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Geometrical reconstruction of fluorescence events observed by the LHAASO experiment

Chinese Physics C 2021年第4期45卷 416-425页

作者： F.Aharonian Q.An Axikegu L.X.bai Y.X.bai Y.W.bao D.bastieri X.J.bi Y.J.bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang b.m.chen J.chen L.chen L.chen L.chen m.J.chen m.L.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen N.cheng Y.D.cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe b.DEtorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang J.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao m.m.Ge L.S.Geng G.H.Gong Q.b.Gou m.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He m.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.L.Liu J.S.Liu J.Y.Liu m.Y.Liu R.Y.Liu S.m.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.mitthumsiri T.montaruli Y.C.Nan b.Y..Pang P.Pattarakijwanich Z.Y.Pei m.Y.Qi D.Ruffolo V.Rulev A.Saiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.b.Sun P.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.m.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.m.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang m.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.m.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng m.Zha X.X.Zhai b.b.Zhang H.m.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.F.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou P Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Paricle Detection and Electronics China University of Science and Technology of China HefeiAnhui 230026China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhouGuangdong 510006China School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhaiGuangdong 519000China School of Physical Science and Technology Guangxi UniversityNanningGuangxi 530004China Hebei Normal University ShijiazhuangHebei 050024China School of Physics and microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Astronomy and Space Science Nanjing UniversityNanjingJiangsu 210023China Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjingJiangsu 210023China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdaoShandong 266237China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology Southwest Jiaotong UniversityChengduSichuan 610031China College of Physics Sichuan UniversityChengduSichuan 610065China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasaTibet 850000China School of physics and technology Wuhan UniversityWuhanHubei 430072Ch

The LHAASO-WFCTA experiment,which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique,uses a new generation of high-performance *** ensure that the experiment has ex-cellent detection capability associated with the measurement of the energy spectrum,the primary composition of cosmic rays,and so on,an accurate geometrical reconstruction of air-shower events is *** paper de-scribes the development and testing of geometrical reconstruction for stereo viewed events using the WFCTA(Wide Field of view Cherenkov/Fluorescence Telescope Array)*** approaches,which take full advantage ofthe WFCTA *** *** is the stereo-angular method,which uses the pointing of triggered SiPms in the shower trajectory,and the other is the stereo-timing method,which uses the triggering time of the fired *** results show that both methods have good geometrical resolution:the resolution of the stereo-timing method is slightly better than the stereo-angular method because the resolution of the latter is slightly limited by the shower track length.

关键词： cosmic ray fluorescence telescope stereo observation geometrical reconstruction

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Observation of the Crab Nebula with LHAASO-Km2A−a performance study

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Chinese Physics C 2021年第2期45卷 518-530页

作者： F.Aharonian Q.An Axikegu L.X.bai Y.X.bai Y.W.bao D.bastieri X.J.bi Y.J.bi H.Cai J.T.Cai Z.Cao J.Chang J.F.Chang X.C.Chang b.m.chen J.chen L.chen m.J.chen m.L.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen N.cheng Y.D.cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai D.della Volpe b.D'Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao m.m.Ge L.S.Geng G.H.Gong Q.b.Gou m.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He m.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu m.Y.Liu R.Y.Liu S.m.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.mitthumsiri T.montaruli Y.C.Nan b.Y.Pang P.Pattarakijwanich Z.Y.Pei m.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.b.Sun P.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.H.Wang Z.X.Wang D.m.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.m.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang m.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.m.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng m.Zha X.X.Zhai b.b.Zhang H.m.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu H.Zhu K.J.Zhu X.Zuo Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of Sciences100049 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China 230026 HefeiAnhuiChina Department of Engineering Physics Tsinghua University100084 BeijingChina National Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina National Space Science Center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina Center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen University519000 ZhuhaiGuangdongChina School of Physical Science and Technology Guangxi University530004 NanningGuangxiChina Hebei Normal University 050024 ShijiazhuangHebeiChina School of Physics and microelectronics Zhengzhou University450001 ZhengzhouHenanChina School of Astronomy and Space Science Nanjing University210023 NanjingJiangsuChina Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210023 NanjingJiangsuChina Institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of Sciences200030 ShanghaiChina Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong University200240 ShanghaiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina College of Physics Sichuan University610065 ChengduSichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of Education850000 LhasaTibetChina School of Physics and Tec

