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Chinese Chemical Letters 2025年第2期36卷 314-318页

作者： Meiling Xu Xinyang Li Pengyuan Liu Junjun Liu Xiao Han Guodong Chai Shuangling Zhong bai yang Liying Cui College of Resources and Environment Jilin Agricultural University State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Key Laboratory of Straw Biology and Utilization The Ministry of Education Jilin Agricultural University

In this study, a simple and effective ratiometric fluorescence method has been developed for carbaryl detection, utilizing red emissive carbon dots（R-CDs）. The underlying principle of this proposed strategy relies on the rapid hydrolysis of carbaryl under an alkaline condition and production of 1-naphthol with blue-emission at 462 nm. Furthermore, the as-synthesized R-CDs（Em. 677 nm）, serve as a reference, enhancing the visual tracking of carbaryl through the transformation of fluorescent color from red to *** concentration of carbaryl exhibits a commendable linear correlation with the ratio of fluorescence intensity, ranging from 0 to 20 μg/m L（R2= 0.9989） with a low detection limit of 0.52 ng/m L. Additionally, the described methodology can be used for the enzyme-free visual assay of carbaryl, even in the presence of other carbamate pesticides and metal ions, in tap water and lake water samples with excellent accuracy（spiked recoveries, 94%–106.1%）, high precision(relative standard deviation（RSD） ≤ 2.42),and remarkable selectivity. This fast and highly sensitive naked-eye ratiometric sensor holds immense promise for carbaryl detection in intricate environments and food safety fields.

关键词： Carbaryl detection Carbon dots Fluorescence sensor Quantum yield Visual detection

Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer

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Chinese Chemical Letters 2025年第2期36卷 289-296页

作者： Ze Wang Hao Liang Annan Liu Xingchen Li Lin Guan Lei Li Liang He Andrew K.Whittaker bai yang Quan Lin State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Department of Endocrinology Lequn Branch the First Hospital of Jilin University Department of Urology the First Hospital of Jilin University Australian Institute for Bioengineering and Nanotechnology the University of Queensland

Prostate cancer(PCa) is characterized by high incidence and propensity for easy metastasis, presenting significant challenges in clinical diagnosis and treatment. Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy. Considering that tumor-derived alkaline phosphatase(ALP) is over-expressed in metastatic PCa, it makes a great chance to develop a theranostics system with ALP responsive in the TME. Herein, an ALP-responsive aggregationinduced emission luminogens(AIEgens) nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa. The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence, and enhanced accumulation and prolonged retention period at the tumor site. In terms of detection, the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR) multi-mode imaging effect of nanoprobe was significantly improved post-aggregation, enabling precise diagnosis through the amalgamation of multiple imaging modes. Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis, and enhanced FL imaging technology can achieve “intraoperative visual navigation”, showing its potential application value in clinical tumor detection and surgical guidance. In terms of treatment, AMNF showed strong absorption in the near infrared region after aggregation, which improved the photothermal treatment effect. Overall, our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.

关键词： AIE ALP responsive Enhanced multi-mode imaging Enhanced photothermal therapy Prostate cancer

W_(18)O_(49)Crystal and ICG Labeled Macrophage:An Efficient Targeting Vector for Fluorescence Imagingguided Photothermal Therapy

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Biomedical and Environmental Sciences 2025年第1期38卷 100-105页

作者： yang bai Guoqing Feng Muskan Saif khan Qingbin yang Tingting Hua Haolin Guo Yuan Liu Bowen Li Yiwen Wu Bin Zheng Niansong Qian Qing Yuan Department of Stomatology Tianjin Medical University General HospitalHeping DistrictTianjin 300052China Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102401China Tianjin Anding Hospital Tianjin 300222China Beijing National Day School Beijing 100000China Department of Respiratory the Eighth Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Urology The Third Medical CenterChinese People’s Liberation Army(PLA)General HospitalBeijing 100853China

Photothermal therapy(PTT)uses heat generated by photothermal agents to efficiently kill cancer cells in the least invasive *** nanoparticles,such as precious metals and carbon nanoparticles,have been extensively studied for their ability to convert near-infrared(NIR)light(700-900 nm)into heat[1].However,these nanoparticles are easily captured by the reticuloendothelial system,which severely limits their clinical applications[2].Despite targeted and stealth modifications,these issues remain unresolved;therefore,researchers are seeking more effective methods.

