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ZP-A5型电脑中频治疗仪治疗小儿肺炎的效果观察探究

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中国医疗器械信息 2024年第4期30卷 87-89页

作者：白丽燕陈慈华漳州市漳浦县医院福建漳州363200

目的:探讨ZP-A5型电脑中频治疗仪治疗小儿肺炎的效果。方法:选择90例小儿肺炎患儿为对象,随机数字表法分组,每组45例。对照组采取抗炎、止咳等常规治疗,观察组辅助ZP-A5型电脑中频治疗仪治疗。结果:观察组总有效率95.56%高于对照组的80.... 详细信息

目的:探讨ZP-A5型电脑中频治疗仪治疗小儿肺炎的效果。方法:选择90例小儿肺炎患儿为对象,随机数字表法分组,每组45例。对照组采取抗炎、止咳等常规治疗,观察组辅助ZP-A5型电脑中频治疗仪治疗。结果:观察组总有效率95.56%高于对照组的80.0%,P0.05。结论:ZP-A5型电脑中频治疗仪对小儿肺炎治疗的效果有增强作用,可缩短临床疗程,改善患儿肺功能,不良反应少。

关键词：小儿肺炎 ZP-A5型电脑中频治疗仪肺功能不良反应

SCAB1 coordinates sequential Ca^(2+) and ABA signals during osmotic stress induced stomatal closure in Arabidopsis

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Science China(life Sciences) 2024年第1期67卷 1-18页

作者： Tianren Zhang li bai yan Guo State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Hyperosmotic stress caused by drought is a detrimental threat to plant growth and agricultural productivity due to limited water *** are gateways of transpiration and gas exchange,the swift adjustment of stomatal aperture has a strong influence on plant drought *** intensive investigations of stomatal closure during drought stress in past decades,little is known about how sequential signals are integrated during complete ***,we discovered that the rapid Ca^(2+) signaling and subsequent abscisic acid(ABA)signaling contribute to the kinetics of both F-actin reorganizations and stomatal closure in Arabidopsis thaliana,while STOMATAL CLOSURE-RELATED ACTIN BINDING PROTEIN1(SCAB1)is the molecular switch for this entire *** the early stage of osmotic shock responses,swift elevated calcium signaling promotes SCAB1 phosphorylation through calcium sensors CALCIUM DEPENDENT PROTEIN KINASE3(CPK3)and *** phosphorylation restrained the microfilament binding affinity of SCAB1,which bring about the Factin disassembly and stomatal closure *** the osmotic stress signal continued,both the kinase activity of CPK3 and the phosphorylation level of SCAB1 attenuated *** further found that ABA signaling is indispensable for these attenuations,which presumably contributed to the actin filament reassembly process as well as completion of stomatal ***,the dynamic changes of SCAB1 phosphorylation status are crucial for the kinetics of stomatal *** together,our results support a model in which SCAB1 works as a molecular switch,and directs the microfilament rearrangement through integrating the sequentially generated Ca^(2+) and ABA signals during osmotic stress induced stomatal closure.

关键词： calcium signal ABA stomatal movement microfilaments kinase

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有压管道内的泥沙冲淤特性

水电能源科学 2024年第8期42卷 70-73页

作者：王永宁祁贵贤李正琪梁俞宋静白妍丽杜立鹏李伟南军虎庆阳市盐环定扬黄续建工程建设管理局甘肃庆阳745000 甘肃省水利水电勘测设计研究院有限责任公司甘肃兰州730000 兰州理工大学能源与动力工程学院甘肃兰州730050

为明确复杂地形条件下有压管道内泥沙的运动特征与临界不淤流速,采用模型试验研究了不同粒径泥沙在不同运动状态下的水流流速,分析了泥沙粒径、加沙量与泥沙级配对临界不淤流速的影响。结果表明,间歇式运动状态下,粒径介于(0.075~0.600... 详细信息

为明确复杂地形条件下有压管道内泥沙的运动特征与临界不淤流速,采用模型试验研究了不同粒径泥沙在不同运动状态下的水流流速,分析了泥沙粒径、加沙量与泥沙级配对临界不淤流速的影响。结果表明,间歇式运动状态下,粒径介于(0.075~0.600)mm的泥沙在管道上升段与水平段呈多个椭圆状运动,较陡的下降段呈带状分布,粒径介于(0.600~1.250)mm的泥沙在管道内呈山丘状运动;泥沙运动状态的临界水流速度随泥沙粒径的增大呈增加趋势,且连续式推移状态为最佳泥沙输送状态;临界不淤流速均随泥沙粒径、加沙量、泥沙级配的增大而增大,泥沙粒径是影响临界不淤流速的主要因素,加沙量与泥沙级配是影响临界不淤流速的次要因素。研究结果可为复杂地形条件下有压引水管道工程的设计和应用提供参考。

关键词：有压管道泥沙运动形态泥沙运动状态流速界定临界不淤流速

Contribution of Baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats

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Neuroscience Bulletin 2020年第4期36卷 396-406页

