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Risk factors and mortality rates of carbapenem-resistant Gram-negative bacterial infections in intensive care units

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Journal of Intensive Medicine 2024年第3期4卷 347-354页

作者： Tulay orhan Kuloglu Gamze Kalin Unuvar Fatma Cevahir Aysegul Ulu Kilic Emine Alp Infection Control Committee Faculty of MedicineErciyes UniversityKayseriTurkey Department of Infectious Diseases Faculty of MedicineErciyes UniversityKayseriTurkey Programme of First and Emergency Aid Sakarya UniversitySakaryaTurkey Department of Infectious Diseases Faculty of MedicineYıldırım Beyazıt UniversityAnkaraTurkey

Background The prevalence of hospital-acquired infections caused by carbapenem-resistant gram-negative bacteria(CRGNB)is increasing *** risk factors have been associated with such *** present study aimed to identify risk factors and determine the mortality rates associated with CRGNB infections in intensive care *** This retrospective case-control study was conducted at Erciyes University Hospital(Kayseri,Turkey)between January 2017 and December *** and laboratory data were obtained from the Infection Control Committee data and record *** who had CRGNB infection 48–72 h after hospitalization were assigned to the case group,while those who were not infected with CRGNB during hospitalization formed the control *** factors,comorbidity,demographic data,and mortality rates were compared between the two *** Approximately 1449 patients(8.97%)were monitored during the active follow-up period;of those,1171 patients were included in this *** infection developed in 14 patients(70.00%)who had CRGNB colonization at admission;in 162(78.26%)were colonized during hospitalization,whereas 515(54.56%)were not *** was no significant difference in age,sex(male/female)or *** total length of hospital stay was statistically significantly longer(P=0.001)in the case group(median:24[interquartile range:3–378]days)than the control group(median:16[interquartile range:3–135]days).The rates of colonization at admission(25.5%;vs.10.6%,P=0.001)and mortality(64.4%vs.45.8%,P=0.001)were also significantly higher in the cases than in the control group,*** the univariate analysis,prolonged hospitalization,the time from intensive care unit admission to the development of infection,presence of CRGNB colonization at admission,transfer from other hospitals,previous antibiotic use,enteral nutrition,transfusion,hemodialysis,mechanical ventilation,tracheostomy,reintubation,central veno

关键词： Multidrug resistance Gram-negative bacteria Infection Intensive care units

Morphological and Physico-Chemical Characteristics and Classification of Vertisol Developed on Deltaic Plain

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Open Journal of Soil Science 2012年第1期2卷 20-27页

作者： orhan Dengiz Mustafa Saglam F. Esra Sarioglu Fikret Saygin Cagla Atasoy Department of Soil Science and Plant Nutrition Faculty of AgricultureOndokuz Mayis UniversitySamsunTurkey

The name of Vertisol is derived from Latin “vertere” meaning to invert. This case restricts development of soil horizons in profile. These soils have the capacity to swell and shrink, inducing cracks in the upper parts of the soil and distinctive soil structure throughout the soil. The formation of these specific features are caused by a heavy texture, a dominance of swelling clay in the fine fraction and marked changes in moisture content. The swell-shrink behavior is attributed to the wetting and drying of the soil mass. In this study, morphology, physico-chemical characteristics and classification of vertisols that were formed on alluvial delta plains, were investigated. Those soils formed on the Bafra Plain found in the K?z?l?rmak Delta and located in the central Black Sea region of Turkey. All studied Vertisols are characterised by a dark colour in surface soil, a heavy clayey texture, hardpan formation under top soil (high bulk density a high compaction) and very high COLE values. In addition, they have deep wide-opened desiccation cracks at the surface, slickensides at the middle part of the profiles and a poor differentiation of their horizons. Physico-chemically, the studied soils are slightly basic to very basic, non-saline and poor in organic matter, which is slightly higher in the surface horizon. In addition, cation exchange capacity, sum of exchangeable bases and base saturation of soils are very high. On the basis of morphological and physicochemical analysis, soil profiles were classified as Sodic Haplustert, Typic Calciaquert, Sodic Calciustert according to Soil Taxonomy (Soil Survey Staff, 1975 and 1999) and as Sodic Vertisol and Calcic Vertisol according to FAO/ISRIC (2006) classification systems.

