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IL-18通过MyD88依赖信号途径调控CSF-1表达(英文)

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生物化学与生物物理进展 2011年第4期38卷 311-319页

作者：薛嬿刘琳琳贺芬姜雪曾宪录巴雪青东北师范大学遗传与细胞研究所长春130024

IL-18是IL-1家族的一个成员,最初发现被命名为IFN-γ诱导因子.现在研究表明,IL-18是炎症反应的重要标志,参与许多慢性炎症和自身免疫性疾病炎性反应.证明了IL-18在JurkatT淋巴细胞的炎症反应中能够调节CSF-1的表达,其信号机制是IL-18通... 详细信息

IL-18是IL-1家族的一个成员,最初发现被命名为IFN-γ诱导因子.现在研究表明,IL-18是炎症反应的重要标志,参与许多慢性炎症和自身免疫性疾病炎性反应.证明了IL-18在JurkatT淋巴细胞的炎症反应中能够调节CSF-1的表达,其信号机制是IL-18通过MyD88-NF-κB-CSF-1信号途径上调CSF-1的基因转录.

关键词：白介素18(IL-18) MyD88 核因子KB 集落刺激因子1

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

《住院患者跌倒风险因素评估表》在神经内科风险管理中的应用

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中国卫生产业 2018年第12期15卷 8-9页

作者：巴学青滨州市沾化区人民医院神经内一科山东滨州256800

目的研究《住院患者跌倒风险因素评估表》对神经内科风险管理的作用。方法观察2015年6月—2017年6月收治的90例神经内科住院患者跌倒情况,以不使用《住院患者跌倒风险因素评估表》为对照,分析观察组使用《住院患者跌倒风险因素评估表》... 详细信息

目的研究《住院患者跌倒风险因素评估表》对神经内科风险管理的作用。方法观察2015年6月—2017年6月收治的90例神经内科住院患者跌倒情况,以不使用《住院患者跌倒风险因素评估表》为对照,分析观察组使用《住院患者跌倒风险因素评估表》价值,比较两组患者对护理工作的满意情况,及跌倒情况。结果两组共17例患者跌倒,其中观察组仅占3例,跌倒率6.67%,对照组占14例,跌倒率31.11%,观察组满意度95.56%,优于对照组的80.00%,两组差异有统计学意义(P<0.05)。结论《住院患者跌倒风险因素评估表》应用于神经内科管理安全可行,避免患者跌倒,提高满意度。

关键词：神经内科风险管理临床效果《住院患者跌倒风险因素评估表》

A robust beam tracking scheme for millimeter wave HetNets

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Digital Communications and Networks 2022年第6期8卷 1115-1121页

作者： qing xue Gang Feng Chongqing Key Laboratory of Mobile Communications Technology Chongqing University of Posts and Telecommunications(CQUPT)Chongqing400065China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China(UESTC)Chengdu611731China State Key Laboratory of Internet of Things for Smart City University of MacaoMacaoChina

Millimeter Wave(mmWave)communication has been widely acknowledged as an attractive solution to address high-speed transmission of massive data in 5G and beyond 5G systems due to the promising spectrum ***,mmWave signals are highly susceptible to blockage and may suffer from rapidly changing ***,directional/beam tracking becomes imperative yet essential for robust mmWave *** address this challenge,we propose a robust beam tracking scheme for mmWave Heterogeneous Networks(HetNets)with *** from most existing schemes,the proposed beam tracking scheme is effective for outage *** first discuss theμWave-assisted beam tracking procedure with and without candidate beams,and then analyze the inherent correlation between mmWave link quality and the operating beamwidth and occlusion range to derive the optimal *** and numerical results show that the proposed beam tracking scheme can improve the robustness of mmWave communications while guaranteeing the rate performance.

关键词： Millimeter wave(mmWave)communication Beam tracking Multi-connectivity Robust

On a Certain Sum-product Estimate in Fields of Prime Order

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1861-1866页

作者： Bo qing xue Academy of Mathematics and Systems Science Chinese Academy of Sciences

Let Fp be the finite field of p elements with p *** A is a subset of Fp and g is an element of F＊p with order ν,then max{｜A ＋ g·A｜,｜A·A｜} （ν/（ν ＋｜A｜2））1/12｜A｜13/12.

