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多发性硬化症患者急性加重甲基泼尼松龙治疗前后中枢运动传导缺陷的量化

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 40-41页

作者： Humm A.M. Z'Graggen W.J. bühler R. K.M. Rsler 郭中孟 Department of Neurology Inselspital CH-3010 Bern Switzerland Prof.

Objective: To compare the effects of intravenous methylprednisolone (IVMP) in patients with relapsing-remitting (rr-MS), secondary progressive (SP-MS), and primary progressive multiple sclerosis (PP-MS). Methods: Clinical and neurophysiological follow up was undertaken in 24 rr-MS, eight SP-MS, and nine PP-MS patients receiving Solu-Medrol 500 mg/d over five days for exacerbations involving the motor system. Motor evoked potentials (MEPs) were used to measure central motor conduction time (CMCT) and the triple stimulation technique (TST) was applied to assess conduction deficits. The TST allows accurate quantification of the number of conducting central motor neurones, expressed by the TST amplitude ratio. Results: There was a significant increase in TST amplitude ratio in rr-MS (p ble at two months. In PP-MS, TST amplitude ratio and muscle force did not change. CMCT did not change significantly in any of the three groups. Conclusions: In rr-MS and SP-MS, IVMP is followed by a prompt increase in conducting central motor neurones paralleled by improvement in muscle force, which most probably reflects partial resolution of central conduction block. The lack of similar clinical and neurophysiol ogical changes in PP-MS corroborates previous clinical reports on limited IVMP efficacy in this patient group and points to pathophysiological differences underlying exacerbations in PP-MS.

关键词：中枢运动传导时间甲基泼尼松龙多发性硬化症治疗前后患者急性加重神经生理学运动神经元

牛蒡子粉中牛蒡苷元在仔猪体内的药物动力学研究

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中国兽药杂志 2020年第7期54卷 48-54页

作者：冉志平吴利军杨文海陈洁陈夏冰邵志勇金尔光周华童伟文李杰何斌武汉市农业科学院畜牧兽医研究所武汉430208

为研究牛蒡子粉中牛蒡苷元在仔猪体内的药物动力学特征,了解其在仔猪体内的吸收、分布、转化和排泄规律,为新兽药的研发和临床用药提供理论参考依据。选取健康仔猪8头(30.0±5.0 kg),以1.0 g/kg·bw的牛蒡子粉灌胃给药,不同时间点前腔... 详细信息

为研究牛蒡子粉中牛蒡苷元在仔猪体内的药物动力学特征,了解其在仔猪体内的吸收、分布、转化和排泄规律,为新兽药的研发和临床用药提供理论参考依据。选取健康仔猪8头(30.0±5.0 kg),以1.0 g/kg·bw的牛蒡子粉灌胃给药,不同时间点前腔静脉采血,采用HPLC法对猪血浆中牛蒡苷元的浓度进行分析。牛蒡子粉灌胃给药后,符合有吸收二室模型,主要药物动力学参数为:吸收半衰期(t 1/2 ka)为0.274±0.102 h,分布半衰期(t 1/2α)1.435±0.725 h;消除半衰期(t 1/2β)63.467±29.115 h;表观分布容积(V d)1.680±0.402 L/kg;清除率(CL b)0.076±0.028 L/(h·kg);达峰时间(t max)为0.853±0.211 h,峰浓度(c max)为0.430±0.035μg/mL,药时曲线下面积(AUC)14.672±4.813μg·h/mL。试验表明:牛蒡子粉口灌后牛蒡苷元在仔猪体内吸收迅速、分布广泛、代谢消除缓慢,能够较长时间发挥药理作用。

关键词：牛蒡子粉牛蒡苷元仔猪药物动力学

三面共振反射器耦合Nd∶YAG振荡器获得光滑调Q脉冲

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中国激光 2001年第12期28卷 1063-1065页

作者：何伟明吕志伟哈尔滨工业大学光电子技术研究所哈尔滨150001

光学共振反射器作为Nd∶YAG振荡器的耦合输出腔镜,具有很强的选纵模能力,三面共振反射器具有规则的反射峰调制结构。为获得稳定的单纵模光滑脉冲输出,理论上对振荡器结构参数作了优化设计,并指出振荡器宜在阈值附近工作,以充分发挥共振... 详细信息

光学共振反射器作为Nd∶YAG振荡器的耦合输出腔镜,具有很强的选纵模能力,三面共振反射器具有规则的反射峰调制结构。为获得稳定的单纵模光滑脉冲输出,理论上对振荡器结构参数作了优化设计,并指出振荡器宜在阈值附近工作,以充分发挥共振反射器的选纵模能力。实验上振荡器获得了 17mJ的光滑单纵模脉冲,光滑脉冲出现几率大于 97%

关键词：共振反射器 Nd:YAG振荡器光滑调Q脉冲

脑钠积累的分布与多发性硬化功能障碍的关系:23NaMR横断面的成像研究

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国际医学放射学杂志 2012年第6期 582-583页

作者： W.Zaaraoui S.Konstandin b.Audoin A.M.Nagel A.Rico I.Malikova 卢平明郑晶晶 CRMbM no.7339Aix-Marseille UniversityCNRSMarseilleFrance

