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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad bachar el baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Existence and Global Asymptotic Behavior of Positive Solutions for Sublinear and Superlinear Fractional Boundary Value Problems

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Chinese Annals of Mathematics,Series B 2016年第1期37卷 1-28页

作者： Imed bachar Habib MAAGLI Faten TOUMI Zagharide ZINE el ABIDINE Mathematics Department College of Science King Saud University P.O.Box 2455 Riyadh 11451 Saudi Arabia. Department of Mathematics College of Sciences and Arts Rabigh Campus King Abdulaz University P.O.Box 344 Rabigh 21911 Saudi Arabia. Departement de Mathematiques Faculte des Sciences de Tunis Campus Universitalre 2092 Tunis Tunisia.

In this paper, the authors aim at proving two existence results of fractional differential boundary value problems of the form （Pa,bα）{D^au（x）＋f（x,u（x））=0,x∈（0,1）,u（0）=u（1）=0,D^a-3u（0）=a,u^（1）=-6where 3 ≤ a 〈 4, D^ is the standard Riemann-Liouville fractional derivative and a, b are nonnegative constants. First the authors suppose that f（x, t） = -p（x）t^σ, with cr ~ （-1, 1） and p being a nonnegative continuous function that may be singular at x - 0 or x - 1 and satisfies some conditions related to the Karamata regular variation theory. Combining sharp estimates on some potential functions and the Sch^uder fixed point theorem, the authors prove the existence of a unique positive continuous solution to problem （P0,0）. Global estimates on such a solution are also obtained. To state the second existence result, the authors assume that a, b are nonnegative constants such that a ＋ b 〉 0 and f（x, t） -= tφ（x, t）, with φ（x, t） being a nonnegative continuous function in （0, 1） × [0, ∞） that is required to satisfy some suitable integrability condition. Using estimates on the Green＇s function and a perturbation argument, the authors prove the existence and uniqueness of a positive continuous solution u to problem （Pa,b）, which behaves like the unique solution of the homogeneous problem corresponding the existence results. to （Pa,b）. Some examples are given to illustrate the existence results.,

关键词： Fractional differential equation Positive solution Fractional Green's function Karamata function Perturbation arguments Sch/iuder fixad point theorem

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Planning and Profit Sharing in Overlay WiFi and LTE Systems toward 5G Networks

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Journal of Software Engineering and Applications 2019年第11期12卷 491-508页

作者： Danielle Saliba Rodrigue Imad Sebastien Houcke bachar el Hassan Signal and Communication Mines Telecom Atlantique Brest France Mechatronics University of Balamand Al Kurah Lebanon Telecommunication and Networking Lebanese University Tripoli Lebanon

With the increasing demand for data traffic and with the massive foreseen deployment of the Internet of Things (IoT), higher data rates and capacity are required in mobile networks. While Heterogeneous Networks (HetNets) are under study toward 5G technology, Wireless Fidelity (WiFi) Access Points (APs) are considered a potential layer within those multiple Radio Access Technologies (RATs). For this purpose, we have proposed in this paper a novel WiFi dimensioning method, to offload data traffic from Long Term Evolution (LTE) to WiFi, by transferring the LTE energy consuming heavy users, to the WiFi network. First, we have calculated the remaining available capacity of the WiFi network based on the estimated load of each WiFi physical channel using the overlapping characteristic of the channels. Then, we were able through this dimensioning method, to calculate the minimum needed number of WiFi APs that ensure the same or better throughput for the LTE transferred users. By this method, we have ensured additional capacity in the LTE network with minimum investment cost in the WiFi network. Finally, we have estimated the profit sharing between LTE and WiFi by considering data bundles subscription revenues and the infrastructure capital and operational costs. We have calculated for each network the profit share using a coalition game theory Shapley value that pinpoints the benefit of the cooperation using the proposed dimensioning method.

关键词： LTE WiFi Offload and Coexistence 5G Heterogeneous Networks Shapley Value Profit Sharing

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Mathematical Model with Energy and Clustering Energy Based Routing Protocols as Remediation to the Directional Source Aware Routing Protocol in Wireless Sensor Networks

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Wireless Sensor Network 2022年第2期14卷 23-39页

