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Diagnostic value of methylated branched chain amino acid transaminase 1/IKAROS family zinc finger 1 for colorectal cancer

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World Journal of Gastroenterology 2023年第36期29卷 5240-5253页

作者： Ke Xu ai-ru Yu Shen-Bin Pan Jie He Clinical Medical College Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of Oncology The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

BACKGROUND The diagnostic value of combined methylated branched chain amino acid transaminase 1(BCAT1)/IKAROS family zinc finger 1(IKZF1)in plasma for colorectal cancer(CRC)has been explored since ***,several related studies have published their results and showed its diagnostic *** To analyze the diagnostic value of methylated BCAT1/IKZF1 in plasma for screening and postoperative follow-up of *** The candidate studies were identified by searching the PubMed,Embase,Cochrane Library,CNKI,and Wanfang databases from May 31,2003 to June 1,***,specificity,and diagnostic accuracy were calculated by merging ratios or *** Twelve eligible studies were included in the analysis,involving 6561 *** sensitivity of methylated BCAT1/IKZF1 in plasma for CRC diagnosis was 60%[95%confidence interval(CI)53-67]and specificity was 92%(95%CI:90-94).The positive and negative likelihood ratios were 8.0(95%CI:5.8-11.0)and 0.43(95%CI:0.36-0.52),*** odds ratio was 19(95%CI:11-30)and area under the curve was 0.88(95%CI:0.85-0.91).The sensitivity and specificity for CRC screening were 64%(95%CI:59-69)and 92%(95%CI:91-93),*** sensitivity and specificity for recurrence detection during follow-up were 54%CONCLUSION The detection of methylated BCAT1/IKZF1 in plasma,as a non-invasive detection method of circulating tumor DNA,has potential CRC diagnosis,but the clinical application prospect needs to be further explored.

关键词： Branched chain amino acid transaminase 1 IKAROS family zinc finger 1 Methylation Liquid biopsy Colorectal cancer

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Effect of sintering temperature on the electrolysis of TiO_2

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 636-641页

作者： Ze-quan Li Li-yue ru Cheng-guang bai Na Zhang Hai-hua Wang College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China College of Materials Science and Engineering Chongqing University Chongqing 400044 China

The effects of sintering temperature on the microstructure and the conductivity of TiO2 cathodes were studied by examining the phase composition, microstructure, and element contents of the sintered cathodes and the cathodic products using X-ray diffraction and scan- ning electronic microscopy-energy dispersive spectrometry. The oxygen vacancy, conductivity, average pore diameter, and specific surface area of the sintered cathodes were detected by X-ray photoelectron spectroscopy, four-point probe, and ASPA 2010. The results showed that TiO2 phase transformations occurred, and oxygen vacancies formed with the increase of sintering temperature. The cathodic conductivity improved, but the average pore diameter and the effective response area of the TiO2 cathode were reduced when the sintering temperature in- creased. These phenomena could weaken the contact between reaction ions and electrons and also had the same effect on the cathodes and the molten salt. Moreover, they were disadvantageous to ion migration, so a lower sintering temperature was favorable for the microstructure of electrolysis. Consequently, the cathodic conductivity may be improved, but the microstrucatre became compact with the increase of sin- tering temperature. The cathodic products at different temperatures indicated that the cathodic conductivity was more important for electroly- sis.

关键词： titanium dioxidegelectrolysis sintering microstructure

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Intuitionistic Fuzzy Laplacian Twin Support Vector Machine for Semi-supervised Classification

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Journal of the Operations Research Society of China 2022年第1期10卷 89-112页

作者： Jia-Bin Zhou Yan-Qin bai Yan-ru Guo Hai-Xiang Lin Department of Mathematics Shanghai UniversityShanghai 200444China Delft Institute of Applied Mathematics Delft University of TechnologyDelft 2600GAThe Netherlands