关键词： seeking thermal spite

下伏溶洞顶板厚度对桩基承载特性影响模型试验研究

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岩石力学与工程学报 2025年第1期44.0卷 236-247页

作者：杨柏肖世国覃超杨源浩石青叶西南交通大学地球科学与工程学院桂林电子科技大学建筑与交通工程学院西南交通大学土木工程学院

为研究下伏溶洞顶板厚度对嵌岩桩承载特性的影响，开展不同顶板厚度(1D～5D,D为试桩桩径)条件下模型桩载荷试验，揭示溶洞顶板破坏模式、荷载–位移曲线、桩身轴力和阻力分布特征、极限承载力随顶板厚度变化的规律，并建立溶洞顶板极限... 详细信息

为研究下伏溶洞顶板厚度对嵌岩桩承载特性的影响，开展不同顶板厚度(1D～5D,D为试桩桩径)条件下模型桩载荷试验，揭示溶洞顶板破坏模式、荷载–位移曲线、桩身轴力和阻力分布特征、极限承载力随顶板厚度变化的规律，并建立溶洞顶板极限承载力计算模型，基于顶板破坏模式和H-B准则提出计算式，得出下伏溶洞桩基极限承载力计算方法。研究结果表明：(1)顶板厚度为1D,2D时，顶板破坏形式为冲切破坏；顶板厚度为3D,4D时，为弯拉–冲切组合破坏；顶板厚度为5D时，为弯拉破坏；下伏溶洞顶板临界厚度为5.9D。(2)试桩荷载–位移曲线呈陡变型，陡变点出现前，荷载–位移关系呈线性形态，荷载–位移曲线陡变点对应桩顶位移为(0.215～0.3)D，规范取0.05D位移对应荷载作为桩基极限承载力偏于保守。(3)顶板厚度每增加1D，试桩极限承载力显著提升，但增幅由158%逐步降低至35%；当顶板厚度超过2D，试桩桩端承载比例超过90%。(4)所建立的下伏溶洞桩基极限承载力计算方法，与试验结果的误差范围为3.29%～15.62%，吻合较好。

关键词：桩基工程嵌岩桩溶洞顶板厚度承载特性模型试验

具身认知视域下《黑神话：悟空》弘扬中华优秀传统体育文化的特征、价值及启示

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沈阳体育学院学报 2025年第01期44卷 138-144页

作者：白洋张晓林四川师范大学体育学院体育健康旅游技术研发四川省文化和旅游厅重点实验室

弘扬中华优秀传统体育文化是铸牢中华民族共同体意识的有力抓手，是提升民族凝聚力、建设体育强国的精神支柱。采用文本分析法、逻辑推理法等研究方法，分析《黑神话：悟空》在具身认知视域下弘扬中华优秀传统体育文化的特征及价值。研... 详细信息

弘扬中华优秀传统体育文化是铸牢中华民族共同体意识的有力抓手，是提升民族凝聚力、建设体育强国的精神支柱。采用文本分析法、逻辑推理法等研究方法，分析《黑神话：悟空》在具身认知视域下弘扬中华优秀传统体育文化的特征及价值。研究认为：《黑神话：悟空》弘扬中华优秀传统体育文化具有突出角色互动、身体感知的动作表现，体现身心合一、内外兼修的具身理念，传递继承传统、创新融合的价值观念等特征，并彰显以融入传统武术的视听符号凸显古为今用、以传递原著精神的西游叙事增强文化自信、以蕴含思政教育的互动机制形塑思想观念的价值。基于此，得出赓续传统文化血脉，增强体育文化影响力与感召力；弘扬中华体育精神，筑牢国家文化软实力精神支柱；赋能体育文化创新，释放文体旅协同发展效能；加强传统体育文化阐发，深化学校体育跨学科交融互鉴的启示。