作者： yang liu Shu-yang Zhao yan Feng Jie Sun Xiao-Long Lu Qiu-Xin yan Ying li Zhuo liu Lu-Qi Wang Xun Sun Shijun li Guo-Fen Qiao bai-yan li Department of Pharmacology State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular Medicine ResearchMinistry of EducationCollege of PharmacyHarbin Medical UniversityHarbin 150081China Department of Clinical Laboratory The First Affiliated Hospital of Dalian Medical UniversityDalian 116011China Department of Pharmacology College of PharmacyDalian Medical UniversityDalian 116044China Riley Heart Center Wells Center for Pediatric ResearchIndiana University School of MedicineIndianapolisIN 46202USA

Neuropeptide Y (NPY), a metabolism-related cardiovascular factor, plays a crucial role in blood pressure(BP) regulation via peripheral and central pathways. The expression of NPY receptors (Y1R/Y2R) specific to baroreflex afferents impacts on the sexually dimorphic neural control of circulation. This study was designed to investigate the expression profiles of NPY receptors in the nodose ganglion (NG) and nucleus tractus solitary (NTS) under hypertensive conditions. To this end, rats with hypertension induced by NG-nitro-L-arginine methylester (L-NAME) or high fructose drinking (HFD), and spontaneously hypertensive rats (SHRs) were used to explore the effects/mechanisms of NPY on BP using functional, molecular, and electrophysiological approaches. The data showed that BP was elevated along with baroreceptor sensitivity dysfunction in model rats;Y1R was up-or down-regulated in the NG or NTS of male and female HFD/L-NAME groups,while Y2R was only down-regulated in the HFD groups as well as in the NG of the male L-NAME group. In SHRs,Y1R and Y2R were both down-regulated in the NTS, and not in the NG. In addition to NPY-mediated energy homeostasis, leptin-melanocortin activation may be essential for metabolic disturbance-related hypertension. We found that leptin and a-melanocyte stimulating hormone (aMSH) receptors were aberrantly down-regulated in HFD rats. In addition, a-MSH concentrations were reduced and NPY concentrations were elevated in the serum and NTS at 60 and 90 min after acute leptin infusion. Electrophysiological recordings showed that the decay time-constant and area under the curve of excitatory post-synaptic currents were decreased by Y1R activation in A-types, whereas, both were increased by Y2R activation in Ah-or C-types. These results demonstrate that sex-and afferent-specific NPY receptor expression in the baroreflex afferent pathway is likely to be a novel target for the clinical management of metabolism-related and essential hypertension.

关键词： Neuropeptide Y Hypertension Nucleus of the solitary tract Excitatory post-synaptic current Baroreflex

Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway

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Neuroscience Bulletin 2019年第1期35卷 15-24页

作者： Jian Guan Miao Zhao Chao He Xue li Ying li Jie Sun Wei Wang Ya-li Cui Qing Zhang bai-yan li Guo-Fen Qiao Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Medicine ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China

Fenofibrate, an agonist for peroxisome proliferator-activated receptor alpha(PPAR-a), lowers blood pressure, but whether this action is mediated via baroreflex afferents has not been elucidated. In this study, the distribution of PPAR-a and PPAR-c was assessed in the nodose ganglion(NG) and the nucleus of the solitary tract(NTS). Hypertension induced by drinking high fructose(HFD) was reduced, along with complete restoration of impaired baroreceptor sensitivity, by chronic treatment with fenofibrate. The molecular data also showed that both PPAR-a and PPAR-c were dramatically up-regulated in the NG and NTS of the HFD group. Expression of the downstream signaling molecule of PPAR-a, the mitochondrial uncoupling protein 2(UCP2), was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD *** results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2 expression and reduction of oxidative stress.

关键词： Fenofibrate Peroxisome proliferator-activated receptor Mitochondrial uncoupling protein Baroreflex afferent function Blood pressure regulation

Hard-carbon hybrid li-ion/metal anode enabled by preferred mesoporous uniform lithium growth mechanism

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Journal of Energy Chemistry 2024年第1期88卷 252-259,I0006页

作者： Fang yan yan liu Yuan li yan Wang Zicen Deng Meng li Zhenwei Zhu Aohan Zhou Ting li Jingyi Qiu Gaoping Cao Shaobo Huang Biyan Wang Hao Zhang School of Chemistry and Biological Engineering University of Science and TechnologyBeijing 100083China Research Institute of Chemical Defense Beijing 100191China College of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023HenanChina National Base for International Science&Technology Cooperation School of ChemistryXiangtan UniversityXiangtan 411105HunanChina Materials and Manufacturing Department Beijing University of TechnologyBeijing 100124China

To achieve high energy density in lithium batteries,the construction of lithium-ion/metal hybrid anodes is a promising *** particular,because of the anisotropy of graphite,hybrid anode formed by graphite/li metal has low transport kinetics and is easy to causes the growth of lithium dendrites and accumulation of dead li,which seriously affects the cycle life of batteries and even causes safety ***,by comparing graphite with two types of hard carbon,it was found that hybrid anode formed by hard carbon and lithium metal,possessing more disordered mesoporous structure and lithophilic groups,presents better *** indicate that the mesoporous structure provides abundant active site and storage space for dead *** the synergistic effect of this structure and lithophilic functional groups(–COOH),the reversibility of hard carbon/lithium metal hybrid anode is maintained,promoting uniform deposition of lithium metal and alleviating formation of lithium *** hybrid anode maintains a 99.5%Coulombic efficiency(CE)after 260 cycles at a specific capacity of 500 m Ah/*** work provides new insights into the hybrid anodes formed by carbon-based materials and lithium metal with high specific energy and fast charging ability.

