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A quantitative microplasticity-based approach to rationalize the poor strengthening response of polycrystalline Mg alloys

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Journal of Magnesium and Alloys 2023年第5期11卷 1656-1671页

作者： X.z.Jin W.C.Xu D.b.Shan b.Guo b.Jin M.T.Pérez-Prado National Key Laboratory for Precision Hot Processing of Metals&School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001PR China IMDEA Materials Institute C/Eric Kandel2GetafeMadrid 28906Spain Advanced Composites Simulation Lab University of Southern CaliforniaLos AngelesCA 90089U.S.A M.C.Gill Composites Center University of Southern CaliforniaLos AngelesCA 90089U.S.A

This work aims to understand the inefficiency of nanoprecipitates to strengthen a weakly textured,polycrystalline Mg-Gd-Y-zr *** experimental micromechanical approach consisting on micropillar compression combined with analytical electron microscopy is put in place to analyze the effect of nanoprecipitation on soft and hard basal slip and twinning in individual grains with different *** study shows that,in grains that are favorably oriented for basal slip(“soft”basal slip),aging leads to extreme localization due to the ability of basal dislocations to shear the nanoparticles,resulting overall in the softening of basal ***,in grains in which the c-axis is almost perpendicular to the compression axis,prismatic slip dominates deformation in the solid solution state and nanoprecipitation favors twinning due to the concomitant lattice solute ***,in grains oriented with their c-axis making an angle of about 5-7°with respect to the compression axis,which deform mainly by“hard”basal slip,precipitation leads to the strengthening of basal systems in the absence of obvious *** work reveals that the poor hardening response of the polycrystalline alloy is related to the capability of basal dislocations to shear the nanoparticles,in the absence of Orowan looping events,and to the associated basal slip localization.

关键词： Magnesium Precipitation basal slip Particle shearing Slip localization

Superb Strengthening Effect of Net-Like Distributed Amorphous Al_(2)O_(3)on Creep Resistance of(b_(4)C+Al_(2)O_(3))/Al Neutron-Absorbing Materials

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Acta Metallurgica Sinica(English Letters) 2022年第12期35卷 2007-2013页

作者： Y.N.zan X.Lei J.F.zhang D.Wang Q.z.Wang b.L.Xiao z.Y.Ma Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Nuclear Equipment Division Beijing Institute of Nuclear EngineeringChina Nuclear Power Engineering Co.LtdBejing 100840China

b4C reinforced Al composites are widely used as neutron absorbing materials(NAMs)due to excellent neutron absorbing efficiency,however,such NAMs exhibit poor high-temperature *** meet the requirement for structure-function integration,NAMs with enhanced high-temperature mechanical properties are *** this work,a novel(b4 C+Al_(2)O_(3))/Al NAM with netlike distribution of Al_(2)O_(3)was fabricated by powder metallurgy method and subjected to high-temperature tensile creep *** was shown that the creep resistance was enhanced by several orders of magnitude via the addition of only2.1 vol.%netlike-distributed Al_(2)O_(3).(b_(4)C+Al_(2)O_(3))/Al exhibited high apparent stress exponents ranging from 16 to 25 and high apparent activation energy of 364 kJ/*** creep behaviour could be rationalized using the substructure-invariant model and its rupture behaviour could be described by the Dobes-Milicka equation.

关键词： Neutron absorber material Al matrix composite Tensile creep b_(4)C/Al

Recent development of chemically complex metallic glasses: from accelerated compositional design, additive manufacturing to novel applications

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Materials Futures 2022年第1期1卷 9-31页

作者： J Y zhang z Q zhou z b zhang M H Park Q Yu z Li J Ma A D Wang H G Huang M Song b S Guo Q Wang Y Yang Department of Mechanical Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China School of Materials Science and Engineering Dongguan University of TechnologyDongguanGuangdong 523808People’s Republic of China Institute of Materials China Academy of Engineering PhysicsJiangyouSichuan 621907People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangshaHunan 410083People’s Republic of China Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhouGuangdong 510632People’s Republic of China Institute of Materials Laboratory for MicrostructuresShanghai UniversityShanghai 200444People’s Republic of China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China Department of Advanced Design and System Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China

Metallic glasses(MGs)or amorphous alloys are an important engineering material that has a history of research of about 80–90 *** different fast cooling methods were developed for multi-component MGs between 1960s and 1980s,1990s witnessed a surge of research interest in the development of bulk metallic glasses(bGMs).Since then,one central theme of research in the metallic-glass community has been compositional design that aims to search for MGs with a better glass forming ability,a larger size and/or more interesting properties,which can hence meet the demands from more important *** this review article,we focus on the recent development of chemically complex MGs,such as high entropy MGs,with new tools that were not available or mature yet until recently,such as the state-of-the-art additive manufacturing technologies,high throughput materials design techniques and the methods for big data analyses(*** learning and artificial intelligence).We also discuss the recent use of MGs in a variety of novel and important applications,from personal healthcare,electric energy transfer to nuclear energy that plays a pivotal role in the battle against global warming.

关键词： metallic glasses amorphous alloys alloy design additive manufacturing machine learning high throughput materials design

青藏高原及其周边成冰纪-埃迪卡拉纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 936-967页

作者：孙郎 Malik Muhammad Saud Sajid KHAN 杨传孙智新潘兵 Shehryar AHMED 苗兰云孙玮辰胡春林孙晓娟罗翠陈波殷宗军赵方臣李国祥朱茂炎中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学地球与行星科学学院北京100049

青藏高原及其周边的块体,包括印度板块、拉萨地块、羌塘地块、塔里木板块、欧龙布鲁克地块、中祁连地块、阿拉善地块、华北板块、扬子板块、中伊朗地块和阿曼等,以及各块体之间造山带的复杂演化历史是地球科学研究的前沿和热点.成冰系... 详细信息

青藏高原及其周边的块体,包括印度板块、拉萨地块、羌塘地块、塔里木板块、欧龙布鲁克地块、中祁连地块、阿拉善地块、华北板块、扬子板块、中伊朗地块和阿曼等,以及各块体之间造山带的复杂演化历史是地球科学研究的前沿和热点.成冰系和埃迪卡拉系广泛分布于该地区的各个构造单元,其中阿曼、印度板块、扬子板块以及塔里木板块发育有相对完整的成冰系和埃迪卡拉系;而在中伊朗地块、南羌塘地块、中祁连地块、阿拉善地块及华北板块,目前已知仅有埃迪卡拉系发育.基于前人对青藏高原及其周边地区成冰系和埃迪卡拉系的研究,结合第二次青藏高原综合科学考察研究项目开展以来获得的新资料和研究进展,本文建立了该地区成冰系和埃迪卡拉系代表性地层序列对比表.在此基础上,本文梳理了该地区这一时期生物群和重大地质事件的研究现状和存在的问题.结果表明,该地区各板块埃迪卡拉纪化石的保存和组合面貌各具特色,但普遍发现有典型埃迪卡拉纪末期化石分子Cloudina和Shaanxilithes;除成冰纪两次全球性冰期事件外,在青藏高原北缘各块体(华北板块、阿拉善地块、北祁连构造带、中祁连地块、欧龙布鲁克地块、塔里木板块)以及伊朗中南部普遍记录了一次埃迪卡拉纪晚期的冰川事件,但该事件的时限、分布范围和成因有待进一步揭示;同时,埃迪卡拉纪中期DOUNCE/Shruam碳同位素负异常事件在青藏高原周边地区也具有广泛记录.综合现有研究资料发现,在成冰纪-埃迪卡拉纪期间,青藏高原及其周边地区大多数块体从罗迪尼亚超大陆裂解出来后,可能通过泛非运动构成东冈瓦纳大陆的一部分,而部分板块(如华北板块)位于冈瓦纳大陆和劳伦大陆之间.总体而言,该地区的主要块体在成冰纪-埃迪卡拉纪期间具体的古地理演化模型存在较多争议,亟需开展进一步的研究工作.

关键词：青藏高原成冰系埃迪卡拉系地层古地理生物群冈瓦纳大陆

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FMHADP: Design of an Efficient Pre-Forensic Layer for Mitigating Hybrid Attacks via Deep Learning Pattern Analysis

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Meesala Sravani b Kiran Kumar M Rekha Sundari D Tejaswi Department of Computer Science and Engineering GMR Institute of Technology Information Technology Anil Neerukonda Institute of Technology & Science(Autonomous)

Network attack detection and mitigation require packet collection， pre-processing， feature analysis， classification， and post-processing. Models for these tasks sometimes become complex or inefficient when applied to real-time data samples. To mitigate hybrid assaults， this study designs an efficient forensic layer employing deep learning pattern analysis and multidomain feature extraction. In this paper， we provide a novel multidomain feature extraction method using Fourier， z， Laplace， Discrete Cosine Transform (DCT)， 1D Haar Wavelet， Gabor， and Convolutional Operations. Evolutionary method dragon fly optimisation reduces feature dimensionality and improves feature selection accuracy. The selected features are fed into VGGNet and GoogLeNet models using binary cascaded neural networks to analyse network traffic patterns， detect anomalies， and warn network administrators. The suggested model tackles the inadequacies of existing approaches to hybrid threats， which are growing more common and challenge conventional security measures. Our model integrates multidomain feature extraction， deep learning pattern analysis， and the forensic layer to improve intrusion detection and prevention systems. In diverse attack scenarios， our technique has 3.5% higher accuracy， 4.3% higher precision， 8.5% higher recall， and 2.9% lower delay than previous models.

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Research of Neural Network based on Improved PSO Algorithm for Carbonation Depth Prediction of Concrete

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武汉理工大学学报 2010年第17期32卷 170-175页

作者： dai W SHUI z H School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China School of Economics and Management Huangshi Institution of TechnologyHuangshi 435003China

Firstly,neural network based on improved particle swarm optimization (PSO)algorithm is introduced in this paper. based on the data collected from projects in typical areas,the concrete carbonation depth is assessed with consideration of various factors such as unit cement consumption (C),unit water consumption (W),binder material content (b),water binder ratio (W/b ),concrete strength (MPa),rapid carbonization days (D),fly ash consumption of unit volume concrete(FA),fly ash percentage of total cementitious materials (FA%),expansion agent consumption of unit volume concrete(EA),expansion agent percentage of total cementitious materials (FA%).Gaining the data from project-experiment,a model is presented to calculate and forecast carbonation depth using neural network based on improved PSO algorithm. The calculation results indicate that this algorithm accord with the prediction carbonation depth of concrete accuracy requirements and has a better convergence and generalization,worth being popularized.

关键词： PSO bP neural network concrete carbonation depth prediction

Influence of Angiotensin II on αb>1b>-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Smooth Muscle Cells

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Journal of biosciences and Medicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz Juan Pablo de Jesús benítez-Garrido Santiago C. Sigrist-Flores Juan Javier López-Guerrero Enrique Hong Rafael Villalobos-Molina Unidad de biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departamento de Farmacobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth fac... 详细信息

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on ATb>1b> and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of αb>1b>-adrenergic receptors (αb>1b>-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incubated for 24 h in DMEM at 37˚C, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10−5 M), and in some experiments, 5-Methylurapidil (αb>1Ab>-AR antagonist), AH11110A (αb>1bb>-AR antagonist), or bMY-7378 (αb>1Db>-AR antagonist), were used to identify the αb>1b>-AR involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. αb>1Db>-AR was protected from desensitization by bMY-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and αb>1b>-ARs proteins were evaluated. αb>1Db>-AR increased at 30 and 60 min post Ang II exposure, the αb>1Ab>-AR diminished from 1 to 4 h, while αb>1bb>-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of αb>1Db>-AR at short times, and bMY-7378 protected αb>1Db>-AR from desensitization.

