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C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 61-78页

作者： bai-bei li Lei-Jie Chen Shi-liu Lu Biao Lei Gui-lin Yu Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021Guangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory of Immunology and Metabolism for liver Diseases Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The Second Xiangya Hospital of Central South UniversityNanning 410011Guangxi Zhuang Autonomous RegionChina Department of Emergency The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival ***,significant heterogeneity surrounds the outcomes of most ***,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with *** To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for *** The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of Guangxi Medical University were retrospectively *** The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile *** proportional risk model was used to determine the factors affecting *** Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall ***(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for *** nomograms were constructed based on independent prognostic *** C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction *** ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical *** Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 *** further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis.

关键词： C-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis Nomogram

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Da Vinci robot-assisted pancreato-duodenectomy in a patient with situs inversus totalis:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1363-1371页

作者： bai-bei li Shi-liu Lu Xiang He Biao Lei Jian-Ni Yao Si-Chen Feng Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Situs inversus totalis(SIT)is an extremely rare congenital malformation characterized by mirror displacement of the thoracoabdominal organs such as the heart,liver,spleen,and ***,we describe a patient with SIT complicated with cholangiocarcinoma who underwent successful pancreaticoduodenectomy with the assistance of a da Vinci *** SUMMARY A 58-year-old female presented to the hospital with paroxysmal pain in her left upper abdomen,accompanied by jaundice and staining of the sclera as chief *** examination detected a mass at the distal end of the common bile duct,with inverted thoracic and abdominal *** retrograde cholangiopancreatography forceps biopsy revealed the presence of a well-differentiated *** patient successfully underwent robotic-assisted pancreaticoduodenectomy;the operation lasted 300 min,the intraoperative blood loss was 500 mL,and there were no intraoperative and postoperative *** SIT is not directly related to the formation of *** preoperative imaging examination is conducive to disease diagnosis and also convenient for determining the feasibility of tumor ***-assisted pancreaticoduodenectomy for SIT complicated with cholangiocarcinoma provides a safe,feasible,minimally invasive,and complication-free alternative with adequate preoperative planning combined with meticulous intraoperative procedures.

关键词： Situs inversus totalis Cholangiocarcinoma Da Vinci robot Whipple Surgery Case report

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Ultrasound sensing with optical microcavities

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light(Science & Applications) 2024年第8期13卷 1487-1511页

作者： Xuening Cao Hao Yang Zu-Lei Wu bei-bei li beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Songshan Lake Materials Laboratory Dongguan 523808 GuangdongChina

Ultrasound sensors play an important role in biomedical imaging,industrial nondestructive inspection,*** ultrasound sensors that use piezoelectric transducers face limitations in sensitivity and spatial resolution when miniaturized,with typical sizes at the millimeter to centimeter *** overcome these challenges,optical ultrasound sensors have emerged as a promising alternative,offering both high sensitivity and spatial *** particular,ultrasound sensors utilizing high-quality factor(Q)optical microcavities have achieved unprecedented performance in terms of sensitivity and bandwidth,while also enabling mass production on silicon *** this review,we focus on recent advances in ultrasound sensing applications using three types of optical microcavities:Fabry-Perot cavities,π-phase-shifted Bragg gratings,and whispering gallery mode *** provide an overview of the ultrasound sensing mechanisms employed by these microcavities and discuss the key parameters for optimizing ultrasound ***,we survey recent advances in ultrasound sensing using these microcavity-based approaches,highlighting their applications in diverse detection scenarios,such as photoacoustic imaging,ranging,and particle *** goal of this review is to provide a comprehensive understanding of the latest advances in ultrasound sensing with optical microcavities and their potential for future development in high-performance ultrasound imaging and sensing technologies.

关键词： optical millimeter offering

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Function-reversible facets enabling SrTiO_(3)nanocrystals for improved photocatalytic hydrogen evolution

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Frontiers in Energy 2024年第1期18卷 101-109页

作者： Bin WANG bei AN Xiaoqian li Shaohua SHEN School of Physics Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter(Ministry of Education)Key Laboratory of Shaanxi for Advanced Materials and Mesoscopic PhysicsXi’an Jiaotong UniversityXi’an 710049China International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an 710049China

It has been widely reported that,for faceted nanocrystals,the two adjacent facets with different band levels contribute to promoted charge separation,and provide active sites for photocatalytic reduction and oxidation reaction,*** such cases,only one family of facets can be used for photocatalytic hydrogen ***,by using SrTiO_(3)nanocrystals enclosed by{023}and{001}facets as a model photocatalyst,this paper proposed a strategy to achieve the full-facets-utilization of the nanocrystals for photocatalytic hydrogen via chemically depositing Pt nanoparticles on all *** photo-deposition experiment of CdS provided direct evidence to demonstrate that the{023}facets which were responsible for photooxidation reaction can be function-reversed for photocatalytic hydrogen evolution after depositing Pt nanoparticles,together with the{001}***,the full-facets-utilization led to a much-improved activity for photocatalytic hydrogen,in contrast to those SrTiO_(3)nanocrystals with only{001}facets deposited by Pt nanoparticles via a photo-deposition method.

