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Optimization of Wire-EDM Parameters for Ti-6Al-4V Using Taguchi-MRSN Optimization Approach

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Ipsita nayak Jaydev Rana Department of Mechanical Engineering， Veer Surendra Sai University of Technology

Ti-6Al-4V is a lightweight， extremely strong material with high resistance to corrosion and is widely used in aerospace industries， medical implants and many more. Contour cutting in such material with sharp corner radius， narrow kerf width， and maintaining high dimensional accuracy and surface integrity is a challenge for the modern manufacturing industry. Wire electrical discharge machining （WEDM） is a feasible process to meet the above challenges. However， proper control of process parameters is highly necessary for quality cutting of such material. In order to meet the above challenges， the present work focuses on the optimum selection of different process parameters such as pulse-on time (TON)， pulse-off time (TOFF)， spark gap voltage （SV） and wire feed rate （WF） using Taguchi-based multi response signal to noise ratio （MRSN） technique. This is a very simple multi response optimization technique to simultaneously optimize vital responses like thickness of white layer formed on the machined surfaces， average crack density， surface roughness and dimensional accuracy， without the assistance of any software. Moreover， simple regression models are developed to determine the above responses for any combination of process parameters. Industry personnel will find this study useful in utilizing this expensive non-conventional machining method in a techno-economic manner.

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Characterization of early maturing elite genotypes based on MTSI and MGIDI indexes:an illustration in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2024年第3期7卷 253-265页

作者： D S RAJ Supritha PATIL Rajesh S. PATIL bhuvaneshwara R. nayak Spurthi N. PAWAR Kasu N. Department of Genetics and Plant breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural Research Station Dharwad 580005India Department of biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Physiology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

background Globally,the cultivation of cotton is constrained by its tendency for extended periods of *** maturity plays a potential role in rainfed-based multiple cropping system especially in the current era of climate *** the current study,a set of 20 diverse Gossypium hirsutum genotypes were evaluated in two crop seasons with three planting densities and assessed for 11 morphological traits related to early *** study aimed to identify genotype(s)that mature rapidly and accomplish well under diverse environmental conditions based on the two robust multivariate techniques called multi-trait stability index(MTSI)and multi-trait genotype-ideotype distance index(MGIDI).Results MTSI analysis revealed that out of the 20 genotypes,three genotypes,viz.,NNDC-30,A-2,and S-32 accomplished well in terms of early maturity traits in two ***,three genotypes were selected using MGIDI method for each planting densities with a selection intensity of 15%.The strengths and weaknesses of the genotypes selected based on MGIDI method highlighted that the breeders could focus on developing early-maturing genotypes with specific traits such as days to first flower and boll *** selected genotypes exhibited positive genetic gains for traits related to earliness and a successful harvest during the first and second ***,there were negative gains for traits related to flowering and boll *** The study identified three genotypes exhibiting early maturity and accomplished well under different planting *** multivariate methods(MTSI and MGIDI)serve as novel approaches for selecting desired genotypes in plant breeding programs,especially across various growing *** methods offer exclusive benefits and can easily construe and minimize multicollinearity issues.

关键词： Cotton MTSI MGIDI Genotype environment interaction Early maturity Multi-trait Multi-environment

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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?

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Stroke & Vascular Neurology 2024年第3期9卷 279-288,I0247页

作者： Adam Ingleton Marko Raseta Rui-En Chung Kevin Jun Hui Kow Jake Weddell Sanjeev nayak Changez Jadun Zafar Hashim Noman Qayyum Phillip Ferdinand Indira natarajan Christine Roffe Neurosciences University Hospitals of North Midlands NHS TrustStoke-on TrentUK Statistics and Mathematical Modelling Department of Molecular GeneticsErasmus Medical CenterRotterdamZuid-HollandThe Netherlands Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK School of Medicine Keele UniversityKeeleUK Interventional Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK Stroke Research Keele UniversityKeeleUK

background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy(MT).Most patients undergoing MT are also given *** agents are contraindicated within 24 hours of *** evaluated outcomes and complications of patients stented with and without intravenous aspirin during *** All patients who underwent emergent extracranial stenting during MT at the Royal Stoke University Hospital,UK between 2010 and 2020,were *** were thrombolysed before MT,unless *** 500 mg intravenously was given intraoperatively at the discretion of the *** intracranial haemorrhage(sICH)and the National Institutes for Health Stroke Scale score(NIHSS)were recorded at 7 days,and mortality and functional recovery(modified Rankin Scale:mRS≤2)at 90 *** Out of 565 patients treated by MT 102 patients(median age 67 IQR 57–72 years,baseline median NIHSS 18 IQR 13–23,76(75%)thrombolysed)had a stent *** these 49(48%)were given aspirin and 53(52%)were *** treated with aspirin had greater NIHSS improvement(median 8 IQR 1–16 vs median 3 IQR-9–8 points,p=0.003),but there were no significant differences in sICH(2/49(4%)vs 9/53(17%)),mRS≤2(25/49(51%)vs 19/53(36%))and mortality(10/49(20%)vs 12/53(23%))with and without *** improvement(median 12 IQR 4–18 vs median 7 IQR-7–10,p=0.01)was greater,and mortality was lower(4/33(12%)vs 6/15(40%),p=0.05)when aspirin was combined with thrombolysis,than for aspirin alone,with no increase in *** Our findings based on registry data derived from routine clinical care suggest that intraprocedural intravenous aspirin in patients undergoing emergent stenting during MT does not increase sICH and is associated with good clinical outcomes,even when combined with intravenous thrombolysis.

关键词： patients aspirin intravenous

Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： Souvik Kar Andrea Perrelli Kiran Kumar bali Raffaella Mastrocola Arpita Kar bushra Khan Luis Gand Arnab nayak Christian Hartmann Wolfram SKunz Amir Samii Helmut bertalanffy Saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and biological Sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-Street-10b Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH bALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK PANDEY RAKSHA nayak V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.bAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

Coastal zone management in India-present status and future needs

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Geo-Spatial Information Science 2017年第2期20卷 174-183页

作者： Shailesh nayak Earth System Science Organization New DelhiIndia

The coastal zone is a region where land,ocean and atmosphere interact and hence it is dynamic in *** has a long coastline which was not adequately monitored until the advent of the satellite remote sensing era in the *** has a very robust remote sensing program that the Indian Remote Sensing Satellite(IRS)series of satellites were effectively used to monitor coastal habitats,landforms,shoreline,water quality,etc.,and changes were identified during the last 40 *** classification system for coastal habitats and the classification and geometric accuracies of products were *** information for mangroves communities and characteristics of coral reefs were *** high and low tide lines were delineated seamlessly for the entire coastline using satellite *** these data were organized in a GIS and the coastal database for the entire country was *** of various hazards on such as cyclones,tsunami and sea level changes on coastal habitats were *** on topography,shoreline changes and tides,coastal multi-hazard vulnerability maps were characterized by employing the elevation data derived from satellite data and were prepared for the coastline of *** information on ocean color and sea surface temperature was used to generate potential fishery advisories,which are provided daily to *** coastal database was utilized effectively to identify coastal regulation zones,marine protected areas,vulnerable zones,*** services for tsunami,fishery and coral reef bleaching were generated for societal *** is planned to develop models for the coastal zone,so that impeding dangers and likely changes in the coastal zone can be predicted and suitable actions can be *** is necessary to integrate socio-economic data with the knowledge database of coastal zone to understand the impact of anthropogenic activities and the changing climate on the coastal zone.

关键词： Coastal zone india habitats processes water quality living resources coastal management

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats

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Animal Models and Experimental Medicine 2021年第3期4卷 243-248页

作者： Pranav nayak b Minaz Nathani Khadar Pasha Pharmacology Department and Al-Ameen College of Pharmacy and Rajiv Gandhi University BangaloreIndia

Diabetic neuropathy is a disorder which affects various regions of the nervous sys-tem and there is no specific treatment available for ***,the present study eval-uated protective effect of molsidomine in diabetic neuropathy in *** was induced in male Wistar rats by administrating streptozotocin(52 mg/kg i.p).Diabetic rats were administered with molsidomine 5 mg/kg p.o,and 10mg/kg *** *** 8 weeks of treatment,Motor coordination,Mechanical allodynia,Mechanical hyperalgesia,Nerve conduction velocity,Glycosylated hemoglobin were *** animals were sacrificed and sciatic nerve was *** was used for reduced glutathione,lipid peroxidation and for *** with molsidomine significantly improved motor coordination,paw withdrawal threshold,mechanical threshold and nerve conduction ***,mol-sidomine treatment also reduced malondialdehyde levels and prevented depletion of reduced glutathione in sciatic nerve *** shows molsid-omine treatment maintained normal architecture of sciatic *** results of our study strengthens the alterative use of molsidomine in diabetic neuropathy.

关键词： diabetic neuropathy molsidomine streptozotocin Wistar rats

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反挚断风波愈演愈烈谷歌应用商店面临收入冲击

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商业周刊（中文版） 2024年第16期 16-18页

作者： Malathi nayak Leah Nylen Davey Alba Rachel Graf Julia Love 程玺(译) 不详

法官裁定Alphabet Inc.必须撤销限制开发者构建与谷歌Play商店竞争的应用市场和计费系统的规定,这将颠覆这家搜索巨头在利润丰厚的安卓应用市场上的主导地位,并可能对其收入造成冲击。10月7日,基于旧金山联邦法官的裁定,Epic Games公司... 详细信息

法官裁定Alphabet Inc.必须撤销限制开发者构建与谷歌Play商店竞争的应用市场和计费系统的规定,这将颠覆这家搜索巨头在利润丰厚的安卓应用市场上的主导地位,并可能对其收入造成冲击。10月7日,基于旧金山联邦法官的裁定,Epic Games公司对谷歌应用商店的长期挑战迎来了重大胜利。

关键词：谷歌应用商店计费系统安卓应用裁定开发者收入冲击旧金山

Effectiveness of state incentives for promoting wind energy： A panel data examination

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Frontiers in Energy 2015年第3期9卷 247-258页

作者： Deepak SANGROYA Jogendra nayak Department of Management Studies Indian Institute of Technology IIT Roorkee Roorkee 247667 India

Over the last decade, India has started to concentrate earnestly on renewable energy. The Indian government, as well as different state governments, are adopting policy instruments such as feed in tariff, captive consumption, renewable purchase obligation and genera- tion based incentive etc. aimed at renewable energy development. This paper evaluates the effectiveness of state level incentives for the development of wind energy in India. Fixed effect panel data modelling technique of econometric analysis is used to analyse the data of 26 Indian states in 11 years. The results show that feed in tariff and captive consumption are the significant predictors of wind energy development. However, renewable purchase obligation does not affect wind energy significantly.

关键词： India wind energy development state incen-tives econometric analysis panel data

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