检索结果-南通市图书馆

Prospective Analysis of Patients Treated with Chemotherapy in Metastatic Adenocarcinoma of Lung—Single Centre Experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2017年第9期8卷 838-844页

作者： b. J. Srinivasa L. P. bhanu Girish badarke Mohammad Nasiruddin Sulav Sapkota D. Tousif Vishal Kulkarni P. K. Kiran Vinu Sarathy G. S. Deepika Amritanshu Ram Raghavendra Rao Shekar Patil Radheshyam naik Department of Medical Oncology HCG SC Bangalore India

background: Lung cancer is the leading cause of cancer-related death worldwide with an estimated 1.6 million new cases diagnosed each year. According to standard guidelines in NSCLC, the effectiveness of combined chemotherapy regimen comprises of pemetrexed and platinum, and very few reports are available in Indian population. This study shows the experience with pemetrexed and platinum combination chemotherapy in metastatic NSCLC in first line setting. Methods: Total 61 patients with following inclusion criteria were recruited such as: 1) PS of 1 and 2;2) NSCLC of non-squamous histology;3) locally advanced or metastatic disease at diagnosis;4) should have received minimum 3 cycles of pemetrexed and platinum as first line treatment and or continued for 6 cycles;5) EGFR/ALK mutated or EGFR/ALK unknown patients but must have received upfront chemo. Primary endpoint of the present study is to assess Disease Control Rate (DCR) (CR + PR + SD). Progression Free Survival, OS and Toxicity assessment were secondary endpoints. Results: The mean number of average chemotherapy cycles was found to be 4.38. The range of chemotherapy was 2 - 6 cycles. Disease control rate, defined as (CR + PR + SD), was seen in 44 (72.1%) patients. (PR in 26 (42.62%), SD 18 (29.5%)), Progressive disease (PD) was observed in 17 (27.9%) patients. Overall study showed that patients had PFS of 9.414 months (95% CI 6.709 - 12.120) and OS of 13.437 months (95% CI 10.721 - 16.153). Conclusion: Pemetrexed and platinum combination is effective and well-tolerated chemotherapy regimen in patients with metastatic adenocarcinoma lung cancer patients. Pemetrexed and cisplatin may be more effective in particular. Early switch over to TKIs is preferred immediately after obtaining molecular subtype result.

关键词： Pemetrexed Carboplatin NSCLC Cisplatin EGFR

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

印度Ispat CSP工厂生产优质热轧卷

钢铁 2004年第Z1期39卷 393-400页

作者： Fritz-Peter Pleschiutschnigg Vilas Vishnu Jamnis Sukhdev Raj Talwar Atul Kumar Misra Ratna Prasad V. Atluri R. b. Singh Prem shankar Rajendra K. Verma Rajesh K. Goyal Vidiya P. Mishra bidyapati Deepu b. Peter Meierling Joseph Pleschiutschnig United Steel Center Operations SIP&HSM Operations Steel Melt Shop Operations Caster Operations Process Quality Rolling Mill Operations 　　　　 Ispat Industries Ltd Ispat Industries Ltd

　　1998年,印度Ispat公司开始投产CSP生产线(图1).这个生产线原计划年产300万t热轧卷,年产210万t高炉提供铁水.Midren装置年产160万吨海绵铁.……

关键词：印度工厂生产热轧卷生产线海绵铁装置投产铁水高炉

Vegetative propagation of Dalbergia sissoo:effect of growth regulators,length,position of shoot and type of cuttings on rooting potential in stem cuttings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forestry Studies in China 2012年第3期14卷 187-192页

作者： bhupendra SINGH Rajendra YADAV b.P. bHATT Department of Forestry H.N.B.Garhwal UniversitySrinagar (Garhwal)Uttarakhand 246174India Chhattisgarh Minor Forest Produce Federation A-25VIP EstateKhamhardihShankar NagarRaipur 492007India ICAR Research Complex for Eastern Region PatnaBihar 800014India

