检索结果-南通市图书馆

Journal of China University of Mining and Technology 2008年第4期18卷 599-605页

作者： FU Yong DONG Qing-hong bai zhen-rui WANG Wan-jun School of Resources and Environments Henan Polytechnic University Jiaozuo Henan 454000 China School of Resource and Earth Science China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China School of Energy China University of Geosciences Beijing 100083 China

The hydro-geologic stages in the Biyang Depression, Henan Province, were defined and factors controlling the evolution of the hydrodynamic field in this area were analyzed. The evolution of the paleo-hydrodynamic field was studied by using the method of sedimentary-water-head and the changing patterns of the present hydrodynamic field as determined from measured pressure data. The results show that the evolution of the hydrodynamic field is one of inheritance and that it controls hydrocarbon accumulation. The deposition center in the southeast of the depression is always a high-value zone for water-head and a dynamic- source zone of the hydrodynamic field. The slope zone in the northwest of the depression is always a low-value zone for water-head and is the main discharge area for groundwater; this is the hydrocarbon accumulation zone. Hydrocarbon accumulation is controlled by the hydrodynamic field. The reservoir shows a ring-shaped horizontal pattern. Accumulation occurs in a pressure equilibrium zone at the frontal surface between sedimentary water and infiltrating water. The hydrocarbon accumulations occur in two vertically different discharge units, Eh31 and Eh32, under the action of overpressure.

关键词： Biyang depression hydrodynamic field hydrocarbon accumulation pressure equilibrium zone discharge unit

Zoledronic acid inhibits growth of hepatocellular carcinoma cells in vitro and in vivo

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第8期126卷 1486-1490页

作者： LIU Quan TAO Yong-hui bai rui-zhen CHANG Shu-jian HUA Dong Oncology Institute the Fourth Affiliated Hospital of SoochowUniversity Wuxi Jiangsu 214062 China Key Laboratory on Technology for Parasitic Disease Preventionand Control Ministry of Health Jiangsu Institute of ParasiticDiseases Wuxi Jiangsu 214062 China

Background Growing preclinical evidence shows that zoledronic acid （ZOL） exhibits direct antitumor activity in various cancer cell lines. However, the cytotoxic effects of ZOL on human hepatocellular carcinoma （HCC） cells have not been established. In the present study, we investigated the effect of ZOL on HCC both in vitro and in vivo. Methods Cytotoxicity and cell cycles were assessed with Sulforhodamine B colorimetric assay and flow cytometry. Expression levels of cell cycle phase-linked proteins were examined. The effect of ZOL on HCC in vivo was explored based on H22-subcutaneous injection （s.c.） and H22-intraperitoneal injection （i.p.） mice model. Results ZOL inhibited the growth of SK-HEP-1 and H22 cells and induced S-phase arrest through downregulating cdc2 protein and upregulating cyclin A. It inhibited the growth of s.c tumors, and increased the survival of both H22-s.c. and H22-i.p. mice in vivo. Conclusion ZOL inhibits qrowth of HCC cells in vitro and in vivo.

关键词： zoledronic acid, hepatocellular carcinoma S phase arrest

塔里木盆地早、中志留世沉积序列及其对构造-海平面变化的响应:以柯坪露头区为例

在线全文

学校读者我要写书评

暂无评论

地球科学（中国地质大学学报） 2011年第3期36卷 541-554页

作者：邢凤存白振瑞李祯李思田中国地质大学海洋学院北京100083 中国地质大学能源学院北京100083 中国石化石油勘探开发研究院北京100083

志留纪是晚加里东运动对塔里木盆地古地理和古构造格局产生重要影响的构造变格阶段,以全盆地规模的不整合面为界,前志留纪以海相碳酸盐岩沉积为主的古环境转变为志留纪以海相碎屑岩沉积为主的古环境.开展志留纪沉积充填序列及岩矿特征研... 详细信息

