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CCS Chemistry 2024年第4期6卷 964-975页

作者： Xu Han Tian-Yu Sun Yi Isaac Yang Jun Zhang Jing qiu Zhaoping Xiong Nan qiao Yun-Dong Wu Yi qin Gao Institute of Theoretical and Computational Chemistry College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Shenzhen bay Laboratory Shenzhen 518132 Changping Laboratory Beijing 102200 Laboratory of Health Intelligence Huawei Cloud Computing Technologies Co.Ltd.Guizhou 550025

The bond breaking and forming in chemical reactions is a typical rare event,which is one of the difficult problems in molecular dynamics *** enhanced sampling methods have been developed to extend the time scale covered by molecular ***,the difficulties of obtaining appropriate collective variables from complicated reaction pathways and a controlled sampling over the desired phase space remain as ***,we use MetaITS,which combines metadynamics and integrated tempered sampling,to increase the sampling efficiency for chemical *** with collective variables obtained by harmonic linear discriminant analysis can efficiently decrease the main energy barrier of chemical ***,integrated tempered sampling can enhance the exploration of other degrees of *** this study,we applied the MetaITS method to two transition-metal-catalyzed organic reactions with complicated reaction *** simulated here a zirconocene-catalyzed propylene polymerization to investigate the regioselectivity and temperature *** also studied a Sharpless epoxidation reaction,for which both chiral products are observed through simulation.

关键词： molecular dynamics enhanced sampling metadynamics integrated tempering sampling propylene polymerization Sharpless epoxidation

Study on improving hematopoietic function of rats with blood deficiency syndrome by Shengxuebao mixture

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Traditional Medicine Research 2024年第8期9卷 35-46页

作者： Yan Shu Hong-Na Liu Yang Zhao Jin-Yi Cao Yue Chen Yi qiao Hui Guo Zhi-Fu Yang College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Tsing Hua De Ren Xi’an Happiness Pharmaceutical Co. Ltd.Xi’an 710400China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710000China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of PharmacySchool of Stomatologythe Fourth Military Medical UniversityXi’an 710000China

background:Shengxuebao mixture(SXbM)is a novel herbal drug approved by China State Food and Drug Administration for the treatment of Leukopenia and iron deficiency anemia caused by radiotherapy and ***:To explore the mechanism of SXbM in treating blood deficiency syndrome(bDS).Firstly,network pharmacology and in vivo experiments were used to screen candidate targets and important signaling pathways of SXbM,GO functional enrichment and KEGG pathway analysis were ***,a bDS rat model was established to verify the results of the analysis of network pharmacological *** and routine peripheral blood examination were *** expressions of tumor necrosis factor-α,interleukin(IL)-6,HIF-1αand NF-κb were detected by Western blot,and the expressions of IL-6,IL-1βwere detected by ***:62 bioactive components,66 potential targets and 131 signaling pathways of bDS were successfully identified by network *** docking simulation techniques showed that key targets tumor necrosis factor-α,IL-6,IL-1βcan dock well with crucial components,and the bDS-related signaling pathways HIF-1 and JAK-STAT play a vital *** combined model experiment of acetylphenylhydrazine and cyclophosphamide showed that the model group had obvious blood deficiency,and the histopathology and blood routine were effectively restored after *** findings indicate that SXbM’s therapeutic effect on bDS primarily involves the mediation of the HIF-1α/NF-κb signaling pathway and the regulation of hematopoietic factor ***:This study not only affirmed the protective properties of SXbM against bDS but also provided insights into a potential mechanism for blood replenishment in the treatment of bDS using SXbM.

关键词： network pharmacology molecular docking technology blood deficiency syndrome hematopoietic factors HIF-1α/NF-κb

Cornus officinalis with high pressure wine steaming enhanced anti-hepatic fibrosis: Possible through SIRT3-AMPK axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 758-771页

作者： Xin Han Yan Ning Xinyue Dou Yiwen Wang qiyuan Shan Kao Shi Zeping Wang Chuan Ding Min Hao Kuilong Wang Mengyun Peng Haodan Kuang qiao Yang Xianan Sang Gang Cao School of Pharmacy Zhejiang Chinese Medical UniversityHangzhou311400China

Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying *** vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw *** ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-qTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)*** note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and *** interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through *** conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.