作者： Samir Haddad Jinane Sayah bachar el-Hassan Chadi Kallab Mohamad Chakroun Nisrine Turkey Jinan Charafeddine Hani Hamdan Faculty of Arts and Sciences Department of Computer Science and Mathematics University of Balamand Koura Lebanon Issam Fares Faculty of Technology Department of Telecom and Networks University of Balamand Koura Lebanon Faculty of Engineering Branch 1 Department of Electricity and Electronics Lebanese University Lebanon Faculty of Computer Science and electrical Engineering The University of Rostock Rostock Germany Faculty of Engineering Notre Dame University Lebanon Université Paris-Saclay P&ocirc le scientifique et technologique de Vélizy Laboratoire d'Ingénierie des Systèmes de Versailles (LISV EA4048) Vélizy France Université Paris-Saclay CentraleSupélec CNRS Laboratoire des Signaux et Systèmes (L2S UMR CNRS 8506) Gif-sur-Yvette France

In this paper, a routing protocol for wireless sensor network, baptized energy based protocol (EBP) is proposed. Wireless sensor network presents many challenges and constraints, and one of the major constraints is the routing problem. Due to the limited energy of sensor nodes, routing in this type of network shall perform efficiently to maximize the network lifetime. One of the proposed algorithms is the directional source aware routing protocol (DSAP) which, after simulation, showed a lot of limitations and drawbacks. The modified directional source aware routing protocol (MDSAP) was proposed by the authors of this paper to address some of the DSAP’s limitations but remains limited to a fixed topology, fixed source and stationary nodes. So EBP is proposed and operated under different scenarios and showed, after its simulation using TinyOS, many advantages in terms of load balancing, free looping, minimizing packet error rate and maximizing network lifetime.

关键词： Cluster DSAP Energy MDSAP Routing Sensor Network Topology Energy Based Protocol

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Profile of Maternally Derived Antibody in Broiler Chicks and In-Ovo Vaccination of Chick Embryo against Newcastle Disease

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World Journal of Vaccines 2014年第2期4卷 72-80页

作者： George O. Okwor Abduldahiru el-Yuguda Saka S. baba Animal Virus Research Laboratory Department of Veterinary Microbiology and Parasitology Faculty of Veterinary Medicine University of Maiduguri Maiduguri Nigeria

In this study, we determined the suitability of lentogenic LaSota and naturally occurring avirulent I2 vaccine strains of Newcastle disease (ND) virus for efficacious in-ovo vaccination of broiler chickens. A total of 114 embyonated eggs divided into five groups (A, B, C, D and E) consisting of 25 eggs in each of groups A and B, 20 eggs in each of groups C and D and 24 eggs in group E were used in the study. Eighteen-day-old embryonated eggs in group A were vaccinated in-ovo with ND-I2 vaccine while the same age of embryos in group B were vaccinated with ND-LaSota. Thirteen-day-old embryonated eggs in groups C and D were vaccinated with ND-I2 and ND-LaSota respectively. Group E served as unvaccinated control. There was significant difference (p 2) used for the in-ovo vaccination were pathogenic for chick embryos, however, ND-I2 vaccine was better tolerated when administered to 18-day-old chick embryo.

关键词： In-Ovo Vaccination ND-LaSota ND-I2 Maternal Antibody Broiler Chicks

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Immunostimulatory Effect of Levamisole on the Immune Response of Goats to <i>Peste des petits ruminants </i>(PPR) Vaccination

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World Journal of Vaccines 2014年第2期4卷 88-95页

作者： Undiandeye Jude Undiandeye Bamidele Soji Oderinde Abduldahiru el-Yuguda Saka Saheed baba Animal Virus Research Laboratory Department of Veterinary Microbiology and Parasitology Faculty of Veterinary Medicine Maiduguri Nigeria Department of Medical Laboratory Science College of Medical Sciences University of Maiduguri Maiduguri Nigeria

The use of Levamisole hydrochloride as an immunostimulant has been successful in the control of certain diseases such as Derzsy’s disease in chicken as well as in increasing lymphocytes and weight gain in pigs. However, its use as immunostimulant in the prevention of Peste des petits ruminants (PPR) in goats has not been investigated. In this study, the use of Levamisole in enhancing immune response to PPR vaccination including its effects on weight gain was investigated among groups of goats (groups A, B, C and D). Virus neutralization test was used to determine the antibody profile in vaccinated goats while the total and differential leucocyte counts and body mass index (BMI) were determined using standard procedures. Goats in group A (Levamisole primed and PPR vaccinated) seroconverted to more than 3-folds of the initial pre-vaccination geometric mean titre (GMT) of neutralizing antibody beginning from second week post-vaccination and remained high throughout the period of the experiment. Similarly, there was significant increase (p 0.05) in BMI of animals in other groups throughout the period of the experiment. The results of this study further confirm the immunostimulatory effect of Levamisole when used in combination with a vaccine.