The effect of auxins （IAA or IbA at 100, 200, 500 mg.L J） on rooting and sprouting parameters differed significantly （p 〈 0.05）. Rooting and sprouting percentages were higher in some treatments while other parameters were significantly higher in other treatments. The results of the present study revealed that rooting was significantly （p 〈 0.05） affected by the length of cuttings, as well as the position of shoots and type of cuttings. On average, 86.0 per cent rooting was observed in the 30-cm long cuttings com- pared to the other two lengths of cuttings, i.e., 20 and 25 cm, irrespective of any auxin treatment. In a control set, without any auxin treatment, a maximum of 60.0% rooting was recorded in the 30-cm long cuttings and a minimum of 40.0% of the cuttings rooted in the 20-cm long cuttings. Similarly, cuttings collected from the lower and upper portions of shoots resulted in 72.5 and 52.5 per cent rooting respectively, irrespective of auxin treatments. Maximum rooting was observed in the lower portion （40.0%） of cutting com- pared to the upper portion （30.0%） in the control set without auxin treatment. Leafless branches produced maximum （72.0%） rooting compared to the leafy cuttings （35.0%）, irrespective of the auxin treatment. The leafy cuttings produces a minimum of 15.0% sprout- ing and rooting in the control set.

关键词： auxin Dalbergia sissoo length position of shoots type of cuttings vegetative propagation

Effects of mother tree ages, different rooting mediums, light conditions and auxin treatments on rooting behaviour of Dalbergia sissoo branch cuttings

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2011年第1期22卷 53-57页

作者： bhupendra Singh Rajendra Yadav b. P. bhatt Department of Forestry Post Box No-59 H.N.B. Garhwal University Srinagar Garhwal - 246 174 Uttarakhand India Chhattisgarh Minor Forest Produce Federation A-25 VIP Estate Khamhardih Shankar Nagar Raipur- 492 007. ICAR Research Complex for NEH Region Nagaland Centre Medziphema- 797 106 Nagaland India

Dalbergia sissoo Roxb. is one of the promising multipurpose tree species of South Asia. Most of the plantations of D. sissoo from seeds are facing severe threats due to the die-back disease, which ultimately causes death of this potential tree-species within a few months. Vegetative propagation could avoid the die-back disease. Thirty mother trees of different age-groups of D. sissoo were selected for evaluating the rooting behaviour of branch cuttings from D. sissoo as influenced by auxins （IAA or IbA at 100, 200, 500 mg·L^-1）, ages of mother trees （10, 4 and 2 years old） and different environment conditions, i.e., different mediums （soil and sand） or light conditions （in shade and open condition）. The results show that application of IAA and IbA induced more numbers of cuttings （collected from 10-year-old mother trees） to root compared to control. branch cuttings of D. sissoo collected from 10-year-old mother trees and planted in soil bed in open conditions had 100.0% of cuttings to root in IAA （100 mg·L^-1） and IbA （200 mg·L^-1） treatments. both rooting medium （Soil and sand） influenced significantly （p〈0.05） on rooting response of branch cuttings. Soil medium was found to achieve maximum no. of branch cuttings to root, compared to sand medium.

关键词： Dalbergia sissoo hormonal treatments rooting medium shading vegetative propagation branch cutting

口腔医学生在自然光和日光灯下比色效果的对比研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国口腔医学继续教育杂志 2016年第2期19卷 55-58页

作者： Jitendra J.Mete shankar EDange Arun N.Khalikar Smita EVaidya 梁悦娥刘琦 shankar P.Dange Smita P.Vaidya 不详南方医科大学口腔医学院广州市广州大道北1838号510515

背景：视觉比色法常受到光源因素的影响，本研究的目的是比较口腔医学生分别在自然光和商用日光灯两种光源条件下的比色表现。材料和方法：准备两组陶瓷圆片。第一组是由Vitapan经典比色板系统中A2、A3、A3．5、b2、b3、C2、C3和D3八种... 详细信息

背景：视觉比色法常受到光源因素的影响，本研究的目的是比较口腔医学生分别在自然光和商用日光灯两种光源条件下的比色表现。材料和方法：准备两组陶瓷圆片。第一组是由Vitapan经典比色板系统中A2、A3、A3．5、b2、b3、C2、C3和D3八种颜色的陶瓷圆片组成。第二组是由A2、b2和C2三种颜色的陶瓷圆片组成，与第一组对应颜色的陶瓷圆片有非常相似的L＊a＊b＊值。要求40位口腔医学生分别在自然光和目光灯下从第一组中找出与第二组A2、b2和C2颜色最相似的。分别计算两种光源下每位参与者选择的颜色和陶瓷圆片实际颜色的平均色差值△E。采用配对t检验进行统计学分析。结果：在自然光下每位参与者选择的颜色和陶瓷圆片实际颜色的平均色差值△E范围为0～4．84，平均值为2．24；而在日光灯下的平均色差值△E范围为0～3．68，平均值为114。差异具有统计学意义（P〈0．0001）。结论：日光灯有利于提高口腔医学生的比色效果。

