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Development and validation of a prognostic immunoinflammatory index for patients with gastric cancer

World Journal of Gastroenterology 2024年第24期30卷 3059-3075页

作者： Zhi-Chang ba Xi-Qing Zhu Zhi-Guo li Yuan-Zhou li Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

baCKGROUND Studies have demonstrated the influence of immunity and inflammation on the development of *** single biomarkers of immunity and inflam-mation have been shown to be clinically predictive,the use of biomarkers integrating both to predict prognosis in patients with gastric cancer remains to be *** To investigate the prognostic and clinical significance of inflammatory biomarkers and lymphocytes in patients undergoing surgical treatment for gastric *** Univariate COX regression analysis was performed to identify potential prognostic factors for patients with gastric cancer undergoing surgical *** absolute shrinkage and selection operator-COX(LASSO-COX)regression analysis was performed to integrate these factors and formulate a new prognostic immunoinflammatory index(PII).The correlation between PII and clinical charac-teristics was statistically *** incorporating the PII score were devised and validated based on the time-dependent area under the curve and decision curve *** Patients exhibiting elevated neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and systemic immune inflammatory index displayed inferior progression-free survival(PFS)and overall survival(OS).Conversely,low levels of CD3(+),CD3(+)CD8(+),CD4(+)CD8(+),and CD3(+)CD16(+)CD56(+)T lymphocytes were associated with improved PFS and OS,while high CD19(+)T lymphocyte levels were linked to worse PFS and *** PII score demonstrated associations with tumor characteristics(primary tumor site and tumor size),establishing itself as an independent prognostic factor for both PFS and ***-dependent area under the curve and decision curve analysis affirmed the effectiveness of the PII-based nomogram as a robust prognostic predictive *** PII may be a reliable predictor of prognosis in patients with gastric cancer undergoing surgical treatment,and it offers insights into cancer-related immune-inflammatory re

关键词： Gastric cancer Immunity Inflammation Prognosis Nomogram

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飞龙掌血茎和根不同炮制品对小鼠的急性毒性试验

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湖北农业科学 2024年第1期63卷 90-95页

作者：陈龙陈小燕张淼罗静邓玲玉朱华许立拔广西中医药大学广西壮瑶药重点实验室南宁530200

旨在了解飞龙掌血[Toddalia asiatica(linn)Lam.]茎和根不同炮制对小鼠急性毒性作用。130只KM小鼠适应性喂养3 d后,随机分为13组,包括溶媒组和12个药物试验剂量组(1个药材茎生品组和5个茎炮制组,1个根生品组和5个根炮制组,其中5种药材... 详细信息

旨在了解飞龙掌血[Toddalia asiatica(linn)Lam.]茎和根不同炮制对小鼠急性毒性作用。130只KM小鼠适应性喂养3 d后,随机分为13组,包括溶媒组和12个药物试验剂量组(1个药材茎生品组和5个茎炮制组,1个根生品组和5个根炮制组,其中5种药材炮制品包括水煮制品、水洗制品、水蒸制品、酒蒸制品和酒炙制品)。溶媒组小鼠按40 mL/kg给予纯净水灌胃,给药3次,间隔4~5 h;茎各炮制品试验组小鼠按40 mL/kg灌胃,给药3次,间隔4~5 h;根各炮制品试验组小鼠按30 mL/kg灌胃,给药2次,间隔4~5 h,记录给药后各组小鼠14 d的主要临床症状、体重变化,并统计死亡率。结果表明,飞龙掌血及各炮制品可对小鼠产生急性毒性作用,临床中毒症状有自主活动减少、安静怠动、俯卧和翻正反射消失。炮制品组与溶媒组比较,在14 d内茎和根各炮制品均可致小鼠体重明显降低,且死亡率显著高于溶媒组(P<0.05或P<0.01);而与生品组比较,茎和根的5种炮制品在14 d内对小鼠体重的影响不显著,可有效降低小鼠的死亡率,其中以水煮法效果最佳。水煮、水洗、水蒸、酒蒸、酒炙炮制方法可以减小飞龙掌血茎和根(生品)对小鼠的毒性作用,但对小鼠体脂影响不显著。

