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High-Tc superconductor Fe（Se,Te） monolayer:an intrinsic,scalable and electrically tunable Majorana platform

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National Science Review 2022年第3期9卷 11-18页

作者： Xianxin wu Xin liu Ronny Thomale Chao-Xing liu Institut für Theoretische Physik und Astrophysik Julius-Maximilians-Universit?t Würzburg School of Physics Huazhong University of Science and Technology wuhan National High Magnetic Field Center Huazhong University of Science and Technology Department of Physics the Pennsylvania State University

Iron-based superconductors have been identified as a novel platform for realizing Majorana zero modes（MZMs） without heterostructures, due to their intrinsic topological properties and high-Tc superconductivity. In the two-dimensional limit, the FeTe;1-x;Se;x;monolayer, a topological band inversion has recently been experimentally observed. Here, we propose to create MZMs by applying an in-plane magnetic field to the FeTe;1-x;Se;x;monolayer and tuning the local chemical potential via electric *** to the anisotropic magnetic couplings on edges, an in-plane magnetic field drives the system into an intrinsic high-order topological superconductor phase with Majorana corner modes. Furthermore, MZMs can occur at the domain wall of chemical potentials at either one edge or certain type of tri-junction in the two-dimensional bulk. Our study not only reveals the FeTe;1-x;Se;x;monolayer as a promising Majorana platform with scalability and electrical tunability and within reach of contemporary experimental capability,but also provides a general principle to search for realistic realization of high-order topological superconductivity.

关键词： high-order topological superconductivity Majorana zero modes iron-based superconductors

光果柱花草转基因毛状根及其原生质体制备体系的建立

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草地学报 2024年第5期32卷 1583-1591页

作者：孙昊张建禹罗丽娟刘攀道海南大学热带农林学院海南海口570228 海南大学三亚南繁研究院海南三亚572025 中国热带农业科学院热带作物品种资源研究所农业农村部华南作物基因资源与种质创制重点实验室&海南省热带作物资源遗传改良与创新重点实验室海南海口571101

光果柱花草(Stylosanthes leiocarpa)是柱花草属(Stylosanthes Sw.)中可用于林果园间作的一个野生种。截至目前,光果柱花草的转基因体系尚未建立。本研究以光果柱花草的子叶节为外植体,比较不同的发根农杆菌菌株与潮霉素b浓度对毛状根... 详细信息

光果柱花草(Stylosanthes leiocarpa)是柱花草属(Stylosanthes Sw.)中可用于林果园间作的一个野生种。截至目前,光果柱花草的转基因体系尚未建立。本研究以光果柱花草的子叶节为外植体,比较不同的发根农杆菌菌株与潮霉素b浓度对毛状根诱导率及转基因阳性率的影响。结果发现,以K599为诱导菌株且培养基添加8 mg·L^(-1)潮霉素b为筛选压,是最优的毛状根诱导条件,诱导率达23.33%,阳性率为100%。在此基础上,利用转基因毛状根制备原生质体,结果表明,添加2.5%纤维素酶和2%离析酶,以及8 h的酶解时间为最优条件,原生质体的产量达2.745×10^(5)个·g^(-1),活力为91.02%,制备的原生质体100%为转基因细胞。本研究成功建立了一种发根农杆菌介导的光果柱花草转基因毛状根诱导体系及原生质体制备体系,为后续光果柱花草的基因功能研究奠定了基础。

关键词：光果柱花草发根农杆菌转基因毛状根原生质体制备

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基于网络药理学探讨苦参治疗结直肠癌活性成分、作用靶点及潜在作用机制

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辽宁中医杂志 2024年第2期51卷 29-32,I0004页

作者：袁晨越刘湘君刘怡黄人可陆鑫熠任建琳上海中医药大学附属市中医医院上海200071

目的使用网络药理学方法分析抗肿瘤中药苦参活性成分及其治疗结直肠癌的潜在靶点与作用机制。方法通过中药系统药理学数据库与分析平台(TCMSP)数据库筛选中药苦参活性成分,并使用PubChem数据库验证所收集活性成分化合物结构,运用SwissTa... 详细信息

