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Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya bay

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Chinese Physics C 2021年第5期45卷 190-201页

作者： F.P.An A.b.balantekin H.R.band M.bishai S.blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.b.Hsiung b.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.b.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.b.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg b.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.b.Luk X.b.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero b.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull b.viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh b.L.Young H.Z.Yu Z.Y.Yu b.b.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou Instiute of Modern Physics East China University of Science and TechnologyShanghai 200237 University of Wisconsin MadisonWisconsin 53706 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 brookhaven National Laboratory UptonNew York 11973 Department of Physics National Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBejing 100084 Shenzhen University Shenzhen 518060 Sun Yat-Sen(Zhongshan)University Guangzhou North China Electric Power University Bejjing 102206 Chinese University of Hong Kong Hong Kong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCaliformia 92697 University of Science and Technology of China Hefei 230026 Charles University Faculty of Mathematics and PhysicsPrague Department of Physics University of llinois at Urbana-ChampaignUrbanaIlinois 61801 Lawrence berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 Joint Institute for Nuclear Research DubnaMoscow Region beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Department of Physics University of HoustonHoustonTexas 77204 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250100 Guangxi University Nanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics National Chiao-Tung UniversityHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physies Collge of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHong Kong 999077 School

The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars *** the Daya bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW *** used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino *** detected electron-antineutrino candidates were consistent with the expected background rates for all the three time *** monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w *** the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows.

关键词： grav itational waves electron-antineutrinos fluence upper limit

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Antineutrino energy spectrum unfolding based on the Daya bay measurement and its applications

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Chinese Physics C 2021年第7期45卷 1-19页

