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Chronic hepatitis b and occult infection in chemotherapy patients-evaluation in oncology and hemato-oncology settings:The CHOICE study

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World Journal of virology 2024年第1期13卷 61-68页

作者： Nayana Sudevan Manish Manrai T v S v G K Tilak Harshit Khurana Harikrishnan Premdeep Department of Internal Medicine Armed Forces Medical CollegePune 411040India Department of Gastroenterology Command Hospital Cantonment RdSadar BazaarCantonmentLucknowUttar PradeshIndia 226002 Department of Internal Medicine Command HospitalBangalore 560007India Department of Geriatric Medicine Armed Forces Medical CollegePune 411040India

bACKGROUND Reactivation of hepatitis b virus(Hbv)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer *** reactivation can cause significant morbidity and even mortality,which are preventable if at-risk individuals are identified through screening and started on antiviral *** To determine the prevalence of chronic Hbv(CHb)and occult Hbv infection(ObI)among oncology and hematology-oncology patients undergoing *** In this observational study,the prevalence of CHb and ObI was assessed among patients receiving *** markers of Hbv infection[hepatitis b surface antigen(HbsAg)/anti-hepatitis b core antigen(Hbc)]were evaluated for all *** DNA levels were assessed in those who tested negative for HbsAg but positive for total *** The prevalence of CHb in the study cohort was determined to be 2.3%[95%confidence interval(95%CI):1.0-4.2].Additionally,the prevalence of ObI among the study participants was found to be 0.8%(95%CI:0.2-2.3).CONCLUSION The findings of this study highlight the importance of screening for hepatitis b infection in oncology and hematology-oncology patients undergoing *** individuals with CHb and ObI is crucial for implementing appropriate antiviral prophylaxis to prevent the reactivation of Hbv infection,which can lead to increased morbidity and mortality.

关键词： Hepatitis b virus Chronic hepatitis b Occult b infection Oncology Hepatitis b reactivation Hematologyoncology

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Adaptive-optical 3D microscopy for microfluidic multiphase flows

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Light(Advanced Manufacturing) 2024年第3期5卷 105-119页

作者： Clemens bilsing Erik Nützenadel Sebastian burgmann Jürgen Czarske Lars büttner Laboratory of Measurement and Sensor System Techniques TUD Dresden University of Technology01069 DresdenGermany Chair of Fluid Mechanics Bergische Universitát Wuppertal42119 WuppertalGermany bIOLAS Laboratory of Measurement and Sensor System Techniques01069 DresdenGermany

Measurements based on optical microscopy can be severely impaired if the access exhibits variations of the refractive *** the case of fluctuating liquid-gas boundaries,refraction introduces dynamical aberrations that increase the measurement *** is prevalent at multiphase flows(***,film flows)that occur in many technical applications as for example in coating and cleaning processes and the water management in fuel *** this paper,we present a novel approach based on adaptive optics for correcting the dynamical aberrations in real time and thus reducing the measurement *** shape of the fluctuating water-air interface is sampled with a reflecting light beam(Fresnel Guide Star)and a Hartmann-Shack sensor which makes it possible to correct its influence with a deformable mirror in a closed ***-dimensional flow measurements are achieved by using a double-helix point spread *** measure the flow inside a sessile,oscillating 50-μl droplet on an opaque gas diffusion layer for fuel cells and show that the temporally varying refraction at the droplet surface causes a systematic underestimation of the flow field magnitude corresponding to the first droplet eigenmode which plays a major role in their detachment *** demonstrate that the adaptive optics correction is able to reduce this systematic ***,the adaptive optics system can pave the way to a deeper understanding of water droplet formation and detachment which can help to improve the efficiency of fuels cells.

关键词： Double-Helix point spread function Adaptive optics Particle tracking velocimetry Aberration correction Depth-resolving microscopy Closed-loop control

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新型耐磨损ONYX切削具制作的PDC钻头

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钻探工程 2024年第3期51卷 111-117页

作者：汤凤林赵荣欣 Нескоромных b.b. 李博周欣段隆臣上海市建筑科学研究院有限公司上海200032 中国地质大学(武汉)工程学院湖北武汉430074 Сибирский Федеративный университет г.КрасноярскРоссия660095 湖北省地震局湖北武汉430064

PDC钻头在石油天然气钻井和地质勘探钻进中得到了广泛的应用,取得了很好的技术经济效果。但是,钻进中产生的PDC切削具非正常磨损,影响了这种先进方法的机械钻速和钻头进尺的提高。俄罗斯史密斯钻头(Smith bits)公司研发了一种钻进过程... 详细信息

PDC钻头在石油天然气钻井和地质勘探钻进中得到了广泛的应用,取得了很好的技术经济效果。但是,钻进中产生的PDC切削具非正常磨损,影响了这种先进方法的机械钻速和钻头进尺的提高。俄罗斯史密斯钻头(Smith bits)公司研发了一种钻进过程中可以沿着自身轴线回转的ONYX切削具,抑制了PDC切削具的非正常磨损,具有创新性和实用价值。НecкopoMныx b.b.教授等对镶有ONYX切削具的钻头的结构和性能参数进行了分析研究。试验表明,这种ONYX切削具的耐磨性比常规固定式PDC切削具的耐磨性好,钻头钻进效果也比较好,俄罗斯正在积极推广使用,建议中国有关专家和部门对此进行研究和试验。

关键词： PDC钻头切削具非正常磨损 ONYX切削具钻头结构性能参数钻进效果

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The transition from backarc extension to Andean growth:Insights from geochronologic,sedimentologic,and structural studies of Mesozoic and Cenozoic sedimentary and volcanic rocks in south-central Chile(36°S)

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Geoscience Frontiers 2024年第5期15卷 93-117页

作者： Alfonso Encinas Nicolás Henríquez Daniel Castro Darío Orts Diego Kietzmann Franco Iovino Paulo vásquez Andrés Folguera victor valencia Facundo Fuentes Departamento de Ciencias de la Tierra Facultad de Ciencias QuímicasUniversidad de ConcepciónVíctor Lamas 1290Concepción 4030000Chile Universidad Nacional de Río Negro.Instituto de Investigación en Paleobiología y Geología.General Roca Río NegroArgentina Instituto de Investigación en Paleobiología y Geología(IIPG).CONICET.Av.J.A.Roca 1242 8332 General RocaRío NegroArgentina Universidad de buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de Ciencias GeológicasCiudad UniversitariaPabellón IIIntendente Güiraldes 2160C1428EHA Ciudad Autónoma de Buenos AiresArgentina CONICET-Universidad de buenos Aires Instituto de Geociencias BásicasAmbientales y Aplicadas de Buenos Aires(IGeBA)Ciudad UniversitariaPabellón IIIntendente Güiraldes 2160C1428EHA Ciudad Autónoma de Buenos AiresArgentina Instituto de Estudios Andinos‘‘Don Pablo Groeber”(IDEAN) CONICET-Universidad de Buenos AiresBuenos AiresArgentina Facultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos AiresArgentina Washington State University School of the EnvironmentPullmanUSA Yacimientos Petrolíferos Fiscales(YPF)S.A. Buenos AiresArgentina

Many studies propose a significant shift in the tectonic and paleogeographic evolution of the Andes in south-central Chile and Argentina during the Late *** has been proposed that the preceding Jurassic-Early Cretaceous extensional regime that resulted in a low-relief volcanic arc and the backarc Neuquén basin came to an end,giving way to shortening and Andean growth from the Late Cretaceous ***,there are disagreements regarding the timing and nature of this transition to Andean *** address these issues,we conducted geochronologic(U-Pb and^(40)Ar/&(39)Ar),sedimentologic,and structural studies on Mesozoic-Cenozoic sedimentary and volcanic rocks in the Río Maule area(Principal Cordillera,Chile,36°S).From our findings and prior analyses,we propose the following tectono-stratigraphic evolution of the region.(1)Marine deposition of the Tithonian-Hauterivian baños del Flaco Formation took place in an extensional backarc basin.(2)After a~40 Myr hiatus,fluvial deposits of the Colimapu Formation and volcanic rocks of the Plan de los Yeuques Formation accumulated during the *** the Colimapu Formation displays evidence of syndepositional shortening,the Plan de los Yeuques Formation exhibits synextensional growth *** to other studies,our results suggest that the Chilean part of the Principal Cordillera was largely a zone of active deposition rather than an elevated fold-thrust belt during the Late *** propose that sedimentation occurred within a series of relatively stable intermontane subbasins generated by shortening,followed by extension.(3)After a~20 Myr hiatus,middle Eocene to early Miocene(Lutetian-Aquitanian)accumulation of a thick succession of andesitic lavas and minor clastic sediments of the Abanico Formation occurred in an intraarc extensional basin.(4)Finally,major shortening and uplift of previously deposited Mesozoic-Cenozoic rocks took place throughout the *** phase constitu

