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Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GAbA_b-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro martín-belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Parametrization of the Teichmüller Space of bordered Surface NEC Groups

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Acta Mathematica Sinica,English Series 2008年第6期24卷 1039-1056页

作者： b.ESTRADA E.martíNEZ Departamento de Matemdticas Fundamentales UNEDPaseo Senda del Rey 928040 MadridSpain

A non-Euclidean crystallographic group F （NEC group, for short） is a discrete subgroup of isometries of the hyperbolic plane H, with compact quotient space H/Г. These groups uniformize Klein surfaces, surfaces endowed with dianalytic structure. These surfaces can be seen as a generalization of Riemann surfaces. Fundamental polygons play an important role in the study of parametrizations of the Teichmuller space of NEC groups. In this work we construct a class of right-angled polygons which are fundamental regions of bordered surface NEC groups. The free parameters used in the construction of the polygons give a parametrization of the Teichmuller space. From the parameters we obtain explicit matrices of the generators of the groups. Finally, we give examples to exhibit how different relations between the parameters reflect the existence of automorphisms on the quotient surfaces.

关键词： non-Euclidean crystallographic groups hyperbolic polygons Klein surfaces automorphisms of surfaces Teichmfiller space

Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-barreira Paula Oreiro-martínez Ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality biological activity Molecule magnet

Tuning MXenes Towards Their Use in Photocatalytic Water Splitting

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Energy & Environmental Materials 2024年第6期7卷 321-331页

作者： Diego Ontiveros Sergi vela Francesc Viñes Carmen Sousa Departament de Ciència de Materials i Química Física&Institut de Química Teòrica i Computacional(IQTCUb) Universitat de Barcelonac/Martíi Franquès 1-1108028 BarcelonaSpain

Finding appropriate photocatalysts for solar-driven water(H_(2)O)splitting to generate hydrogen(H_(2))fuel is a challenging task,particularly when guided by conventional trial-and-error experimental ***,density functional theory(DFT)is used to explore the MXenes photocatalytic properties,an emerging family of two-dimensional(2D)transition metal carbides and nitrides with chemical formula M_(n+1)X_(n)T_(x),known to be semiconductors when having T_(x)*** than 4,000 MXene structures have been screened,considering different compositional(M,X,T_(x),and n)and structural(stacking and termination position)factors,to find suitable MXenes with a bandgap in the visible region and band edges that align with the water-splitting half-reaction *** from bandgap analysis show how,in general,MXenes with n=1 and transition metals from group III present the most cases with bandgap and promising sizes,with C-MXenes being superior to *** band alignment calculations of candidate systems with a bandgap larger than 1.23 eV,the minimum required for a water-splitting process,Sc_(2)CT_(2),Y_(2)CT_(2)(T_(x)=Cl,br,S,and Se)and Y_(2)CI_(2)are highlighted as adequate photocatalysts.

关键词： Density Functional Theory MXenes Photocatalysis Water Splitting

Science Letters:Detection of Catabacter hongkongensis in polluted European water samples

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2009年第12期10卷 867-869页

作者： Francesc CODONY bárbara ADRADOS Leonardo martín PéREZ Mariana FITTIPALDI Jordi MORATó Health and Environmental Laboratory (MSMLab) Universitat Politècnica de CatalunyaViolinista Vellsolà 37 08222 Terrassa Barcelona Spain Mataró Waters-Municipal Laboratory C/Pitágores 1-7 08302 Mataró Barcelona Spain

The Catabacteriaceae is a new bacterial family aerobic, non-sporulating, Gram-positive coccobacillus that is with a unique member： Catabacter hongkongensis is a strictly anphylogenetically related to some clostridial clusters. Little is known of its epidemiology and environmental distribution, but the inclusion of its 16S rRNA gene sequence in Genbank has allowed it to be detected qualitatively. As a first approach for prospective surveys, a real-time polymerase chain reaction （PCR） procedure to identify C. hongkongensis has been developed. The presence of Catabacteriaceae in 29 water bodies subjected to possible human or animal impact has been investigated. Four of them were positive. The results confirm that highly polluted water can contain C hongkongensis.