In general,data contain noises which come from faulty instruments,flawed measurements or faulty *** with data in the context of classification or regression is inevitably affected by noises in the *** order to remove or greatly reduce the impact of noises,we introduce the ideas of fuzzy membership functions and the Laplacian twin support vector machine(Lap-TSVM).A formulation of the linear intuitionistic fuzzy Laplacian twin support vector machine(IFLap-TSVM)is ***,we extend the linear IFLap-TSVM to the nonlinear case by kernel *** proposed IFLap-TSVM resolves the negative impact of noises and outliers by using fuzzy membership functions and is a more accurate reasonable classi-fier by using the geometric distribution information of labeled data and unlabeled data based on manifold *** with constructed artificial datasets,several UCI benchmark datasets and MNIST dataset show that the IFLap-TSVM has better classification accuracy than other state-of-the-art twin support vector machine(TSVM),intuitionistic fuzzy twin support vector machine(IFTSVM)and Lap-TSVM.

关键词： Twin support vector machine Semi-supervised classification Intuitionistic fuzzy Manifold regularization Noisy data

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Estimation of OCDD degradation rate in soil

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Journal of Environmental Sciences 2005年第6期17卷 981-983页

作者： ZHAO Xing-ru ZHENG Ming-hui ZHANG Bing QIAN Yong XU Xiao-bai State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of ScienceBeijing 100085 China

The current concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans （PCDD/Fs） were determined in soils contaminated with Chinese technical product sodium pentachlorophenate （ Na- PCP）. The estimated half-life of octachlorodioxin （OCDD） was about 14 years in contaminated soils based on the local historical record and mass balance calculation during the past 43 years（ 1960-2003）. The isomer profiles remained the same regardless of paddy field soil or riverbank soil. The results indicated that the congenerspecific information was efficient in estimating the PCDD/Fs fate in contaminated soils.

关键词： OCDD degradation rate Na-PCP

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MiR-194-5p suppresses the warburg effect in ovarian cancer cells through the IGF1R/PI3K/AKT axis

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BIOCELL 2023年第3期47卷 547-554页

作者： LIJUN DU KaiKai DOU NIANHai LIANG JIANMIN SUN ru bai School of Basic Medicine Ningxia Medical UniversityYinchuan750004China The Fifth People’s Hospital of Ningxia Shizuishan753000China

Background:The Warburg effect is considered as a hallmark of various types of cancers,while the regulatory mechanism is poorly *** previous study demonstrated that miR-194-5p directly targets and regulates insulin-like growth factor1 receptor(IGF1R).In this study,we aimed to investigate the role of miR-194-5p in the regulation of the Warburg effect in ovarian cancer ***:The stable ovarian cell lines with miR-194-5p overexpression or silencing IGF1R expression were established by lentivirus *** generation,glucose uptake,lactate production and extracellular acidification rate(ECAR)assay were used to analyze the effects of aerobic glycolysis in ovarian cancer *** expression was analyzed by quantitative polymerase chain reaction(qPCR)and western *** assays were performed to assess the expression of the IGF1R protein in ovarian cancer ***:Overexpression of miR-194-5p or silencing IGF1R expression in ovarian cancer cells decreases ATP generation,glucose uptake,lactate production,and ECAR and inhibits both the mRNA and protein expression of PKM2,LDHA,GLUT1,and *** the knockdown of miR-194-5p expression led to opposite *** of miR-194-5p or silencing IGF1R expression suppressed the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway,whose activation can sustain aerobic glycolysis in cancer cells,and the knockdown of miR-194-5p expression promoted the activation of the PI3K/AKT ***:Our results suggest that miR-194-5p can inhibit the Warburg effect by negative regulation of IGF1R and further repression of the PI3K/AKT pathway,which provides a theoretical basis for further test of miR-194-5p as a target in the treatment of ovarian cancer.

