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Extracellular vesicles as tools and targets in therapy for diseases

Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.kumar Sadaf k.baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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A NEW BICOUMARIN FROM PLEUROSPERMUM RIVULORUM (DIELS)

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Chinese Chemical Letters 1995年第5期6卷 385-386页

作者： Xiao, YQ Liu, XH baba, k Taniguchi, M Chinese Acad Tradit Chinese Med Inst Chinese Meteria Med Beijing 100700 Peoples R China Osaka Univ Pharmaceut Sci Osaka 580 Japan

From the BtOAc extract of the underground parts of Pleurospermum rivulorum (Diels), a new bicoumarin, rivulobirin was isolated along with eight known furocoumarins.

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Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

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World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi Ohmura kazuki komatsu kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACkGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

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(Ba_(0.9)Sr_(0.1))(Ti_(0.999)Nb_(0.001))O_3陶瓷晶粒生长的动力学因子

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硅酸盐学报 2001年第2期29卷 146-150页

作者：熊兆贤冼定国 baba-kishikZ 厦门大学材料科学与工程系厦门361005 香港理工大学应用物理系

研究了半导化 (Ba0 .9Sr0 .1 ) (Ti0 .999Nb0 .0 0 1 )O3 陶瓷晶粒生长的动力学因子 ,采用固相反应法工艺制备该陶瓷样品 ,化学原材料为纯度高于 99%的BaCO3,SrCO3,TiO2 和Nb2 O5 等 ,并用到微量原料Al2 O3 和MnSiO3 以改善陶瓷的电学性... 详细信息

研究了半导化 (Ba0 .9Sr0 .1 ) (Ti0 .999Nb0 .0 0 1 )O3 陶瓷晶粒生长的动力学因子 ,采用固相反应法工艺制备该陶瓷样品 ,化学原材料为纯度高于 99%的BaCO3,SrCO3,TiO2 和Nb2 O5 等 ,并用到微量原料Al2 O3 和MnSiO3 以改善陶瓷的电学性能 .同样化学配方的 8种样品在130 0℃中保温时间分别为 1,3,6 ,10 ,30 ,6 0 ,10 0和 30 0min ,以获得晶粒生长不同程度的块状陶瓷 .利用扫描电子显微技术分析发现 ,随着保温时间的延长样品的平均晶粒尺寸变大 .经自动图像处理技术发现 ,晶粒生长的动力学因子不是常数 :在烧结初期大致为 1.5 ,而在烧结后期为 3.5 .这与大多数报道的实验和模拟结果一致 .

关键词：陶瓷晶粒生长动力学因子固相反应法图像处理半导化 BST陶瓷

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Aqueous-phase reforming of hydroxyacetone solution to bio-based H_(2)over supported Pt catalysts

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Green Energy & Environment 2024年第4期9卷 777-788页

作者： A.k.k.Vikla k.koichumanova Songbo He k.Seshan Joint International Research Laboratory of Circular Carbon Nanjing Tech UniversityNanjing211816China Faculty of Science and Technology University of Twente7500 AE EnschedeThe Netherlands CoRe Pro 9723 BL GroningenThe Netherlands

Aqueous-phase reforming(APR)is an attractive process to produce bio-based hydrogen from waste biomass streams,during which the catalyst stability is often challenged due to the harsh reaction *** this work,three Pt-based catalysts supported on C,AlO(OH),and ZrO_(2)were investigated for the APR of hydroxyacetone solution in afixed bed reactor at 225℃and 35 *** them,the Pt/C catalyst showed the highest turnover frequency for H_(2)production(TOF of 8.9 molH_(2)molPt^(-1)min^(-1))and the longest catalyst *** the AlO(OH)and ZrO_(2)supported Pt catalysts,the side reactions consuming H_(2),formation of coke,and Pt sintering result in a low H_(2)production and the fast catalyst *** proposed reaction pathways suggest that a promising APR catalyst should reform all oxygenates in the aqueous phase,minimize the hydrogenation of the oxygenates,maximize the WGS reaction,and inhibit the condensation and coking reactions for maximizing the hydrogen yield and a stable catalytic performance.

关键词： APR Hydroxyacetone TOF Bio-based H_(2) Support effect

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Investigating environmental quality among G20 nations: The impacts of environmental goods and low-carbon technologies in mitigating environmental degradation

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Geoscience Frontiers 2024年第1期15卷 84-96页

作者： Ernest baba Ali Samira Shayanmehr Riza Radmehr Richard Bayitse Ebenezer Agbozo Department of Economics University for Development StudiesTamale P.O.Box TL1350Ghana Department of Agricultural Economics Ferdowsi University of MashhadIran Council for Scientific and Industrial Research Institute of Industrial ResearchAccra P.O.Box LG 576Ghana Department of Big Data Analytics and Methods of Video Analysis Ural Federal University19 Mira Str60002 EkaterinburgRussia

Environmental goods and low-carbon technologies have long been identified as having the potential to drive long-term economic progress without compromising environmental quality. However, their exact role in mitigating environmental degradation are yet to be unravelled. In addressing this shortfall, the extant literature relied on research funding and patent application as proxies for green technologies. Having established the weaknesses in the use of these variables as proxies for green technologies, this study explored the role of trade in environmental goods and low-carbon technologies in boosting environmental quality among G20 nation using a panel dataset from 1994 to 2018. The study employed the Method of Moment quantile regression for the model estimation and the Ridge regression, Discroll-kraay standard error, and the Newey-West standard error estimators to test the robustness of our findings. Our findings indicate that whereas environmental goods promote environmental quality, low-carbon technologies decrease same. Also, the study found economic growth to exert an aggravating effect on environmental quality, while foreign direct investments, natural resource rents, human capital development, and renewable energy consumption exert positive influence on environmental quality. Based on the findings of the study, G20 nations are encouraged to improve green market structures to improve the trade in environmental goods and low-carbon technologies. Also the share of renewable energy sources in the overall energy basket must be improved to help improve environmental quality.