关键词： Catabacter hongkongensis Real-time polymerase chain reaction (PCR) Environmental water samoles

THE bANACH-LIE GROUP OF LIE TRIPLE AUTOMORPHISMS OF AN H^＊-ALGEbRA^＊

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Acta Mathematica Scientia 2010年第4期30卷 1219-1226页

作者： A.J.Calderón martín C.martín González Departamento de Matemáticas Universidad de Cádiz Departamento de Algebra Geometría y Topología Universidad de Málaga

We study the banach-Lie group Ltaut（A） of Lie triple automorphisms of a complex associative H^＊-algebra A. Some consequences about its Lie algebra, the algebra of Lie triple derivations of A, Ltder（A）, are obtained. For a topologically simple A, in the infinite-dimensional case we have Ltaut（A）0 = Aut（A） implying Ltder（A） = Der（A）. In the finite-dimensional case Ltaut（A）0 is a direct product of Aut（A） and a certain subgroup of Lie derivations δ from A to its center, annihilating commutators.

关键词： banach-Lie group Lie triple automorphism Lie triple derivation

Influence of agriculture and aquaculture activities on the response of autotrophic picoplankton in Laguna Macapule, Gulf of California (Mexico)

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Ecological Processes 2017年第1期6卷 41-51页

作者： Aída martínez-López Cristian Hakspiel-Segura Diana Cecilia Escobedo-Urías bárbara González-Acosta Centro Interdisciplinario de Ciencias Marinas-IPN(CICIMAR) Av.IPN s/nCol.Playa Palo de Santa RitaLa PazB.C.S.23096Mexico Centro de Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR–Unidad Sinaloa)Bulevar Juan de Dios Bátiz Paredes 250Col.San JoachinGuasaveSinaloa 81101Mexico

Introduction:The lagoon is a component of coastal zones,whose populations of autotrophic picoplankton(APP)remain largely *** lagoons display high-nutrient productivity and additionally may also be subjected to anthropogenic *** study selected Laguna Macapule,located on the eastern shore in the mid-region of the Gulf of California,due to the fact that a drainage network servicing the surrounding agricultural region(>230,000 hectares under cultivation)directs irrigation runoff,shrimp farm effluents,and urban wastewater containing large quantities of nutrients to be discharged into this *** propose to identify the APP’s response to various types of environmental and anthropogenic influence in this highly impacted coastal ***:Two sites(separated by 2.7 km)were monitored from December 2007 to December ***,located at the entrance to Laguna Macapule(oceanic influence)and the other a discharge canal(eutrophic conditions)inside the lagoon at El Tortugó***:APP was the numerically dominant phytoplankton fraction(15×106 to 620×106 cells L−1)with coccoidal cyanobacteria as the dominant fraction throughout the *** levels were reached in spring-early autumn and they were the second largest contributor to *** of APP cells corresponds to the lagoon’s eutrophic *** numbers and a higher average of APP were recorded at the El Tortugón channel during the warm season(months with SST higher than 24°C).The general positive relationship of the APP’s annual cycle at both sites as well as a negative relationship with heterotrophic nanoflagellates(HNF)abundance,supports the idea that natural forcing,in particular sea surface temperature(SST)is the predominant influences on APP’s seasonal ***:Distinguishable significant differences in APP abundances and nutrients were recognizable between the two *** interplay of these variables contributed to lower densities of APP in winter and high de

关键词： Aquaculture Autotrophic picoplankton Eutrophic conditions Heterotrophic ciliates Heterotrophic nanoflagellates Urea

Effects of feeding yeast(Saccharomyces cerevisiae), organic selenium and chromium mixed on growth performance and carcass traits of hair lambs

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Journal of Integrative Agriculture 2015年第3期14卷 575-582页