A sub-array of the Large High Altitude Air Shower Observatory(LHAASO),Km2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 *** though the detector construction is still underway,half of the Km2A array has been operating stably since the end of *** this paper,we present the Km2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray *** detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the Km2A data of 136 live days between December 2019 and may *** the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection *** energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other *** opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered.

关键词： γ-ray Crab Nebula extensive air showers cosmic rays

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Line-of-shower trigger method to lower energy threshold for GRb detection using LHAASO-WCDA

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Radiation Detection Technology and methods 2021年第4期5卷 531-541页

作者： F.Aharonian Q.An Axikegu L.X.bai Y.X.bai Y.W.bao D.bastieri X.J.bi Y.J.bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chan b.m.chen J.chen L.chen L.chen L.chen m.J.chen m.L.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen N.chen Y.D.chen S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe b.D’Ettorre Piazzoli X.J.Don J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fan C.F.Feng L.Feng S.H.Fen Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao m.m.Ge L.S.Gen G.H.Gong Q.b.Gou m.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He m.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huan W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu m.Y.Liu R.Y.Liu S.m.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.mitthumsiri T.montaruli Y.C.Nan b.Y.Pang P.Pattarakijwanich Z.Y.Pei m.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Shen J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.b.Sun P.H.T.Tam Z.b.Tang W.W.Tian b.D.Wan C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wan R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wan X.Y.Wang Y.D.Wan Y.J.Wan Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.m.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.m.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang m.J.Yan R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.m.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng m.Zha X.X.Zhai b.b.Zhang H.m.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhan X.Zhang X.P.Zhan Y.Zhan Y.Zhang Y.F.Zhang Y.L.Zhan b.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G. Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of Physical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237ShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina School of Physic

Purpose Observation of high energy and very high emission from Gamma Ray bursts(GRbs)is crucial to study the gigantic explosion and the underline *** a large field-of-view and almost full duty cycle,the Water Cherenkov Detector Array(WCDA),a sub-array of the Large High Altitude Air Shower Observatory(LHAASO),is appropriate to monitor the very high energy emission from unpredictable transients such as *** Nevertheless,the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the *** address this issue a new trigger method is developed in this article to lower the energy threshold of WCDA for GRb *** The proposed method significantly improves the detection efficiency of WCDA for gamma-rays around the GRb direction at 10-300 *** sensitivity of the WCDA for GRb detection with the new trigger method is *** achieved sensitivity of the quarter WCDA array above 10 GeV is comparable with that of *** data analysis process and corresponding fluence upper limit for GRb 190719C is presented as an example.

关键词： LHAASO WCDA GRb

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Prospects for a multi-TeV gamma-ray sky survey with the LHAASO water Cherenkov detector array

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Chinese Physics C 2020年第6期44卷 123-132页