关键词：口腔医学生视觉比色法日光灯自然光统计学分析配对t检验色差值平均值

Delineation of Cavity in Downstream Surge Chamber at Punatsangchhu-II Hydroelectric Project, bhutan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geological Research 2019年第1期1卷 5-11页

作者： b.N.V.Siva Prasad A.P. Thapliyal Rabi bhusan Sripad R. naik Scientist National Institute of Rock MechanicsBengaluruIndia Senior Geologist Geological Survey of IndiaDehradunIndia

On 3^rd March, 2016, there occurred a massive roof fall incidence in one of the major caverns of Punatsangchhu-II Hydroelectric Project (PHEP-II), bhutan which halted the operations in the major caverns and required additional strengthening measures. Prior to concluding any thing on the treatment measures for the muck flown into the cavern and the cavity formed over the crown of Downstream Surge Chamber, there was a strong need to determine the extents of cavity. Even to understand the influence of cavity formation on adjacent caverns, the cavity needs to be delineated. Therefore, the management of PHEP-II adopted several techniques to decipher the shape and dimensions of the cavity like, surveying, geophysical, cross-hole seismic surveys, borehole scanning, and exploratory drilling. The tentative shape of the cavity could finally be established. The findings from each method are explained in this paper.

关键词： Cavity Large caverns Hydroelectric project Tomography Cavity monitoring system

水分胁迫情况下甘蔗叶片脯氨酸累积和活体内硝酸还原酶活性的遗传

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

福建甘蔗 2004年第2期 42-44页

作者： R．M．naik b．S．Kadam R．A．Pandhare S．M．Pawar R．C．Patil P.G．bhoi 陈玉水中央甘蔗研究站，Padegaon 不详

评价了以甘蔗品种Co740和Co671作为父本或母本杂交选育的几个甘蔗品系在水分胁迫下叶片渗透保护剂脯氨酸和叶片体内硝酸还原酶活性的遗传。结果表明，在水分胁迫下，抗旱耐盐甘蔗品种Co740的叶片脯氨酸含量比Co671高，叶片硝酸还原酶活... 详细信息

评价了以甘蔗品种Co740和Co671作为父本或母本杂交选育的几个甘蔗品系在水分胁迫下叶片渗透保护剂脯氨酸和叶片体内硝酸还原酶活性的遗传。结果表明，在水分胁迫下，抗旱耐盐甘蔗品种Co740的叶片脯氨酸含量比Co671高，叶片硝酸还原酶活性比Co671低，而且，以Co740作为母本的甘蔗杂种的叶片脯氨酸含量也比较高，叶片硝酸还原酶活性也比较低。从同样都以Co671作为父本的甘蔗杂种Co86032与Co94014之间抗旱性的不同或许可以认为所用母本的抗旱性具有天然遗传潜力。

关键词：水分胁迫甘蔗叶片脯氨酸硝酸还原酶遗传品系

Physical Activity, Mediterranean Diet and biomarkers-Assessed Risk of Alzheimer’s: A Multi-Modality brain Imaging Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Molecular Imaging 2014年第4期4卷 43-57页

作者： Dawn C. Matthews Michelle Davies John Murray Schantel Williams Wai H. Tsui Yi Li Randolph D. Andrews Ana Lukic Pauline McHugh shankar Vallabhajosula Mony J. de Leon Lisa Mosconi ADM Diagnostics Chicago USA Department of Psychiatry New York University School of Medicine New York USA Citigroup biomedical Imaging Center Weill Cornell Medical College New York USA