关键词： Levamisole Hydrochloride Homologous PPR Vaccine Immunostimulant Goats Maiduguri Nigeria

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Crude Oil Degradation Potential of Indigenous Hydrocarbonoclastic Bacterial Strain Acinetobacter johnsonii Firstly Isolated from Marine Sediments of Oran Port,Algeria

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Journal of Environmental Science and Engineering(A) 2019年第4期8卷 131-140页

作者： Faiza Bendadeche Mohamed Bey baba Hamed Sidi-Mohammed el-Amine Abi Ayad Laboratory of Aquaculture and Bioremediation(AquaBior) Department of BiotechnologyFaculty of Nature and Life SciencesUniversity of Oran 1 Ahmed Ben BellaOran 31000Algeria Higher School of Biological Sciences of Oran Oran 31000Algeria

Petroleum contaminants caused great damages to environment and human ***,the port of Oran is subject of pollution mainly by PAHs(Polycyclic Aromatic Hydrocarbons)as a result of the large flow of *** bioremediation by indigenous microorganisms is an important means for their reduction and *** the present work,a hydrocarbonoclastic bacterium strain SP49F2 was considered,firstly isolated from the contaminated marine sediments and seawater at the port of Oran(Algeria),using Bushnell-Hass mineral salt medium,and identified on the basis of morphological and biochemical characteristics and molecular tools by analysis of partial 16S rRNA gene sequence,using the Basic Local Alignment Search Tool program on the data base of NCBI(National Centre for Biotechnology Information),and the EzBioCloud 16S rRNA *** of growth of this isolate on crude oil during 20 days of culture was studied at temperature 25℃,3%(w/v)of NaCl concentration and pH 7,at 140 rpm(Revolutions Per Minute).Strain SP49F2 was identified molecularly as Acinetobacter johnsonii,and might support high concentrations of crude oil(up to 10%,v/v).Results of growth kinetic on crude oil as sole energy and carbon source by the isolate strain showed that the stationary phase was attained at day ***,train Acinetobacter johnsonii SP49F2 could efficiently utilize crude oil as its sole carbon and energy source,and could be used as a wonderful native biological alternative for the bioremediation of the port of Oran,and marine area polluted by petroleum hydrocarbons,as an eco-friendly efficacy degrader,and may be suitable for biotechnological applications.

关键词： Crude oil Acinetobacter johnsonii bioremediation marine sediments 16S rDNA.

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Field Trial of a Thermostable Peste des petits ruminants (PPR) Vaccine in a Semi-Arid Zone of Nigeria

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World Journal of Vaccines 2014年第1期4卷 1-6页

作者： Abdul-Dahiru el-Yuguda Saka Saheed baba Abdul Ganiyu Ambali Gordon Onyebuchi Egwu Animal Virus Research Laboratory Department of Veterinary Microbiology and Parasitology Faculty of Veterinary Medicine University of Maiduguri Maiduguri Nigeria Department of Veterinary Medicine Faculty of Veterinary Medicine University of Ilorin Ilorin Nigeria Department of Veterinary Medicine Faculty of Veterinary Medicine University of Maiduguri Maiduguri Nigeria

The field trial of a candidate thermostable Peste des petits ruminants (PPR) vaccine was carried out in flocks of sheep and goats under the extensive system of management. The immune response of vaccinated animals was determined using the neutralisation test to detect PPR virus specific antibody. Vaccinated animals seroconverted and a four-fold or more rise in antibody titre were observed between pre-vaccination and post-vaccination antibodies. The vaccine elicited significant antibody response in goats through the different routes of administration (intramuscular, intranasal, intraocular, subcutaneous and orally), but was poorly transmitted between the vaccinees and in-contact animals. The sheep responded poorly to the vaccine administered through most of the routes, except for those vaccinated through intramuscular and subcutaneous routes that seroconverted significantly (≥4 fold rise). The vaccine retained a potent titre of 3.1 log10 TCID50 for more than 8 hours after reconstitution in PBS at room temperature. Based on the response of goats to oral vaccination, it is suggested that the vaccine could be administered on the field through the oral routes and has the potential to be adapted to a feed-based administration for wider application to the scattered livestock populations under the extensive system of management.