目的使用网络药理学方法分析抗肿瘤中药苦参活性成分及其治疗结直肠癌的潜在靶点与作用机制。方法通过中药系统药理学数据库与分析平台(TCMSP)数据库筛选中药苦参活性成分,并使用PubChem数据库验证所收集活性成分化合物结构,运用SwissTargetPrediction数据库反向分子对接预测苦参活性成分可能作用靶点。采用GeneCards、DisGeNET、TTD、MalaCards数据库预测结直肠癌疾病靶点,通过Cytoscape 3.8软件构建“药物-活性成分-靶点-疾病”关系网络图,利用STRING数据库分析苦参-结直肠癌共同靶蛋白PPI蛋白间相互作用网络,采用DAVID数据库对关键靶点进行基因本体论(GO)富集分析以及京都基因和基因组百科全书(KEGG)通路富集分析。结果共筛选获得中药苦参活性成分45个,通过调控结直肠癌相关作用靶点54个,参与体内信号传导、蛋白质磷酸化、凋亡等生物学过程,并通过调控癌症相关信号通路、PI3K-Akt信号通路、癌症蛋白聚糖信号通路等途径发挥治疗作用。结论中药苦参能够通过多途径、多靶点协同发挥抗结直肠癌作用。

关键词：苦参结直肠癌网络药理学活性成分作用机制信号通路

High-quality perovskite MAPbI_3 single crystals for broad-spectrum and rapid response integrate photodetector

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Journal of Energy Chemistry 2018年第3期27卷 722-727页

作者： Yunxia Zhang Yucheng liu Zhou Yang Shengzhong(Frank)liu Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices ShaanxiEngineering Lab for Advanced Energy TechnologyInstitute for Advanced Energy MaterialsSchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina iChEM Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Organic–inorganic single-crystalline perovskites have attracted significant attentions due to their exceptional progress in intrinsic properties＇ investigation and applications in photovoltaics and optoelectronics. In this study, the large perovskite CH3NH3PbI3 single crystal with the largest length of 80 mm was prepared through the method of inverse-temperature crystallization. Meanwhile, the mass production of integrate photodetectors have been fabricated on the single-crystalline wafer and the photoresponse performances were investigated. The results show that the single-crystalline photodetectors have broad spectrum response to 900 nm, rapid response speed（〈40 μs） and excellent stability. These findings are of great importance for future promising perovskite single crystalline for integrated photoelectronic application.

关键词： Single-crystalline Perovskite Photodetector Rapid response

Impact of the national hepatitis b immunization program in China:a modeling study

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Infectious Diseases of Poverty 2022年第5期11卷 99-100页

作者： Zhixi liu Mengying Li David w.Hutton Abram L.wagner Ye Yao wenlong Zhu Lingsheng Cao Shenglan Tang Jinhua Pan Yesheng wang Qi Zhao Hong Ren Ying wang weibing wang School of Public Health Shanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina Department of Social Medicine School of Public HealthFudan UniversityShanghaiChina 不详

background:Elimination of hepatitis b virus(HbV)is a striking challenge for countries with high or moderate disease ***,using China as a practical case to share experiences for similar countries may accelerate the achievement of the wHO 2030 target of 90%reduction in HbV-related *** aim to evaluate the impact of national HbV immunization strategies in China;and the feasibility to achieve wHO 2030 targets under diferent ***:we constructed an expanded Susceptible-Exposed-Infectious-Recovered(SEIR)model and decision treeMarkov model to estimate the epidemic of HbV in China,assess the feasibility of 2030 Elimination Goals through the projections and conduct the economic *** square method was used to calibrate the expanded SEIR model by yearly data of laboratory-confrmed HbV cases from 1990 to *** models were separately used to evaluate the impact and cost-efectiveness of HbV vaccine by comparing prevalence of chronic HbV infections,qualityadjusted life-years(QALYs),incremental cost efectiveness ratio and beneft–cost ratio(bCR)under various intervention options,providing a basis for exploring new containment ***:between 1990 and 2020,the number of chronic HbV infections decreased by 33.9%.The current status quo would lead to 55.73 million infections(3.95%prevalence)in 2030,compared to 90.63 million(6.42%prevalence)of the“without the NIP”scenario(NIP:National Immunization Program),114.78 million(8.13%prevalence)without any *** prevention of mother to child transmission(PMTCT)strategy showed a net beneft as 12,283.50 dollars per person,with bCR as 12.66,which is higher than that of universal vaccination at *** with no screening and no vaccination,the PMTCT strategy could save 7726.03 dollars for each QALY ***:Our fndings proved the HbV vaccination has demonstrated a substantial positive impact on controlling the epidemic of HbV in terms of efectiveness and economy af

关键词： Hepatitis b National immunization program Prevalence Economic analysis Susceptible-ExposedInfectious-Recovered modeling

