检索结果-南通市图书馆

维普期刊数据库

Identification of the key genes and mechanisms associated with transcatheter arterial chemoembolisation refractoriness in hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第1期15卷 62-88页

作者： jie-Zhuang Huang Jian-Di Li Gang Chen rong-Quan He Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Transcatheter arterial embolisation(TACE)is the primary treatment for intermediate-stage hepatocellular carcinoma(HCC)patients while some HCC cases have shown resistance to *** To investigate the key genes and potential mechanisms correlated with TACE refractoriness in *** The microarray datasets of TACE-treated HCC tissues,HCC and non-HCC tissues were collected by searching multiple public *** respective differentially expressed genes(DEGs)were attained via limma R *** gene co-expression network analysis was employed for identifying the significant modules related to TACE *** refractoriness-related genes were obtained by intersecting up-regulated TACE-associated and HCC-associated DEGs together with the genes in significant modules related to TACE *** key genes expression in the above two pairs of samples was compared respectively via Wilcoxon tests and standard mean differences *** prognostic value of the key genes was evaluated by Kaplan-Meier *** analysis was utilised to investigate the independent prognostic factor in key ***-cell RNA(scRNA)sequencing analysis was conducted to explore the cell types in *** refractoriness-related genes activity was calculated via AUCell *** CellChat R package was used for the investigation of the cell–cell communication between the identified cell *** HCC tissues of TACE non-responders(n=66)and TACE responders(n=81),HCC(n=3941)and non-HCC(n=3443)tissues were *** five key genes,DLG associated protein 5(DLGAP5),Kinesin family member 20A(KIF20A),Assembly factor for spindle microtubules(ASPM),Kinesin family member 11(KIF11)and TPX2 microtubule nucleation factor(TPX2)in TACE refractoriness-related genes,were *** five key genes were all up-regulated in the TACE non-responders group and the HCC *** expression of the five key genes predicted poor prognosis in *** the key genes,TP

关键词： Hepatocellular carcinoma Transcatheter arterial embolisation refractoriness Weighted gene co-expression network analysis Single-cell RNA sequencing AUCell CellChat

Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang Xiang-Cui Liu Yu-Chao Wang Huan-Ran Zheng Jin-Xian Wang Jia-Yi Zheng Meng-jie Liu Dan-Ni Deng Yu bai Ying-Bi Chen Tong Zhang Zhi-Ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

维普期刊数据库

Fast compressed sensing spectral measurement with adaptive gradient multiscale resolution

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第2期33卷 298-304页

作者：蓝若明刘雪峰李天平白成杰 School of Physics and Electronics Shandong Normal UniversityJinan 250014China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing 100190China

We propose a fast,adaptive multiscale resolution spectral measurement method based on compressed *** method can apply variable measurement resolution over the entire spectral range to reduce the measurement time by over 75%compared to a global high-resolution *** the characteristics of the human retina system,the resolution distribution follows the principle of gradually *** system allows the spectral peaks of interest to be captured dynamically or to be specified a priori by a *** system was tested by measuring single and dual spectral peaks,and the results of spectral peaks are consistent with those of global high-resolution measurements.

关键词： spectrometer compressed sensing adaptive gradient multiscale resolution fast measurement

维普期刊数据库

Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors

在线全文

学校读者我要写书评

暂无评论

胰腺病学杂志(英文) 2024年第2期7卷 97-105页

作者： Chen jie Wu Wenming bai Chunmei Chi Yihebali Huo Li Jiang Liming Ji Yuan Luo jie Li jie Li Jingnan Lou Wenhui Shao Chenghao Shen Lin Wang Feng Wang Yu Xue Ling Xu Jin Yuan Chunhui Yu Xianjun Yin Xiaoyu Zhao Hong Zhu Xiongzeng Zhao Yupei Centre for Neuroendocrine Tumors Fudan University Shanghai Cancer Center Shanghai China Department of General Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China Department of Medical Oncology Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical College Beijing China Department of Medical Oncology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Nuclear Medicine State Key Laboratory of Complex Severe and Rare Diseases Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology Zhongshan Hospital Fudan University Shanghai China Department of Pathology China-Japan Friendship Hospital Beijing China Department of Gastroenterological Oncology Beijing Cancer Hospital Peking University Cancer Hospital &amp Institute Beijing China Department of Gastroenterology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Pancreatic Surgery Zhongshan Hospital Fudan University Shanghai China Department of Pancreatic-Biliary Surgery Second Affiliated Hospital of Naval Medical University Shanghai China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp Department of Nuclear Medicine Nanjing First Hospital Nanjing Medical University Nanjing China Depar

The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (pNECs), according to the mitotic count, Ki-67 index, and cell differentiation. As a new category, G3 pNETs remain a challenging group of tumors to manage by lacking large randomized trials and consensus to support its clinical practice. Therefore, the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association gathered experts in this field to formulate this consensus for the diagnosis and treatment of G3 pNETs.