摘要目的通过23NaMR成像,在复发-缓解型多发性硬化(rr MS)的不同阶段定量分析脑钠积累并首次描述钠异常的空间位置的特征。材料与方法该研究由当地伦理委员会批准,所有参与者均签署知情同意书

关键词：多发性硬化功能障碍 NaMR

QTL analysis for ascorbic acid content in strawb.rry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler björn Usadel Wilfried Schwab béatrice Denoyes bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya Centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced biotechnology Universidad de Málaga29071MálagaSpain Finca el Cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&Co.KG 01108DresdenGermany INVENIO 33800BordeauxFrance biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural Crop breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de biología Molecular y bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-CSIC biotecnología y Mejora en Fresa 29010MálagaSpain.

Strawb.rry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawb.rry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5b,LG 6b and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawb.rry cultivars with increased AsA content.

关键词： straw cultivar content

Intravenous immune globulin suppresses angiogenesis in mice and humans

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma benjamin J Fowler Charles b Wright Ivana Apicella Adelaide Greco Arturo brunetti balamurali K Ambati Sevim barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek bradley D Gelfand Ana bastos-Carvalho Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly bio-Ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc ***,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human Fcγ***,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of IVIg on blood vessels.

关键词： doses inhibited degeneration

日常实践中的乳腺X线摄影筛查：数字乳腺断层成像和数字乳腺摄影的多中心研究

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国际医学放射学杂志 2023年第4期 476-476页

作者： E.F.Conant M.M.Talley C.R.Parghi b.C.Sheh S.Y.Liang S.Pohlman 张凯

摘要随着研究显示更低的召回率（rr）和更高的癌症检出率（CDR），数字乳腺断层成像（DbT）的使用正在超过数字乳腺摄影（DM）。然而，对乳腺X线摄影风险和益处的证据

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血压正常受试者发生卒中的危险因素:前瞻性队列研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 51-51页

作者： Engstrm G. Hedblad b. 王晓琳

background and Purpose:Although stroke is strongly associated with hypertensi on, some individuals with normal blood pressure (bP) experience a stroke. This p rospective study explored risk factors for stroke in subjects with normal *** hods:A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort *** bP was defined as bP bP. Of the m, 56 patients experienced a first ever stroke (12%of all stroke). Compared wit h subjects without stroke during follow-up, these stroke subjects were older, h ad lower education, were often smokers and alcohol nondrinkers,and had a history of coronary heart disease (CHD), gastric ulcer,or renal calculus. Subjects with stroke had a higher body mass index (bMI) and a high-normal bP (130 to 139/85 to 89 mmHg) more often. In a backward step wise Cox-regression analysis,age (pe r 1 year; relative risk [rr], 1.12), current smoking(rr, 3.21), bMI (per SD; rr, 1.39), high-normal diastolic bP (rr, 2.35), history of CHD (rr, 4.92), and gas tric ulcer(rr, 2.21) remained significantly associated with incidence of stroke. Conclusion -In subjects with normal bP, there are a number of potentially modi fiable risk factors associated with an increased incidence of stroke.

关键词：前瞻性队列研究正常受试者卒中发病率肾结石病 potentially incidence cohort alcohol backward smoking

急性A型主动脉夹层的早期和晚期预后:487例连续病例危险因素的分析

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 45-45页

作者： Chiappini b. Schepens M. Tan E. 任付先 Department of Cardiovascular Surgery Policlinico S.Orsola- Malpighi via Massarenti 9 40138 Bologno Italy

Aims: The purpose of this retrospective study was to assess the risk factors for the early and late outcome of the surgical treatment of acute typeA aortic dissection, in terms of mortality and morbidity. Methods and results: From 1976 to 2003, 487 patients with acute type A aortic dissection treated surgically were enrolled. Twenty- five pre- operative and intra- operative variables were analysed to identify conditions influencing early and late morbidity and early mortality. The in- hospital mortality rate including operative death was 22% (107 patients). Multivariable analysis indicated that pre- existing cardiac disease(rr=3.7, 95% CI=1.8- 7.4) and cardiopulmonary resuscitation(rr=6.8, 95% CI=2.3- 20.2) were independent predictors of in- hospital death. The causes of in- hospital mortality were low cardiac output in 32 patients(6.6% ), major brain damage in 24 patients(5.9% ), haemorrhage in 11 patients(2.2% ), sepsis in nine patients(1.8% ), visceral ischaemia in eight patients(1.6% ), multiple organ failure in seven patients(1.4% ), rupture of the thoracic aorta in six patients(1.2% ), respiratory failure in six patients(1.2% ), and four intra- operative deaths. The follow- up was 100% complete. The actuarial survival was 94.9± 1.2% and 88.1± 2.6% , at 5 and 10 years, respectively. Conclusions: Patients pre- operative co- morbidities and dissection- related complications significantly affect early and late survival and morbidity after surgical treatment of acute type A aortic dissection.

关键词：主动脉夹层心肺复苏脓毒症早期死亡率心输出量呼吸衰竭胸主动脉多器官衰竭多因素分析