关键词： Ovarian cancer Aerobic glycolysis microRNA

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Determination of multilevel chirality in nickel molybdate films by electron crystallography

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Nano Research 2024年第9期17卷 8571-8577页

作者： Jing ai Yu Wang Liyuan Li Jianqiang Wang Te bai Shunai Che Lu Han Sinopec(Shanghai)Research Institute of Petrochemical Technology Co. Ltd.Shanghai 201208China School of Chemical Science and Engineering Tongji UniversityShanghai 200092China School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Chiral inorganic materials have attracted great attention owning to their unique physical and chemical properties attributed to the symmetry-breaking of their *** inorganic materials can be endowed with chiral geometric configurations from achiral space group crystals through lattice twisting,screw dislocations or hierarchical self-assembled spiral morphologies,showing various characteristic chiral ***,the multilevel chirality in chiral nickel molybdate films(CNMFs)remains to be elaborately *** this paper,we report three hierarchical levels of chirality in CNMFs,spanning from the atomic to the micron scale,including primary helically coiled nanoflakes with twisted atomic crystal lattices,secondary helical stacking of layered nanoflakes,and tertiary asymmetric morphology between adjacent *** findings may enrich the chiral self-assembly structural types and provide valuable insights for the comprehensive analysis path of hierarchical chiral crystals.

关键词： chiral inorganic material nickel molybdate structural analysis transmission electron microscopy electron crystallography

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Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect

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Acta Pharmacologica Sinica 2004年第7期25卷 81-85页

作者： Xiao-hong CHEN, Jin-ye bai, Fang SHEN, ai-ping bai, Zong-ru GUO, Gui-fang CHENG2 Departmentof Pharmacology, Institute of Materia Medica, Chinese Academyof Medical Sciencesand Peking Union Medical College, Beijing 100050, China Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College 北京 100050 Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 Department of Pharmacology Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

aiM: To investigate the inhibitory effect of imrecoxib, a synthetic compound of completely new structure, on cyclooxygenase 1 (COX-1) and 2 (COX-2) and its anti-inflammatory effect in vivo. METHODS: The inhibitory effects of imrecoxib on cyclooxygenase 1 and 2 were studied using whole cell assay with murine peritoneal mac- rophages induced by calcimycin and LPS. The inhibitory effects of imrecoxib on mRNA level of COX-1 and COX- 2 in human macrophage cell line U937 were detected by reverse transcription polymerase chain reaction (RT-PCR) analysis. Effects of imrecoxib on acute and chronic inflammation were evaluated in rat carrageenan induced edema model and rat adjuvant-induced arthritis model, respectively. RESULTS: Imrecoxib was found to inhibit COX-1 and COX-2 with IC50 value of 115±28 nmol/L and 18±4 nmol/L, respectively. Imrecoxib was shown to selectively and dose-dependently inhibit COX-2 mRNA level. Imrecoxib effectively inhibited carrageenan-induced acute in- flammation at the doses of 5, 10, and 20 mg·kg-1 ig and adjuvant-induced chronic inflammation at the doses of 10 and 20 mg·kg-1·d-1 ig. CONCLUSION: Imrecoxib is a novel and moderately selective COX-2 inhibitor that pos- sesses anti-inflammatory effect by inhibition of COX-2 mRNA expression.

关键词： imrecoxib cyclooxygenase 1 cyclooxygenase 2 cyclooxygenase inhibitors inflammation

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Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for complex anorectal fistula

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World Journal of Gastroenterology 2010年第26期16卷 3279-3286页

作者： Ma-Mu-Ti-Jiang A ba-bai-ke-re Er-Ha-Ti ai Anorectal Surgical Department First Aff iliated Hospital of Xinjiang Medical University