关键词： Clinical diagnosis Grade 3 Pancreatic neuroendocrine tumors Treatment

反旋双色椭圆偏振激光场中Ar原子的非序列双电离

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

物理学报 2024年第9期73卷 78-87页

作者：葛振杰苏旭白丽华上海大学理学院物理系上海200444

利用经典系综方法研究了不同椭偏率的反旋双色椭圆偏振(two-color elliptically polarized,TCEP)激光场中Ar原子非序列双电离(nonsequential double ionization,NSDI)的电子关联特性和再碰撞动力学.不同于反旋双色圆偏振激光场,反旋TCE... 详细信息

利用经典系综方法研究了不同椭偏率的反旋双色椭圆偏振(two-color elliptically polarized,TCEP)激光场中Ar原子非序列双电离(nonsequential double ionization,NSDI)的电子关联特性和再碰撞动力学.不同于反旋双色圆偏振激光场,反旋TCEP激光场不再具有空间对称性,返回电子主要从一个方向返回母离子,从而导致电子动量分布表现出很强的不对称性.数值结果显示随着椭偏率的增大,Ar原子NSDI的产量逐渐减小,并且电子对在椭圆偏振激光场长轴方向上的关联电子动量分布,从主要位于第一和第三象限的正相关逐渐演变为主要位于第二和第四象限的反相关.通过对不同特征时间的统计分析表明,随着椭偏率的增大,旅行时间和返回电子的重碰撞能量逐渐减小,而延迟时间却增大,这是电子对关联特性发生变化的主要原因.此外,进一步分析发现,无论是“短轨迹”还是“长轨迹”,椭偏率的增大都会使两个电子由同向出射逐渐转变为反向出射,这表明椭偏率和旅行时间都影响着电子的出射方向.

关键词：反旋双色椭圆偏振激光场非序列双电离椭偏率电子关联

维普期刊数据库博看期刊

同方期刊数据库

Trends in Incidence of HIV and Syphilis Among Men Who Have Sex with Men—Tianjin Municipality,China,2013-2022

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2024年第27期6卷 651-657页

作者： Yan Guo Fangfang Chen Hui Gong Ziming Wu Xinying Zhang Tielin Ning Zhongquan Liu Jianyun bai Long Li jie Yang Fangning Zhao Jinyu Hou Maohe Yu Houlin Tang STD&AIDS Control and Prevention Section Tianjin Center for Disease Control and PreventionTianjinChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina STD&AIDS Control and Prevention department Tianjin Hongqiao District Center for Disease Control and PreventionTianjinChina Tianjin Shenlan Public Health Counseling Service Center TianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina

Summary What is already known about this topic?Given the common modes of transmission,outbreaks of both human immunodeficiency virus(HIV)and syphilis are primarily observed in men who have sex with men(MSM).However,minimal research has been conducted to concurrently evaluate the rates and trends of HIV and syphilis incidence within this community in *** is added by this report?

关键词： Incidence primarily immunodeficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数字经济与国内价值链长度

中山大学学报（社会科学版） 2024年第3期64卷 171-181页

作者：李杰倪容潘捷暨南大学产业经济研究院广州510632 广东金融学院经济贸易学院广州510521

数字经济的崛起给国内价值链的结构和分工优势带来了新的发展机遇。文章以2011—2020年中国31省、自治区、直辖市42个部门的数据为样本,在测度数字经济的发展水平和国内价值链长度的基础上,实证检验数字经济对国内价值链长度的影响及其... 详细信息

数字经济的崛起给国内价值链的结构和分工优势带来了新的发展机遇。文章以2011—2020年中国31省、自治区、直辖市42个部门的数据为样本,在测度数字经济的发展水平和国内价值链长度的基础上,实证检验数字经济对国内价值链长度的影响及其影响机制。研究发现,整体上数字经济水平的提高能够显著推动国内价值链长度的增加,数字经济发展更能增加资本密集型制造业、非生产性服务业以及西部和东北地区的国内价值链长度。进一步研究发现,数字经济可以通过前向和后向产业关联机制来影响国内价值链的长度,且前向和后向产业关联的影响具有行业异质性。

关键词：数字经济国内价值链产业关联价值链长度

维普期刊数据库博看期刊

重视MR扩散加权成像在骨骼肌肉系统肿瘤诊断中的作用

在线全文

学校读者我要写书评

暂无评论

中华放射学杂志 2009年第6期43卷 565-566页

作者：屈辉白荣杰北京积水潭医院放射科 100035

恶性骨肿瘤的诊断一直是骨骼肌肉系统影像学研究的重要课题之一。随着医学影像技术的发展，MRDWI在骨骼肌肉系统肿瘤诊断中的应用逐渐增多。本期刊出的有关MRDWI的数篇论文，探讨DWI在骨骼肌肉系统肿瘤诊断中的应用价值和其不足之处。... 详细信息

恶性骨肿瘤的诊断一直是骨骼肌肉系统影像学研究的重要课题之一。随着医学影像技术的发展，MRDWI在骨骼肌肉系统肿瘤诊断中的应用逐渐增多。本期刊出的有关MRDWI的数篇论文，探讨DWI在骨骼肌肉系统肿瘤诊断中的应用价值和其不足之处。为进一步提高骨骼肌肉系统肿瘤的影像诊断水平，要重视常规影像检查对骨肿瘤的诊断作用，并开展MRI新技术，如DWI在骨骼肌肉系统肿瘤诊断中的应用。

关键词：骨骼肌肉系统肿瘤诊断 MR扩散加权成像 MRDWI 恶性骨肿瘤医学影像技术影像学诊断水平

Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第19期30卷 2523-2537页

作者： Mu-Han Li Ge-Chong Ruan Wei-Xun Zhou Xiao-Qing Li Sheng-Yu Zhang Yang Chen Xiao-Yin bai Hong Yang Yu-jie Zhang Peng-Yu Zhao Ji Li Jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Scinences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Tianjin First Central HospitalNankai UniversityTianjin 300192China Affairs Office Chinese Academy of Medical Sciences&Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE *** To improve overall understanding of this disease’s diagnosis and *** We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic *** Diarrhea in AIE patients was characterized by secretory *** common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and *** blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal ***,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte *** patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)*** were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s *** cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,*** Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult *** long-term prognosis is still unsatisfac

关键词： Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis