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黄龙汤的药用历史考证及性味归经与功能主治探讨

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时珍国医国药 2024年第2期35卷 421-424页

作者：郑依玲 David G.y.wang 马俊李皓翔王增铎金阳王仲蓀梅全喜广州市中西医结合医院广东广州510800 广州中医药大学附属第七临床医学院广东深圳518100 深圳万和制药有限公司广东深圳518107 广州中医药大学第二临床医学院广东广州510006 深圳市宝安区中医院广东深圳518100

黄龙汤由人粪制作而成,古代多有应用。笔者通过查阅古今记载的本草医籍及文献,对黄龙汤的首载古籍、药用历史进行考证。结果显示,黄龙汤入药首载于《华佗神方》,为性味苦寒且无毒之物,入心、胃、小肠经,具有清热,解毒,燥湿,清痰,消食积... 详细信息

黄龙汤由人粪制作而成,古代多有应用。笔者通过查阅古今记载的本草医籍及文献,对黄龙汤的首载古籍、药用历史进行考证。结果显示,黄龙汤入药首载于《华佗神方》,为性味苦寒且无毒之物,入心、胃、小肠经,具有清热,解毒,燥湿,清痰,消食积,降阴火的功效,其中尤善清热解毒,适用于中毒,湿热或热毒炽盛之证等,临床疗效显著,具有悠久的应用历史和重要的药用价值,值得进一步研究开发、推广使用。

关键词：黄龙汤金汁药用历史性味归经功效主治临床应用

bio-inspired barnacle cement coating of biodegradable magnesium alloy for cerebrovascular application

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Rare Metals 2024年第10期43卷 5164-5185页

作者： Hang Li Fei wang Xiao-Jing Sun Liu-Jie Qi Jing-An Li Mujahid Iqbal Shao-Kang Guan School of Material Science and Engineering Zhengzhou University Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold (Ministry of Education) Zhengzhou University Department of Physics University of Agriculture Faisalabad

Ischemic stroke is increasing worldwide, and stent intervention has gradually become one of the effective treatments. Owing to its good mechanical properties and biocompatibility, biodegradable Mg-Zn-y-Nd alloy(ZE21b) has good application prospects in vascular ***, too fast degradation and delayed endothelialization are the bottleneck problem to limit its further application. In this study, the bio-inspired coating barnacle cement cp19k is constructed on ZE21b surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization ability. The coating was evaluated through electrochemistry, static immersion corrosion,in vitro blood experiments and cell experiments. Cp19k effectively improved the corrosion resistance of the substrate ZE21b, reduced the degradation rate, improved endothelial cell proliferation and migration capabilities,inhibited smooth muscle cells proliferation and regulated contractile phenotype, inhibited macrophage adhesion,regulated macrophage M2 phenotype, and reduced the expression of inflammatory factor of TNF-a and inhibited fibroplasia in vivo. Our data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent.

关键词： barnacle cement cp19k biodegradable magnesium alloy Cerebrovascular stent M2 phenotype Pro-endothelialization

Finite deformation analysis of the rotating cylindrical hollow disk composed of functionally-graded incompressible hyper-elastic material

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Applied Mathematics and Mechanics(English Edition) 2023年第8期44卷 1367-1384页

作者： Libiao XIN yang wang Zhiqiang LI y.b.LI College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Aeronautics and Astronautics Taiyuan University of TechnologyTaiyuan 030024China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNC 27606U.S.A.

The deformations and stresses of a rotating cylindrical hollow disk made of incompressible functionally-graded hyper-elastic material are theoretically analyzed based on the finite elasticity *** hyper-elastic material is described by a new micro-macro transition ***,the material shear modulus and density are assumed to be a function with a power law form through the radial direction,while the material inhomogeneity is thus reflected on the power index *** integral forms of the stretches and stress components are *** the obtained complicated integral forms,the composite trapezoidal rule is utilized to derive the analytical solutions,and the explicit solutions for both the stretches and the stress components are numerically *** comparing the results with two classic models,the superiority of the model in our work is ***,the distributions of the stretches and normalized stress components are discussed in detail under the effects of *** results indicate that the material inhomogeneity and the rotating angular velocity have significant effects on the distributions of the normalized radial and hoop stress components and the *** believe that by appropriately choosing the material inhomogeneity and configuration parameters,the functionally-graded material(FGM)hyper-elastic hollow cylindrical disk can be designed to meet some unique requirements in the application fields,e.g.,soft robotics,medical devices,and conventional aerospace and mechanical industries.

关键词： functionally-graded material(FGM) incompressible hyper-elastic model rotating hollow cylindrical disk

Ca and Sr co-doping induced oxygen vacancies in 3DOM La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)catalysts for boosting low-temperature oxidative coupling of methane

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Journal of Energy Chemistry 2024年第4期91卷 331-344页

作者： Tongtong Wu yuechang Wei Jing Xiong yitao yang Zhenpeng wang Dawei Han Zhen Zhao Jian Liu State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Key Laboratory of Optical Detection Technology for Oil and Gas China University of PetroleumBeijing 102249China

It is urgent to develop catalysts with application potential for oxidative coupling of methane(OCM)at relatively lower ***,three-dimensional ordered macro porous(3 DOM)La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)(A_(2)b_(2)O_(7)-type)catalysts with disordered defective cubic fluorite phased structure were successfully prepared by a colloidal crystal template method.3DOM structure promotes the accessibility of the gaseous reactants(O2and CH4)to the active *** co-doping of Ca and Sr ions in La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)catalysts improved the formation of oxygen vacancies,thereby leading to increased density of surface-active oxygen species(O_(2)^(-))for the activation of CH4and the formation of C2products(C2H6and C2H4).3DOM La_(2-x)Sr_(x)Ce_(2-y)CayO_(7-δ)catalysts exhibit high catalytic activity for OCM at low temperature.3DOM La1.7Sr0.3Ce1.7Ca0.3O7-δcatalyst with the highest density of O_(2)^(-)species exhibited the highest catalytic activity for low-temperature OCM,i.e.,its CH4conversion,selectivity and yield of C2products at 650℃are 32.2%,66.1%and 21.3%,*** mechanism was proposed that the increase in surface oxygen vacancies induced by the co-doping of Ca and Sr ions boosts the key step of C-H bond breaking and C-C bond coupling in catalyzing low-temperature *** is meaningful for the development of the low-temperature and high-efficient catalysts for OCM reaction in practical application.

关键词： 3DOM catalysts Ca ions Sr ions Low-temperature oxidative couplingof methane Oxygen vacancies O_(2)^(-) species

Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator

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Microsystems & Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon Srinivas Merugu Jaibir Sharma Amit Lal Eldwin J.Ng yul Koh Joshua E.-y.Lee Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMEMS Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves(GFWs)generated by a membrane acoustic waveguide actuator(MAWA).by harnessing the potential of GFWs,cavity-agnostic advanced particle manipulation functions are achieved,unlocking new avenues for microfluidic systems and lab-on-a-chip *** localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising *** traditional acoustofluidic technologies,the GFWs propagating on the MAWA’s membrane waveguide allow for cavity-agnostic particle manipulation,irrespective of the resonant properties of the fluidic ***,the acoustofluidic functions enabled by the device depend on the flexural mode populating the active region of the membrane *** demonstrations using two types of particles include in-sessile-droplet particle transport,mixing,and spatial separation based on particle diameter,along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS *** experiments emphasize the versatility and potential applications of the MAWA as a microfluidic platform targeted at lab-on-a-chip development and showcase the MAWA’s compatibility with existing microfluidic systems.

关键词： waveguide fluid cavity

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen wang yuchen wang Mengjie Zhu Zhile Liang Kanghong Zhang yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Enhanced electrochemical performance of Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3) solid electrolyte by anion doping

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Nano Research 2024年第3期17卷 1465-1472页

作者： Jingrui Kang Xu Guo Rui Gu Honglei Hao yi Tang Jiahui wang Li Jin Hongfei Li Xiaoyong Wei Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Energy and Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai 201209China

Nowadays,the majority of the studies on the substitution are focused on cations(such as y^(3+),Ti^(4+),P^(5+),etc.)in Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP),while there are few studies on the substitution of anion O^(2-).In this work,the modified LATP with a series of LiCl(LATPClx,x=0.1,0.2,0.3,0.4)additives is prepared to enhance ionic *** successful introduction of Cl-makes the length of the c axis decrease from 20.822(2)to 20.792(1)Å,and the bulk conductivity of 2.13×10^(-3) S·cm^(-1) is achieved in LATPCl_(0.3).Moreover,the Al/Ti-O1/Cl1 and Al/Ti-O_(2)/Cl_(2) distance decrease,while the Li1-O_(2)/Cl_(2) distance *** ions migrate more easily in the nanochannel of *** addition,the LiCl additive increases the relative density and the grain boundary conductivity of LATPClx ***,a higher ionic conductivity of 2.12×10^(–4) S·cm^(-1) and a low activation energy of 0.30 eV are obtained in LATPCl_(0.3).Correspondingly,the symmetric cell exhibits a low overpotential of±50 mV for over 200 h in LATPCl_(0.3).The solid-state Li|LATPCl_(0.3)|NCM811(NCM811=LiNi0.8Co0.1Mn0.1O_(2))battery exhibits high initial capacity 185.1 mAh·g^(-1) with a capacity retention rate of 95.4%after 100 cycles at 0.5 *** result suggests that LiCl additive is an effective strategy to promote electrochemical properties of LATP solid electrolyte and can be considered for reference to other inorganic solid electrolytes systems.

关键词： Li_(1.3)Al_(0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid electrolyte anion doping ionic conductivity cyclic performance

Design and experimental investigation of potential low-thermalconductivity high-entropy rare-earth zirconates

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Journal of Advanced Ceramics 2024年第8期13卷 1132-1142页

作者： Lu Liu Hongying Dong Peng Zhang Shaokun wang Haolei Qil Mengyu Ding Zhefeng Li yu bai Wen Ma School of Chemical Engineering Inner Mongolia University of TechnologyHohhot 010051China Inner Mongolia Key Laboratory of Thin Film and Coatings School of Materials Science and EngineeringInner Mongolia University of TechnologyHohhot 010051China

Developing new high-entropy rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7))ceramics with low thermal conductivity is essential for thermal barrier coating *** this work,the average atomic spacings,interatomic forces,and average atomic masses of 16 rare-earth elements occupying the A site of the cubic A_(2)b_(2)O_(7) crystal structure were calculated by density functional *** three physical qualities,as vectors,characterize the corresponding rare-earth *** distance between two vectors quantitatively describes the difference between two rare-earth *** greater differences between two rare-earth elements,the disorder degree of HE-RE_(2)Zr_(2)O_(7)is greater,and therefore,the thermal conductivity is *** to the theoretical calculations,the thermal conductivity of the ceramics gradually increases in the order of(SC_(0.2)y_(0.2)La_(0.2)Ho_(0.2)yb_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)Ce_(0.2)Nd_(0.2)Eu_(0.2)Gd_(0.2))_(2)Zr_(2)0_(7),(SC_(0.2)y_(0.2)Tm_(0.2)yb_(0.2)Lu_(0.2))_(2)Zr_(2)0_(7),and(Sc_(0.2)Er_(0.2)Tm_(0.2)yb_(0.2)Lu_(0.2))_(2)Zr_(2)O_(7).Using the solution precursor plasma spray method and pressureless sintering method,four types of HE-RE2Zr2Oz powder and bulk samples were *** samples all showed a single defective fluorite structure with a uniform distribution of the elements and a stable phase *** thermal conductivities of the sintered HE-RE_(2)Zr_(2)0_(7) bulk samples ranged from 1.30 to 1.45 Wm^(-1).K^(-1) at 1400℃,and their differences were consistent with the theoretical calculation *** the ceramics,(Sc_(0.2)y_(0.2)La_(0.2)Ho_(0.2)yb_(0.2))_(2)Zr_(2)O_(7) had the lowest thermal conductivity(1.30 W·m^(-1)·K^(-1),1400℃),highest thermal expansion coefficient(10.19×10^(-6) K^(-1),200-1400℃),highest fracture toughness(1.69±0.28 MPa·m^(1/2)),and smallest brttleness index(3.03μm^(1/2)).Therefore,(Sc_(0.2)y_(0.2)La_(0.2)Ho_(0.2)yb_(0.2))_(2)Zr_(2)0_(7)is considered to be an ideal candidate material for

关键词： high-entropy ceramics rare-earth zirconate(HE-RE_(2)Zr_(2)O_(7)) composition design thermal conductivity thermal barriercoatings(TbCs)

补体相关蛋白在HIV/AIDS湿热内蕴证患者中的差异性表达

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中国艾滋病性病 2024年第6期30卷 579-583页

作者：孙雪晴王亚楠张海燕冯龙 David y.W.Lee 苏铄涵徐立然 Alan wang 李青雅河南中医药大学中医学院郑州450000 河南中医药大学第一附属医院郑州450000 河南中医药大学医学院郑州450000 Harvard Medical School MA Boston 02115 Faculty of Medicine and Health Sciences of Auckland University New Zealand 6000

目的探讨补体系统相关因子在HIV/AIDS患者中及其与HIV/AIDS湿热内蕴证侯的表达特征。方法共纳入2023年3-5月于广西壮族自治区某地区就诊的HIV/AIDS患者(简称HIV组),其中包括HIV/AIDS湿热内蕴证患者组(简称HIVsr组)与HIV/AIDS无证可辨... 详细信息

目的探讨补体系统相关因子在HIV/AIDS患者中及其与HIV/AIDS湿热内蕴证侯的表达特征。方法共纳入2023年3-5月于广西壮族自治区某地区就诊的HIV/AIDS患者(简称HIV组),其中包括HIV/AIDS湿热内蕴证患者组(简称HIVsr组)与HIV/AIDS无证可辨患者组(简称HIVwz组)及同期在门诊进行体检的健康对照组。收集其基本信息并采集抗凝血液,应用流式细胞术检测T细胞亚群数量,酶联免疫吸附试验检测补体相关因子血浆表达水平,对数据进行统计分析。结果共纳入HIV组45例,其中包括HIVsr组30例与HIVwz组15例,与健康对照组15例。免疫指标对比中,HIVsr组与健康对照组相比TH/TS表达下降(P3、C5aR、C5b因子外,C1q、MASP2、MbL等12个因子表达均下降(P3aR与湿热内蕴证证候学量表积分呈负相关(r=-0.613,P3aR是量表积分的影响因素。结论补体系统中经典及凝集素通路参与HIV/AIDS患者病理过程,且HIV/AIDS湿热内蕴证患者的证候生物学基础与经典通路相关。C3aR对临床诊断HIV/AIDS湿热内蕴证患者有一定鉴别价值。

关键词：艾滋病湿热内蕴证补体证候诊断