作者： F.Aharonian V.Alekseenko Q.An Axikegu L.X.bai Y.W.bao D.bastieri9 X.J.bi H.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang X.C.Chang S.P.Chao b.m.chen J.chen L.chen L.chen m.L.chen m.J.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen N.cheng Y.D.cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluobu b.D'Ettorre Piazzoli J.Fang J.H.Fan Y.Z.Fan C.F Feng L.Feng S.H.Feng Y.L.Feng b.Gao Q.Gao W.Gao m.m.Ge L.S.Geng G.H.Gong Q.b.Gou m.H.Gu Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He J.C.He m.Heller S.L.He Y.He C.Hou D.H.Huang Q.L.Huang W.H.Huang X.T.Huang H.b.Hu S.Hu H.Y.Jia K.Jiang F.Ji C.Jin X.L.Ji K.Levochkin E.W.Liang Y.F Liang cheng Li Cong Li F.Li H.Li H.b.Li H.C.Li H.m.Li J.Li K.Li W.L.Li X.Li X.R.Li Y.Li Z.Li Z.Li b.Liu C.Liu D.Liu H.D.Liu H.Liu J.Liu J.Y.Liu m.Y.Liu R.Y.Liu S.m.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.ma L.L.ma J.R.mao A.masood X.H.ma W.mitthumsiri T.montaruli Y.C.Nan P.Pattarakijwanich Z.Y.Pei b.Q.Qiao m.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi Y.Stenkin V.Stepanov Z.b.Sun P.H.T.Tam Z.b.Tang W.W.Tian D.D.Volpe C.Wang H.Wang H.G.Wang J.C.Wang L.Y.Wang W.Wang W.Wang X.G.Wang X.Y.Wang X.J.Wang Y.D.Wang Y.J.Wang Y.N.Wang Y.P.Wang Z.Wang Z.H.Wang Z.X.Wang D.m.Wei J.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu G.m.Xiang G.Xiao G.G.Xin Y.Xing R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang L.L.Yang m.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.m.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Q.Yuan Y.H.Yu Z.J.Jiang H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng m.Zha b.b.Zhang H.m.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang P.F.Zhang P.P.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Yi Zhang Yong Zhang Y.F.g Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao F.Zheng Y.Zheng J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu H.Zhu K.J.Zhu X.Zuo Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduShichuanChina University of Science and Technology of China 230026 HefeiAnhuiChina Tsinghua University 100084 BeijingChina National Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina National Space Science Center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina Center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina Sun Yat-sen University 519000 ZhuhaiGuangdongChina Shool of Physics and Technology Guangxi University530004 NanningGuangxiChina Hebei Normal University 050024 ShijiazhuangHebeiChina School of Physics and Engineering Zhengzhou University450001 ZhengzhouHenanChina Nanjing University 210023 NanjingJiangsuChina Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210034 NanjingJiangsuChina Institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Shanghai Astronomical Observatory Chinese Academy of Sciences200030 ShanghaiChina School of Physical Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina Sichuan University 610065 ChengduSichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of Education850000 LhasaTibetChina School of physics and technology Wuhan university430072 WuhanChina Yunnan University 650091 KunmingYunnanChina Yunnan Astronomical Observatories Chinese Academy of Sciences650216 KunmingYunnanChina Institute for Nuclear Research Russian Academy of SciencesMoscowRussia Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde GenéveGenevaSwitzerland Department of Physics Faculty of ScienceMahidol UniversityBangkokThailand Dublin Institute for Advanced Studies 31 Fitzwilliam PlaceDublin 2Ireland max-Planc

The Water Cherenkov Detector Array(WCDA) is a major component of the Large High Altitude Air Shower Array Observatory(LHAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WCDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WCDA, we present a projection of the one-year sensitivity of WCDA to TeV γ-ray sources from TeVCat using an all-sky approach. Out of 128 TeVCat sources observable by WCDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei(AGN).

关键词： TeVγ-ray astronomy observational prospect LHAASO-WCDA

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A dynamic range extension system for LHAASOWCDA-1

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Radiation Detection Technology and methods 2021年第4期5卷 520-530页

作者： F.Aharonian Q.An Axikegu L.X.bai Y.X.bai Y.W.bao D.bastieri X.J.bi Y.J.bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang b.m.chen J.chen L.chen L.chen L.chen m.J.chen m.L.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen N.cheng Y.D.cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe b.D’Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao m.m.Ge L.S.Geng G.H.Gong Q.b.Gou m.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He m.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Y.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu m.Y.Liu R.Y.Liu S.m.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.mitthumsiri T.montaruli Y.C.Nan b.Y.Pang P.Pattarakijwanich Z.Y.Pei m.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.b.Sun P.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.m.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.m.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang m.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.m.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng m.Zha X.X.Zhai b.b.Zhang H.m.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of Physical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237ShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina School of Physics

Purpose The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 *** observe high-energy shower events,especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV,a dynamic range extension system(WCDA++)is designed to use a 1.5-inch PmT with a dynamic range of four orders of magnitude for each cell in *** The dynamic range is extended by using these PmTs to measure the effective charge density in the core region of air shower events,which is an important parameter for identifying the composition of primary *** and Conclusion The system has been running for more than one *** this paper,the details of the design and performance of WCDA++are presented.