关键词：飞龙掌血[Toddalia asiatica(linn)Lam.] 根和茎炮制品小鼠急性毒性中药炮制减毒

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Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/photothermal therapy

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Nano Research 2020年第5期13卷 1389-1398页

作者： li Zhang Zhe Yang Jinghua Ren li ba Wenshan He Chun-Yuen Wong Department of Chemistry City University of Hong KongHong KongChina Department of Breast and Thyroid Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongHong KongChina Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The combination of photodynamic therapy(PDT)and photothermal therapy(PTT)has attracted much interest in recent years,but non-specific distribution of photosensitizers and intrinsic tumor hypoxic microenvironment have continued to limit its therapeutic *** herein report a nano-theranostic system,denoted as Ce6-CuS/MSN@PDA@MnO2-FA NPs,which combines PDT,PTT,magnetic resonance(MR)imaging with hypoxia-relieving and tumor-targeting *** to this design is the use of mussel-inspired polydopamine(PDA)coating to encapsulate the chlorin e6(Ce6)and copper sulfide nanoparticles(CuS NPs)loaded mesoporous silica nanoparticle(MSN)*** PDA coating not only acts as pH sensitive gatekeeper to prevent the premature release of Ce6 under non-acidic tumor microenvironment(TME),but also facilitates post-functionalization so that hypoxia-relieving MnO2 nano-sheets and tumor-targeting ligand folic acid-PEG-thiol(FA-PEG-SH)can be decorated on the outer part of the drug *** vitro and in vivo measurements clearly demonstrated that all these functionalities worked synergistically as *** system,having a low dark cytotoxicity,can be effectively internalized by 4T1 cells and decrease the cell viability to 2%upon 660 nm/808 nm laser *** in 4T1 tumor-bearing mice can almost be completely destroyed in 2 weeks via combined PDT/*** with the TME-sensitive MR imaging performance demonstrated,Ce6-CuS/MSN@PDA@MnO2-FA NPs represent a multifunctional prototype which holds great potential to be developed into clinical theranostics.

关键词： hypoxia relief MnO2 nano-sheet photodynamic therapy photothermal therapy magnetic resonance imaging

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Optimization of antioxidant activity by response surface methodology in hydrolysates of jellyfish(Rhopilema esculentum) umbrella collagen

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 572-579页

作者： Yong-liang ZHUANG Xue ZHAO ba-fang li College of Food Science and Engineering Ocean University of China Qingdao 266003 China

To optimize the hydrolysis conditions to prepare hydrolysates of jellyfish umbrella collagen with the highest hydroxyl radical scavenging activity,collagen extracted from jellyfish umbrella was hydrolyzed with trypsin,and response surface methodology(RSM) was *** optimum conditions obtained from experiments were pH 7.75,temperature(T) 48.77 °C,and enzyme-to-substrate ratio([E]/[S]) 3.50%.The analysis of variance in RSM showed that pH and [E]/[S] were important factors that significantly affected the process(Pliquid chromatography(HPLC),and three fractions(HF-1>3000 Da,1000 Dality and the best tyrosi-nase-inhibitory activity.

关键词：水解胶原蛋白抗氧化活性海蜇优化自由基清除活性表面反应最佳工艺条件

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Fluid identification and tight oil layer classification for the southwestern Mahu Sag,Junggar basin using NMR logging-based spectrum decomposition

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Energy Geoscience 2024年第2期5卷 62-69页

作者： Wenbiao Huang Yibing Guo Jun Qin Zhongchen ba Zongbin Zhang Luning bai Heng li School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China PetroChina Xinjiang Oilfield Company KaramayXinjiang834000China

The intricate distribution of oil and water in tight rocks makes pinpointing oil layers *** conventional identification methods offer potential solutions,their limited accuracy precludes them from being effective in their applications to unconventional *** study employed nuclear magnetic resonance(NMR)spectrum decomposition to dissect the NMR T_(2)spectrum into multiple ***,it employed laboratory NMR experiments to ascertain the fluid properties of these sub-spectra,aiming to enhance identification *** findings indicate that fluids of distinct properties overlap in the T_(2)spectra,with bound water,movable water,bound oil,and movable oil appearing sequentially from the low-value zone to the high-value ***,an oil layer classification scheme was proposed,which considers the physical properties of reservoirs,oil-bearing capacity,and the characteristics of both mobility and the oil-water two-phase *** applied to tight oil layer identification,the scheme's outcomes align closely with actual test results.A horizontal well,deployed based on these findings,has produced high-yield industrial oil flow,underscoring the precision and dependability of this new approach.