关键词： Sum-product estimate different sets fields of prime order

Measuring H0 from low-z datasets

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Science China(Physics,Mechanics & Astronomy) 2020年第9期63卷 2-6页

作者： xue Zhang qing-Guo Huang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Synergetic Innovation Center for Quantum Effects and Applications Hunan Normal UniversityChangsha 410081China

The Hubble constant H0 represents the expansion rate of the Universe at present and is closely related to the age of the *** accurate measurement of Hubble constant is crucial for modern ***,different cosmological observations give diverse values of Hubble constant in *** to now,there are two methods to measure the Hubble *** is to directly measure the Hubble constant based on distance ladder estimates of Cepheids and so *** other is to globally fit the Hubble constant under the assumption of a cosmological model,for example the "standard" ACDM *** the low-redshift observational datasets,including the Pantheon sample of Type Ⅰa supernovae,baryon acoustic oscillation measurements,and the tomographic Alcock-Paczynski method,we determine the Hubble constant to be 67.95-1.03+0.78,69.81-2.70+2.22 and66.75-4.23+3.42 km s^-1 Mpc^-1 at 68% confidence level in the △CDM,wCDM and W0Wa CDM models,*** to the Hubble constant given by Riess et *** 2019,we conclude that the new physics beyond the standard △CDM model is needed if all of these datasets are reliable.

关键词： Hubble constant dark energy equation of state

基于两阶段DEA模型的江苏省动力电池行业回收效率评价研究

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价值工程 2025年第1期44卷 9-11页

作者：张雪晴张晓青江苏师范大学商学院徐州221116

本文选取江苏省2014年至2023年30家动力电池回收企业的实际数据,通过构建DEA模型对这些行业的回收效率进行评价分析。研究结果表明:第一,近十年以来,江苏省动力电池回收行业的回收效率总体处于较低水平,还有很大的提高余地。第二,近十... 详细信息

本文选取江苏省2014年至2023年30家动力电池回收企业的实际数据,通过构建DEA模型对这些行业的回收效率进行评价分析。研究结果表明:第一,近十年以来,江苏省动力电池回收行业的回收效率总体处于较低水平,还有很大的提高余地。第二,近十年以来,江苏省动力电池回收行业的配置效率处于不断提高阶段。

关键词： DEA模型动力电池回收行业回收效率

维普期刊数据库博看期刊

Microstructure of ferrospheres in fly ashes: SEM, EDX and ESEM analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1595-1600页

作者： qing-feng xue Sheng-gao LU Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition College of Environmental and Resource Sciences Zhejiang University Hangzhou 310027 China

Ferrospheres in fly ashes from a coal-fired power plant were extracted by a magnetic separation technique and their microstructure was studied by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and environmental scanning electron microscopy (ESEM). Ferrospheres in fly ashes show significant iron enrichment compared to their respective fly ashes. Iron oxides in ferrospheres mainly occur as minerals magnetite (Fe3O4) and hematite (α-Fe2O3), which are derived mainly from the decomposition and oxidation of iron-bearing minerals in coal during combustion. EDX data indicate that ferrospheres also contain Si, S, Al and Ca resulting from quartz, mullite, anhydrite and amorphous materials. A large percentage of ferrospheres are commonly 5～50 μm in size. The microstructure of ferrospheres includes smooth, polygonal, dendritic, granular and molten drop characteristics. SEM coupled with EDX provided fast and accurate results of the microstructure and chemical composition of ferrospheres, and helped us to assess environmental issues related to the disposal and utilization of fly ashes.

关键词： Fly ash Ferrosphere Microstructure Scanning electron microscopy (SEM)

Influence of Cl substitution on the electronic structure and catalytic activity of ceria

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Science China Chemistry 2015年第4期58卷 601-606页

作者： Li-Li Yin xue-qing Gong Key Laboratory for Advanced Materials Centre for Computational Chemistry and Research Institute of Industrial Catalysis East China University of Science and Technology

Cl-containing cerium dioxide(Ce O2) catalysts have been found to exhibit unique catalytic activities. In the present work, using density functional theory calculations with the inclusion of on-site Coulomb correction, we systematically studied the effect of Cl on the physicochemical properties of Ce O2 surfaces by substituting one subsurface O with Cl. The calculated results show that substituting an O atom with a Cl atom results in structural distortion and the reduction of one surface Ce4+ cation to Ce3+. The protruding Ce3+ cation greatly improves the adsorption energy of O2 to produce an active O2- species, and maintains the catalytic oxidation cycle of CO on Ce O2(110). These results may help us obtain a better understanding of Cl-ceria interacting systems and provide some guidance for the design of effective Ce O2-based catalysts.

关键词： cerium dioxide Cl substitution DFT+U O2 adsorption CO oxidation