关键词： Thermostable PPR Vaccine Sheep Goats Virus Neutralisation Test Nigeria

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Characterization of Endophytic Microorganisms of Rice(Oryza sativa L.)Potentials for Blast Disease Biocontrol and Plant Growth Promoting Agents

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 3021-3041页

作者： Shugufta Parveen Fayaz A.Mohiddin M.Ashraf Bhat Zahoor Ahmed baba Fehim Jeelani M.Anwar Bhat Sajad Un Nabi Burhan Hamid Saba Bandey Farhanaz Rasool Zakir Amin Ibrahim Al-Ashkar Muhammad Adnan Ayman el Sabagh Division of Plant Pathology Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Mountain Research Centre for Field Crops SKUAST-KashmirKhudwaniIndia Division of Genetics and Plant Breeding Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Microbiology Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Statistics Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Division of Agronomy Faculty of AgricultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirWaduraIndia Indian Council of Agricultural Research-Central institute of Temperate Horticulture(ICAR-CITH) Old AirportRangrethSrinagarIndia Division of Plant Pathology Faculty of HorticultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia Directorate of Extension Sher-e-Kashmir University of Agricultural Sciences and Technology of KashmirShalimarIndia Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadhSaudi Arabia College of Food Agricultural and Environmental SciencesThe Ohio State UniversityColumbusOHUSA Department of Agronomy Faculty of AgricultureUniversity of KafrelsheikhKafrelsheikhEgypt

One hundred twenty-five endophytic microorganisms were isolated from the roots,stems,and leaves of four prominent rice cultivars growing in temperate *** potential to combat rice blast disease and promote plant growth was *** dual culture tests highlighted the strong antagonistic activity of five fungal(ranging from 89%–70%)and five bacterial(72%–61%)*** examination focused on volatile compounds produced by selected isolates to counter the blast *** these,the highest chitinase(13.76μg mL−1)and siderophore(56.64%),was exhibited by Aspergillus flavus,and the highest HCN production was shown by Stenotrophomonas maltophilia(36.15μM mL−1).In terms of growth promotion traits,Aspergillus flavus and Enterobacter cloacae excelled in activities viz,phosphorous solubilization,ammonia production,auxin and gibberellic acid production,and nitrogen *** Identity of these endophytes was confirmed through molecular analysis as Trichoderma afroharzianum,Trichoderma harzianum,Penicillium rubens,Aspergillus flavus,Stenotrophomonas rhizophila,Stenotrophomonas maltophilia,Bacillus cereus,Enterobacter cloacae,and Bacillus *** greenhouse conditions,the highest disease control was shown by isolate Bacillus licheniformis and *** with an inhibition of 79%,followed by ***(77%)and ***(73%).The overall results of this study showed that Bacillus licheniformis and Stenotrophomonas rhizophila have great potential to be used as bio-stimulant and biocontrol agents to manage rice blast disease.

关键词： Endophytes phylogeny antagonistic activity Pyricularia phytohormones

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A Novel Approach in Hydrogeochemical Exploration for Uranium Mineralization:an Example from West Central Sinai,Egypt

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Acta Geologica Sinica(English Edition) 2015年第6期89卷 1895-1913页

作者： Ahmed E.el-RAYES Mohamed O.ARNOUS Suez Canal University Faculty of SciencesGeology Department

Groundwater in contact with ore deposits may acquire a chemical composition that could be used as a guide for exploration. Eight well-water samples are collected from a known uraniummineralized area near Abu Zenima, west central Sinai to examine the applicability of using the hydrogeochemical technique in the search for uranium mineralization in similar arid areas. The analytical chemical data of the ground water is compared with ground radiometric measurements. The obtained results indicate that groundwater affected by uranium mineralization has a specific relativity of major anions expressed essentially as SO_4〉Cl〉HCO_3 and to a lesser extent as Cl〉SO_4〉HCO_3, associated as a rule with low magnesium content. This association constitutes a signature of uranium mineralization on the composition of groundwater in west central Sinai and could be used as an important exploration guide in the search for uranium deposits in similar areas. Anomalies in Ni, Fe, Zn and Cr and other pathfinder elements in groundwater can furnish geochemical guides to uranium ores. The immobile trace element anomalies, including Zn, Ni and Fe are strongly distributed near the orebody; whereas the relatively mobile trace elements, including Co, U, V and Cr, constitute the dispersion haloes away from the orebody. A new hydrogeochemical discrimination diagram is constructed to be used as a quick and cost effective exploration tool in the search for uranium occurrences in environmentally similar arid areas. Based on the obtained results, a new site for uranium occurrence, west of W. baba, is delineated and recommended for future detailed geological and geochemical surveying.

关键词： Hydrogeochemical exploration Uranium ores geospatial mapping graphical explorationtool remote sensing Sinai

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