关键词： Nuclear magnetic resonance Fluid identification Oil layer identification NMR T_(2)spectrum decomposition Normal distribution simulation

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Carbon dots-derived three-dimensional-ordered macroporous host with high penetrability and catalytic activity for LSBs under lean electrolyte

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Rare Metals 2024年第6期43卷 2560-2573页

作者： Jiao-Zi Duan Hua-Yu Pei Quan Yang Xue li Xin ba Xue Yong Jun-ling Guo Si-Yu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Country State Center for International Cooperation On Designer Low-Carbon&Environmental Materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Hubei Institute of Quality Supervision Inspection Wuhan 430061China Department of Chemistry University of SheffieldSheffeld S37HFUK

The practical energy density of lithium-sulfur batteries(LSBs)is seriously limited by the high electrolyte-to-sulfur ratios(E/S).The E/S can be reduced by employing hosts with easy-to-infiltrate structure that ensures the uniform distribution of a lean electrolyte and high catalytic activity that can suppress"shuttle effect"via accelerating the slow conversion of soluble poly sulfides to insoluble *** the easy-to-infiltrate structures,the three-dimensional-ordered macroporous(3DOM)structure is easier to scale preparation and more suitable for the existing industrial ***,it is difficult to obtain the 3DOM with(1)high penetrability due to the high viscosity of frequently-used organic polymer precursors and(2)high catalytic activity due to the low confinement effect,meaning that uniformly dispersed small-sized catalytic materials are difficult to load on ***,using carbon dots(CDs)with both organic and inorganic properties as a precursor and aggregation limiting agent,a 3DOM host with high penetrability and homodispersed Ni particles of small sizes(Ni-CDs-3DOM)was *** this host:(1)CDs precursor with suitable viscosity can improve the penetrability.(2)CDs can effectively inhibit the agglomeration of Ni particles.(3)Uniformly dispersed small-size Ni particles offer high-efficiency catalytic activity toward sulfur ***,the Ni-CDs-3DOM/sulfur cathode exhibits high sulfur utilization and stable cycling performance even under high sulfur loading(5.5 mg·cm^(-2))and low E/S(6.5μl·mg^(-1)).This work indicates the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： lithium-sulfur batteries Carbon dots Catalytic action Easy-to-infiltrate structure Lean electrolyte

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Effect of glass removal on the GMI effect of Co_(71.8)Fe_(4.9)Nb_(0.8)Si_(7.5)B_(15) amorphous glass-covered wires

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Rare Metals 2006年第Z1期25卷 633-636页

作者： CHEN Zheng ba Shan li Deren LU Zhichao ZHOU Shaoxiong Central Iron & Steel Research Institute Nanomaterials Engineering and Research Center Beijing 100081 China Research and Development Center Advanced Technology & Materials Co. Ltd. Beijing 100081 China Beijing Institute of Technology School of Science Beijing 100081 China Central Iron & Steel Research Institute Nanomaterials Engineering and Research Center Beijing 100081 China Research and Development Center Advanced Technology & Materials Co. Ltd. Beijing 100081 China Central Iron & Steel Research Institute Nanomaterials Engineering and Research Center Beijing 100081 China Research and Development Center Advanced Technology & Materials Co. Ltd. Beijing 100081 China

During the past several years, giant magneto-impedance effect (GMI) in amorphous wires has generated growing interest in the science community because of their applications in sensors. The giant magneto-impedance effect in Co71.8Fe4.9Nb0.8Si7.5B15 amorphous glass-covered wires (AGCW) consists of strong changes in the high frequency impedance with a small DC magnetic field. When f=1 MHz, there is no GMI effect due to the fact that the magnetic penetration depth is higher than their radius. As the frequency increases, the GMI effect becomes important in both the glass-covered wire and the wire after glass removal. Field dependence of the impedance has a similar behaviour to the AGCW ones, when a tensile stress is applied to the wire without glass cover.

