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Organic Chemistry Frontiers 2022年第5期9卷 1395-1402页

作者： Palani natarajan Deachen Chuskit Priya Department of Chemistry&Centre for Advanced Studies in Chemistry Panjab UniversityChandigarh-160014India

Easily accessible alkylbenzenes are highly valuable starting materials and solvents in synthetic organic chemistry for the production of pharmaceuticals,plastics,synthetic rubber,dyes,etc.

关键词： alkyl visible rubber

Smart Fraud Detection in E-Transactions Using Synthetic Minority Oversampling and Binary Harris Hawks Optimization

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Computers, Materials & Continua 2023年第5期75卷 3171-3187页

作者： Chandana Gouri Tekkali Karthika natarajan School of Computer Science and Engineering VIT-AP University522237Andhra PradeshIndia

Fraud Transactions are haunting the economy of many individuals with several factors across the *** research focuses on developing a mechanism by integrating various optimized machine-learning algorithms to ensure the security and integrity of digital *** research proposes a novel methodology through three ***,Synthetic Minority Oversampling Technique(SMOTE)is applied to get balanced ***,SMOTE is fed to the nature-inspired Meta Heuristic(MH)algorithm,namely Binary Harris Hawks Optimization(BinHHO),Binary Aquila Optimization(BAO),and Binary Grey Wolf Optimization(BGWO),for feature *** has performed well when compared with the other ***,features from BinHHO are fed to the supervised learning algorithms to classify the transactions such as fraud and *** efficiency of BinHHO is analyzed with other popular MH *** BinHHO has achieved the highest accuracy of 99.95%and demonstrates amore significant positive effect on the performance of the proposed model.

关键词： Metaheuristic algorithms K-nearest-neighbour binary aquila optimization binary grey wolf optimization BinHHO optimization support vector machine

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1391-1392页

作者： Sandeep Rana Amarnath natarajan Division of Predinical Innovation National Center for Advancing Translational SciencesNational Institutes of HealthRockvilleMDUSA Eppley Institute for Cancer Research Fred&Pamela Buffett Cancer CenterUniversity of Nebraska Medical CenterOmahaNEUSA

The recent report by Slabicki et *** Nature used an array of techniques including cryo-electron microscopy to elucidate the mechanism of action of BI-3802,a molecular glue.1 The discovery of small molecules that highjack cellular quality control machinery to selectively degrade proteins has generated considerable excitement in the drug discovery community,particularly toward targets often deemed"undruggable".Whether its proteolysis targeting chimeras(PROTACs),consisting of heterobifunctional molecules connected by a linker that facilitates the recruitment of an E3 ligase to the protein of interest(POI)or small molecules that function as molecular glues2 to induce a novel interaction between an E3 ligase and the POI,the ultimate goal is to tag the POI for destruction in *** design is relatively straight forward,wherein a POI binding small molecule,and an E3 ligase binding ligand are connected through a linker that enables stable ternary complex formation(POI:PROTAC:E3 ligase)followed by POI degradation.

关键词： POI connected straight

Studies on thermally grown oxide as an interface between plasma-sprayed coatings and a nickel-based superalloy substrate

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矿物冶金与材料学报：英文版 2017年第6期24卷 681-690页

作者： Adam Khan Mahaboob Basha Sundarrajan Srinivasan natarajan Srinivasan Department of Mechanical Engineering Centre for Surface Engineering Kalasalingam University Krishnankoil 626126 Tamil Nadu India Department of Metallurgical and Materials Engineering National Institute of Technology Tiruchirapalli 620015 Tamil Nadu India Centre of Excellence in Corrosion and Surface Engineering (CECASE) National Institute of Technology Tiruchirapalli 620015 Tamil Nadu India

A thermally grown oxide layer formed by hot corrosion was investigated as an interface between plasma-sprayed coatings and a nickel-based superalloy substrate. The hot corrosion mechanism of NiCr–Cr_2O_3 and Al_2O_3–40wt% TiO_2(A40T) plasma coated Inconel 617 was evaluated. The experiments were carried out at 1000°C using a combination of Na_2SO_4, NaCl, and V_2O_5 salts to simulate the conditions of a gas turbine in a marine environment. The hot corrosion results revealed the spallation and dissolution of oxides upon prolonged exposure. Optical images and scanning electron micrographs of the exposed samples revealed the formation of oxide scale and provided details of its morphology in NiCr–Cr_2O_3 coated samples. Microstructure characterization of A40T coatings demonstrated a thermally grown oxide(TGO) layer at 1000°C. Increasing the thickness of the TGO layer decreased the corrosion resistance. The elemental analysis and image mapping revealed the migration of active elements from the substrate and coatings toward the corrosive environment.