关键词： Liver fibrosis SIRT3 Cornus officinalis AMPK Caspase6

pH-controlled reversible sol-gel inversion by cerous phosphate nanofibers for hemostasis

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Rare Metals 2024年第10期43卷 5141-5151页

作者： Tuo Su Jun-Chen Xu Wei Yu Dan Su Di-Er Shi Yi-Chao Pang Yao Ying Wang-Chang Li Juan Li Jing-Wu Zheng Liang qiao Sheng-Lei Che Jing Yu Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of Technology State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang University Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province Department of Clinical MedicineHangzhou Medical College Department of Chemistry Zhejiang University Clinical Medical College Yangzhou University

Developing biomimetic soft materials that display stimuli responsiveness using solely inorganic materials has been regarded as a challenge owing to that such materials?properties typically vary from those of living ***,biomimetic soft materials have been developed using organic materials or inorganic materials modified with organic small *** this study,we prepared cerium phosphate nanofibers （CePO4NFs） by using inorganic agents only without further *** CePO4NFs demonstrate sol-ge switching properties in response to pH value,allowing them to form a gel under high hydroxide ion （OH-） concentrations and turn back into sol under low *** formation of gel could be ascribed to the physical cross-linking of the nanofibers induced by the attractive electrostatic force of OH-and surface Ce3+.As a result,CePO4NFs are able to form a gel when in contac with blood of high pH value for *** specific clotting mechanism makes them better candidates for hemostasis of heavy bleeding.

关键词： Cerium phosphate nanofibers Hemostasis pH-responsive Reversible Sol-gel switching

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问题求解视角下工程机械产品的体验设计研究

包装工程 2024年第4期45卷 87-95页

作者：梁峭江南大学江苏无锡214122

目的从问题求解的角度出发,构建工程机械产品的体验设计层级,探讨各层级对应的问题求解内涵。方法通过文献研究法,梳理设计问题求解的研究脉络,奠定理论出发点,即设计问题求解方式已经从产品拓展到了体验设计。基于工程机械产品及行业... 详细信息

目的从问题求解的角度出发,构建工程机械产品的体验设计层级,探讨各层级对应的问题求解内涵。方法通过文献研究法,梳理设计问题求解的研究脉络,奠定理论出发点,即设计问题求解方式已经从产品拓展到了体验设计。基于工程机械产品及行业的特殊性,分别从工程性思考和b2b行业视角分析工程机械问题求解的特点。借助实证案例分析方法,结合工程机械行业所涉及到的众多利益相关者,提出由用户体验(UX)客户体验(CX)品牌体验(bX)构成的工程机械体验设计层级,并对各层级问题求解内容及方式进行了阐释。结论用户体验涉及到物理层的可用性问题和行为层的交互问题;客户体验关系到服务层的价值问题;品牌体验主要关注系统层的整合问题。未来工程机械产品问题求解的核心思路将是以“体验设计目标”为整体出发点。

关键词：体验设计问题求解工程机械产品

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生存与疯狂:论辛格的长篇小说《疯狂》

外语与外语教学 2024年第1期 118-127,150,F0003页

作者：乔国强上海外国语大学区域国别研究院上海200083

小说《疯狂》以“疯狂”的笔触,描述了犹太大屠杀幸存者们的“疯狂”性爱生活。作者辛格通过同情、理解甚至还把自己化成人物形象,介入故事文本中,使其与小说中的人物构成了一种互文性关系。一贯喜欢对犹太大屠杀幸存者说三道四的辛格,... 详细信息