志留纪是晚加里东运动对塔里木盆地古地理和古构造格局产生重要影响的构造变格阶段,以全盆地规模的不整合面为界,前志留纪以海相碳酸盐岩沉积为主的古环境转变为志留纪以海相碎屑岩沉积为主的古环境.开展志留纪沉积充填序列及岩矿特征研究,有助于进一步认识塔里木盆地该变格阶段构造运动特征及其沉积充填响应.为此,精选柯坪露头区志留系出露连续、完整的大湾沟及四石场剖面,进行了露头精细沉积学观察采样及室内分析测试工作,描述和重建了早、中志留世沉积环境、沉积序列及其所反映的海平面变化,在此基础上划分了层序地层单元.下、中志留统可识别出陆棚、三角洲和潮汐影响的海岸等沉积体系类型,大型三角洲的存在则是柯坪露头区的特色.通过砂岩碎屑组分构成研究,并与Dickinson的砂岩组构大地构造背景模式图解对比,揭示该区早、中志留世砂岩沉积物主要来自碰撞造山带和前陆隆起区以及大陆块的物源区,该结果反映了志留纪早期,受晚加里东运动影响,塔里木周缘发生汇聚碰撞,并由此造成塔里木地块南部和北部构造抬升并形成剥蚀区的背景.综合分析揭示早、中志留世沉积序列对构造和海平面变化响应特征.受晚加里东运动影响,早期(柯坪塔格组沉积期)构造活动较强,海平面波动明显,在陆棚基础上发育有大型三角洲沉积.其砂岩岩屑含量高、成分成熟度低,总体反映了构造活动期快速抬升导致大量物源注入的特点;后期(柯坪塔格组上部-依木干他乌组沉积期)构造活动逐渐减弱并趋于稳定,海平面低幅度波动,主要以潮坪、潮道、小型三角洲和泻湖沉积为主,砂岩成分成熟度高,细粒沉积物比例加大.总体上,早、中志留世沉积序列反映了构造活动由强逐渐减弱并对凹陷区逐渐填平补齐的演化特征.

关键词：塔里木盆地志留系沉积序列砂岩组构构造

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan bai Qiong Wu Yushan Chen zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

腺病毒介导的bFGF基因对大鼠大脑中动脉闭塞模型的作用

在线全文

学校读者我要写书评

暂无评论

四川大学学报（自然科学版） 2009年第5期46卷 1478-1482页

作者：刘康杨莉李洁白瑞珍刘劝胡火珍宋桂芹四川大学生命科学学院成都610064 四川大学华西医院生物治疗国家重点实验室成都610041 川北医学院医学生物学教研室南充637007

采用改良的zea Longa法制备大鼠脑缺血模型,研究腺病毒介导的bFGF的基因治疗对大鼠大脑中动脉闭塞(MCAO)模型的治疗作用及脑血管发生的影响.将30只SD大鼠随机分为假手术组、空载体组(Ad-null组)和治疗组(Ad-bFGF组),于造模成功后24h尾... 详细信息

采用改良的zea Longa法制备大鼠脑缺血模型,研究腺病毒介导的bFGF的基因治疗对大鼠大脑中动脉闭塞(MCAO)模型的治疗作用及脑血管发生的影响.将30只SD大鼠随机分为假手术组、空载体组(Ad-null组)和治疗组(Ad-bFGF组),于造模成功后24h尾静脉给药.检测实验各组脑组织含水率的变化,通过核磁共振的和免疫组化分别检测实验各组大脑梗死体积和血管发生的变化.结果发现治疗组大鼠脑组织含水率和脑梗死面积明显小于空载体组,脑血管密度显著高于空载组.说明腺病毒介导的bFGF基因可显著减小脑组织含水率和脑梗死面积,促进脑部血管发生.

关键词：大脑中动脉闭塞 bFGF 重组腺病毒载体基因治疗

在线全文

学校读者我要写书评

暂无评论

淋球菌主要外膜蛋白的部分纯化与鉴定

微生物学通报 2000年第1期27卷 28-30页

作者：刘先洲蒋正明白瑞珍汤纪路张秋萍湖北医科大学微生物学教研室武汉430071

应用国产十六烷基三甲基溴化铵提取淋球菌外膜蛋白Ｉ（ＰＩ），继用Ｓｅｐｈａｒｏｓｅ６Ｂ纯化，并通过ＳＤＳ－ＰＡＧＥ鉴定所提ＰＩ的纯度，以及用琼脂双扩散法测定其抗原性。该法提取淋球菌ＰＩ的纯度高，收获量大，对抗原结构无... 详细信息

应用国产十六烷基三甲基溴化铵提取淋球菌外膜蛋白Ｉ（ＰＩ），继用Ｓｅｐｈａｒｏｓｅ６Ｂ纯化，并通过ＳＤＳ－ＰＡＧＥ鉴定所提ＰＩ的纯度，以及用琼脂双扩散法测定其抗原性。该法提取淋球菌ＰＩ的纯度高，收获量大，对抗原结构无破坏，适宜在淋球菌的生物学研究中应用。

关键词：淋球菌外膜蛋白纯化鉴定

肺炎支原体膜脂蛋白通过TLR2介导mICAM-1表达的上调

在线全文

学校读者我要写书评

暂无评论

中华微生物学和免疫学杂志 2005年第2期25卷 103-106页

作者：董碧麟汤纪路白瑞珍宗润芝刘先洲武汉大学医学院微生物教研室 430071

目的　观察肺炎支原体膜脂蛋白 (Mp LAMP)对THP 1 (前单核白血病细胞系 )细胞TLR2 (Toll样受体 )与mICAM 1 (膜结合型细胞间黏附分子 1 )表达的影响 ,探讨膜脂蛋白中的活性成分及二者表达的相互关系。方法　用流式细胞术检测Mp LAM... 详细信息

