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Neuroscience bulletin 2024年第4期40卷 517-532页

作者： Yuhui Shen Mingting Shao Zhao-Zhe Hao Mengyao Huang nana Xu Sheng Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou510060China Guangdong Province Key Laboratory of brain Function and Disease Guangzhou510080China

Primates exhibit complex brain structures that augment cognitive *** neocortex fulfills high-cognitive functions through billions of connected *** neurons have distinct transcriptomic,morphological,and electrophysiological properties,and their connectivity principles *** features endow the primate brain atlas with a multimodal *** recent integration of next-generation sequencing with modified patch-clamp techniques is revolutionizing the way to census the primate neocortex,enabling a multimodal neuronal atlas to be established in great detail:(1)single-cell/single-nucleus RNA-seq technology establishes high-throughput transcriptomic references,covering all major transcriptomic cell types;(2)patch-seq links the morphological and electrophysiological features to the transcriptomic reference;(3)multicell patch-clamp delineates the principles of local ***,we review the applications of these technologies in the primate neocortex and discuss the current advances and tentative gaps for a comprehensive understanding of the primate neocortex.

关键词： Neuron brain atlas Patch-seq Connectivity Primate

Long‐life lithium batteries enabled by a pseudo‐oversaturated electrolyte

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Carbon Energy 2024年第4期6卷 115-127页

作者： Youchun Yu Simeng Wang Juyan Zhang Weiwei Qian nana Zhang Guangjie Shao Haiyan bian Yuwen Liu Lan Zhang Hebei Key Laboratory of Applied Chemistry College of Environmental and Chemical EngineeringYanshan UniversityQinhuangdaoChina beijing Key Laboratory of Ionic Liquids Clean Process CAS Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijingChina Haike Group Research Institute of Innovation&Technology DongyingChina Langfang Green Industrial Technology Center LangfangChina

The specific energy of Li metal batteries(LMbs)can be improved by using high‐voltage cathode materials;however,achieving long‐term stable cycling performance in the corresponding system is particularly challenging for the liquid ***,a novel pseudo‐oversaturated electrolyte(POSE)is prepared by introducing 1,1,2,2‐tetrafluoroethyl‐2,2,3,3‐tetrafluoropropyl ether(TTE)to adjust the coordination structure between diglyme(G2)and lithium bis(trifluoromethanesulfonyl)imide(LiTFSI).Surprisingly,although TTE shows little solubility to LiTFSI,the molar ratio between LiTFSI and G2 in the POSE can be increased to 1:1,which is much higher than that of the saturation state,1:*** and experimental results prove that TTE promotes closer contact of the G2 molecular with Li^(+)in the ***,it also participates in the formation of electrolyte/electrode *** electrolyte shows outstanding compatibility with both the Li metal anode and typical high‐voltage ***||Li symmetric cells show a long life of more than 2000 h at 1 mA cm^(−2),1 mAh cm^(−2).In the meantime,Li||LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)cell with the POSE shows a high reversible capacity of 134.8 mAh g^(−1 )after 900 cycles at 4.5 V,1 C *** concept of POSE can provide new insight into the Li^(+)solvation structure and in the design of advanced electrolytes for LMbs.

关键词： high voltage lithium metal batteries pseudo‐oversaturated electrolyte solid electrolyte interphases(SEI) solvation structure

ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating bCL2–bECN1 interaction

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Acta Pharmaceutica Sinica b 2024年第5期14卷 2026-2038页

作者： Shiqiang Xu Qilian Ma Junwen Shen Ningning Li Shan Sun nana Wang Yang Chen Chunsheng Dong Kin Yip Tam Jochen H.M.Prehn Hongfeng Wang Zheng Ying Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China MOE Key Laboratory of Geriatric Diseases and Immunology College of Pharmaceutical SciencesSuzhou Medical College of Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China Dept.of Physiology&Medical Physics and FUTURE-NEURO Research Centre Royal College of Surgeons in IrelandDublin D02 YN77Ireland Faculty of Health Sciences University of MacaoTaipaMacao 999078China Insititutes of biology and Medical Science Soochow UniversitySuzhou 215123China

Growing evidences indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD),two neurodegenerative *** GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72(C9orf72)is the most genetic cause of both ALS and *** to the previous studies,GGGGCC·GGCCCC repeat undergoes the unconventional repeat-associated non-ATG translation,which produces dipeptide repeat(DPR)*** there is a growing understanding that C9orf72 DPRs have a strong ability to harm neurons and induce C9orf72-linked ALS/FTD,whether these DPRs can affect autophagy remains *** the present study,we find that poly-GR and poly-PR,two arginine-containing DPRs which display the most cytotoxic properties according to the previous studies,strongly inhibit starvation-induced ***,our data indicate that arginine-rich DPRs enhance the interaction between bCL2 and bECN1/beclin 1 by inhibiting bCL2 phosphorylation,therefore they can impair autophagic clearance of neurodegenerative disease-associated protein aggregates under starvation condition in ***,our study not only highlights the role of C9orf72 DPR in autophagy dysfunction,but also provides novel insight that pharmacological intervention of autophagy using SW063058,a small molecule compound that can disrupt the interaction between bECN1 and bCL2,may reduce C9orf72 DPR-induced neurotoxicity.