小说《疯狂》以“疯狂”的笔触,描述了犹太大屠杀幸存者们的“疯狂”性爱生活。作者辛格通过同情、理解甚至还把自己化成人物形象,介入故事文本中,使其与小说中的人物构成了一种互文性关系。一贯喜欢对犹太大屠杀幸存者说三道四的辛格,之所以未在这部小说中对犹太幸存者的种种混乱生活进行指责,是因为此时的他对犹太幸存者不合常规的社会行为与心理结构,有了一种新的理解与感悟:他们是一群战争的幸存者,但更是受害者——无论身体还是精神都深受重创,走不出曾经被迫害与屠杀的阴霾。为了活下去,他们不得不用抱团取暖的方式彼此温暖和鼓励着。对犹太幸存者而言,性爱不但是活下去的一种动力和手段,同时也是犹太民族存续下去的一种象征。

关键词：艾萨克·巴舍维斯·辛格《疯狂》大屠杀性爱

The light and hypoxia induced gene ZmPORb1 determines tocopherol content in the maize kernel

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Science China(Life Sciences) 2024年第3期67卷 435-448页

作者： Nannan Liu Yuanhao Du Shijuan Yan Wei Chen Min Deng Shutu Xu Hong Wang Wei Zhan Wenjie Huang Yan Yin Xiaohong Yang qiao Zhao Alisdair R.Fernie Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Agronomy Northwest A&F UniversityXi'an 710000China State Key Laboratory of North China Crop Improvement and Regulation Hebei Sub-center of National Maize Improvement Center of ChinaCollege of AgronomyHebei Agricultural UniversityBaoding 071001China College of Life Sciences South-Central Minzu UniversityWuhan 430070China Plant Science Facility of the Institute of botany Chinese Academy of SciencesBeijing 100093China National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100093China Shenzhen Key Laboratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476Germany

Tocopherol is an important lipid-soluble antioxidant beneficial for both human health and plant growth. Here, we fine mapped a major qTLqVE1 affecting γ-tocopherol content in maize kernel, positionally cloned and confirmed the underlying gene ZmPORb1(por1), as a protochlorophyllide oxidoreductase. A 13.7 kb insertion reduced the tocopherol and chlorophyll content, and the photosynthetic activity by repressing ZmPORb1 expression in embryos of NIL-K22, but did not affect the levels of the tocopherol precursors HGA(homogentisic acid)and PMP(phytyl monophosphate). Furthermore, ZmPORb1 is inducible by low oxygen and light, thereby involved in the hypoxia response in developing embryos. Concurrent with natural hypoxia in embryos, the redox state has been changed with NO increasing and H_(2)O_(2) decreasing, which lowered γ-tocopherol content via scavenging reactive nitrogen species. In conclusion, we proposed that the lower lightharvesting chlorophyll content weakened embryo photosynthesis, leading to fewer oxygen supplies and consequently diverse hypoxic responses including an elevated γ-tocopherol consumption. Our findings shed light on the mechanism for fine-tuning endogenous oxygen concentration in the maize embryo through a novel feedback pathway involving the light and low oxygen regulation of ZmPORb1 expression and chlorophyll content.

关键词： maize tocopherol hypoxia photosynthesis ZmPORb1

A case report of bilateral lateral ventricle calcified pseudoneoplasm of the neuraxins

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Chinese Neurosurgical Journal 2024年第1期10卷 67-72页

作者： Xiaolong qiao Yinan Chen Ying Ji Chaoshi Niu Chuandong Cheng Anhui University of Science and Technology HuainanAnhui 232001People’s Republic of China Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China1st Tianehu RoadHefeiAnhui 230031People’s Republic of China

background Calcifying pseudoneoplasm of the neuraxis(CAPNON)is indeed a rare central nervous system lesion that can occur in central nervous system(CNS).Due to its infrequency and limited literature reports,it is challenging to diagnose and manage *** presentation In this intriguing study,we embarked on a quest to uncover the story of a 16-year-old girl who experienced bothersome *** advanced imaging techniques like computed tomography(CT)and magnetic resonance imaging(MRI),we glimpsed a delicate calcified growth within the lateral ventricles’posterior *** by our unwavering commitment to solving mysteries,we embarked on a surgical journey that not only freed the young patient from her ailment but also shed light on the true nature of her puzzling adversary—a remarkable *** For patients with CAPNON who have multiple or non-respectable lesions,the primary goal is to alleviate *** alleviating the symptoms with partial resection,close monitoring of any residual lesions is *** there is no evidence for disease progression,a strategy of continued close observation is appropriate.