关键词： Hard carbon/li metal hybrid anode Mesoporous structure Surface oxygen functional group Fast charging lithium batteries

A Systematic Study on Scaling Law of Spiral Waves

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Communications in Nonlinear Science and Numerical Simulation 1999年第3期4卷 3-5页

作者： Shufeng bai,yan li and Qi QUyanG(These auhors attribute equally to this article)(Department of Physics,Peking University,Beijing 100871,China) Department of Physics Peking University Beijing 100871 China

Pactedsformationfarfromthermodynamicsequilibriumareubiquitousintheworld,typicalofwhichisthespiralpattern,***-diffusionsystems,***,whOSetiporbitsaci... 详细信息

Pactedsformationfarfromthermodynamicsequilibriumareubiquitousintheworld,typicalofwhichisthespiralpattern,***-diffusionsystems,***,whOSetiporbitsaci...

关键词： spirals non-linear waves scaling law

Exploring the Interplay between Local Chain Structure and Stress Distribution in Polymer Networks

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Chinese Journal of Polymer Science 2024年第6期42卷 874-885页

作者： Jin-Tong Xue yang bai li Peng Xian-Bo Huang Zhao-yan Sun School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China National-certified Enterprise Technology Center Kingfa Science and Technology Co.Ltd.Guangzhou510663China

The mechanical behavior of polymer networks is intrinsically correlated with the local chain topology and chain *** this study,we delve into this relationship through the lens of coarse-grained molecular dynamics(CG-MD)*** aim is to illuminate the intricate interplay between local topology and stress distribution within polymer monomers,cross-linkers,and various components with distinct cross-link connections,thereby elucidating their collective impact on the mechanical properties of polymer *** mainly focus on how specific local structures contribute to the overall mechanical response of the *** particular,we employ local stress analysis to unravel the mechanics of these *** findings reveal the diverse responses of individual components,such as junctions,strands,cross-linkers between junctions,and dangling chain ends,when subjected to ***,we observe that these components exhibit varying degrees of deformation tolerance,underscoring the significance of their roles in determining the mechanical characteristics of the *** investigations highlight junctions as primary contributors to stress accumulation,and particles with higher local stress showing a stronger correlation between stress and Voronoi ***,our results indicate that both strands and cross-linkers between junctions exhibit heightened stress levels as strand lengths *** study enhances our understanding of the multifaceted factors governing the mechanical attributes of cross-linked polymer systems at the microstructural level.

关键词： Local chain structure Local stress Molecular dynamics simulation

LPCS Ni-Zn-Al_(2)O_(3) Intermediate Layer Enhanced SPS NiCr-Cr_(3)C_(2) Coating with Higher Corrosion and Wear Resistances

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 188-195页

作者：白杨 li yan XING Lukuo li Xiangbo WANG Zhenhua State Key Laboratory of Marine Coatings Marine Chemical Research Institute Co.Ltd.Qingdao 266071China College of Mechanical and Electrical Engineering University of China Petroleum(East China)Qingdao 266580China Science and Technology on Marine Corrosion and Protection Laboratory Luoyang Ship Materials Research InstituteQingdao 266101China

The double-layer NiCr-Cr_(3)C_(2)/Ni-Zn-Al_(2)O_(3) coatings with sufficient corrosion and wear resistance were prepared on low carbon steel *** intermediate layers Ni-Zn-Al_(2)O_(3) were fabricated by using low-pressure cold spray (LPCS) method to improve the salt fog corrosion resistance properties of the supersonic plasma spray (SPS) NiCr-Cr_(3)C_(2) *** friction and wear performance for the double-layer and single-layer NiCr-Cr_(3)C_(2) coatings were carried out by line-contact reciprocating sliding,*** with the coating surface analysis techniques,the effect of the salt fog corrosion on the tribological properties of the double-layer coatings was *** results showed that the double-layer coatings exhibited better wear resistance than that of the single-layer coatings,due to the better corrosion resistance of the intermediate layer;the wear mass losses of the double-layer coatings was reduced by 70%than that of the single layer coatings and the wear mechanism of coatings after salt fog corrosion conditions is mainly corrosion wear.

关键词： low-pressure cold spray NiCr-Cr_(3)C_(2)coating wear behavior salt fog corrosion