关键词： corrosion coatings superalloy oxides

First Complete Genome Sequence of a Probiotic Enterococcus faecium Strain T-110 and Its Comparative Genome Analysis with Pathogenic and Non-pathogenic Enterococcus faecium Genomes

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Journal of Genetics and Genomics 2015年第1期42卷 43-46页

作者： Purushothaman natarajan Madasamy Parani Genomics Laboratory Department of Genetic EngineeringSRM University

Enterococci bacteria are important in environmental, food and clinical microbiology. Enterococcus faecium is a nosocomial pathogen that causes bacteremia, endocarditis and other infections. It is among the most prevalent organisms encountered in hospital-associated infections accounting for approximately 12% of nosocomial infections in the USA （Linden and Miller, 1999）. However, certain strains of E. faecium are not only non-pathogenic but also have beneficial effects on human health with probiotic potential. For example, E. faecium T-110 is a consortium member in several probiotic products including BIO-THREE~ which is widely prescribed for human, animal and aqua-cultural use. This strain was originally developed by TOA Pharmaceuticals in Japan, and later used in the probiotic products of several other companies.

关键词： 110 First Complete Genome Sequence of a Probiotic Enterococcus faecium Strain T-110 and Its Comparative Genome Analysis with Pathogenic and Non-pathogenic Enterococcus faecium Genomes ORFs

Machine-learning the configurational energy of multicomponent crystalline solids

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npj Computational Materials 2018年第1期4卷 191-197页

作者： Anirudh Raju natarajan Anton Van der Ven Materials Department University of CaliforniaSanta Barbara 93106 CAUSA

Machine learning tools such as neural networks and Gaussian process regression are increasingly being implemented in the development of atomistic ***,we develop a formalism to leverage such non-linear interpolation tools in describing properties dependent on occupation degrees of freedom in multicomponent ***-adapted cluster functions are used to differentiate distinct local *** local features are used as input to neural networks that reproduce local properties such as the site *** apply the technique to reproduce a synthetic cluster expansion Hamiltonian with multi-body interactions,as well as the formation energies calculated from first-principles for the intercalation of lithium into *** formalism and results presented here show that complex multi-body interactions may be approximated by non-linear models involving smaller clusters.

关键词： solids cluster multicomponent

Transient Thermal Management Comparison of a Microprocessor Using PCMs in Various Configurations

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Journal of Thermal Science 2011年第6期20卷 516-520页

作者： Thenmozhi R Sharmeela C natarajan P Velraj R Ganthipathy Tulsis' Engineering College AUIndia Anna University ChennaiIndia Bharathidasan Engineering college AUIndia

There has been a strong interest in the use of Phase Change Materials (PCMs) for the transient thermal abatement of high powered *** paper presents a set of transient computational analysis for selected IC packages with the purpose of calibrating the merits of PCM in different *** transient analysis of high powered microprocessors with heat sinks was performed as a benchmark for comparison with the same microprocessors fitted with PCM in the following configurations:a) PCM imbedded into the finned region of the heat sink,b) PCM mounted between the microprocessor and heat sink,c) sealed PCM underfill to the microprocessor and d) PCM fitted to the underside of the printed circuit board directly beneath the *** analysis was performed using a commercial CFD tool together with an approximation to the phase change mechanism using the slope *** indicate the merit of each configuration.