新型含(卤代)烷氧基类双酰胺化合物的合成、杀虫活性及构效关系研究

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有机化学 2024年第5期44卷 1584-1591页

作者：刘吉永吴明慧相君成庞怀林李斌吕亮沈阳农业大学植物保护学院沈阳110866 南通泰禾化工股份有限公司江苏南通226407 上海晓明检测技术服务有限公司上海200335

为了发现结构新颖、活性优异、环境友好的新型杀虫剂,以环丙氟虫胺为先导化合物,在其苯胺部分引入(卤代)烷氧基单元,设计合成了一系列未见文献报道的新型含(卤代)烷氧基类双酰胺化合物,其结构经过^(1)H NMR、^(13)C NMR和HRMS确证.初步... 详细信息

为了发现结构新颖、活性优异、环境友好的新型杀虫剂,以环丙氟虫胺为先导化合物,在其苯胺部分引入(卤代)烷氧基单元,设计合成了一系列未见文献报道的新型含(卤代)烷氧基类双酰胺化合物,其结构经过^(1)H NMR、^(13)C NMR和HRMS确证.初步的生物活性测试结果表明,大部分化合物对小菜蛾表现出优异的杀虫活性,其中N-[2-溴-4-(全氟丙烷-2-基)-6-(二氟甲氧基)苯基]-3-[N-(环丙甲基)苯甲酰胺基]-4-氟苯甲酰胺(4a)、N-[2-溴-4-(全氟丙烷-2-基)-6-(三氟甲氧基)苯基]-3-[N-(环丙甲基)苯甲酰胺基]-4-氟苯甲酰胺(4b)、N-(2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)-3-(N-(环丙基甲基)苯甲酰胺基)-2-氟苯甲酰胺(4h)、N-[2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基]-3-[4-氰基-N-(环丙基甲基)苯甲酰胺]-2-氟苯甲酰胺(4j)~N-(3-((2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)氨基甲酰基)-2-氟苯基)-N-(环丙基甲基)异烟酰胺(4o)、N-(3-((2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)氨基甲酰基)-2-氟苯基)-N-(环丙基甲基)-2,4-二氟苯甲酰胺(4q)和N-(3-((2-溴-6-(二氟甲氧基)-4-(全氟丙烷-2-基)苯基)氨基甲酰基)-2-氟苯基)-N-(环丙基甲基)-2-氟异烟酰胺(4t)在1mg/L浓度下显示出100%的杀虫活性.同时,化合物4a不仅对小菜蛾和二化螟的杀虫活性接近于环丙氟虫胺,而且对苜蓿蚜和朱砂叶螨的杀虫活性也较高,表现出比环丙氟虫胺更广的杀虫谱,其田间试验正在进行中.

关键词：双酰胺化合物合成杀虫活性构效关系

Locomotion Optimization and Manipulation Planning of a Tetrahedron-based Mobile Mechanism with binary Control

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 78-99页

作者： Ran liu Yan-An Yao wan Ding Xiao-Ping liu School of Mechanical Electronic and Control EngineeringBeijing Jiaotong University Department of Mechanism Theory and Dynamics of Machines RWTH Aachen University Department of Systems and Computer Engineering Carleton University

Locomotion and manipulation optimization is essential for the performance of tetrahedron-based mobile mechanism. Most of current optimization methods are constrained to the continuous actuated system with limited degree of freedom(DOF), which is infeasible to the optimization of binary control multi-DOF system. A novel optimization method using for the locomotion and manipulation of an 18 DOFs tetrahedron-based mechanism called 5-TET is proposed. The optimization objective is to realize the required locomotion by executing the least number of *** control strategy is adopted, and forward kinematic and tipping dynamic analyses are performed, *** on a developed genetic algorithm(GA), the optimal number of alternative struts between two adjacent steps is obtained as 5. Finally, a potential manipulation function is proposed, and the energy consumption comparison between optimal 5-TET and the traditional wheeled robot is carried out. The presented locomotion optimization and manipulation planning enrich the research of tetrahedron-based mechanisms and provide the instruction to the successive locomotion and operation planning of multi-DOF mechanisms.