关键词： SrTiO_(3)nanocrystals crystal facets photocatalysis hydrogen evolution

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Dual-additives enable stable electrode-electrolyte interfaces for long life li-SPAN batteries

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Chinese Chemical Letters 2024年第5期35卷 459-465页

作者： Zhenqiang Guo Huicong Yang Qian Wei Shengjun Xu Guangjian Hu Shuo bai Feng li School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Biochemistry and Molecular Biology College of Life ScienceChina Medical UniversityShenyang 110122China Dalian National Laboratory for Clean Energy Dalian 116023China Shenyang King Power Technology Co. Ltd.Shenyang 110016China

Sulfurized polyacrylonitrile(SPAN)is proposed as a promising cathode material for lithium sulfur ***,the continuous side reactions at the electrolyte-electrode interfaces as well as the slow redox kinetics of SPAN cathode deteriorate the electrochemical *** this study,an electrolyte with dual-additives comprising 2-fluoropyridine(2-FP)and lithium difluorobis(oxalato)phosphate(liDFBOP)was used to improve the performance of li||SPAN cells.2-FP has a lower lowest occupied molecular orbital energy than that of the solvents in the electrolyte,leading to its prior reduction.A liF-rich film can be formed on the electrode,effectively improving the stability of the electrolyte-electrode interfaces and prolonging the ***,liDFBOP could form an electrolyte-electrode interface film containing a large amount of li_(x)PO_(y)F_(z) species,compensating for the kinetic deterioration caused by the lower ionic conductive of liF formed at the electrolyte-electrode ***,an electrode-interface film with good chemical stability and high li^(+) transport was established by liF and li_(x)PO_(y)F_(z)-rich *** li||SPAN cell with the electrolyte containing dual-additives demonstrates an excellent capacity retention of 97.5%after 200 cycles at 1.0 C,25℃,comparing to 56.2%capacity retention without ***,the rate capacities of cells with dual-additives can reach 1128.1 mAh/g at 5 C,comparing to only 813.5 mAh/g using electrolyte without *** results shown that the dual-additives in electrolyte provide a promising strategy for practical application of lithium sulfur batteries with SPAN cathodes.

关键词： Sulfurized polyacrylonitrile lithium metal Interface film 2-Fluoropyridine Difluorobis(oxalato)phosphate

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AI enhances drug discovery and development

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National Science Review 2024年第3期11卷 52-54页

作者： Fang bai Shiliang li Honglin li Shanghai Institute for Advanced Immunochemical Studies and School of life Science and Technology ShanghaiTech University lingang Laboratory Innovation Center for AI and Drug Discovery East China Normal University

The advent of the third wave of artificial intelligence(AI) heralds a new era in drug discovery. AI-powered techniques can be characteristic of identifying features that are difficult for humans to interpret from big ...

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The role of gut microbiota in acute pancreatitis:new perspectives in pathogenesis and therapeutic approaches

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Journal of Pancreatology 2024年第1期7卷 61-71页

作者： Zu-Chao Du Guan-Qun li Yan Luo Xue-Wei bai bei Sun Department of Pancreatic and Biliary Surgery the First Affiliated Hospital of Harbin Medical UniversityHarbinChina Key Laboratory of Hepatosplenic Surgery Ministry of Educationthe First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Hepatobiliary and Pancreatic Surgery Qunli Branchthe First Affiliated Hospital of Harbin Medical UniversityHarbinChina Key Laboratory of Critical Care Research Qunli Branchthe First Affiliated Hospital of Harbin Medical UniversityHarbinChina

Acute pancreatitis(AP)is one of the most common acute abdomen diseases with increasing incidence and substantial healthcare *** microbiota disturbance,mucosal barrier failure,and bacterial translocation are identified as the dominant cause of infected pancreatic necrosis and high *** the advance of high-throughput sequencing,imbalance between beneficial and facultative pathogenic microorganisms with their metabolic activities in the development of AP has been increasingly recognized,whereas it remains unclear whether dysbacteriosis is the dominant cause of aggravating AP,or merely reflecting different epidemiological or environmental factors at the individual *** review discussed the alterations of the gut microbiota and their metabolites during AP with detailed molecular ***,it highlights microbiome-based medical therapies which influence gut barrier function and immune homeostasis to mitigate inflammatory responses in *** review will provide a novel roadmap of gastrointestinal microecology in AP progression,and contribute to the future development of microbiome-based diagnostic and therapeutic strategies in clinical practice.