关键词： Amyotrophic lateral sclerosis Frontotemporal dementia C9orf72 Autophagy bCL2 bECN1/beclin 1 Dipeptide repeat Neurodegeneration

Telomere-to-telomere genome assemblies of cultivated and wild soybean provide insights into evolution and domestication under structural variation

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Plant Communications 2024年第8期5卷 92-95页

作者： Kai-Hua Jia Xiaoyan Zhang Lei-Lei Li Tian-Le Shi Dan Liu Yongyi Yang Yunzhe Cong Runfang Li Yanyan Pu Yongchao Gong Xue Chen Yu-Jun Si Rumei Tian Zhenya Qian Hanfeng Ding nana Li National Saline-Alkali Tolerant Crop Germplasm Resources Nursery(Dongying) Shandong International Joint Laboratory of Agricultural Germplasm Resources InnovationInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan 250100China College of biological Sciences and Technology Beijing Forestry UniversityBeijing 100083China Shandong Provincial Center of Forest and Grass Germplasm Resources Jinan 250102China Weifang Academy of Agricultural Sciences Weifang 261017China Shandong Huaya Agricultural Technology Co. Ltd.Jining 272400China

Dear Editor,Soybean(Glycine max)is a critical crop worldwide,renowned as a major source of edible oil and *** was domesticated approximately 5000-9000 years ago in China,between latitudes 32°N and 40°N,from its wild progenitor,Glycine *** recent years,numerous genome assemblies for both cultivated and wild soybeans have been published,with cultivated soybean genomes even achieving telomere-to-telomere(T2T)completeness(Zhang et al.,2023a,2023b;Wang et al.,2023;Huang et al.,2024).

关键词： soybean insight evolution

化学链重整过程中LaFeO_(3)载氧体的CH_(4)部分氧化反应机理研究

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燃料化学学报（中英文） 2024年第4期52卷 586-594页

作者：王娜娜冯于川郭欣马素霞太原理工大学电气与动力工程学院山西太原030024 华中科技大学煤燃烧国家重点实验室湖北武汉430074

本研究基于密度泛函理论(DFT)计算揭示了化学链重整过程中LaFeO_(3)载氧体的CH_(4)部分氧化反应机理,通过系统研究CH_(4)吸附活化、H_(2)和CO形成以及氧扩散等基元反应步骤,构建了CH_(4)部分氧化反应网络。研究发现,CH_(4)发生逐步脱氢... 详细信息

本研究基于密度泛函理论(DFT)计算揭示了化学链重整过程中LaFeO_(3)载氧体的CH_(4)部分氧化反应机理,通过系统研究CH_(4)吸附活化、H_(2)和CO形成以及氧扩散等基元反应步骤,构建了CH_(4)部分氧化反应网络。研究发现,CH_(4)发生逐步脱氢反应形成H原子,其中,CH3脱氢反应所需要克服的能垒(1.50 eV)最高,是CH_(4)逐步脱氢反应的限速步骤。载氧体表面H_(2)形成有两种路径,其中,H原子从O顶位迁移到Fe顶位,然后与另外O顶位的H原子成键形成H_(2)分子是主要途径。由于其相对较低的能垒(1.27 eV),CO的形成过程较易发生。氧扩散需要克服1.35 eV的能垒,表明氧扩散过程需要在高温下进行且扩散速率较低。通过比较各基元反应能垒,发现H_(2)形成是LaFeO_(3)载氧体CH_(4)部分氧化反应动力学的限速步骤,而H迁移是限制H_(2)形成的关键,加快H迁移是增强LaFeO_(3)载氧体性能的主要途径。基于DFT计算研究系列A/b位点掺杂LaFeO_(3)载氧体的H迁移过程,有望实现潜在A/b位点有效掺杂剂的快速筛选,指导高性能LaFeO_(3)载氧体的设计开发。

关键词：化学链重整 LaFeO_(3)载氧体 CH_(4)部分氧化反应机理密度泛函理论

基于景观质量评价的桂林漓江风景区生态优化设计

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森林工程 2024年第3期40卷 66-75页

作者：唐娜娜唐旭军桂林旅游学院艺术设计学院广西桂林541000

为提升自然遗产的生态环境保护水平,推动桂林漓江风景区可持续发展,以桂林漓江风景区为研究对象,基于层次分析法构建桂林漓江风景区生态景观质量评价指标体系,并确定各指标因子权重;采用模糊综合评价法对桂林漓江风景区生态景观质量进... 详细信息