关键词： Tetrahedron-based mobile mechanism binary control GA Locomotion optimization Manipulation planning

LncRNA109897-JrCCR4-JrTLP1b forms a positive feedback loop to regulate walnut resistance against anthracnose caused by Colletotrichum gloeosporioides

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Horticulture Research 2023年第6期10卷 214-227页

作者： Rui Zhou Yuhui Dong Changxi wang Jianning liu Qiang Liang Xiaoye Meng Xinya Lang Shengyi Xu wenjun liu Shuhui Zhang Nan wang Ke Qiang Yang Hongcheng Fang State Forestry and Grassland Administration Key Laboratory of Silviculture in the Downstream Areas of the Yellow River Shandong Taishan Forest Ecosystem Research StationCollege of ForestryShandong Agricultural UniversityTai’anShandongChina271018 Department of Natural Resources Of Shandong Province Forestry Protection and Development Service CenterJinanShandongChina250000 State Key Laboratory of Crop biology College of Horticulture Sciences and EngineeringShandong Agricultural UniversityTai’anShandongChina271018

walnut anthracnose induced by Colletotrichum gloeosporioides is a disastrous disease that severely restricts the development of the walnut industry in *** non-coding RNAs(lncRNAs)are involved in adaptive responses to disease,but their roles in the regulation of walnut anthracnose resistance response are not well *** this study,transcriptome analysis demonstrated that a ***-induced lncRNA,lncRNA109897,located upstream from the target gene JrCCR4,upregulated the expression of ***4 interacted with JrTLP1b and promoted its transcriptional *** turn,JrTLP1b induced the transcription of lncRNA109897 to promote its ***,transient expression in walnut leaves and stable transformation of Arabidopsis thaliana further proved that lncRNA,JrCCR4,and JrTLP1b improve the resistance of ***,these findings provide insights into the mechanism by which the lncRNA109897-JrCCR4-JrTLP1b transcriptional cascade regulates the resistance of walnut to anthracnose.

关键词： CCR4 resistance TLP

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双侧第四鳃裂畸形1例并文献复习

口腔疾病防治 2024年第7期32卷 532-538页

作者：田禾刘玉铰张昊喻学洲十堰市人民医院(湖北医药学院附属人民医院)口腔科湖北十堰442000

目的探讨第四鳃裂畸形的诊断与治疗方法。方法对1例颈部双侧第四鳃裂畸形的患者临床资料进行总结与文献回顾分析。结果患者,17岁,男性,颈部无痛性肿块10年,专科检查:颈前偏右皮下可触及一肿块,大小约4.0 cm×3.0 cm,边界清楚,形态规则,... 详细信息

目的探讨第四鳃裂畸形的诊断与治疗方法。方法对1例颈部双侧第四鳃裂畸形的患者临床资料进行总结与文献回顾分析。结果患者,17岁,男性,颈部无痛性肿块10年,专科检查:颈前偏右皮下可触及一肿块,大小约4.0 cm×3.0 cm,边界清楚,形态规则,质软,触有波动感,无明显压痛。颈前偏左可见一大小约0.5 cm×0.5 cm的瘘口,瘘口可见黄色清亮液体流出,周围皮肤局部红肿,皮肤表面温度升高;计算机断层扫描检查示:右侧锁骨上区、颈前区见类圆形囊性低密度影,大小约4.4 cm×3.4 cm,其内片絮状等密度影,边缘见结节状钙化,周围脂肪间隙模糊,增强扫描囊壁轻度强化,内容物未见明显强化;其左侧可见直径约1.4 cm类圆形结节影,增强扫描环形强化,周围皮肤增厚,皮下脂肪间隙模糊;双侧颈部见多发小淋巴结显示,较大者短径约0.8 cm;甲状腺大小、形态未见明显异常,其内未见明显异常密度影。入院诊断为右颈部第四鳃裂囊肿,左颈部第四鳃裂瘘管。在全麻静脉复合麻醉下行右侧鳃裂囊肿切除术+左侧鳃裂瘘管切除术。术后病理检查提示为右鳃裂囊肿,左鳃裂瘘管。伤口I期愈合,术后随访6个月无复发。文献回顾复习结果表明,第四鳃裂畸形是鳃器的先天性发育异常,发生率仅占所有鳃裂畸形的1%,常发生于左侧。解剖学位置常位于颈根部、锁骨上区,表现为与甲状腺相毗邻的囊肿或窦道。通过其解剖学位置、影像学检查或喉镜检查结合术后病理结果明确诊断,需要与颈部肿块如甲状舌管囊肿、淋巴结转移瘤等相鉴别。主要治疗手段为外科手术和内窥镜烧灼内瘘口,预后一般较好,有复发风险,但很少发生癌变。结论第四鳃裂畸形十分罕见,应早期识别,避免过多无效的手术引流,减少切除时的潜在并发症并彻底切除病变防止复发。

关键词：第四鳃裂鳃裂囊肿鳃裂瘘管外科手术鳃器内窥镜烧灼癌变囊肿