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On the functions of astrocyte-mediated neuronal slow inward currents

Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： balázs pál Department of physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

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Flood risk on arid alluvial fans:a case study in the Joghatay Mountains,Northeast Iran

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Journal of Mountain Science 2023年第5期20卷 1183-1200页

作者： Kaveh GHAHRAMAN balázs NAGY Department of physical Geography Eotvos Loránd UniversityPázmány Péter stny.1/CH-1117 BudapestHungary

Among the common hazards related to alluvial fans,flooding is one of the most ***,in populated alluvial fans,not only the natural processes are effective in floods,but the artificial structures and modifications can change the behavior of flooding and its potential *** study aims to indicate the flood-prone landforms in a set of populated alluvial fans in an arid region and investigate the role of anthropogenic activities in controlling/exacerbating flooding in alluvial *** achieve this goal,15 Ground Range Detected in High resolution(GRDH)SAR Sentinel-1 images,covering a total of 24 alluvial fans,were ***-processing and post-processing steps were applied to all images to identify flood-prone sections of the studied alluvial *** results showed that feeder channels,spreading sites,and wide interfluves are the most flood-prone landforms of alluvial *** terms of anthropogenic modifications to mitigate flooding,a rampart system is distributed in the study *** are levee like structures formed from the fan *** aim to mitigate flood hazard on residential areas,infrastructures,and agricultural lands of the study *** show that the rampart system can reduce the danger of floods,but it cannot be considered a long-term ***,a comprehensive flood protection system distributed throughout the whole alluvial fan system is *** also reveal that in regions where flood monitoring is challenging,SAR images can be used as a freely available data set to monitor and identify flooding hotspots.

关键词： Alluvial fan Flood Anthropogenic activities Rampart Sentineli SAR

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Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors

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The Innovation 2024年第3期5卷 129-137页

作者： balázs Gyorffy Department of Biophysics Medical SchoolUniversity of Pecs7624 PecsHungary Department of Bioinformatics Semmelweis University1094 BudapestHungary Cancer Biomarker Research Group Institute of Molecular Life SciencesHUN-REN Research Centre for Natural Sciences1117 BudapestHungary

Identifying genes with prognostic significance that can act as biomarkers in solid tumors can help stratify patients and uncover novel therapy ***,our goal was to expand our previous ranking analysis of survival-associated genes in various solid tumors to include colon cancer specimens with available transcriptomic and clinical data.A Gene Expression Omnibus search was performed to identify available datasets with clinical data and raw gene expression measurements.A combined database was set up and integrated into our Kaplan-Meier plotter,making it possible to identify genes with expression changes linked to altered *** a demonstration of the utility of the platform,the most powerful genes linked to overall survival in colon cancer were identified using uni-and multivariate Cox regression *** combined colon cancer database includes 2,137 tumor samples from 17 independent *** most significant genes associated with relapse-free survival with a false discovery rate below 1%in colon cancer carcinoma were RBpMS(hazard rate[HR]=2.52),TIMp1(HR=2.44),and COl4A2(HR=2.36).The three strongest genes associated with shorter survival in stage II colon cancer include CSF1R(HR=2.86),FlNA(HR=2.88),and TpBG(HR=2.65).In summary,a new integrated database for colon cancer is presented.A colon cancer analysis subsystem was integrated into our Kaplan-Meier plotter that can be used to mine the entire database(https://***).The portal has the potential to be employed for the identification and prioritization of promising biomarkers and therapeutic target candidates in multiple solid tumors including,among others,breast,lung,ovarian,gastric,pancreatic,and colon cancers.

关键词： colon tumors analysis

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Artificial intelligence methods available for cancer research

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Frontiers of Medicine 2024年第5期18卷 778-797页

作者： Ankita Murmu balázs Győrffy Institute of Molecular life Sciences HUN-REN Research Centre for Natural SciencesBudapest 1117Hungary National laboratory for Drug Research and Development Budapest 1117Hungary Department of Bioinformatics Semmelweis UniversityBudapest 1094Hungary Department of Biophysics University of PecsPecs 7624Hungary

Cancer is a heterogeneous and multifaceted disease with a significant global *** substantial technological advancements for battling cancer,early diagnosis and selection of effective treatment remains a *** the convenience of large-scale datasets including multiple levels of data,new bioinformatic tools are needed to transform this wealth of information into clinically useful decision-support *** this field,artificial intelligence(AI)technologies with their highly diverse applications are rapidly gaining *** learning methods,such as Bayesian networks,support vector machines,decision trees,random forests,gradient boosting,and K-nearest neighbors,including neural network models like deep learning,have proven valuable in predictive,prognostic,and diagnostic *** have recently employed large language models to tackle new dimensions of ***,leveraging the opportunity to utilize AI in clinical settings will require surpassing significant obstacles—a major issue is the lack of use of the available reporting guidelines obstructing the reproducibility of published *** this review,we discuss the applications of AI methods and explore their benefits and *** summarize the available guidelines for AI in healthcare and highlight the potential role and impact of AI models on future directions in cancer research.