为提升自然遗产的生态环境保护水平,推动桂林漓江风景区可持续发展,以桂林漓江风景区为研究对象,基于层次分析法构建桂林漓江风景区生态景观质量评价指标体系,并确定各指标因子权重;采用模糊综合评价法对桂林漓江风景区生态景观质量进行综合评价。结果表明,桂林漓江风景区生态景观质量综合评价得分为3.8762分,处于“较好”水平;4项准则层(整体风貌b_(1)、文化服务价值b_(2)、美学价值b_(3)、生态调节b_(4))评分均在“一般”等级之上,得分值分别为b_(1)=3.5871、b_(2)=4.2971、b_(3)=3.2913、b_(4)=3.0093,由大到小表现为文化服务价值、整体风貌、美学价值、生态调节。桂林漓江风景区生态景观质量在文化服务价值方面表现较好,在生态调节方面表现较弱。研究结果显示桂林漓江风景区需在保持山水形态原真性和完整性、实现生态保护与可持续发展方面持续发力,保持景观原生态美学价值,进而提升社会经济价值。

关键词：桂林漓江风景区层次分析法模糊综合评价法生态景观质量评价生态保护

基于Akt/mTOR通路研究地榆皂苷Ⅱ诱导肝癌细胞凋亡和自噬作用机制

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中草药 2024年第11期55卷 3726-3734页

作者：朱晓敏钟颖黄娜娜孙蓉山东大学第二医院山东济南250033 山东大学高等医学研究院山东济南250012

目的探讨地榆皂苷Ⅱ抑制肝癌细胞增殖、诱导肝癌细胞凋亡和自噬的作用机制。方法采用不同浓度(0、10、20、40μmol/L)地榆皂苷Ⅱ处理人肝癌HepG2细胞和小鼠肝癌Hepa1-6细胞,通过CCK-8和EdU实验观察地榆皂苷Ⅱ对HepG2和Hepa1-6细胞增殖... 详细信息

目的探讨地榆皂苷Ⅱ抑制肝癌细胞增殖、诱导肝癌细胞凋亡和自噬的作用机制。方法采用不同浓度(0、10、20、40μmol/L)地榆皂苷Ⅱ处理人肝癌HepG2细胞和小鼠肝癌Hepa1-6细胞,通过CCK-8和EdU实验观察地榆皂苷Ⅱ对HepG2和Hepa1-6细胞增殖的影响;运用流式细胞术检测地榆皂苷Ⅱ对细胞凋亡的影响;通过Western blotting检测地榆皂苷Ⅱ对细胞凋亡和自噬相关蛋白半胱氨酸天冬氨酸蛋白酶-3(cysteine-aspartic acid protease-3,Caspase-3)、Caspase-8、Caspase-9、b细胞淋巴瘤2(b-cell lymphoma-2,bcl-2)、bcl-2相关X蛋白(bcl-2-associated X protein,bax)、cleaved Caspase-3、微管相关蛋白1A/1b-轻链3-Ⅱ(microtubule-associated protein light chain3-Ⅱ,LC3Ⅱ)、微管相关蛋白1A/1b-轻链3-Ⅰ(microtubule-associated protein light chain3-Ⅰ,LC3Ⅰ)、自噬相关蛋白p62、beclin1及蛋白激酶b(protein kinase b,Akt)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)通路关键蛋白表达的影响。结果地榆皂苷Ⅱ显著抑制HepG2和Hepa1-6细胞活力,且呈现一定的剂量相关性;流式细胞检测发现地榆皂苷Ⅱ给药后细胞凋亡率显著增加(Pblotting结果显示,与对照组比较,地榆皂苷Ⅱ给药后Caspase-3、Caspase-8、Caspase-9、bcl-2表达显著降低(Pbax蛋白表达显著升高(Pbeclin1蛋白表达量显著升高(P<0.05、0.01),p62蛋白表达量显著下降(P<0.05、0.01),p-Akt/Akt、p-mTOR/mTOR值显著降低(P<0.05、0.01、0.001)。结论地榆皂苷Ⅱ通过Akt/mTOR通路诱导HepG2和Hepa1-6细胞自噬和凋亡实现对肝癌细胞增殖的抑制,为抗肝细胞癌新药发现提供药理学证据。

关键词：地榆皂苷Ⅱ 增殖凋亡自噬肝细胞癌 Akt/mTOR

“双碳”目标下新疆“三生”空间时空演变特征及碳效应

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干旱区研究 2024年第7期41卷 1238-1248页