关键词： Vertisol Soil Morphology Soil Classification Bafra Delta Plain

Erythrocyte Membrane Protein Band 3 Predicts Interferon Ribavirin-Induced Anemia

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Open Journal of Regenerative Medicine 2019年第2期8卷 5-16页

作者： Engin Altintas Serap Yalin orhan Sezgin Enver Ucbilek Anil Tombak Arzu Kanik Department of Gastroenterology Faculty of Medicine University of Mersin Mersin Turkey Faculty of Pharmacy University of Mersin Mersin Turkey Department of Biostatistics Faculty of Medicine University of Mersin Mersin Turkey

Aim & Background: It was proposed that the differences in erythrocyte membrane protein contents—especially band 4—take a role in the serious anemia related to interferon plus ribavirin (I/R). The aim of this study is to evaluate whether the erythrocyte membrane protein contents predict anemia related to I/R or not. Methods: 180 mcg interferon α 2a once a week and weight adjusted ribavirin daily were given for 48 weeks to fifty patients with chronic hepatitis C. It was diagnosed as anemia when haemoglobin concentration was Results: Anemia developed in 17 patients (34%). The levels of erythrocyte membrane proteins were as;spectrin: 20.468 ± 2.5902, ankyrin: 4.576 ± 1.2706, B3: 19.240 ± 2.8358, B4.1: 5.628 ± 1.8832, and B4.2: 5.848 ± 1.8030. When the relation between the development of anemia and erythrocyte membrane proteins was investigated, a relation was only found at B3 which was not statistically significant (p = 0.058). When ROC analysis was performed, 95% CI p = 0.035 for B3 (0.517 - 0.792) was found. In patients whose B3 level was below 17.7%, the sensitivity of anemia development risk was calculated as 64.7% and the specificity thereof was calculated as 66.7%. Erythrocyte membrane protein contents by gender were only different at B3 (p = 0.042). Anemia developed in 17 patients (34%). 14 of these patients were of female and 3 were of male gender;the gender played a significant role in terms of anemia (p = 0.003). Conclusions: Erythrocyte membrane protein B3 is not only useful in predicting the patient under the risk of developing anemia, but also it may be useful in preventing it and it may explain why women inclined to anemia.

关键词： Anemia Erythrocyte Membrane Protein Interferon Ribavirin

Production of porous Ni-Ti alloy and test of its biocompatibility under in-vivo conditions

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Journal of Biomedical Science and Engineering 2010年第12期3卷 1161-1168页

作者： Ali Kaya Gur Nuri orhan Emine Unsaldi Ali Said Durmus Neriman Colakoglu Department of Metallurgy Education Technical Education FacultyFirat UniversityElazigTurkey Department of Surgery Faculty of VeterinaryFirat UniversityElazigTurkey Histology and Embryology Department Medical FacultyFirat UniversityElazigTurkey

Biomaterials have been out of commonly used materials in biomedical applications in recent years. Today among the mostly-used biocompatible metals are especially Ni-Ti alloys. For conducting this study, having extensive usage area in biomedical applications, Ni and Ti materials were utilized for an alloy production. Following being mixed using a suitable mixer at 49Ni/51Ti %wt., the alloy was exposed to cold pressure of 200 MPa and sintered in a mold. In addition, the material gained porosity appearance thanks to usage of the synthesized (SHS) method and then the final shape of the specimen was taken using the method of wire electro erosion discharge machining (WEDM). Afterwards, the specimen was subjected to the biocompatibility test in in-vivo environment by means of on a 3-year-old female dog.

关键词： Biomaterials NiTi Igntion Implant In-Vivo

Diagnosis of long QT syndrome via support vector machines classification

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Journal of Biomedical Science and Engineering 2011年第4期4卷 264-271页

