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Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia D.V.Mashtalyar M.A.Piatkova A.I.Pleshkova I.M.Imshinetskiy M.s.Gerasimenko E.A.belov V.V.Kumeiko D.N.Kozyrev K.A.Fomenko V.V.Mostovaya b.R.Torpanov A.R.biktimirov I.s.Osmushko s.L.sinebryukhov s.V.Gnedenkov Institute of Chemistry FEb RAs 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmunsky National scientific Center of Marine biology FEb RAs 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical Dermatovenerological Dispensary 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic vancomycin,widely used in the treatment of infections caused by staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to sEM,EDs,XRD and XPs data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PEO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： bioactive coatings biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite Vancomycin

Antibodies Targeting a Conserved surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing b-1-6-Linked Poly-N-Acetylglucosamine(PNAG)

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Engineering 2024年第7期38卷 69-76页

作者： Xi Lu Guoqing Li Jing Pang Xinyi Yang Colette Cywes-bentley Xuefu You Gerald b.Pier beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

The b-1-6-linked poly-N-acetylglucosamine(PNAG)polymer is a conserved surface polysaccharide produced by many bacteria,fungi,and protozoan(and even filarial)*** wide-ranging expression makes PNAG an attractive target for vaccine development,as it potentially encompasses a broad range of *** progress has been made in discovering important properties of the biology of PNAG expression in recent *** molecular characterization and regulation of operons for the production of PNAG biosynthetic proteins and enzymes have been studied in many *** addition,the physiological function of PNAG has been further ***-based vaccines and PNAG-targeting antibodies have shown great efficacy in preclinical ***,clinical tests for both vaccines and antibodies have been carried out in humans and economically important animals,and the results are *** it is not destined to be a smooth road,we are optimistic about new vaccines and immunotherapeutics targeting PNAG becoming validated and eventually licensed for clinical use against multiple infectious agents.

关键词： Poly-N-acetylglucosamine Conjugate vaccine Monoclonal antibody

CompactChain:an efficient stateless chain for UTXO-model blockchain

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Frontiers of Computer science 2024年第2期18卷 167-179页

作者： b swaroopa REDDY T Uday Kiran REDDY Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UTXO(Unspent Transaction Output)based blockchain systems into two RsA *** first accumulator is called Transaction Output(TXO)commitment which represents the TXO *** second one is called spent Transaction Output(sTXO)commitment which represents the sTXO *** this work,we discuss three algorithms:(i)To update the TXO and sTXO commitments by the *** miner also provides the proofs for the correctness of the updated commitments;(ii)To prove the transaction’s validity by providing a membership witness in TXO commitment and non-membership witness against sTXO commitment for a coin being spent by a user;(iii)To update the witness for the coin that is not yet spent;The experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the *** compare the performance of CompactChain with the existing state-of-the-art works on stateless *** shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(Transactions per second(TPs)).

关键词： stateless blockchain RsA Accumulator sTXO commitment TXO commitment UTXO Non-interactive Proof of Exponentiation(NI-PoE) Transactions per second(TPs)

Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG school of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

Old-growth mixed dipterocarp forests show variable losses and gains in aboveground biomass and standing carbon over forty years

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Forest Ecosystems 2024年第1期11卷 14-23页

作者： sisira Ediriweera Champika bandara Tithira Lakkana shanika Jayasinghe David Woodbury Arun Dayanandan b.M.P.singhakumara Xiangcheng Mi I.A.U.N.Gunatilleke C.V.s.Gunatilleke Mark sAshton Department of science and Technology Uva Wellassa UniversityBadullaSri Lanka The Forest school Yale School of the EnvironmentYale UniversityNew HavenCT06511USA Department of Forestry and Environmental science University of Sri JayewardenepuraNugegodaSri Lanka state Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing100093China botany Department University of PeradeniyaPeradeniyaSri Lanka

background:No studies have documented long-term trends in aboveground biomass(AGb)for mixed-dipterocarp forests(MDF),the dominant rain forest type in tropical wet equatorial *** our study,we sought to document such trends over forty years across three sites representing lowland to lower montane ***:To do this,we established fifty 100 m×25 m plots in 1978 across three sites sampled along an elevation gradient,identified as mature old-growth *** measured trees for diameter at breast height that we identified to species and *** took wood samples to calculate species wood-specific *** re-measured plots in 1998 and again in ***:We show standing AGb for all sites combined to be 517.52 Mg·ha^(-1)in 1978,but this declined by 17%over 40 years to 430.11 Mg·ha^(-1).No differences exist among sites in AGb primarily because of considerable within site variation;but interactions of time with site show declines across sites were not uniform,one remained about the *** few species represented a high proportion of the AGb with the top five species comprising between 34%and 65%,depending upon site and year *** species,Mesua nagassarium,represented a disproportionately large amount of AGb and decline over time,particularly at the low elevation ***:Our results are directly relevant to estimating AGb and standing carbon sequestered in *** study is the first to demonstrate varying but overall,declining trends in amounts of AGb among forests making predictions of biomass and standing carbon in MDF difficult over wide regions.