作者：菅政博罗浩单娜娜新疆农业大学公共管理学院新疆乌鲁木齐830052 新疆农业大学资源与环境学院新疆乌鲁木齐830052 新疆农业科学院土壤肥料与农业节水研究所农业农村部西北绿洲农业环境重点实验室新疆乌鲁木齐830052

研究“双碳”目标下“三生”空间时空演变特征及碳效应,对干旱区生态经济可持续发展及实现国土空间绿色低碳发展有重要的实践意义。本文基于新疆土地利用遥感监测数据和能源消耗数据,运用“三生”空间动态度、转移矩阵及碳排放系数等方... 详细信息

研究“双碳”目标下“三生”空间时空演变特征及碳效应,对干旱区生态经济可持续发展及实现国土空间绿色低碳发展有重要的实践意义。本文基于新疆土地利用遥感监测数据和能源消耗数据,运用“三生”空间动态度、转移矩阵及碳排放系数等方法,借助ArcGIS空间分析功能对新疆2000—2020年“三生”空间时空演变特征及碳效应进行分析。结果表明:(1)新疆近20 a“三生”空间综合动态度达0.11%,2005—2010年综合动态度最高。(2)20 a间“三生”空间总体上呈现生活生产空间急剧扩张,生态空间面积缩减的趋势。(3)生活生产空间是新疆最主要的碳排放空间类型,呈现出持续增长的趋势;生态生产空间对碳吸收的贡献率较大。研究结果可为构建符合新疆减排需求的“三生”空间分类体系提供科学支撑,对建设高质量“一带一路”,实现干旱区新疆低碳发展和“双碳”目标具有重要意义。

关键词： “三生”空间时空演变碳源和碳汇碳效应新疆

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儒家视域下角抵活动发展演变的内在矛盾剖析

河南理工大学学报（社会科学版） 2024年第2期25卷 105-110页

作者：李娜娜河南理工大学体育学院河南焦作454000

本文通过对儒家视域下角抵活动发展演变的内在矛盾进行剖析,来管窥中国古代体育运动发展的内外在因素及体育本体的生命力。研究认为,儒士既痛斥角抵玩物丧志不好的一面,又要秉持忠君爱国的价值观念,这种欲罢不能的复杂心态是他们对角抵... 详细信息

本文通过对儒家视域下角抵活动发展演变的内在矛盾进行剖析,来管窥中国古代体育运动发展的内外在因素及体育本体的生命力。研究认为,儒士既痛斥角抵玩物丧志不好的一面,又要秉持忠君爱国的价值观念,这种欲罢不能的复杂心态是他们对角抵活动态度的真实反映。角抵作为宣扬教化的一种政治手段,虽然其奢靡浪费的行为与教导人们勤俭节约的传统观念背道而驰,但角抵兴衰又与执政者的导向密切相关。也正是在这样的价值观念背景下,角抵在政见与争论的批判声中不断演进,虽被屡加禁止但仍沿传至今,这足以说明中国古代摔跤活动发展路径曲折,体育活动内在的生命力不可小觑。

关键词：角抵儒家摔跤体育史

Adding sweet sorghum juice into current dry-grind ethanol process for improving ethanol yields and water efficiency

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International Journal of Agricultural and biological Engineering 2015年第2期8卷 97-103页

作者： nana b Appiah-Nkansah Kaelin Saul William L Rooney Donghai Wang IGERT Trainee in biorefining Kansas State UniversityManhattan KS 66506USA Department of biological and Agricultural Engineering Kansas State UniversityManhattanKS 66506USA Department of Soil and Crop Science Texas A&M UniversityCollege StationTX 77843USA

Sweet sorghum is a promising energy crop due to its low fertilizer and water requirements,short growth period,and high biomass ***,the challenge for sweet sorghum as a feedstock for ethanol production is its short harvest period and the extreme instability of its juice,both of which make achieving a year-round production process *** way to solve this challenge and to meet the growing demand of bio-renewable ethanol is to incorporate sweet sorghum juice into the current dry-grind ethanol *** the dry-grind process,the whole grain kernel is milled and fermented to produce *** this study,sweet sorghum juice with varying grain sorghum flour contents was liquefied,saccharified,fermented,and distilled to produce *** yield from sweet sorghum juice with the optimum grain sorghum flour loading was about 28% higher than that from the conventional ethanol *** hydrolysis with this process could be reduced by 30 *** fermentation performance of sweet sorghum juice with grain flour using a raw starch hydrolyzing enzyme was also investigated,and ethanol yield was about 21% higher than that from the conventional *** innovative technology enabling ethanol production from sweet sorghum juice could improve ethanol yield,save energy,and significantly decrease water use in the current dry-grind ethanol process.

关键词： sweet sorghum biomass ethanol yield hydrolyzing time conversion efficiency