作者：安丰鹏 A.b.balantekin M.bishai S.blyth 曹国富曹俊常劲帆张昀陈和生陈少敏陈羽陈义学程捷成兆侃 J.J.Cherwinka 朱明中 J.P.Cummings O.Dalager 邓凡水丁雅韵 M.V.Diwan T.Dohnal D.Dolzhikov J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar 龚光华宫辉 M.Grassi 顾文强郭竞渊郭磊郭新恒郭宇航郭子溢 R.W.Hackenburg S.Hans 何苗 K.M.Heeger 衡月昆贺远强熊怡胡貝楨胡健润胡涛胡焯钧黄翰雄黄金浩黄性涛黄永波 P.Huber D.E.Jaffe 任國綸季筱璐季向盼 R.A.Johnson D.Jones 康丽 S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee 李曉菁雷瑞霆 R.Leitner 梁干庄李飞李慧玲李进京李秋菊李茹慧黎山峰 S.C.Li 李卫东李小男李学潜李玉峰李志兵梁昊林政儒林贵林林盛鑫凌家杰 L.Littenberg b.R.Littlejohn 刘金昌刘江来刘佳熙陆昌国路浩奇陆锦标马帮争马续波马骁妍马宇倩 R.C.Mandujano C.Marshall K.T.McDonald R.D.McKeown 孟月 J.Napolitano D.Naumov E.Naumova T.M.T.Nguyen J.P.Ochoa-Ricoux A.Olshevskiy 潘孝儒 J.Park S.Patton 彭仁杰潘振声齐法制祁鸣钱鑫任杰 C.Morales Reveco R.Rosero b.Roskovec 阮锡超 H.Steiner 孙吉良 T.Tmej K.Treskov 謝雲皓 C.E.Tull b.viren V.Vorobel 王正祥王俊王萌王乃彦王瑞光王为王维王玺王玉漫王贻芳王铮王喆王志民魏瀚宇韦良红温良剑 K.Whisnant C.GWhite 黄显诺 E.Worcester 吴帝儒武方亮吴群吴文杰夏冬梅谢章权邢志忠许杭锟徐吉磊徐彤薛涛杨长根杨雷杨玉梓姚海峰叶梅叶铭芳杨炳麟余泓钊于泽源岳保彪 V.Zavadskyi 曾珊曾裕达占亮张超张飞洋张宏浩张家文张清民张石其张玄同张玉美张一心张园园张志坚张子平张智勇赵洁赵润泽周莉庄红林邹佳恒 Institute of Modern Physics East China University of Science and TechnologyShanghai 200337 University of Wisconsin MadisonWisconsin 53706 brookhaven National Laboratory UptonNew York 11973 Department of Physics Nnational Taiwan UniversityTaipei Institute of High Energy Physics Beijing 100049 National United University Miao-Li Department of Engineering Physics Tsinghua UniversityBeijing 100048 Shenzhen University Shenzhen 518061 Sun Yat-Sen(Zhongshan)University Guangzhou 510275 North China Electric Power University Beijing 102206 Chinese University of Hong Kong Hongkong 999077 Siena College LoudonvilleNew York 12211 Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697 University of Science and Technology of China Hefei 230022 Charles University Faculty of Mathematics and PhysicsPrague Joint Institute for Nuclear Research DubnaMoscow Region Department of Physics University of Illinois at Urbana-ChampaignUrbanaIllinois 61801 Lawrence berkeley National Laboratory BerkeleyCalifornia 94720 Department of Physics Illinois Institute of TechnologyChicagoIllinois 60616 beijing Normal University Beijing 100875 Department of Nuclear Science and Technology School of Energy and Power EngineeringXi'an Jiaotong UniversityXi'an 710049 Wright Laboratory and Department of Physics Yale UniversityNew HavenConnecticut 06520 China Institute of Atomic Energy Beijing 102413 Shandong University Jinan 250002 Guangxi University No.100 Daxue East RoadNanning 530004 Center for Neutrino Physics Virginia TechBlacksburgVirginia 24061 Institute of Physics NCTUHsinchu Department of Physics University of CincinnatiCincinnatiOhio 45221 Department of Physics College of Science and TechnologyTemple UniversityPhiladelphiaPennsylvania 19122 Dongguan University of Technology Dongguan 523808 Department of Physics University of CaliforniaBerkeleyCalifornia 94720 Department of Physics The University of Hong KongPokfulamHongkong 999077 School of Physics Nankai UniversityTianjin 300071 Department o