关键词： giant magneto-impedance amorphous wires frequency

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Rational Use of Computed Tomography for Individual Health Assessment in Asymptomatic Population： Chinese Experience

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Chinese Medical Journal 2016年第3期129卷 348-356页

作者： liang Wang ba-Sen li Wen-Zhen Zhu Qiong li Xiao-Yuan Feng Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Radiology Integrated Supervision Bureau of Health and Family Planning Commission of Hubei Province Wuhan Hubei 430079 China Department of Radiology Huashan Hospital Fudan University Shanghai 200040 China

INTRODUCTIONSince computed tomography （CT） was invented and used clinically or in research, it is currently widely used in the diagnosis, staging, assessment of disease response to treatment, with clearer image quality and shorter scanning time. There are many diseases which are not easily found at an early stage with noticeable symptoms,

关键词： Asymptomatic Population Computed Tomography Individual Health Assessment

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Relationship between microstructure and corrosion behavior of high-grade pipeline steel in a low-temperature environment

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Journal of Iron and Steel Research(International) 2021年第8期28卷 1037-1046页

作者： Jia-qiang Jing Jie Guo ba li Shu-jun Jia Yi Ren School of Oil and Gas Engineering Southwest Petroleum UniversityChengdu 610500SichuanChina Department of Structural Steels Central Iron and Steel Research InstituteBeijing 100081China State Key Laboratory of Metal Material for Marine Equipment and Application of Iron and Steel Research Institutes of Ansteel Group Corporation Anshan 114009LiaoningChina

The relationship between micro structure and corrosion behavior of high-grade pipeline steel under low-temperature conditions was comparatively investigated by the potentiodynamic polarization and electrochemical impedance spec-troscopy test combining with optical micrographs,scanning electron microscopy,transmission electron microscopy and electron back-scattered *** results showed that,compared with room and high temperature,low temperature could influence the corrosion behavior of high-grade pipeline steel,which means that the corrosion potential and current density decreased and the corrosion resistance increased ***,double layer structures of the interface became thicker and more *** low-temperature environment,acicular ferrite had the martensite/austenite constituents with less amount and smaller size,a higher density of low angle grain boundaries and smaller effective grain sizes compared with granular bainite,which demonstrated higher corrosion resistance.

关键词： Low temperature High-grade pipeline steel Corrosion behavior Resistance Acicular ferrite Granular bainite Martensite/austenite constituent

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Effect of Pre-deformation on Grain Ultrafining by Intercritical Deformation in Low-Carbon Microalloyed Steels

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Acta Metallurgica Sinica(English Letters) 2018年第10期31卷 1038-1048页

作者： ba li Qing-You liu Shu-Jun Jia Yi Ren Bing Wang Central Iron and Steel Research Institute Beijing 100081China Iron and Steel Research Institute Ansteel Group Co. Ltd.Anshan 114009 China

In this study, the effect of pre-deformation at recrystallization and non-recrystallization zone on the grain ultrafining by the subsequent intercritical deformation （ID） was investigated on low-carbon microalloyed steel. The results showed that ultrafine grain microstructure with an average size of - 1.0 μm was fabricated through pre-deformation in the recrys- tallization zone followed by ID. When pre-deformed at the non-recrystallization zone prior to ID, the grain size increased to 1.6 μm with a heterogeneous distribution along with the well-developed dynamic recovery of ferrite. The grain ultrafining mechanism was attributed to the combined action of the deformation-induced ferrite transformation and the continuous dynamic recrystallization. In particular, the continuous dynamic recrystallization process during ID occurred on the pro-eutectoid ferrite as a result of the subgrain rotation mechanism and the absorbing dislocations mechanism.

关键词： Low-carbon microalloyed steels Intercritical deformation Ultrafine grain Continuous dynamic recrystallization Deformation-induced ferrite transformation

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