关键词： machine learning artificial neural network deep learning natural language processing prediction guideline diagnosis

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prediction of the Resonance Characteristics of Combustion Chambers on the Basis of large-Eddy Simulation

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Journal of Thermal Science 2005年第2期14卷 156-161页

作者： Franco MAGAGNATO balázs pRITZ Horst BCHNER Martin GABI Department of Fluid Machinery University of Karlsruhe GermanyDepartment of Fluid Machinery University of KarlsruheGermanyEngler-Bunte-Institute/Division for Combustion Technology University of KarlsruheGermanyDepartment of Fluid Machinery University of KarlsruheGermany

In the last few years intensive experimental investigations were performed at the University of Karlsruhe to develop an analytical model for the Helmholtz resonator-type combustion system. In the present work the resonance characteristics of a Helmholtz resonator-type combustion chamber were investigated using large-eddy simulations (lES), to understand better the flow effects in the chamber and to localize the dissipation. In this paper the results of the lES are presented, which show good agreement with the experiments. The comparison of the lES study with the experiments sheds light on the significant role of the wall roughness in the exhaust gas pipe.

关键词： compressible large-eddy simulation combustion instabilities oscillating flow damping ratio.

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long-term rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric IOl:a 1.5-year follow-up

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 573-578页

作者： balázs Gyongyossy paul Jirak Ulrich Schonherr Konventhospital der Barmherzigen Bruder Linz 4021 Austria Eyelaser Linz 4020 Austria

AIM：To evaluate the rotational stability and visual outcomes of a single-piece hydrophilic acrylic toric intraocular lenses（IOl） over a 1.5-year follow-up *** from the 6-month follow-up study have been previously ***：Forty eyes of 26 cataract patients（mean age：72.8±7.9y） with pre-existing corneal astigmatism of 1.0 to 2.6 D were enrolled in the *** axial length was 23.17±0.88 *** outcome measures after implantation of the Torica-a A IOl（Human Optics） were IOl rotational stability,subjective refraction,astigmatism correction,uncorrected and corrected distance visual acuity（UDVA,CDVA）.RESUlTS：There was no significant change in the parameters evaluated between the 6-month and 1.5-year *** last visit,mean absolute IOl rotation（objective method） was 1.81°±1.87°（range 0.00° to 7.20°） with 78.6% of eyes having IOl rotation 〈3°,92.9% of eyes 〈5° and 100% of eyes 〈8°.No patient required secondary IOl repositioning during the course of the *** residual refractive cylinder was-0.60±0.40 *** was a significant reduction in the magnitude of the J0 vector postoperatively（p〈0.0001） with a mean absolute change of 0.76±0.40 *** mean J45 vector was close to zero preoperatively and postoperatively and didn＇t change significantly（p=0.28）.Mean monocular UDVA and CDVA was 0.09±0.12 log MAR and-0.01±0.12 log MAR,*** treatment with Nd：YAG laser was ***：The Torica-a A IOl shows good and stable visual performance and rotational stability over a 1.5-year follow-up period.

关键词： hydrophilic acrylic astigmatism intraocular lenses cataract rotational stability

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A predictive chance constraint rebalancing approach to mobility-on-demand services

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Communications in Transportation Research 2023年第1期3卷 107-117页

作者： Sten Elling Tingstad Jacobsen Anders lindman balázs Kulcsár Department of Electrical Engineering Chalmers University of TechnologyGothenburg41258Sweden Volvo Cars AB Gothenburg41878Sweden

This paper considers the problem of supply-demand imbalances in Mobility-on-Demand(MoD)*** imbalances occur due to uneven stochastic travel demand and can be mitigated by proactively rebalancing empty vehicles to areas where the demand is *** achieve this,we propose a method that takes into account uncertainties of predicted travel demand while minimizing pick-up time and rebalance mileage for autonomous MoD *** precisely,first travel demand is predicted using Gaussian process Regression(GpR)which provides uncertainty bounds on the *** then formulate a stochastic model predictive control(MpC)for the autonomous ride-hailing service and integrate the demand predictions with uncertainty *** order to guarantee constraint satisfaction in the optimization under estimated stochastic demand prediction,we employ a probabilistic constraining method with user-defined confidence interval,using Chance Constrained MpC(CCMpC).The benefits of the proposed method are ***,travel demand uncertainty prediction from data can naturally be embedded into the MoD optimization framework,allowing us to keep the imbalance at each station below a certain threshold with a user-defined ***,CCMpC can be relaxed into a Mixed-Integer-linear-program(MIlp)and the MIlp can be solved as a corresponding linear-program,which always admits an integral *** transportation simulations show that by tuning the confidence bound on the chance constraint,close to optimal oracle performance can be achieved,with a median customer wait time reduction of 4%compared to using only the mean prediction of the GpR.