关键词： Angiotensin II α1D-AR α1-AR Expression Rat aorta Smooth Muscle Cells

Grain refinement of Mg-alloys by native MgO particles: An overview

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Journal of Magnesium and Alloys 2022年第11期10卷 2919-2945页

作者： z.Fan F.Gao Y.Wang S.H.Wang J.b.Patel brunel Centre for Advanced Solidification Technology(bCAST) Brunel University LondonUxbridgeUB83PHUK

A fine and equiaxed solidification process delivers multidimensional benefits to Mg-alloys, such as improved castability, reduced casting defects, enhanced mechanical properties, increased corrosion resistance and potential for increased recycled contents. Despite extensive research on grain refinement of Mg-alloys in the last few decades, currently, there is no effective grain refiner available for refining Mg-Al alloys, and our current understanding of grain refining mechanisms is not adequate to facilitate the development of effective grain *** the EPSRC(UK) Li ME Hub’s research program, substantial advances have been made in understanding the early stages of solidification covering prenucleation, heterogeneous nucleation, grain initiation and grain refinement. In this paper, we provide a comprehensive overview of grain refinement of Mg-alloys by native MgO particles. We show that native MgO particles can be made available for effective grain refinement of Mg-alloys by intensive melt shearing regardless of the alloy compositions. More importantly, we demonstrate that(1) the addition of more potent exogenous particles will not be more effective than native MgO;and(2) MgO particles are difficult to be made more impotent for grain refinement through promoting explosive grain initiation. We suggest that the most effective approach to grain refinement of Mg-alloys is to make more native MgO particles available for grain refinement through dispersion, such as by intensive melt shearing.

关键词： Mg-alloys Grain refinement Magnesia(MgO) Nucleation Grain initiation

Pharmacovigilance guidelines of Chinese patent medicines

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zhongguo zhongyao zazhi 2024年第16期49卷 4261-4265页

作者： Wang L.-X. Wang M.-M. Li Y.-Y. Wang z.-F. Cui X. zhao X.-X. Liu F.-M. Yang S. Wei R.-L. Wang Y.-X. zhang b. Xie Y.-M. Institute of basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China beijing University of Chinese Medicine Beijing 100029 China

Drug administration law of the People′s Republic of China (2019 revised edition), which came into effect on December 1, 2019, proposed that " the state shall establish a pharmacovigilance system" . Pharmacovigilance work of Chinese patent medicines is more difficult, and it is necessary to carry out Pharmacovigilance activities that are in line with the characteristics of Chinese patent medicines. Pharmacovigilance guidelines of Chinese patent medicines (T / CACM 1563. 1-2024), based on the principles of Drug Administration Law of the People′ s Republic of China (2019 revised edition) and Pharmacovigilance quality management standards (No. 65 of 2021) of the National Medical Products Administration, draws on the EU Pharmacovigilance regulation and the secondary guidelines of International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH), and it is drafted in accordance with the provisions of Guidelines for standardization work part 1: structure and drafting rules of standardization documents (Gb / T1. 1-2020) based on the characteristics of Chinese patent medicines. It serves as a general document for a series of pharmacovigilance guidelines of Chinese patent medicines, such as Guidelines for construction of traditional Chinese medicine pharmacovigilance system in medical institutions (T / CACM 1563. 2-2024), Pharmacovigilance guidelines for clinical application of oral Chinese patent medicines (T / CACM 1563. 3-2024), Pharmacovigilance guidelines for clinical application of traditional Chinese medicine injections (T / CACM 1563. 4-2024), Pharmacovigilance guidelines for clinical application of Chinese patent medicines for external use (T / CACM 1563. 5-2024), and Pharmacovigilance guidelines for clinical application of Chinese patent medicines for mucosal administration (T / CACM 1563. 6-2024), including four major elements of pharmacovigilance monitoring and reporting of Chinese patent medicines, signal identification, ri

关键词： Chinese patent medicine group standard guideline pharmacovigilance safe drug use