关键词： Environmental quality Environmental goods Low-carbon technology G20 nations

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Direct scaling of residual displacements for bilinear and pinching oscillators

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 129-149页

作者： Mohammad Saifullah Vinay k.Gupta Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

The estimation of residual displacements in a structure due to an anticipated earthquake event has increasingly become an important component of performance-based earthquake engineering because controlling these displacements plays an important role in ensuring cost-feasible or cost-effective repairs in a damaged structure after the *** attempt is made in this study to obtain statistical estimates of constant-ductility residual displacement spectra for bilinear and pinching oscillators with 5%initial damping,directly in terms of easily available seismological,site,and model *** of the available models for the bilinear and pinching oscillators are useful when design spectra for a seismic hazard at a site are not *** statistical estimates of a residual displacement spectrum are proposed in terms of earthquake magnitude,epicentral distance,site geology parameter,and three model parameters for a given set of ductility demand and a hysteretic energy capacity coefficient in the case of bilinear and pinching models,as well as for a given set of pinching parameters for displacement and strength at the breakpoint in the case of pinching model *** proposed scaling model is applicable to horizontal ground motions in the western *** earthquake magnitudes less than 7 or epicentral distances greater than 20 km.

关键词： residual displacement spectrum bilinear hysteresis model pinching hysteresis model nonlinear analysis scaling model

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Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： k JAMES Jintu kIM Heuy Dong Department of Mechanical Engineering Andong National UniversityAndong36729Republic of Korea CAD-IT korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectangular *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit height of H,and the effect of duct resonance on multiple shock oscillations is investigated by attaching exit ducts of lengths 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading-edge location,shock train length,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct length for the self-excited oscillation *** analysis of the shock train leading edge and the spectral analysis of wall static pressure variations are *** variation in the shock train length is analyzed using the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train length(ζ_(ST))increases with an increase in the exit duct length for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct designs and downstream forcing frequencies,the size of the separation bubble grows and shrinks during the shock oscillations,demonstrating the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

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Impact of Fin Arrangement on Heat Transfer and Melting Characteristics of Phase Change Material

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Journal of Thermal Science 2024年第2期33卷 435-456页

作者： Arun UNIYAL Yogesh k.PRAJAPATI Department of Mechanical Engineering National Institute of Technology UttarakhandSrinagar(Garhwal)246174India Department of Mechanical Engineering BIT SindriDhanbadJharkhand828123India

Present work investigates the heat transfer and melting behaviour of phase change material(PCM) in six enclosures(enclosure-1 to 6) filled with paraffin *** enclosures are equipped with distinct arrangements of the fins while keeping the fin's surface area equal in each *** analysis has been presented to recognize the suitable fin arrangements that facilitate improved heat transfer and melting rate of the *** wall of the enclosure is maintained isothermal for the temperature values 335 k,350 k and 365 *** length of the enclosure including fins is ranging between 0 and *** have been illustrated through the estimation of important performance parameters such as energy absorbing capacity,melting rate,enhancement ratio,and Nusselt *** has been found that melting time(to melt 100% of the PCM) is 60.5%less in enclosure-2(with two fins of equal length) as compared to the enclosure-1,having no *** the fin surface area equal,if the longer fin is placed below the shorter fin(enclosure-3),melting time is further decreased by 14.1% as compared to ***,among all the configurations,enclosure-6 with wire-mesh fin structure exhibits minimum melting time which is 68.4% less as compared to the *** on the findings,it may be concluded that fins are the main driving agent in the enclosure to transfer the heat from heated wall to the *** design and positioning of the fins improve the heat transfer rate followed by melting of the PCM in the entire area of the *** of the favourable vortices and natural convection current in the enclosure accelerate the melting phenomenon and help to reduce charging time.

关键词： phase change material enclosure fin melting fraction energy storage heat transfer

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MDCN:Modified Dense Convolution Network Based Disease Classification in Mango Leaves

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Computers, Materials & Continua 2024年第2期78卷 2511-2533页

作者： Chirag Chandrashekar k.P.Vijayakumar k.Pradeep A.Balasundaram School of Computer Science and Engineering Vellore Institute of Technology(VIT)ChennaiIndia Center for Cyber Physical Systems School of Computer Science and EngineeringVellore Institute of Technology(VIT)ChennaiIndia

The most widely farmed fruit in the world is *** the production and quality of the mangoes are hampered by many *** diseases need to be effectively controlled and ***,a quick and accurate diagnosis of the disorders is *** convolutional neural networks,renowned for their independence in feature extraction,have established their value in numerous detection and classification ***,it requires large training datasets and several parameters that need careful *** proposed Modified Dense Convolutional Network(MDCN)provides a successful classification scheme for plant diseases affecting mango *** model employs the strength of pre-trained networks and modifies them for the particular context of mango leaf diseases by incorporating transfer learning *** data loader also builds mini-batches for training the models to reduce training ***,optimization approaches help increase the overall model’s efficiency and lower computing *** employed on the MangoLeafBD Dataset consists of a total of 4,000 *** the experimental results,the proposed system is compared with existing techniques and it is clear that the proposed algorithm surpasses the existing algorithms by achieving high performance and overall throughput.

关键词： Leaf disease detection deep convolutional neural networks transfer learning optimization MangoLeafBD Dataset

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