.Ahamed Faculty of Biomedical Sciences Asia Metropolitan University Faculty of Pharmacy Asia Metropolitan University

This study was aimed at evaluating the anti-diabetic potential of passion fruit Passiflora edulis(EPE) extracts in diabetic rats, following Streptozotocin(STZ) induced oxidative stress. Thirty adult Wistar rats were divided into five groups, with six rats in each group. The control rats were injected intraperitoneally with citrate buffer(pH 4.5). The remaining groups of rats were administered single dose of 45 mg·kg-1 of STZ by intraperitoneal route to induce diabetes. The diabetic animals were treated with 250 and 500 mg·kg-1 of EPE and glibenclamide 0.6 mg·kg-1 for fifteen days by oral route. Blood glucose, end organ oxidative stress marker, and anti-oxidants were assayed. Further, histopathological investigation of pancreas was studied at the end of the experimentation. The results revealed that subacute administration of EPE significantly(P < 0.001) controlled the blood glucose level in the diabetic rats. In addition, EPE extract protected the end organs by restoring the anti-oxidants enzyme, significantly increasing super oxide dismutase level(SOD) and decreasing catalase(CAT) and TBARS level in visceral organs. In conclusion, that EPE extracts showed anti-diabetic and anti-oxidant potential against streptozotocin-induced diabetes.

关键词： Streptozotocin Diabetic rats Reactive oxygen species Oxidative stress Anti-oxidant enzymes Visceral organs

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Phase Transition Behavior of Nanocrystalline Al<sub>2</sub>O<sub>3</sub>Powders

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Soft Nanoscience Letters 2013年第4期3卷 69-74页

作者： balaraman Sathyaseelan Iruson Baskaran Kandasamy Sivakumar Department of Physics Anna University Chennai Chennai India. Department of Physics Arignar Anna Govt. Arts College Cheyyar India Department of Physics University College of Engineering Arni (A Constituent College of Anna University Chennai) Arni India

Alumina (Al2O3) has been synthesized through combustion synthesis (CS) technique. The calcined products were characterized using X-ray diffractional analysis (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and thermo-gravimetric analysis (TGA). TG-DTA results reveal the various stages involved in transition from γ-phase to α-Al2O3 phase. The first phase γ-Al2O3 was presented in the temperature range from 600°C-875°C as deduced from the XRD patterns with cubic crystal structure. The second stage occurs in the temperature range from 900°C-1000°C. In the final step, above 1000°C, the aluminium oxide appears completely as α-Al2O3, showing high crystallinity. The particle sizes are closely related to γ- to α-Al2O3 phase transition.

关键词： Nanocrystalline Al2O3 Phase Transitions γ-Al2O3 α-Al2O3 Differential Scanning Calorimetry (DSC) Electron Microscopy (TEM and SEM)

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Case Study Strategy in Business and Marketing Research

Case Study Strategy in Business and Marketing Research

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The 4th International Conference on Engineering and Business Management

作者： Xu Huang Pravin balaraman Business School University of theWest of Scotland

This paper is based on the consideration of the adoption of case study strategy in marketing and business research, as well as case selection and case study research process.

关键词： Case Study Research Method Methodology

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Study on Enhanced Antibacterial and Cytotoxicity of Pure and Cadmium Doped Cerium Oxide against Gram-Positive and Gram-Negative Bacteria

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Soft Nanoscience Letters 2019年第1期9卷 1-16页

作者： Killivalavan Govindarasu Kavitha Gnanasekaran Sathyaseelan balaraman Baskaran Iruson Senthilnathan Krishnamoorthy Sathyaseelan balaraman Babu Padmaraj Elayaperumal Manikandan Sivakumar Dhananjayan Department of Physics Bharathiar University Coimbatore India P. G. Research & Department of Physics A. M. Jain College Meenambakkam India Department of Physics University College of Engineering Arni (A Constituent College of Anna University Chennai)Arni India Department of Physics University College of Engineering Arni (A Constituent College of Anna University Chennai)ArniIndia Department of Physics Arignar Anna Govt. Arts College Cheyyar Tamil Nadu India Department of Physics VIT University Vellore India Department of Physics Thiruvalluvar University TUCAS Campus Thennangur India UNESCO UNISA Africa Chair in Nanosciences & Nanotechnology College of Graduate Studies University of South Africa Muckleneuk Ridge Pretoria South Africa Department of Physics Sree Krishna College of Engineering Unai Anai India

Pure and Cadmium (Cd) doped Cerium oxide nanoparticles (CeNPs) have been synthesised by the simple chemical co-precipitation technique. Cadmium ions of concentrations 1, 3 and 5 mol% were doped to investigate their influence on the structural and optical properties of CeO2. The synthesised samples have been subjected to X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis and high-resolution transmission electron microscopy (HRTEM). The XRD and Raman patterns have witnessed the cubic structure of the cerium oxide nanoparticles. The average particle size of CeO2 was found to be around 10 nm. SEM image has also ascertained that the grain size of pure CeO2 appeared is bigger than that of the Cd-doped, which intern indicates the grain growth upon doping. Besides, the antibacterial activity of the cadmium doped cerium oxide nanoparticles against some human pathogens revealed that they have exhibited the maximum zone of inhibition against gram-positive bacteria than the gram-negative species. Further, the cytotoxic effect of Cd-doped CeO2 sample is examined in cultured (MCF-7, A549 and Hep-2) cell.

关键词： Co-Precipitation XRD SEM HRTEM Antibacterial Activity

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