关键词：《黑神话:悟空》中华优秀传统体育文化具身认知武术文化传承

中国快速交通系统与旅游生态效率脱钩关系及时空格局演化

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生态经济 2025年第1期41卷 176-184页

作者：白洋李亚茹新疆大学新疆历史文化旅游可持续发展重点实验室新疆乌鲁木齐830046 新疆大学旅游学院新疆乌鲁木齐830046

厘清快速交通系统与旅游生态效率发展的动态脱钩关系,对依托快速交通建设布局驱动旅游业高质量发展具有重要意义。论文基于2009—2020年中国省域面板数据,通过熵权法、旅游碳排放测算模型、Super-SBM模型测算快速交通系统和旅游生态效... 详细信息

厘清快速交通系统与旅游生态效率发展的动态脱钩关系,对依托快速交通建设布局驱动旅游业高质量发展具有重要意义。论文基于2009—2020年中国省域面板数据,通过熵权法、旅游碳排放测算模型、Super-SBM模型测算快速交通系统和旅游生态效率的综合发展水平,采用Tapio脱钩模型和马尔科夫模型揭示二者脱钩关系的时空演化规律与状态转移特征。研究发现:(1)整体来看,中国快速交通系统发展水平呈现稳定增长态势,旅游生态效率则波动下降。(2)研究期内,省域和区域层次的脱钩关系均以强负脱钩为主。(3)省域主流脱钩关系呈现多种脱钩类型交替嬗变的时序演化特征,存在连接状态覆盖范围逐渐压缩、脱钩北上和负脱钩南下的空间转移趋向。(4)省域脱钩状态主要发生向“上”转移,负脱钩关系的稳定性最强且存在空间集聚倾向,不同脱钩状态的邻域对省域脱钩状态转移存在明显异质影响。

关键词：快速交通系统旅游生态效率脱钩关系马尔科夫链中国

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面向机器学习的自动化特征工程研究综述

计算机应用与软件 2025年第1期42卷 1-10,40页

作者：刘玉琳白杨崔斌黎洋北京大学信息科学技术学院北京100871

自动化特征工程是一种无须人为干预且高效的特征工程解决方案,是当前机器学习研究领域的热点问题之一。为了更好地帮助用户使用自动化特征工程方法构建高质量特征,在特征生成、特征选择、系统实现三个方面对当前自动化特征工程方法的技... 详细信息

自动化特征工程是一种无须人为干预且高效的特征工程解决方案,是当前机器学习研究领域的热点问题之一。为了更好地帮助用户使用自动化特征工程方法构建高质量特征,在特征生成、特征选择、系统实现三个方面对当前自动化特征工程方法的技术特点以及存在的不足进行总结分析与归纳,并在已有分析的基础上,指出自动化特征工程的未来研究方向以及面临的问题和挑战。

关键词：自动化特征工程特征生成特征选择系统实现机器学习

Gastric gastrointestinal stromal tumor in a patient with neurofibromatosis type I presenting with anemia: A case report

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 394-401页

作者： bai, Guang-yang Shan, Ke-Shu Li, Chen-Sheng Wang, Xiang-Hua Feng, Ming-yang Gao, Yan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated Shandong First Medical University Shandong Province Jinan 250021 China Department of Hematology Shandong Provincial Hospital Affiliated Shandong First Medical University Shandong Province Jinan 250021 China Department of Gastrointestinal Surgery Yinan County People’s Hospital Shandong Province Linyi 276399 China Department of Pathology Shandong Provincial Hospital Affiliated Shandong First Medical University Shandong Province Jinan 250021 China

