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酸再生(ARP)集中处理:氧化铁生产节能减排的有效途径

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磁性材料及器件 2009年第1期40卷 64-67页

作者：李霸宇邯钢附企公司开发部河北邯郸056001

简要介绍了邯钢现在酸再生存在的问题,并就存在的问题提出了酸再生集中处理及相关的运输、废酸再生酸存储等的解决方案,通过方案实施前后生产成本的对比验证了酸再生集中处理是邯钢氧化铁生产节能减排的有效途径。

关键词：酸再生氧化铁集中处理成本

Modeling and optimizing of steel and mushy Al-28Pb alloy bonding

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中国有色金属学会会刊：英文版 2001年第2期11卷 239-243页

作者：张鹏杜云慧曾大本任学平崔建忠巴立民 Department of Mechanical Engineering Tsinghua University Department of Metal Forming University of Science and Technology Beijing Department of Metal Forming Northeastern University Ansha Automobile Fittings Factory

The bonding of steel and mushy Al 28Pb alloy was studied. The relationship model about preheat temperature of steel plate, solid fraction of mushy Al 28Pb alloy, rolling speed and interfacial shear strength of the bonding plate was established by artificial neural network perfectly. This model can be optimized by a genetic algorithm, and the optimum bonding parameters for the largest interfacial shear strength are: 546 ℃ for preheat temperature of steel plate, 43.5% for solid fraction of mushy Al 28Pb alloy and 8.6 mm/s for rolling speed, and the corresponding largest interfacial shear strength of bonding plate is 70.3 MPa. [

关键词： bonding of steel and mushy Al 28Pb alloy artificial neural network genetic algorithm

EBSD技术在厚规格管线钢DWTT研究中的应用

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金属热处理 2016年第4期41卷 197-200页

作者：贾书君刘清友李拔钢铁研究总院工程用钢研究所北京100081

利用电子背散射衍射（EBSD）技术和金相分析软件,结合DWTT性能测试,对3种厚规格X70管线钢板的微观组织、取向成像特点、有效晶粒尺寸和DWTT性能进行了分析。结果表明,3种管线钢的取向差分布均在2°~15°和47°~60°两区间,呈现＂双峰＂... 详细信息

利用电子背散射衍射（EBSD）技术和金相分析软件,结合DWTT性能测试,对3种厚规格X70管线钢板的微观组织、取向成像特点、有效晶粒尺寸和DWTT性能进行了分析。结果表明,3种管线钢的取向差分布均在2°~15°和47°~60°两区间,呈现＂双峰＂分布特点。铁素体基体与母相奥氏体间存在一定的取向关系是管线钢中晶界取向差＂双峰＂分布的主要原因。在针状铁素体或贝氏体为基体的显微组织中,引入适量细化的多边形铁素体可以降低其平均有效晶粒尺寸,但多边形铁素体体积分数过多、晶粒尺寸过大时,反而会使有效晶粒尺寸增大。有效晶粒细化是提高试验钢DWTT断裂韧性的主要原因。

关键词：电子背散射衍射大角度晶界晶粒取向有效晶粒尺寸落锤撕裂试验(DWTT)

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考虑批量装配的柔性作业车间调度问题研究

中国机械工程 2015年第23期26卷 3200-3207页

作者：巴黎李言曹源杨明顺刘永西安理工大学西安710048

柔性作业车间调度是生产调度领域中的一个重要组合优化问题,由于取消了工序与加工设备的唯一性对应关系,因而相较于作业车间调度问题,具有更高的复杂度。针对该问题在批量装配方面的不足,考虑将批量因素与装配环节同时集成到柔性作业车... 详细信息

柔性作业车间调度是生产调度领域中的一个重要组合优化问题,由于取消了工序与加工设备的唯一性对应关系,因而相较于作业车间调度问题,具有更高的复杂度。针对该问题在批量装配方面的不足,考虑将批量因素与装配环节同时集成到柔性作业车间调度问题当中。以成品件的完工时间为优化目标,对该批量装配柔性作业车间调度问题进行了数学建模。针对该模型,提出一种多层编码结构的粒子群算法,并对该算法的各个模块进行了设计。最后,以实例验证了该数学模型的正确性及算法的有效性。

关键词：柔性作业车间调度问题批量装配 6 层编码结构 flexible job-shop scheduling problem (FJSP)

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考虑多目标的工艺规划与调度集成问题研究

中国机械工程 2015年第17期26卷 2344-2351,2373页

作者：李言巴黎曹源刘永杨明顺西安理工大学西安710048

针对工艺规划与调度集成问题在多目标优化方面的不足,考虑将多目标优化集成到工艺规划与调度集成问题中。以最长完工时间、加工成本及设备最大负载为优化目标,对该多目标工艺规划与调度集成问题进行建模,并提出了一种非支配排序遗传算法... 详细信息

针对工艺规划与调度集成问题在多目标优化方面的不足,考虑将多目标优化集成到工艺规划与调度集成问题中。以最长完工时间、加工成本及设备最大负载为优化目标,对该多目标工艺规划与调度集成问题进行建模,并提出了一种非支配排序遗传算法,鉴于加工信息的多样性,使用多层结构表示可行解,对该算法的选择及遗传操作等步骤进行了设计。最后,以实例验证了上述模型的正确性及算法的有效性。