关键词： CAPNON Imaging Pathology Operation

Converting intercalation-type cathode in spent lithium-ion batteries into conversion-type cathode

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Nano Research 2024年第5期17卷 4602-4609页

作者： Dingding Zhu Yong Su Jingzhao Chen Xiangze Ou Xuedong Zhang Wen Xie Yuyan Zhou Yunna Guo qiushi Dai Peng Jia Jitong Yan Lin Geng baiyu Guo Liqiang Zhang Yongfu Tang qiao Huang Jianyu Huang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066000China

The widespread applications of lithium-ion batteries(LIbs)generate tons of spent ***,recycling LIbs is of paramount importance in protecting the environment and saving the *** commercialized LIbs mostly adopt layered oxides such as LiCoO_(2)(LCO)or LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)(NMC)as the cathode *** the intercalation-type spent oxides into conversion-type cathodes(such as metal fluorides(MFs))offers a valid recycling strategy and provides substantially improved energy densities for ***,two typical Co-based cathodes,LCO and LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NMC622),in spent LIbs were successfully converted to CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) cathodes by a reduction and fluorination *** as converted CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) delivered cell energy densities of 650 and 700 Wh/kg,*** atomic-level electron microscopy revealed that the used LCO and NMC622 were converted to highly phase pure Co metal and Ni_(0.6)Co_(0.2)Mn_(0.2) alloys in the used graphite-assisted reduction roasting,simultaneously producing the important product of Li_(2)CO_(3) using only environment friendly *** study provided a versatile strategy to convert the intercalation-type Co-based cathode in the spent LIbs into conversion-type MFs cathodes,which offers a new avenue to recycle the spent LIbs and substantially increase the energy densities of next generation LIbs.

关键词： spent lithium-ion batteries recycling energy densities conversion-type cathode

Soliton microcomb generation by cavity polygon modes

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Opto-Electronic Advances 2024年第8期7卷 6-14页

作者： botao Fu Renhong Gao Ni Yao Haisu Zhang Chuntao Li Jintian Lin Min Wang Lingling qiao Ya Cheng State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-Intense Laser Science Shanghai Institute of Optics and Fine Mechanics(SIOM)Chinese Academy of Sciences(CAS)Shanghai 201800China Research Center for Frontier Fundamental Studies Zhejiang LabHangzhou 311100China Engineering Research Center for Nanophotonics&Advanced Instrument Ministry of EducationSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Physical Science and Technology ShanghaiTech UniversityShanghai 200031China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Center for quantum Sciences Shanghai 201315China Hefei National Laboratory Hefei 230088China

Soliton microcombs,which require the hosting cavity to operate in an anomalous dispersion regime,are essential to integrate photonic *** the past,soliton microcombs were generated on cavity whispering gallery modes(WGMs),and the anomalous dispersion requirement of the cavity made by normal dispersion material was achieved through structural dispersion *** inevitably degrades the cavity optical quality factor(q)and increases pump threshold power for soliton comb *** overcome the challenges,here,we report a soliton microcomb excited by cavity polygon *** modes display anomalous dispersion at near-infrared while optical q factors exceeding 4×10^(6) are ***,a soliton comb spanning from 1450 nm to 1620 nm with a record low pump power of 11 m W is demonstrated,a three-fold improvement compared to the state of the art on the same material platform.

关键词： thin-film lithium niobate nonlinear optics microresonators