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普通人群胸主动脉壁厚度的MRI参考值测定

国际医学放射学杂志 2014年第6期 592-592页

作者： b.Mensel A.Quadrat T.Schneider J.P.Kühn M.Drr H.Vlzke 陈永林 Institute of Diagnostic Radiology and Neuroradiology University Medicine GreifswaldFerdinand-Sauerbruch-Straβe17475 GreifswaldGermany

摘要目的针对不同年龄及性别的普通人群,提供升主动脉和降主动脉管壁厚度的MRI测量参考值。方法本研究共纳入年龄为21～81岁之间的受试者753名(女性311

关键词：参考值降主动脉壁厚主动脉降部主动脉升部主动脉壁普通人群 MRI

他汀类药物、血管紧张素转换酶抑制剂和血管紧张素受体阻断剂降低慢性阻塞性肺病患者的发病率和死亡率

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 52-53页

作者： Mancini G.b.J. Etminan M. 马超 Division of Cardiology Vancouver Hospital Jack Bell Research Centre Vancouver BC Canada Dr.

Objectives: The purpose of this study was to determine if statins(hydroxymethylglutaryl CoA reductase inhibitors[HMG-CoA]), angiotensin-converting enzyme(ACE) inhibitors, and angiotensin receptor blockers(ARbs) reduce cardiovascular(CV) events and pulmonary morbidity in chronic obstructive pulmonary disease(COPD) patients. background: Few current COPD therapies alter prognosis. Although statins, ACE inhibitors, and ARbs improve outcomes in CV populations, their benefits in COPD patients both with and without concomitant heart disease has not previously been studied. Methods: A time-matched nested case-control study of two population-based retrospective cohorts was undertaken: 1) COPD patients having undergone coronary revascularization(high CV risk cohort); and 2) COPD patients without previous myocardial infarction (MI) and newly treated with nonsteroidal anti-inflammatory drugs(low CV risk cohort). Prespecified outcomes were COPD hospitalization, MI, and total mortality. Results: These drugs reduced both CV and pulmonary outcomes, with the largest benefits occurring with the combination of statins and either ACE inhibitors or ARbs. This combination was associated with a reduction in COPD hospitalization(risk ratio[rr] 0.66, 95%confidence interval[CI] 0.51 to 0.85) and total mortality(rr 0.42, 95%CI 0.33 to 0.52) not only in the high CV risk cohort but also in the low CV risk cohort(rr 0.77, 95%CI 0.67 to 0.87, and rr 0.36, 95%CI 0.28 to 0.45, respectively). The combination also reduced MI in the high CV risk cohort(rr 0.39, 95%CI 0.31 to 0.49). benefits were similar when steroid users were included. Conclusions: These agents may have dual cardiopulmonary protective properties, thereby substantially altering prognosis of patients with COPD. These findings need confirmation in randomized clinical trials.

关键词：慢性阻塞性肺病血管紧张素受体阻断剂他汀类药物肺部疾患联合用药临床结局疾病人群随机临床

早产双胞胎发生囊性脑室周围白质软化症的研究

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世界核心医学期刊文摘（儿科学分册） 2005年第2期1卷 14-15页

作者： Resch b. Jammernegg A. Vollaard E. 李开 Dr.Division of NeonatologyDepartment of Paediatrics University Hospital GrazAuenbruggerplatz 308036 GrazAustria

目的:明确双胞胎早产儿发生囊性脑室周围白质软化症(PVL)的风险因素。试验设计:回顾性病例对照研究。机构:奥地利Graz市第三护理大学附属医院儿科学系新生儿科。受试者:收集该院1988-2000年间的早产双胞胎病例。

关键词：儿科学附属医院脑室周围白质低碳酸血症病例对照研究新生儿科窘迫综合征出生后超声扫描试验设计

FADD mediated activation of an apoptosis program in bovine follicular granulosa cells in vitro

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FADD mediated activation of an apoptosis program in bovine f...

Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level

中国畜牧兽医学会养牛学分会2011年学术研讨会

作者： Run-jun Yang~(1,2),Jun-ya Li~2,Xue Gao~2,Zhi-hui Zhao~1,Lu-pei Zhang~2, Hui-jiang Gao~2,Shang-zhong Xu~(2*) 1 College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,rr.China. 2 Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Yuanmingyuan West Road no.2 Haidian District,beijing 100193,P.R.China

Fas-associated death domain(FADD) is a signal connection protein in the Fas/FasL system,which may play a key role in *** atresia and luteolysis are thought to occur by *** reveal the intracellular signal transduction molecules involved in the process of follicular development in the bovine *** was accomplished by cloning the FADD gene using RT-PCR,deleting the termination codon in its cDNA,and directionally cloning the amplified FADD gene into the eukaryotic expression vector *** pAcGFP-bFADD recombinant plasmid was then transfected into bovine follicular granulosa cells by using lipofectamine *** of AcGFP was observed under fluorescent microscopy and the transcription and expression of FADD was detected by RT-PCR and *** the methyl-tetrazolium(MTT) assay was performed to determine the growth inhibition of *** apoptosis was observed by using Hoechst33342 staining and DNA-Ladder *** results showed that the pAcGFP-bFADD recombinant plasmid was successfully *** expression was detected as early as 24 h after transfection.A 654 bp fragment was amplified by RT-PCR and a 51.4 kD target protein was detected by Western-blot,cells viability decreased significantly at 72 h after transfection,and the apoptosis rate of the cells transfected with pAcGFP-FADD was significantly higher than the control *** in the FADD transfection group showed ladder patterns characteristic of apoptosis,and the nuclei were shrunken and densely hyperchromatic or fragmented,suggesting that FADD is capable of inhibiting the proliferation of bovine follicular granulosa cells and inducing cell apoptosis when over-expressed.

关键词： FADD bovine follicle Apoptosis Granulosa cell

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Light(Science & Applications) 2013年第1期2卷 154-162页

作者： Zhen Ma Qiuying Liu Huaxiao Yang Raymond b Runyan Carol A Eisenberg Meifeng Xu Thomas K borg Roger Markwald Yifei Wang bruce Z Gao Department of bioengineering and COMSET Clemson UniversityClemsonSC 29634USA Department of bioengineering University of CaliforniaBerkeleyBerkeleyCAUSA biomedical R&D Center Jinan UniversityGuangzhouChina Department of Cellular and Molecular Medicine University of ArizonaTucsonAZ 85724USA New York Medical College/Westchester Medical Center Stem Cell Laboratory New York Medical CollegeValhallaNew YorkUSA Department of Pathology and Laboratory Medicine University of Cincinnati Medical CenterCincinnatiOHUSA Department of Regenerative Medicine and Cell biology Medical University of South CarolinaCharlestonSCUSA

Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical *** to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte *** conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell ***,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur ***,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological *** this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic ***,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions.

关键词： cardiogenic differentiation mesenchymal stem cells microenvironment optical force single-cell analysis

白人、黑人和西班牙人深部和颞叶脑内出血的发生率

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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 55-56页

作者： Labovitz D.L. Halim A. boden-Albala b. 史焕昌 Dr.Stroke Center 1111 Amsterdam Avenue New York NY 10025 United States

background: black and Hispanic Americans have a greater risk of primary intracerebral hemorrhage (ICH) than whites. Deep ICH is most often associated with hypertension, while lobar ICH is associated with cerebral amyloid angiopathy. The authors conducted a population-based incidence study to directly compare the incidence of deep vs lobar ICH in all three raceethnic groups. Methods: The authors used an active hospital and community surveillance program and autopsy reports to identify incident ICH cases among white, black, and Caribbean Hispanic adults in Northern Manhattan between July 1993 and June 1997. Incidence rates were adjusted for age and sex to the 1990 US Census. CIs for risk ratios (rr) were calculated with byar’s χ2 approximation of the Poisson distribution. Results: The authors identified 155 cases of ICH for an annual incidence of 30.9/100,000 (26.7 to 35.0). Men had a higher risk of ICH than women (rr 1.5, 95%CI 1.2 to 1.8), driven entirely by the incidence of deep ICH (rr 1.8) rather than lobar ICH (rr 1.0). Compared with whites, rr for blacks was all ICH 3.8 (2.2 to 8.9), deep 4.8 (2.3 to 21.1), lobar 2.8 (1.2 to 14.4); rr for Hispanics was all 2.6 (1.4 to 6.1), deep 3.7 (1.7 to 16.5), lobar 1.4 (0.4 to 7.4). Conclusions: ICH is a heterogeneous disease with deep and lobar subtypes distinguishable on an epidemiologic basis. The different patterns of these two subtypes in our race-ethnically diverse population lend credence to the notion that ICH should no longer be treated as a single entity.