关键词：工艺规划与调度集成多目标非支配排序遗传算法选择操作

Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World Journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu li-Bo Zhang Yi-Yi Luo ling Wang Ye-Pin Zhang Pei-Qi Chen Xue-Ying ba Jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

baCKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,EliSA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

维普期刊数据库评论

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厚壁X70管线钢的组织和性能

材料热处理学报 2016年第4期37卷 129-134页

作者：贾书君刘清友李拔钢铁研究总院工程用钢研究所北京100081

借助TEM、SEM、EBSD等显微组织分析手段及力学性能测试,研究了深海用超厚规格X70管线钢板的显微组织与力学性能的关系。实验结果表明:为满足深海用厚壁X70管线钢对纵向变形能力及DWTT(落锤撕裂实验)断裂韧性的严格要求,组织设计可采用... 详细信息

借助TEM、SEM、EBSD等显微组织分析手段及力学性能测试,研究了深海用超厚规格X70管线钢板的显微组织与力学性能的关系。实验结果表明:为满足深海用厚壁X70管线钢对纵向变形能力及DWTT(落锤撕裂实验)断裂韧性的严格要求,组织设计可采用针状铁素体+多边形铁素体的双相组织方法。针状铁素体为硬相、多边形铁素体为软相的双相组织中,屈强比随多边形铁素体数量的增加而降低,增大铁素体晶粒尺寸也能降低材料屈强比;在针状铁素体为基体的显微组织中,引入适量的细化多边形铁素体还可降低其有效晶粒尺寸,提高材料DWTT性能,但多边形铁素体体积分数过多、晶粒尺寸过大时,平均有效晶粒尺寸增加,DWTT性能反而降低。

关键词：深海厚壁管线钢屈强比 DWTT性能大小角度晶界有效晶粒尺寸 M/A岛

Diagnostic Performance and Interobserver Consistency of the Prostate Imaging Reporting and Data System Version 2： A Study on Six Prostate Radiologists with Different Experiences from Half a Year to 17 Years

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Chinese Medical Journal 2018年第14期131卷 1666-1673页

作者： Zan Ke liang Wang Xiang-De Min Zhao-Yan Feng Zhen Kang Pei-Pei Zhang ba-Sen li Hui-Juan You Sheng-Chao Hou Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of library Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

background： One of the main aims of the updated Prostate Imaging Reporting and Data System Version 2 （PI-RADS v2） is to diminish variation in the interpretation and reporting of prostate imaging, especially among readers with varied experience levels. This study aimed to retrospectively analyze diagnostic consistency and accuracy for prostate disease among six radiologists with different experience levels from a single center and to evaluate the diagnostic pcrformance of PI-RADS v2 scores in the detection of clinically significant prostate cancer （PCa）. Methods： From December 2014 to March 2016, 84 PCa patients and 99 benign prostatic shyperplasia patients who underwent 3.0T multiparametric magnetic resonance imaging before biopsy were included in our study. All patients received evaluation according to the PI-RADS v2 scale （1 5 scores） from six blinded readers （with 6 months and 2, 3, 4, 5, or 17 years of experience, respectively, the last reader was a reviewer/contributor for the PI-RADS v2）. The correlation among the readers＇ scores and the Gleason score （GS） was determined with the Kendall test. lntra-/inter-observer agreement was evaluated using K statistics, while receiver operating characteristic curve and area under the curve analyses were performed to evaluate the diagnostic performance of the scores. Results： based on the PI-RADS v2, the median k score and standard error among all possible pairs of readers were 0.506 and 0.043, respectively： the average correlation between the six readers＇ scores and the GS was positive, exhibiting weak-to-moderate strength （r = 0.391, P = 0.006）. The AUC values of the six radiologists were 0.883, 0.924, 0.927, 0.932, 0.929, and 0.947, respectively. Conclusion： The inter-reader agreement for the PI-RADS v2 among the six readers with different experience is weak to moderate. Different experience levels affect the interpretation of MRI images.

关键词： Benign Prostatic Hyperplasia Diagnosis Magnetic Resonance Imaging Prostate Cancer Prostate Imaging Reporting andData System Version 2

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考虑柔性分批的IPPS问题研究

机械科学与技术 2017年第3期36卷 426-435页

作者：巴黎李言杨明顺刘永西安理工大学机械与精密仪器工程学院西安710048

工艺规划与调度是制造系统的两个重要组成环节,二者的集成是制造系统发展的关键技术之一。针对工艺规划与调度集成问题在批量方面考虑的不足,考虑将批量划分问题集成到工艺规划与调度集成问题中。为避免等批分批可能导致调度过程中生产... 详细信息

工艺规划与调度是制造系统的两个重要组成环节,二者的集成是制造系统发展的关键技术之一。针对工艺规划与调度集成问题在批量方面考虑的不足,考虑将批量划分问题集成到工艺规划与调度集成问题中。为避免等批分批可能导致调度过程中生产能力与负载不均衡,采用柔性分批策略。同时考虑准备时间和加工时间,以最大完工时间最小为目标,对该问题进行建模。针对该问题,提出一种粒子群算法进行求解。最后,以实例验证了该数学模型的正确性及算法的有效性。

关键词：工艺规划与调度集成问题批量柔性分批准备时间