目的　观察肺炎支原体膜脂蛋白 (Mp LAMP)对THP 1 (前单核白血病细胞系 )细胞TLR2 (Toll样受体 )与mICAM 1 (膜结合型细胞间黏附分子 1 )表达的影响 ,探讨膜脂蛋白中的活性成分及二者表达的相互关系。方法　用流式细胞术检测Mp LAMP刺激组、抗人TLR2功能纯化抗体(TL2 .1 )阻断组及消化酶处理组的THP 1细胞mICAM 1和TLR2的表达水平。结果　与对照组相比 ,不同刺激浓度的Mp LAMP对THP 1细胞膜上TLR2及mICAM 1的表达均有明显的上调作用 (P <0 .0 5 ) ,且表达水平的增加对Mp LAMP的刺激具有浓度依耐性 ;用TL2 .1将THP 1细胞膜上的TLR2阻断后 ,Mp LAMP对mICAM 1表达的诱导作用明显受到抑制 (P <0 .0 1 ) ,其阻断效果随TL2 .1量的增加而加强 ;酶消化试验证实Mp LAMP的活性成分是其脂质部分。相关分析表明 ,mICAM 1在THP 1细胞上的表达水平与TLR2密切相关 (r=0 .989,P <0 .0 1 )。结论　肺炎支原体膜脂蛋白通过TLR2介导上调THP 1细胞mICAM 1的表达 ,在一定程度上影响着肺炎支原体感染所导致的炎性反应的强弱。

关键词： ICAM-1表达 TLR2 THP-1细胞介导白通体膜细胞问黏附分子 Toll样受体流式细胞术检测肺炎支原体感染白血病细胞系膜脂蛋白活性成分膜结合型相互关系上调作用诱导作用阻断效果相关分析炎性反应水平酶处理

Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin Peng Yu bai Hang Li Meixiu Qu zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

NIR photothermal enhancement to achieve high-efficiency nitrogen reduction to ammonia by polyoxometalates@Fe-polydopamine

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 118-128页

作者： Xiaofei Chen Lixin Wu Feng bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Nanoscience and Materials EngineeringHenan UniversityKaifeng 475004China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

The development of atmospheric pressure N_(2)reduction to NH_(3)is attracting much attention in green chemistry,yet it is still a challenge to obtain satisfactory activity under mild ***,an efficient near-infrared(NIR)photothermal catalysis reduction of N_(2)constitutes an occurrence is *** or without V-substitute polyoxometalates(POMs)loaded on the surface of Fechelated polydopamine(Fe-PDA)photothermal support through the electrostatic interactions,NIR photothermal catalysts POMs@Fe-PDA are *** induction of“FeV”cofactor facilitates electron transfer between V(V)/V(IV)&Fe(III)/Fe(II)and N_(2),thereby activating N_(2)*** synergy between the catalytic activity of V-POMs and the local NIR photothermal effect of Fe-PDA dramatically enhances N_(2)***,PMo_(10)V_(2)@Fe-PDA exhibits a significantly enhanced NH_(3)production rate of 181.1μmol·LN^(-1)with a turnover frequency of 1006.1 mmol·MN^(-1)·hN^(-1)under 808 nm NIR laser radiation,being the highest values reported at atmospheric *** expect that this work could provide an alternative approach for photothermal catalysis N_(2)reduction under mild conditions.

关键词： polyoxometalate near-infrared photothermal catalysis N_(2)reduction mild condition

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肝脏局灶性结节性增生的临床病理分析

中国当代医药 2017年第36期24卷 13-15,23页

作者：白瑞珍何玉洁徐莉浦勇江南大学附属医院病理科江苏无锡214062 江南大学附属医院影像科江苏无锡214062

目的探讨肝脏局灶性结节性增生(FNH)的临床病理学特点、病因、治疗及预后。方法收集2013年5月~2017年8月我院收治的5例FNH患者的临床资料,观察其病理学形态及免疫组化染色,并结合国内外最新文献对该病变的特点进行总结分析。结果典型的... 详细信息

目的探讨肝脏局灶性结节性增生(FNH)的临床病理学特点、病因、治疗及预后。方法收集2013年5月~2017年8月我院收治的5例FNH患者的临床资料,观察其病理学形态及免疫组化染色,并结合国内外最新文献对该病变的特点进行总结分析。结果典型的FNH大体有特征性的中央瘢痕,镜下见肿块由结节状增生的肝细胞构成,结节内肝细胞呈1~2层排列,结节间由杂乱的纤维分隔,肝细胞无明显异型。不典型FNH需要与肝细胞腺瘤、肝细胞癌鉴别。结论 FNH是一种少见的良性病变,临床切除后,预后良好。

关键词：肝局灶性结节性增生肝细胞腺瘤肝细胞癌