关键词：脑内出血脑淀粉样血管病西班牙人发病风险监督计划尸检报告人口普查资料异质性疾病泊松分布美国黑人

未感染的分娩产妇预防性应用抗生素的时机:一项临床随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 5-6页

作者： Thigpen b.D Hood W.A Chauhan S 朱国栋 Department of Obstetrics and Gynecology University of Mississippi Medical Center Jackson MS United States.Dr

Objective: The purpose of this prospective study was to determine whether the timing of prophylactic antibiotics at cesarean delivery influences maternal/neonatal infectious morbidity. Study design: In this double- blind placebo- controlled trial, cefazolin was given at skin incision (group A) or at cord clamping (group b). Patients were eligible for the trial if they had labored and required a cesarean delivery. Results: Over a 30- month period 303 patients with singleton pregnancies entered the trial; 153- group A, 149- group b. Demographics, indication for cesarean delivery (P =. 54), and operative time (P =. 999), as well as rates of endometritis (rr 0.67, 95% CI 0.42- 1.07), wound infection (rr 0.84, 95% CI 0.45- 1.55), neonatal sepsis (rr 1.28, 95% CI 0.91- 1.79), and NICU admissions (rr 1.28, 95% CI 0.91- 1.79) were similar between the 2 groups. Conclusion: There was no difference in maternal infectious morbidity whether antibiotics were given before skin incision or at cord clamping.

关键词：剖宫产分娩随机试验新生儿感染脐带结扎单胎妊娠手术时间产褥期感染脓毒症入住时间重症监护

AMD进展与C反应蛋白、白介素6及其他心血管生物标记间的前瞻性研究

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 29-30页

作者： Seddon J.M George S Rosner b Rifai N 潘佳鸿 EpidemiologyUnit Massachusetts Eye and Ear Infirmary 243 Charles St Boston MA 02114 United States.Dr

background: Age-related macular degeneration (AMD) and cardiovascular disease share common risk factors. Inflammatory biomarkers, including C-reactive protein (CRP),interleukin 6 (IL- 6), soluble tumor necrosis factor alpha receptor 2, soluble intercellular and vascular adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1), and lipid biomarkers, including lipoprotein(a) and apolipoprotein b, have all been associated with cardiovascular disease. We previously found an association betweenAMD and CRP in a cross-sectional analysis, but the prospective relationships between AMD, CRP, and the other cardiovascular disease markers are unknown. Objective: To test the hypothesis that baseline cardiovascular disease biomarkers are associated with subsequent increased risk for progression ***, Setting, and Participants: This prospective cohort study involved 251 participants aged 60 years and older who had some sign of nonexudative AMD and visual acuity of 20/200 or better in at least one eye at baseline. The AMD status was assessed by standardized grading of fundus photographs, and stored fasting blood specimens obtained at baseline were analyzed for levels of the various biomarkers. The average follow-up time was 4.6 years. Main Outcome Measures: Relationship between biomarkers and incidence rates of progression of AMD. Results: Comparing the highest quartile with the lowest quartile, CRP was associated with progression of AMD, with a multivariate adjusted relative risk (rr) of 2.10 (95% confidence interval (CI), 1.06- 4.18; P for trend, .046) controlling for body mass index, smoking, and other cardiovascular variables and a multivariate adjusted rr of 2.02 (95% CI, 1.00- 4.04; P for trend, .06) controlling additionally for antioxidant nutrients. Interleukin 6 was also related to progression of AMD, with a multivariate adjusted rr of 1.81 (95% CI, 0.97- 3.36; P for trend, .03). Comparing the highest quartile with the lowest quar

关键词： C反应蛋白生物标记 AMD 心血管疾病老年性黄斑变性细胞间黏附分子多变量校正可溶性细胞身高体重指数炎症因子

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银屑病患者的心肌梗死风险

世界核心医学期刊文摘（心脏病学分册） 2007年第3期3卷 6-7页

作者： Gelfand J.M. Neimann A.L. Shin D.b. 郭俊 Dr.Department of Dermatology Center for Clinical Epidemiology and BiostatisticsUniversity of Pennsylvania360Spruce StPhiladelphiaPA 19104United States

背景:银屑病是最常见的1型辅助性T细胞(TH1)免疫性疾病,有证据显示TH1疾病与心肌梗死(MI)相关。据悉,银屑病与心血管疾病相关,但这仅在未校正主要心血管危险因素的医院研究中被探讨过。

关键词：银屑病血管危险因素免疫性疾病心血管疾病医疗记录研究数据库队列研究综合医疗全科医师临