关键词： Andes South-central Chile backarc basin Foreland basin Fold-thrust belt

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Structure, photocatalytic and antibacterial activity study of Meso porous Ni and S co-doped TiO2 nano material under visible light irradiation

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1630-1641页

作者： K.v.Divya Lakshmi T.siva Rao J.Swathi Padmaja I.Manga Raju M.Ravi Kumar Department of Inorganic and Analytical Chemistry Andhra University

Undoped and Ni–S co-doped mesoporous TiO2 nano materials were synthesized by using sol–gel *** characteristic features of as prepared catalyst samples were investigated using various advanced spectroscopic and analytical *** characterization results of the samples revealed that all the samples exhibited anatase phase(XRD),decreasing band gap(2.68 ev)(Uv–vis-DRS),small particle size(9.2 nm)(TEM),high surface area(142.156 m^2·g^-1)(bET),particles with spherical shape and smooth morphology(SEM);there is a frequency shift observed for co-doped sample(FT-IR)and the elemental composition electronic states and position of the doped elements(Ni and S)in the TiO2 lattice analyzed by XPS and *** results supported the photocatalytic degradation of bismarck brown Red(bbR)achieved with in 110 min and also exhibited the antibacterial activity on Staphylococcus aureus(MTCC-3160),Pseudomonas fluorescence(MTCC-1688)under visible light irradiation.

关键词： Sol–gel Ni–S co-doped TiO2 Photocatalysis under visible light Degradation of bismarck brown Red Antibacterial activity

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Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.bowman Alvaro Rodríguez Echarri Fatemeh Kiani Fadil Iyikanat Ted v.Tsoulos Joel D.Cox Ravishankar Sundararaman F.Javier García de Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MbI–Max-born-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the Fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

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Analysis of vibrational spectra of nano-bio molecules: Application to metalloporphrins

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Chinese Physics b 2013年第9期22卷 225-232页

作者： K Srinivasa Rao G Srinivas J.vijayasekhar v.U.M.Rao Y.Srinivas K.Sunil babu v.Sunndadara siva Kumar A.Hanumaiah Department of Electronics & Instrumentation Engineering Lakireddy Bali Reddy College of Engineering Department of Physics KL University Research Scholar Department of MathematicsJawaharlal Nehru Technological University Department of Applied Mathematics College of Science & TechnologyAndhra University Department of Computer Science GITAM University Department of Physics Miracle Engineering College Department of Electronics & Instrumentation Rajeev Gandhi Memorial Engineering College Department of Physics Lara's Vignan Institute of Technology and Science

In this paper, we have applied the Lie algebraic model to nano-bio molecules to determine the vibrational spectra of different stretching and bending vibrational modes. The determined vibrational energy levels by the Lie algebraic model are compared with the experimental data. The results from the theoretical mode[ are consistent with the experimental data. The vibrational energy levels are clustering in the excited states.

关键词： Lie algebraic model vibrational spectra vibrational modes metalloporphyrins

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Observation about the Classical Electromagnetic Gauge Transformation and Its Quantum Correspondence

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Journal of Modern Physics 2024年第4期15卷 474-479页

作者： Gustavo v. López Jorge A. Lizarraga Departamento de Física Universidad de Guadalajara Guadalajara Mexico

Using the Landau and symmetric gauges for the vector potential of a constant magnetic field and the quantum problem of a charged particle moving on a flat surface, we show the classical electromagnetic gauge transformation does not correspond to a one-dimensional unitary group transformation U(1) of the wave function for the quantum case. In addition, with the re-examination of the relation between the magnetic field b and its vector potential A, we found that, in order to have a consistent formulation of the dynamics of the charged particle with both expressions, we must have that b=∇×A if and only if b≠0.