Increased physical activity and higher adherence to a Mediterranean-type diet (MeDi) have been independently associated with reduced risk of Alzheimer’s disease (AD). Their association has not been investigated with the use of biomarkers. This study examines whether, among cognitively normal (NL) individuals, those who are less physically active and show lower MeDi adherence have brain biomarker abnormalities consistent with AD. Methods: Forty-five NL individuals (age 54 ± 11, 71% women) with complete leisure time physical activity (LTA), dietary information, and cross-sectional 3D T1-weigthed MRI, 11C-Pittsburgh Compound b (Pib) and 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans were examined. Voxel-wise multivariate partial least square (PLS) regression was used to examine the effects of LTA, MeDi and their interaction on brain biomarkers. Age, gender, ethnicity, education, caloric intake, bMI, family history of AD, Apolipoprotein E (APOE) genotype, presence of hypertension and insulin resistance were examined as confounds. Subjects were dichotomized into more and less physically active (LTA+ vs. LTA-;n = 21 vs. 24), and into higher vs. lower MeDi adherence groups (n = 18 vs. 27) using published scoring methods. Spatial patterns of brain biomarkers that represented the optimal association between the images and the groups were generated for all modalities using voxel-wise multivariate Partial Least Squares (PLS) regression. Results: Groups were comparable for clinical and neuropsychological measures. Independent effects of LTA and MeDi factors were observed in AD-vulnerable brain regions for all modalities (p β load and lower glucose metabolism) were observed in LTA- compared to LTA+ subjects, and in MeDi- as compared to MeDi+ subjects. A gradient effect was observed for all modalities so that LTA+/MeDi+ subjects had the highest and LTA+/MeDi+ subjects had the lowest AD-burden (p < 0.001), although the LTA × MeDi interaction was significant

关键词： Alzheimer’s Disease Mediterranean Diet Physical activity PET Imaging Amyloid Glucose Metabolism MRI Early Detection brain Aging

FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer’s Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Molecular Imaging 2014年第2期4卷 15-26页

作者： John Murray Wai H. Tsui Yi Li Pauline McHugh Schantel Williams Megan Cummings Elizabeth Pirraglia Lilja Solnes Ricardo Osorio Lidia Glodzik shankar Vallabhajosula Alexander Drzezga Satoshi Minoshima Mony J. de Leon Lisa Mosconi New York University School of Medicine New York USA University of Cologne Cologne Germany University of Washington Seattle USA Weill Cornell Medical College New York USA

Having a parent affected by late-onset Alzheimer’s disease (AD) is a major risk factor for cognitively normal (NL) individuals. This study explores the potential of PET with 18F-FDG and the amyloid-β (Aβ) tracer 11C-Pittsburgh Compound b (Pib) for detection of individual risk in NL adults with AD-parents. Methods: FDG- and Pib-PET was performed in 119 young to late-middle aged NL individuals including 80 NL with positive family history of AD (FH+) and 39 NL with negative family history of any dementia (FH-). The FH+ group included 50 subjects with maternal (FHm) and 30 with paternal family history (FHp). Individual FDG and Pib scans were Z scored on a voxel-wise basis relative to modality-specific reference databases using automated procedures and rated as positive or negative (+/-) for AD-typical abnormalities using predefined criteria. To determine the effect of age, the cohort was separated into younger (49 ± 9 y) and older (68 ± 5 y) groups relative to the median age (60 y). Results: Among individuals of age >60 y, as compared to controls, NL FH+ showed a higher frequency of FDG+ scans vs. FH- (53% vs. 6% p b+ scans (27% vs. 11%;p = 0.19). This effect was observed for both FHm and FHp groups. Among individuals of age ≤60 y, NL FHm showed a higher frequency of FDG+ scans (29%) compared to FH- (5%, p = 0.04) and a trend compared to FHp (11%) (p = 0.07), while the distribution of Pib+ scans was not different between groups. In both age cohorts, FDG+ scans were more frequent than Pib+ scans among NL FH+, especially FHm (p b status was significantly less successful. Conclusions: Automated analysis of FDG- and Pib-PET demonstrates higher rates of abnormalities in at-risk FH+ vs FH-subjects, indicating potentially ongoing early AD-pathology in this population. The frequency of metabolic abnormalities was higher than that of Aβ pathology in the younger c

关键词： Alzheimer’s Disease Early Detection Positron Emission Tomography Amyloid Imaging Glucose Metabolism Normal Aging