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Mental health status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month follow-up questionnaire study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah M Alhammad Namareq F Aldardeer Abdulaziz Alqahtani Mohammad H Aljawadi Bushra Alnefaie Raghad Alonazi Mansour Almuqbil Abdulrahman Alsaadon Rakan M Alqahtani Rashid Alballaa bader alshehri Mohammed I Alarifi Fahad D Alosaimi Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of Pharmacy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of Pharmacy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Pharmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care Medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Psychiatry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUND Psychological assessment after intensive care unit(ICU)discharge is increasingly used to assess patients'cognitive and psychological ***,few studies have examined those who recovered from coronavirus disease 2019(COVID-19).There is a paucity of data from the Middle East assessing the post-ICU discharge mental health status of patients who had *** To evaluate anxiety and depression among patients who had severe *** This is a prospective single-center follow-up questionnaire-based study of adults who were admitted to the ICU or under ICU consultation for>24 h for *** patients were contacted via *** patient’s anxiety and depression six months after ICU discharge were assessed using the Hospital Anxiety and Depression Scale(HADS).The primary outcome was the mean HADS *** secondary outcomes were risk factors of anxiety and/or *** Patients who were admitted to the ICU because of COVID-19 were screened(n=518).Of these,48 completed the *** mean age was 56.3±17.2 *** patients(62.5%)were *** main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** mean overall HADS score for anxiety and depression at 6 months post-ICU discharge was 11.4(SD±8.5).A HADS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from the multivariable ordered logistic regression demonstrated that vasopressor use was associated with the development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;P<0.05].CONCLUSION Six months after ICU discharge,30% of patients who had COVID-19 demonstrated a HADS score that confirmed anxiety and *** compare the psychological status of patients following an ICU admission(with vs without COVID-19),further studies are warranted.

关键词： COVID-19 Critically ill Anxiety Depression HADS Saudi Arabia

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Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds

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BIOCELL 2021年第6期45卷 1601-1610页

作者： FAZLUR RAHMAN SHAMS TABREZ RAHAT ALI SAJJADUL KADIR AKAND MOHAMMED AALAIDAROUS MOHAMMED ALSAWEED bader MOHAMMED alshehri SAEED BANAWAS ABDUR RUB ABDUL AZIZ BIN DUKHYIL Infection and Immunity Laboratory(414) Department of BiotechnologyJamia Millia Islamia-A Central UniversityNew Delhi110025India Department of Medical Laboratory Sciences College of Applied Medical SciencesMajmaah UniversityAl Majmaah11952Saudi Arabia Health and Basic Sciences Research Center Majmaah UniversityAl Majmaah11952Saudi Arabia

Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus *** is transmitted by the bite of female phlebotomies sand *** main clinical manifestations of leishmaniasis include cutaneous,visceral,and mucocutaneous *** leishmaniasis(VL)caused by Leishmania donovani,is an infection of reticuloendothelial system and fatal if ***,a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent in plants,yeast,and protozoa,*** which is absent in human being,is an important constituent of parasite *** C-24 reductase(LdSR)enzyme catalyzes the final step in the ergosterol biosynthesis *** inhibition of biosynthesis of ergosterol may lead to decreased cell viability and ***,we performed the molecular docking-based virtual screening of a library of natural ligands against LdSR to identify a potential inhibitor to fight ***,prenyletin,flavan-3-ol,resveratrol,and gingerol showed the top binding affinity towards *** upon ADME properties and bioactivity score,gingerol showed the best lead-likeness and drug-likeness ***,we further annotated its leishmanicidal *** found that gingerol inhibited the growth and proliferation of promastigotes as well as intra-macrophagic *** exerted its antileishmanial action through the induction of reactive oxygen species(ROS)in concentration-dependent *** induced ROS led to ***,this study described that gingerol would act as possible inhibitor to LdSR.

关键词： Leishmania Gingerol Sterol C-24 reductase Molecular docking ROS

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The Impact of Blood Transfusion on the Efficiency of Stem Cell Transplants

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Case Reports in Clinical Medicine 2024年第8期13卷 328-338页

作者： Amer Saud AL-Humaidan Saleh Saud Almutairi Mohammed Hussain Khubrani Raffah Mahdi Bajudah Waleed Mohammad Alzabidi Mohammed Hafiz Almasabi bader Mohammed Saleh Alhomaid Waad Ali alshehri Wejdan Saleh Alghamdi Raghad Abdullah Alwthinani Department of Pathology and Laboratory King Abdulaziz Medical City Ministry of National Guard Health Affairs Riyadh Saudi Arabia

Background: While blood product transfusion is essential for managing hematologic deficits in Allogenic Hematopoietic stem cell transplant (AHSCT) recipients, it has risks including infectious disease transmission, alloimmunization, and transfusion reactions. These risks have sparked an ongoing debate regarding the overall impact of transfusions on patient outcomes. Thus, this study aimed to evaluate the impact of Red Blood Cells (RBCs) and/or platelet transfusion on the infection incidence and overall survival in AHSCT patients. Methods: We performed a retrospective analysis of clinical and laboratory data of sixty adult patients with primary malignant hematological disorder who had undergone AHSCT. Participants’ data were categorized into two groups;Group 1 (low transfusion group) consisted of patients receiving 10 units. Quantitative data were expressed as mean ± SD. The t-test of significance and Chi-square (χ2) test were used, with p ≤ 0.05 considered significant. Result: A total of 60 patients’ data was included. In Group 1, out of 30 patients, 13 (43.33%) developed infections. In contrast, Group 2 had 21 (70%) out of 30 patients develop infections. Group 1 had a higher survival rate (57.8%) than Group 2 (transfusion > 10 units) (46.2%) with a chi-square value = 23.56, and p-value Conclusion: The volume of blood product transfusions has a considerable impact on patient outcomes, particularly infection and survival rates. Additional long-term prospective studies and larger randomized controlled trials are needed to strengthen the evidence for determining transfusion protocols for these patients.

关键词： Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Blood Transfusion Survival Rate

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