作者： Halil Bisgin orhan U. Kilinc Ahmet Ugur Xiaowei Xu Volkan Tuzcu 不详

Congenital Long QT Syndrome (LQTS) is a genetic disease and associated with significant arrhythmias and sudden cardiac death. We introduce a noninva-sive procedure in which Discrete Wavelet Trans-form (DWT) is used to extract features from elec-trocardiogram (ECG) time-series data first, then the extracted features data is classified as either abnormal or unaffected using Support Vector Machines (SVM). A total of 26 genetically identified patients with LQTS and 19 healthy controls were studied. Due to the limited number of samples, model selection was done by training 44 instances and testing it on remaining one in each run. The proposed method shows reasonably high average accuracy in LQTS diagnosis when combined with best parameter selection process in the classifica-tion stage. An accuracy of 80%is achieved when Sigmoid kernel is used in v-SVM with parameters v = 0.58 and r = 0.5. The corresponding SVM model showed a classification rate of 21/26 for LQTS pa-tients and 15/19 for controls. Since the diagnosis of LQTS can be challenging, the proposed method is promising and can be a potential tool in the correct diagnosis. The method may be improved further if larger data sets can be obtained and used.

关键词： Long QT Syndrome Discrete Wavelet Transform Support Vector Machine Classification

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伊斯坦布尔：一座“呼愁”弥漫的城市

英语学习 2015年第10期 68-72页

作者： orhan Pamuk

土耳其著名作家奥尔罕·帕慕克（orhan Pamuk，1952-）被认为是当代欧洲最核心的三位文学家之一和最杰出的小说家之一，2006年因《伊斯坦布尔：一座城市的记忆》一书获得诺贝尔文学奖。其作品被译成五十多种语言出版，在众多国家和地区... 详细信息

土耳其著名作家奥尔罕·帕慕克（orhan Pamuk，1952-）被认为是当代欧洲最核心的三位文学家之一和最杰出的小说家之一，2006年因《伊斯坦布尔：一座城市的记忆》一书获得诺贝尔文学奖。其作品被译成五十多种语言出版，在众多国家和地区畅销。

关键词：伊斯坦布尔城市诺贝尔文学奖著名作家帕慕克土耳其小说家文学家

Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers

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World Journal of Gastroenterology 2011年第13期17卷 1701-1709页

作者： Sadettin Hulagu Omer Senturk Cem Aygun orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci Division of Gastroenterology Kocaeli University Medical School Kocaeli 41000 Turkey Division of Gastroenterology American HospitalIstanbul 34365 Turkey Department of Pathology Kocaeli UniversityMedical School Kocaeli 41000 Turkey Division of Gastroenterology Marmara University School of Medicine Altunizade Istanbul 34662 Turkey

AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence.

关键词： Endoscopic submucosal dissection Premalignant gastrointestinal lesion Noninvasive early gastrointestinal cancer Neuroendocrine tumor Gastrointestinal stromal tumor

Plasma catalase,glutathione-s-transferase and total antioxidant activity levels of children with attention deficit and hyperactivity disorder

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Advances in Bioscience and Biotechnology 2013年第2期4卷 183-187页

作者： V.Kenan Celik Erdal Ersan Serpil Ersan Sevtap Bakir orhan Dogan Departments of Biochemistry School of MedicineCumhuriyet UniversitySivasTurkey Numune Hospital SivasTurkey Department of Chemistry Engineering School of MedicineCumhuriyet UniversitySivasTurkey Departments of Clinical Psychiatry School of MedicineCumhuriyet UniversitySivasTurkey

Objective: In this study, we plan to measure plasma Catalase (CAT), Antioxidant Activity (AOA) and Glu- tathione-S-Transferase (GST) levels to understand whether oxidative stress develops or not and whether or not the detoxification mechanism properly functions in children with Attention Deficit and Hyperactivity Disorder (ADHD) with unknown etiology and pathogenesis. Method and Results: Plasma CAT, AOA, and GST activities were spectrophotometrically measured in forty patients (average age 10.27 ± 2.54) and thirty-five (average age, 9.97 ± 2.59) healthy individuals as the control group. While the CAT activity showed no difference in the patient group (P > 0.05) compared to the control group, AOA and GST levels were found significantly meaningful (P = 0.001). Conclusion: In this pilot study ,the study shows that no oxidative stress develops in individuals with ADHD in high AOA and stable CAT activity, and that the de- toxification mechanism functions extremely in high GST activity. These findings need to be supported by other studies.

关键词： ADHD Catalase Antioxidant Activity Oxidative Stress Glutathione-S-Transferase

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英语学习 2017年第12期 64-67页

作者： orhan Pamuk 蒋素华