关键词： Acute pancreatitis Immunity Metabolites Microbiome-based therapeutics Microbiota

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High-lattice-adapted surface modifying Na_(4)MnV(PO_(4))_(3) for better sodium storage

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Nano Research 2024年第4期17卷 2728-2735页

作者： Chongran Song Shiyu li Ying bai International Joint Research Laboratory of New Energy Materials and Devices of Henan Province School of Physics and ElectronicsAcademy for Advanced Interdisciplinary StudiesHenan UniversityKaifeng 475004China

Sodium-ion batteries(SIBs)are required to possess long cycle life when used for large-scale energy *** polyanionic Na_(4)MnV(PO_(4))_(3)(NMVP)reveals good cyclic stability due to its unique three-dimensional(3D)frame structure,but it still faces the challenge of interfacial degradation in practical *** this work,NASICON-type Na_(1.3)Al_(0.7)Ti_(1.3)(PO_(4))_(3)(NATP)was deposited on the surface of NMVP to promote interface stability by surface modification and gradient *** a result,the optimized NMVP@2%NATP released a capacity retention of 44.8%after 1000 cycles at 5 C,much higher than that of the initial NMVP(28.9%).The enhanced electrochemical performance was mainly attributed to NATP coating acting as a fast ion transport carrier and physical barrier,significantly facilitating the Na^(+)diffusion and isolating side reaction at the electrode/electrolyte *** the other hand,Ti_(4)^(+)and Al^(3+)cations from the NATP were partially doped inside the NMVP surface to boost the transport of Na^(+),and the perfect lattice matching of NVMP and NATP improved the interface and structural stability accompanying long *** work demonstrated the effectiveness of surface modification with high lattice match material and provided new perspectives for high energy density solid-state SIBs.

关键词： high-lattice-adapted cathode surface modification sodium-ion batteries

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Optimizing extractants selection for efficient separation of phenols and nitrogen-containing heteroaromatics using hydrogen bond interaction strategies

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Chinese Journal of Chemical Engineering 2024年第4期68卷 43-52页

作者： Pengzhi bei Rui Zhang Jie Feng Antony Rajendran Wenying li State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China Department of Chemistry Mepco Schlenk Engineering College(Autonomous)Sivakasi 626005India

Focusing on the use of imidazolium ionic liquids and quaternary ammonium salts-based deep eutectic solvents for the separation of phenols and nitrogen-containing heteroaromatics,the role of heteroaromatics as specific sites for hydrogen bond-based separation has been *** environmentally friendly solvents are known for their ability to form hydrogen bonds with heteroatoms,a key aspect in separation *** quantified the hydrogen bond interaction energy to reach the threshold energy for efficient O-and N-heteroaromatics *** article provides an in-depth study of the structural nuances of different hydrogen bonding sites and their affinity properties while conducting a comparative evaluation of the separation efficiency of ionic liquids and deep eutectic solvents from a thermodynamic *** showed that phenols with dual hydrogen bonding recognition sites were easier to separate than nitrogen-containing *** ionic liquids were more suitable for the extraction of nonbasic nitrogen-containing heteroaromatics,and quaternary ammonium salts-based deep eutectic solvents are more effective for phenols and basic nitrogen-containing heteroaromatics,which was confirmed by Fourier transform infrared spectroscopy and empirical ***,this study provides a theoretical basis for the strategy design and selection of extractants for the efficient separation of O-and N-containing aromatic compounds.

关键词： Deep eutectic solvents Hydrogen bond Ionic liquids Separation Solvents Structural characteristics

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Risk Factors Asscociated with Hypokalemia during Postanesthesia Recovery and Its Impact on Outcomes in Gynecological Patients:A Propensity Score Matching Study

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Current Medical Science 2024年第2期44卷 441-449页

作者： bei-bei WANG li HU Xin-yue HU Dong HAN Jing WU Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute of Anesthesia and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Anesthesiology and Resuscitation(Huazhong University of Science and Technology) Ministry of EducationWuhan430022China

Objective:This study aimed to explore the risk factors and outcomes of hypokalemia during the recovery period from anesthesia in the gynecological ***:This retrospective cohort study included 208 patients who underwent gynecological surgery at our institution between January 2021 and March *** were collected for each patient,including demographics,disease status,surgical data,and clinical *** bowel preparation,postoperative gastrointestinal function,and electrolyte levels were compared between the two groups using propensity score matching(PSM).Results:The incidence of hypokalemia(serum potassium levellinical outcomes,including postoperative gastrointestinal function,postoperative complications,and length of hospital stay.

关键词： hypokalemia gynecological surgery postanesthesia recovery perioperative electrolyte disturbances postoperative recovery

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