关键词： Phase Change Materials CFD Thermal Management Transient Latent heat

Linking electronic structure calculations to generalized stacking fault energies in multicomponent alloys

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npj Computational Materials 2020年第1期6卷 989-997页

作者： Anirudh Raju natarajan Anton Van der Ven Materials Department University of CaliforniaSanta BarbaraCA 93106USA

The generalized stacking fault energy is a key ingredient to mesoscale models of *** we develop an approach to quantify the dependence of generalized stacking fault energies on the degree of chemical disorder in multicomponent *** introduce the notion of a“configurationally-resolved planar fault”(CRPF)energy and extend the cluster expansion method from alloy theory to express the CRPF as a function of chemical occupation variables of sites surrounding the *** apply the approach to explore the composition and temperature dependence of the unstable stacking fault energy(USF)in binary Mo–Nb ***-principles calculations are used to parameterize a formation energy and CRPF cluster *** Carlo simulations show that the distribution of USF energies is significantly affected by chemical composition and *** formalism is broadly applicable to arbitrary crystal structures and alloy chemistries and will enable the development of rigorous models for deformation mechanisms in high-entropy alloys.

关键词： alloy alloys fault

Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 470-475页

作者： RAGUNATHAN Irulappan PANNEERSELVAM natarajan Research Centre and Postgraduate Studies in Botany the Madura College Madurai-625 011 Tamil Nadu India

Turmeric has long been used as a spice and food colouring agent in Asia. In the present investigation, the antimutagenic potential of curcumin was evaluated in Allium cepa root meristem cells. So far there is no report on the biological properties of curcumin in plant test systems. The root tip cells were treated with sodium azide at 200 and 300 μg/ml for 3 h and curcumin was given at 5, 10 and 20 μg/ml for 16 h, prior to sodium azide treatment. The tips were squashed after colchicine treatment and the cells were analyzed for chromosome aberration and mitotic index. Curcumin induces chromosomal aberration in Allium cepa root tip cells in an insignificant manner, when compared with untreated control. Sodium azide alone induces chromosomal aberrations significantly with increasing concentrations. The total number of aberrations was significantly reduced in root tip cells pretreated with curcumin. The study reveals that curcumin has antimutagenic potential against sodium azide induced chromosomal aberrations in Allium cepa root meristem cells. In addition, it showed mild cytotoxicity by reducing the percentage of mitotic index in all curcumin treated groups, but the mechanism of action remains unknown. The antimutagenic potential of curcumin is effective at 5 μg/ml in Allium cepa root meristem cells.

关键词： Chromosomal aberrations Sodium azide Genotoxicity Allium cepa

Design concepts of an aircraft wing： composite and morphing airfoil with auxetic structures

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 394-408页

作者： P R BUDARAPU Sudhir Sastry Y B R natarajan Department of Aerospace Engineering Indian Institute of Science Bangalore 560 012 India Department of Aeronautical Engineering College of Engineering Defence University Ethiopia Department of Aeronautical Engineering Institute of Aeronautical Engineering Hyderabad India

This paper is categorized into two parts. （1） A frame work to design the aircraft wing structure and （2） analysis ofa morphing airfoil with auxetic structure. The developed design frame work in the first part is used to arrive at the sizes of the various components of an aircraft wing structure. The strength based design is adopted, where the design loads are extracted from the aerodynamic loads. The aerodynamic loads acting on a wing structure are converted to equivalent distributed loads, which are further converted point loads to arrive at the shear forces, bending and twisting moments along the wing span. Based on the estimated shear forces, bending and twisting moments, the strength based design is employed to estimate the sizes of various sections of a composite wing structure. A three dimensional numerical model of the composite wing structure has been developed and analyzed for the extreme load conditions. Glass fiber reinforced plastic material is used in the numerical analysis. The estimated natural frequencies are observed to be in the acceptable limits. Furthermore, the discussed design principles in the first part are extended to the design of a morphing airfoil with auxetic structure. The advantages of the morphing airfoil with auxetic structure are （i） larger displacement with limited straining of the components and （ii） unique deformation characteristics, which produce a theoretical in-plane Poisson＇s ratio of -1. Aluminum Alloy AL6061-T651 is considered in the design of all the structural elements. The compliance characteristics of the airfoil are investigated through a numerical model. The numerical results are observed to be in close agreement with the experimental results in the literature.

关键词： wing design aerodynamic loads morphing airfoil auxetic structures negative Poisson's ratio