关键词： Western ghats shorea spp. southeast Asia sri Lanka Tropical rain forest Wood specific gravity

An update on hormonal regulation of early embryo-fallopian tube interactions: insights for improvements of assisted reproductive technology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku suranga P. Ng Ernest H. Y. Yeung William s. b. Lee Kai-Fai Department of Obstetrics and Gynaecology LKs Faculty of Medicine 3. The University of Hong Kong 4. Hong Kong sAR 999077 5. China

Human fallopian tubes (FTs) play important roles in the whole reproductive process. FTs are the site for the final maturation of gametes, fertilization, transport of preimplantation embryos, and early embryonic development before entering the uterus. All these functions are critical in the establishment of a successful pregnancy. When the embryo is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which involve various hormones and bioactive substances mainly from the neighboring cells. Therefore, the interactions between the embryo and the FT may be the earliest embryo-maternal communications that are essential for the establishment of pregnancy. This review critically discusses the evidence of various hormonal and bioactive mediated control of the microenvironment in the FTs during the earliest embryo-maternal communications. Moreover, we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality embryos for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

On the Features of Thermal Convection in a Compressible Gas

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Fluid Dynamics & Materials Processing 2024年第5期20卷 957-974页

作者： Igor b.Palymskiy Physics Department Siberian State University of Telecommunications and Information SciencesNovosibirsk City630102Russia Physics Department Siberian State University of Geosystems and TechnologiesNovosibirsk City630108Russia

The fully nonlinear equations of gas dynamics are solved in the framework of a numerical approach in order to study the stability of the steady mode of Rayleigh-bénard convection in compressible,viscous and heat-conducting gases encapsulated in containers with no-slip boundaries and isothermal top and bottom *** initial linear temperature profile is assumed.A map of the possible convective modes is presented assuming the height of the region and the value of the temperature gradient as influential *** a relatively small height,isobaric convection is found to take place,which is taken over by an adiabatic mode when the height exceeds the critical value,or by a super-adiabatic mode in case of a relatively high temperature *** the adiabatic mode,convective flow develops due to adiabatic processes given a stable initial *** analytic formula for the critical height of the region is derived taking into account and neglecting the dependence of the gas viscosity on the ***,an analytic formula is obtained for the upper boundary of the region of applicability of the boussinesq approximation for incompressible *** models for compressible gases are relevant to practical situations such as the study of convective flows in spatially extended gas mixtures when dealing with safety issues related to hydrocarbons stored in gas stations.A dangerous situation arises when the tank is almost empty but some hydrocarbon is left at the bottom of the *** the presence of convective flows,the vaporized fuel is mixed with the oxidizer(air)forming a gas-vapor ***,if the volumetric concentration of fuel vapor(hydrocarbon)is in the interval between the lower and upper concentration limits of ignition,then the gas-vapor mixture becomes explosive and any accidental spark is sufficient to cause an emergency.

关键词： Rayleigh-bénard convection gas stable stratification unstable stratification temperature gradient

stromal cell decidualization and embryo implantation: a vulnerable step leading to successful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang sudini R.Fernando suranga P.Kodithuwakku Dandan Cao William s.b.Yeung Kai-Fai Lee Department of Obstetrics and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal science Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal science Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-shenzhen Hospital Shenzhen 518053China

Endometrial stromal cell decidualization is a crucial step in endometrial remodeling during *** is controlled by orchestrated ovarian hormones,followed by the activation of various downstream signaling *** evidence has shown multiple functions of decidualized endometrial stromal cells during embryo implantation,including tissue remodeling,antioxidative stress,angiogenesis,and immune *** distinct secretomes of decidualized stromal cells also reveal their intensive interactions with epithelial,endothelial,and immune ***,aberrant decidualization leads to pregnancy failures,such as recurrent pregnancy loss and repeated implantation *** review aimed to provide an overview of the molecular mechanisms underlying the divergent functions of decidualized endometrial stromal cells and their potential clinical ***,the use of single-cell RNA sequencing data further enhances our understanding of these biological *** review discusses decidualization-related signaling pathways that serve as potential therapeutic targets for treating implantation failure in in vitro fertilization and provides novel approaches to investigate the underlying causes of female infertility.

关键词： Endometrial stromal cell Decidualization Embryo implantation Recurrent pregnancy loss Repeated implantation failure

sANC Monte Carlo programs for small-angle bhabha scattering

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Chinese Physics C 2024年第4期48卷 14-19页

作者： A.b.Arbuzov s.G.bondarenko I.R.boyko L.V.Kalinovskaya A.A.Kampf R.R.sadykov V.L.Yermolchyk bogoliubov Laboratory of Theoretical Physics JINRDubna141980 Russia Dzhelepov Laboratory of Nuclear Problems JINRDubna141980 Russia Dubna state University Dubna141982 Russia

Luminosity monitoring at e^(+)e^(−)colliders was investigated using sANC Monte Carlo event generator RenesANCe and integrator MCsANC for simulation of bhabha scattering at low *** are presented for center-of-mass energies of the Z boson resonance and at 240 GeV for the conditions of typical luminosity *** is shown that bremsstrahlung events with extremely low electron scattering angles are relevant to match the precision tags of future electron-positron colliders.

关键词： luminosity bhabha scattering QED Monte Carlo simulation