关键词： Mobility-on-Demand Travel demand uncertainty Fleet optimization Gaussian process regression Chance constraint optimization Energy efficiency

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Synchronous electrogastrographic and manometric study of the stomach as an esophageal substitute

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World Journal of Gastroenterology 2005年第8期11卷 1172-1178页

作者： Ferenc Izbéki Tibor Wittmann Sándor (O|')dor balázs Botos (A|')ron Altorjay Department of Medicine Department of Surgery

AIM: To investigate the electric and contractile mechanisms involved in the deranged function of the transposed stomach in relation to the course of the symptoms and the changes in contractile and electrical parameters over ***: Twenty-one patients after subtotal esophagectomy and 18 healthy volunteers were *** were compiled by using a questionnaire, and a symptom score was formed. Synchronous electrogastrography and gastric manometry were performed in the fasting state and ***: Eight of the operated patients were symptomfree and 13 had symptoms. The durations of the postoperative periods for the symptomatic (9.1±6.5 mo)and the asymptomatic (28.3±8.8 mo) patients were significantly different. The symptom score correlated negatively with the time that had elapsed since the operation. The percentages of the dominant frequency in the normogastric, bradygastric and tachygastric ranges differed significantly between the controls and the patients.A significant difference was detected between the power ratio of the controls and that of the patients. The occurrence of tachygastria in the symptomatic and the symptom-free patients correlated negatively both with the time that had elapsed and with the symptom score. There was a significant increase in motility index after feeding in the controls, but not in the patients. The contractile activity of the stomach increased both in the controls and in the symptom-free patients. In contrast, in the group of symptomatic patients, the contractile activity decreased postprandially as compared with the fasting ***: The patients' post-operative complaints and symptoms change during the post-operative period and correlate with the parameters of the myoelectric and contractile activities of the stomach. Tachygastria seems to be the major pathogenetic factor involved in the contractile dysfunction.

关键词： Transposed stomach Electrogastrography Gastric manometry post-operative complaints Contractile dysfunction Tachygastria

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Investigating the impacts of urban speed limit reduction through microscopic traffic simulation

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Communications in Transportation Research 2021年第1期1卷 144-157页

作者： Mánuel Gressai balázs Varga Tamás Tettamanti István Varga Dept.of Control for Transportation and Vehicle Systems Fac.of Transportation Engineering and Vehicle EngineeringBudapest University of Technology and Economics

Road traffic congestion has become an everyday phenomenon in today's cities all around the *** reason is clear:at peak hours,the road network operates at full *** this way,growing traffic demand cannot be satisfied,not even with traffic-responsive signal *** external impacts of traffic congestion come with a serious socio-economic cost:air pollution,increased travel times and fuel consumption,stress,as well as higher risk of *** tackle these problems,a number of European cities have implemented reduced speed limit ***,a general urban speed limit measure is in preparatory phase in Budapest,*** this context,a complex preliminary impact assessment is needed using a simulated *** typical network parts of Budapest were analyzed with microscopic traffic *** results revealed that speed limits can affect traffic differently in diverse network types indicating that thorough examination and preparation works are needed prior to the introduction of speed limit reduction.

关键词： Speed limit reduction Microscopic traffic simulation Emission Traffic analysis

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pro-social control of connected automated vehicles in mixed-autonomy multi-lane highway traffic

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Communications in Transportation Research 2021年第1期1卷 158-170页

作者： Jacob larsson Musa Furkan Keskin Bile peng balázs Kulcsár Henk Wymeersch Department of Electrical Engineering Chalmers University of TechnologyGothenburg41296Sweden Institute for Communications Technology TU BraunschweigBraunschweig38106Germany

We propose pro-social control strategies for connected automated vehicles(CAVs)to mitigate jamming waves in mixed-autonomy multi-lane traffic,resulting from car-following dynamics of human-driven vehicles(HDVs).Different from existing studies,which focus mostly on ego vehicle objectives to control CAVs in an individualistic manner,we devise a pro-social control *** latter takes into account the objectives(i.e.,driving comfort and traffic efficiency)of both the ego vehicle and surrounding HDVs to improve smoothness of the entire observable *** a model predictive control(MpC)framework that uses acceleration and lane change sequences of CAVs as optimization variables,the problem of individualistic,altruistic,and pro-social control is formulated as a non-convex mixed-integer nonlinear program(MINlp)and relaxed to a convex quadratic program through converting the piece-wise-linear constraints due to the optimal velocity with relative velocity(OVRV)car-following model into linear constraints by introducing slack ***-fidelity simulations using the OVRV model and high-fidelity simulations using pTV VISSIM simulator show that pro-social and altruistic control can provide significant performance gains over individualistic driving in terms of efficiency and comfort on both single-and multi-lane roads.

关键词： Altruistic control pro-social control Traffic disturbance Model predictive control Connected automated vehicles Stop-and-go waves

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