关键词： Gauge Transformation Harmonic Oscillator Quantum Hall Effect Electromagnetic Potentials

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Damage Mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia

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Journal of biosciences and Medicines 2024年第4期12卷 49-59页

作者： Ignacio vélez-Rodríguez victoria Carranza-Aranda Facultad Mexicana de Medicina Universidad La Salle Tlalpan M&#233xico Hospital General de Mé xico Cuauht&#233moc M&#233xico

Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated b lymphocytes in large numbers in the blood. b cells are distinct from the cell types involved in their development (common lymphoid progenitor cells, pro-b cells, pre-b cells, and mature cells). The process of b cell maturation depends on precise communication within the cell: signals activate specific genes that are essential for proper development. Errors in this intricate signaling network can lead to issues with b cell function and contribute to disease. b-lineage acute lymphoid leukemias, malignancies of precursor-stage b lymphoid cells inhibit lymphoid differentiation, leading to abnormal cell proliferation and survival. The process of developing leukemia (leukemogenesis) can be triggered by an overproduction of both hematopoietic stem cells (the cells that form all blood cells) and the immature versions of white blood cells called lymphoblasts. Acute lymphoblastic leukemia (ALL) with the presence of the Philadelphia chromosome (ALL Ph) is classified as a high-risk manifestation of the disease, this chromosome is the product of the reciprocal translocation, whose product is a bCR-AbL fusion protein. It is a highly active tyrosine kinase that can transform hematopoietic cells into cytokine-independent. Hyperphosphorylation cascades inhibit the differentiating function of IKZF1 as a tumor suppressor gene which leads to an abnormal proliferation of b cells due to the presence of the Philadelphia chromosome;it inhibits the differentiating process, leukemogenesis involving immature b cells in the bloodstream can result from the uncontrolled growth and division of hematopoietic stem cells and immature lymphoblasts (the precursors to b cells).

关键词： Acute Lymphoblastic Leukemia IKAROS Dephosphorylation Philadelphia Chromosome CK2

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Recovery rates of persistent post-COvID-19 olfactory dysfunction using psychophysical assessment:A longitudinal cohort study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 79-87页

作者： Jeremy P.Tervo Patricia T.Jacobson brandon J.vilarello Tiana M.Saak Francesco F.Caruana Liam W.Gallagher Joseph b.Gary David A.Gudis Paule v.Joseph D.P.Devanand Terry E.Goldberg Jonathan b.Overdevest Columbia University vagelos College of Physicians and Surgeons New YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery New York-Presbyterian/Columbia University Irving Medical CenterNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery University of PittsburghPittsburghPennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery University of MinnesotaMinneapolisMinnesotaUSA National Institute of Alcohol Abuse and Alcoholism Section of Sensory Science and Metabolism&National Institute of Nursing ResearchBethesdaMarylandUSA New York-Presbyterian/Columbia University Irving Medical Center New YorkNew YorkUSA

Objectives:Persistent olfactory dysfunction(OD)following loss of smell associated with SARS-Cov-2 infection is a major feature of long *** on the prevalence of persistent OD predominantly rely on self-reported olfactory *** studies have tracked longitudinal rates of recovery using psychophysical assessment among patients presenting for evaluation of persistent OD beyond a window of acute *** anchored in standardized testing methods are needed to counsel patients who fail to acutely regain their sense of *** study aims to quantify the degree of persistent OD in post-COvID-19 patients who experience subjective and psychophysical ***:We grouped participants presenting for OD evaluation into cohorts based on both subjective and psychophysical olfactory status at a baseline assessment and assessed their olfactory abilities with a visual analogue scale and the Sniffin'Sticks extended test at baseline and 1-year time *** had confirmed a history of COvID-19 by lab evaluation or clinical diagnosis if lab evaluation was not ***:baseline olfactory evaluation was completed by 122 participants,53 of whom completed the 1-year follow-up *** participants presenting with perceived OD,74.5%had confirmed psychophysical OD at baseline,with 55.1%at 1-year *** had reliable trends in self-rated versus psychophysically tested olfactory function at both time *** total threshold,discrimination,and identification(TDI)score improved by+3.25 points in the cohort with psychophysical OD(p=0.0005),with this improvement largely attributable to an increase in median threshold scores(+2.75 points;p=0.0004).Conclusions:OD persists in a significant number of patients who fail to acutely recovery their sense of smell after COvID-19,with many demonstrating lingering deficits at *** in threshold,but not discrimination or identification,most significantly mediate improvement

关键词： long COvID olfaction post-COvID condition smell dysfunction

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