作者： Pedro A Hernández-García Alejandro Lara-bueno Germán D Mendoza-martínez José R bárcena-Gama Fernando X Plata-Pérez Rufino López-Ordaz José A martínez-García Faculty of Veterinary and Livestock (University Center) Autonomous University of the State of Mexico Department of Animal Production Chapingo Autonomous University Department of Agriculture and Livestock Metropolitan Autonomous University (Xochimilco Unit) Institute of Genetic and Productivity (Livestock Center) Postgraduate College

Yeasts and organic minerals are used in diets to improve health, productive performance and some carcass characteristics of ruminants and non-ruminants. Thirty-two lambs（Pelibuey×Katahdin; bW=（30.55±1.67） kg; n=8） were used in a 56-d feeding experiment to study the effects of different levels of live yeast（Saccharomyces cerevisiae; yeast）, selenium（Se） and chromium（Cr） mixed（Se-Cr）, and a mixture of yeast-Se-Cr on growth performance and carcass traits. Animals were stratified by body weight（bW） and randomly assigned to one of four treatments： 1） control group（0.0 g kg–1 yeast）; 2） yeast（1.50 g kg–1 dry matter intake（DMI） d–1）; 3） Se-Cr premix（1.5 mg kg–1 DMI d–1 for each mineral）; and 4） yeast-Se-Cr mixture. There were no treatment effects on final bW; whereas lambs fed Se-Cr or yeast-Se-Cr had higher（P〈0.05） DMI than animals supplemented with only yeast. Average daily gain（ADG）, gain：feed ratio, chop area, dorsal fat and carcass yield were similar（P〉0.05） among treatment groups. In conclusion, supplementation with yeast, Se-Cr mixed or yeast-Se-Cr did not improve ADG, final bW, back fat content and carcass yield of growing of Pelibuey×Katahdin lambs. Supplementation with Se-Cr and yeast-Se-Cr increased DMI, and approximately 250 g ADG animal–1 d–1 was produced with no negative effects on growth and health of the animals.

关键词： yeast organic selenium and chromium Pelibuey×Katahdin sheep

Out of Africa: Miocene Dispersal, Vicariance, and Extinction within Hyacinthaceae Subfamily Urgineoideae

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Journal of Integrative Plant biology 2013年第10期55卷 950-964页

作者： Syed Shujait Ali martin Pfosser Wolfgang Wetschnig Mario martínez Azorín Manuel b.Crespo Yan Yu Institute of Plant Sciences Karl Franzens University Graz biocenter Linz Institute of biotechnology and Microbiology University of Swat CIbIO (Instituto Universitario de la biodiversidad) Universidad de Alicante Key Laboratory of bio Resources and Eco Environment of Ministry of Education College of Life Sciences Sichuan University

Disjunct distribution patterns in plant lineages are usually explained according to three hypotheses： vicariance, geodispersal, and long-distance dispersal. The role of these hypotheses is tested in Urgineoideae （Hyacinthaceae）, a subfamily disjunctly distributed in Africa, Madagascar, India, and the Mediterranean region. The potential ancestral range, dispersal routes, and factors responsible for the current distribution in Urgineoideae are investigated using divergence time estimations. Urgineoideae originated in Southern Africa approximately 48.9 Mya. Two independent dispersal events in the Western Mediterranean region possibly occurred during Early Oligocene and Miocene （29.9-8.5 Mya） via Eastern and Northwestern Africa. A dispersal from Northwestern Africa to India could have occurred between 16.3 and 7.6 Mya. Vicariance and extinction events occurred approximately 21.6 Mya. Colonization of Madagascar occurred between 30.6 and 16.6 Mya, after a single transoceanic dispersal event from Southern Africa. The current disjunct distributions of Urgineoideae are not satisfactorily explained by Gondwana fragmentation or dispersal via boreotropical forests, due to the younger divergence time estimates. The flattened winged seeds of Urgineoideae could have played an important role in long- distance dispersal by strong winds and big storms, whereas geodispersal could have also occurred from Southern Africa to Asia and the Mediterranean region via the so-called arid and high-altitude corridors.

关键词： bayesian binary method bayesian divergence estimates biogeography disjunct distribution time-event curve Urgineoideae.