关键词： LHAASO-WCDA WCDA++ Water Cherenkov detector Performance

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Performance of LHAASO-WCDA and observation of the Crab Nebula as a standard candle

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Chinese Physics C 2021年第8期45卷 166-181页

作者： F.Aharonian Q.An Axikegu L.X.bai Y.X.bai Y.W.bao D.bastieri X.J.bi Y.J.bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang b.m.chen J.chen L.chen L.chen L.chen m.J.chen m.L.chen Q.H.chen S.H.chen S.Z.chen T.L.chen X.L.chen Y.chen N.cheng Y.D.cheng S.W.Cui X.H.Cui Y.D.Cui b.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe b.D'Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng b.Gao C.D.Gao Q.Gao W.Gao m.m.Ge L.S.Geng G.H.Gong Q.b.Gou m.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.b.He Y.He m.Heller Y.K.Hor C.Hou X.Hou H.b.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin b.b.Li C.Li C.Li F.Li H.b.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin b.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu m.Y.Liu R.Y.Liu S.m.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv b.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.mitthumsiri T.montaruli Y.C.Nan b.Y.Pang P.Pattarakijwanich Z.Y.Pei m.Y.Qi b.Q.Qiao D.Ruffolo V.Rulev A.Saiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.b.Sun P.H.T.Tam Z.b.Tang W.W.Tian b.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.m.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.m.Xiang G.Xiao H.b.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang m.J.Yang R.Z.Yang S.b.Yang Y.H.Yao Z.G.Yao Y.m.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng m.Zha X.X.Zhai b.b.Zhang H.m.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang b.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng b.Zhou H.Zhou J.N.Zhou Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhai 519082China School of Physical Science and Technology Guangxi UniversityNanning 530004China Hebei Normal University Shijiazhuang 050024China School of Physics and microelectronics Zhengzhou UniversityZhengzhou 450001China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan University

The first Water Cherenkov detector of the LHAASO experiment(WCDA-1)has been operating since April *** data for the first year have been analyzed to test its performance by observing the Crab Nebula as a standard *** WCDA-1 achieves a sensitivity of 65 mCU per year,with a statistical threshold of 5 *** accomplish this,a 97.7%cosmic-ray background rejection rate around 1 TeV and 99.8%around 6 TeV with an ap proximate photon acceptance of 50%is achieved after applying an algorithm to separate gamma-induced *** angular resolution is measured using the Crab Nebula as a point source to be approximately 0.45°at 1 TeV and better than 0.2°above 6 TeV,with a pointing accuracy better than 0.05°.These values all match the design *** energy resolution is found to be 33%for gamma rays around 6 *** spectral energy distribution of the Crab Nebula in the range from 500 GeV to 15.8 TeV is measured and found to be in agreement with the results from other TeV gamma ray observatories.

关键词： LHAASO-WCDA Crab Nebula angular resolution spectral energy distribution

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brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： man Han Deyang Zeng Wei Tan Xingxing chen Shuyuan bai Qiong Wu Yushan chen Zhen Wei Yufei mei Yan Zeng brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase b signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,bDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Unraveling the therapeutic potential of Calculus bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： Xing-Yu chen Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus bovis(Cb)on liver cancer and the underlying *** inhibited m2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of Cb for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus bovis Liver cancer m2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang chen Zhifeng chen menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical biological Resources of ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d b for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3b and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3b,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng Li Jiangtao Sheng Department of microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(Sb203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-mAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

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