aiM: To compare the efficacy and safety of acellular dermal matrix (ADM) bioprosthetic material and endorectal advancement flap (ERAF) in treatment of complex anorectal fistula. METHODS: Ninety consecutive patients with complex anorectal fistulae admitted to Anorectal Surgical Department of First Affi liated Hospital, Xinjiang Medical University from March 2008 to July 2009, were enrolled in this study. Complex anorectal fistula was diagnosed following its clinical, radiographic, or endoscopic diagnostic criteria. Under spinal anesthesia, patients underwent identification and irrigation of the fistula tracts using hydrogen peroxide. ADM was securely sutured at the secondary opening to the primary opening using absorbable suture. Outcomes of ADM and ERAF closure werecompared in terms of success rate, fecal incontinence rate, anorectal deformity rate, postoperative pain time, closure time and life quality score. Success was defined as closure of all external openings, absence of drainage without further intervention, and absence of abscess formation. Follow-up examination was performed 2 d, 2, 4, 6, 12 wk, and 5 mo after surgery, respectively. RESULTS: No patient was lost to follow-up. The overall success rate was 82.22% (37/45) 5.7 mo after surgery. ADM dislodgement occured in 5 patients (11.11%), abscess formation was found in 1 patient, and fistula recurred in 2 patients. Of the 13 patients with recurrent fistula using ERAF, 5 (11.11%) received surgical drainage because of abscess formation. The success rate, postoperative pain time and closure time of ADM were significantly higher than those of ERAF (P < 0.05). However, no difference was observed in fecal incontinence rate and anorectal deformity rate after treatment with ADM and ERAF. CONCLUSION: Closure of fistula tract opening with ADM is an effective procedure for complex anorectal fistula. ADM should be considered a first line treatment for patients with complex anorectal fistula.

关键词： Acellular dermal matrix Surgery Transsphincteric complex fistula

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NIR photothermal enhancement to achieve high-efficiency nitrogen reduction to ammonia by polyoxometalates@Fe-polydopamine

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Nano Research 2025年第1期18卷 118-128页

作者： Xiaofei Chen Lixin Wu Feng bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Nanoscience and Materials EngineeringHenan UniversityKaifeng 475004China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

The development of atmospheric pressure N_(2)reduction to NH_(3)is attracting much attention in green chemistry,yet it is still a challenge to obtain satisfactory activity under mild ***,an efficient near-infrared(NIR)photothermal catalysis reduction of N_(2)constitutes an occurrence is *** or without V-substitute polyoxometalates(POMs)loaded on the surface of Fechelated polydopamine(Fe-PDA)photothermal support through the electrostatic interactions,NIR photothermal catalysts POMs@Fe-PDA are *** induction of“FeV”cofactor facilitates electron transfer between V(V)/V(IV)&Fe(III)/Fe(II)and N_(2),thereby activating N_(2)*** synergy between the catalytic activity of V-POMs and the local NIR photothermal effect of Fe-PDA dramatically enhances N_(2)***,PMo_(10)V_(2)@Fe-PDA exhibits a significantly enhanced NH_(3)production rate of 181.1μmol·LN^(-1)with a turnover frequency of 1006.1 mmol·MN^(-1)·hN^(-1)under 808 nm NIR laser radiation,being the highest values reported at atmospheric *** expect that this work could provide an alternative approach for photothermal catalysis N_(2)reduction under mild conditions.

关键词： polyoxometalate near-infrared photothermal catalysis N_(2)reduction mild condition

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Structural and Thermodynamic Properties of Wurtzitic Boron Nitride from First-Principle Calculations

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Communications in Theoretical Physics 2007年第5X期48卷 925-929页

作者： YU bai-ru ZENG Zhao-Yi GUO Hua-Zhong CHEN Xiang-Rong College of Physical Science and Technology Sichuan University Chengdu 610064 China International Centre for Materials Physics the Chinese Academy of Sciences Shenyang 110016 China

Using ab initio plane-wave pseudopotential density functional theory method, we have studied the structural and thermodynamic properties of the wurtzite boron nitride （w-BN）. Through the quasi-harmonic Debye model, in which the phononic effects are considered, the dependencies of the normalized lattice parameters a/ao and c/co, the axial ratio c/a, and the normalized primitive cell volume V/Vo on pressure P and temperature T are investigated. Furthermore, the Debye temperature θ, the variation of thermal expansion α, as well as the heat capacity Cv as functions of P and T are studied systematically.

关键词： density functional theory thermodynamic properties w-BN

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