BACKGROUND Gastrointestinal stromal tumors (GISTs) are caused by mutations in the KIT and platelet derived growth factor receptor alpha genes in approximately 90% of cases. A minority of wild-type GISTs are associated with neurofibromatosis type 1 (NF1), an autosomal dominant genetic disease resulting from pathogenic mutations in the NF1 gene, which encodes the neurofibromin protein. NF1 patients often exhibit multi-system involvement, with café-au-lait macules and neurofibromas being characteristic symptoms. GISTs are a rare complication of NF1, with the tumors most frequently occurring in the small intestine (90% of cases), while occurrences in the stomach are rare. CASE SUMMARY A 51-year-old woman presented to the emergency department with complaints of dizziness, fatigue, chest tightness, and dark stools. Initial examination revealed a red blood cell count of 1.99 × 1012/L and a hemoglobin level of 43 g/L. She underwent blood transfusions and fluid replacement to stabilize her condition. Further investigations identified typical café-au-lait macules on her trunk, limbs, and face, along with neurofibromas. Endoscopy showed coffee-colored fluid in the gastric cavity, a large submucosal elevation with an exudative covering, and ulcer formation on the gastric fundus. Exploratory laparoscopy confirmed the tumor’s origin in the gastric fundus, and resection of the giant GIST was performed. Pathological analysis revealed a necrotic GIST measuring 18 cm × 14 cm, classified as high-risk, with approximately 5 mitotic figures per 10 high-power fields and no tumor at the margins. Immunohistochemistry results were CD117 (+), delay of germination 1 (+), CD34 (+), and succinate dehydrogenase complex iron sulfur subunit B intact expression. Genetic testing using next-generation sequencing confirmed an NF1 gene mutation. The patient underwent successful tumor resection and was discharged home with postoperative regorafenib therapy. A follow-up at one year showed no re

关键词： Case report Gastrointestinal stromal tumors Neurofibromatosis type 1 Regorafenib: Anemia

朱子与湖湘学派“心性”观的分歧与成因——基于乾道八年(1172)前后辩论的考察

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山东青年政治学院学报 2025年第1期41卷 25-34页

作者：白义洋山东大学儒学高等研究院济南250100

乾道八年(1172)前后,朱子与湖湘学派进行了一场关于“心性关系”的辩论,双方主要围绕着“尽心知性”的工夫对象与次第展开,争论的焦点是如何诠释《中庸》“已发未发说”与《易传·系辞上》“寂感说”。湖湘学者主要强调“寂感一如”的... 详细信息

乾道八年(1172)前后,朱子与湖湘学派进行了一场关于“心性关系”的辩论,双方主要围绕着“尽心知性”的工夫对象与次第展开,争论的焦点是如何诠释《中庸》“已发未发说”与《易传·系辞上》“寂感说”。湖湘学者主要强调“寂感一如”的一贯性,朱子对“寂感”的具体使用情况则较为复杂:(1)“寂然不动”与“静”形容“未发”的状态,其对象既可指心,也可指性。(2)“寂然”表示“主敬”工夫中的心理状态。(3)以“寂然不动”状性,表示性无动静可言;或以“寂感”范畴说明心统贯性情的结构。(4)“寂然常感”表示本心的呈露时断时续、暂明暂灭。双方论争的根源在于两套观念模式的不同,胡宏强调“即体即用”的超越体证,朱子则引入程颢“易道神”的三元模式作为心性论结构的形上根据。两方争论具体表现为:“神之功用”与“心之神感妙用”之争,及“心以用尽情见义”与“性体心用形著义”之争。

关键词：朱子胡宏心性寂感易道神

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纤维素材料在水溶液中吸附净化的研究进展

吉林大学学报(理学版) 2025年第1期63卷 173-181页

作者：刘冠成张喆龙鑫杨柏吉林大学超分子结构与材料国家重点实验室长春130012

纤维素材料作为一种新型吸附剂,具有优异的机械性能和化学稳定性,通过化学改性可显著提升其吸附性能,在去除水溶液中的污染物方面展现出对重金属离子、有机小分子和微塑料等污染物的良好吸附能力,也可作为血液净化吸附剂用于治疗血液疾... 详细信息

纤维素材料作为一种新型吸附剂,具有优异的机械性能和化学稳定性,通过化学改性可显著提升其吸附性能,在去除水溶液中的污染物方面展现出对重金属离子、有机小分子和微塑料等污染物的良好吸附能力,也可作为血液净化吸附剂用于治疗血液疾病.综述纤维素材料在水溶液净化中的应用,并总结纤维素材料作为吸附剂的研究进展.

关键词：纤维素化学改性水净化血液净化