The prediction of reactor antineutrino spectra will play a crucial role as reactor experiments enter the precision *** positron energy spectrum of 3.5 million antineutrino inverse beta decay reactions observed by the Daya bay experiment,in combination with the fission rates of fissile isotopes in the reactor,is used to extract the positron energy spectra resulting from the fission of specific *** information can be used to produce a precise,data-based prediction of the antineutrino energy spectrum in other reactor antineutrino experiments with different fission fractions than Daya *** positron energy spectra are unfolded to obtain the antineutrino energy spectra by removing the contribution from detector response with the Wiener-SVD unfolding *** results are obtained with other unfolding methods.A technique to construct a data-based prediction of the reactor antineutrino energy spectrum is proposed and *** the reactor fission fractions,the technique can predict the energy spectrum to a 2%*** addition,we illustrate how to perform a rigorous comparison between the unfolded antineutrino spectrum and a theoretical model prediction that avoids the input model bias of the unfolding method.

关键词： reactor antineutrino energy spectrum Daya bay application

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Improved measurement of electron antineutrino disappearance at Daya bay

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Chinese Physics C 2013年第1期37卷 1-20页

作者：安丰鹏安琪白景芝 A.b.balantekin H.R.band W.beriguete M.bishai S.blyth R.L.brown 曹国富曹俊 R.Carr W.T.Chan 常劲帆 Y.Chang C.Chasman 陈和生 H.Y.Chen 陈申见陈少敏陈潇聪陈晓辉陈晓苏陈羽陈义学 J.J.Cherwinka 朱明中 J.P.Cummings 邓子艳丁雅韵 M.V.Diwan E.Draeger 杜小峰 D.Dwyer W.R.Edwards S.R.Ely 方绍东付金煜付在伟葛良全 R.L.Gi11 M.Gonchar 龚光华宫辉 Y.A.Gornushkin 顾文强关梦云郭新恒 R.W.Hackenburg R.L.Hahn S.Hans 郝慧峰何苗贺青 K.M.Heeger 衡月昆 P.Hinrichs Y.K.Hor Y.b.Hsiung b.z.Hu 胡涛黄翰雄 H.z.Huang 黄性涛 P.Huber V.Issakov z.Isvan D.E.Jaffe S.Jetter 季筱璐季向盼姜海静焦健斌 R.A.Johnson 康丽 S.H.Kettell M.Kramer 关健强郭文伟郭人能 C.Y.Lai 赖万昌 W.H.Lai K.Lau L.Lebanowski J.Lee 雷瑞霆 R.Leitner 梁干庄梁嘉怡 C.A.Lewis 李飞李高嵩李秋菊李卫东李小波李小男李学潜李仪李志斌梁昊林政儒 C.L.Lin S.K.Lin 林延畅凌家杰 J.M.Link L.Littenberg b.R.Littlejohn D.W.Liu 刘金昌刘江来刘颖彪陆昌国路浩奇陆永康 K.b.Luk 马秋梅马续波马骁妍马宇蒨 K.T.McDonald M.C.McFarlane R.D.McKeown Y.Meng D.Mohapatra Y.Nakajima J.Napolitano D.Naumov I.Nemchenok 倪浩然 W.K.Ngai 聂阳波宁哲 J.P.Ochoa-Ricoux A.Olshevski S.Patton V.Pec J.C.Peng L.E.Piilonen L.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero b.Roskovec 阮锡超邵贝贝师恺 H.Steiner 孙功星孙吉良 N.Tagg 谭耀豪 H.K.Tanaka 唐晓 H.Themann Y.Torun S.Trentalange O.Tsai K.V.Tsang R.H.M.Tsang C.E.Tull Y.C.Tung b.viren V.Vorobe1 C.H.Wang 王灵淑王玲玉王龙泽王萌王乃彦王瑞光 W.Wang 王玺王贻芳王喆王铮王志民 D.M.Webber 魏瀚宇魏亚东温良剑 K.Whisnant C.G.White L.Whitehead Y.Williamson T.Wise H.L.H.Wong E.T.Worcester F.F.Wu 吴群习建博夏冬梅邢志忠徐建一徐晶徐吉磊徐晔薛涛杨长根杨雷叶梅 M.Yeh Y.S.Yeh b.L.Young 于泽源占亮 C.Zhang 章飞虹张家文张清民张书华张一纯张银鸿张一心张志坚张子平张智勇赵洁赵庆旺赵豫斌郑磊钟玮丽周莉周祖英庄红林邹佳恒 Institute of High Energy Physics Chinese Academy of Sciences University of Science and Technology of China University of Wisconsin brookhaven National Laboratory National United University California Institute of Technology Nanjing University Department of Engineering Physics Tsinghua University Chinese University of Hong Kong Shenzhen Univeristy North China Electric Power University Siena College Department of Physics Illinois Institute of Technology Lawrence berkeley National Laboratory Department of Physics University of California Department of Physics University of Illinois at Urbana-Champaign Chengdu University of Technology Joint Institute for Nuclear Research Shanghai Jiao Tong University beijing Normal University Joseph Henry Laboratories Princeton University Center for Neutrino Physics Virginia Tech Department of Physics National Taiwan University Institute of Physics National Chiao-Tung University China Institute of Atomic Energy University of California Shandong University School of Physics Nankai University University of Cincinnati Dongguan University of Technology Department of Physics The University of Hong Kong Department of Physics University of Houston Charles University Faculty of Mathematics and Physics Sun Yat-Sen(Zhongshan)University College of William and Mary Rensselaer Polytechnic Institute China Guangdong Nuclear Power Group Iowa State University Xi'an Jiaotong University

We report an improved measurement of the neutrino mixing angle θ13 from the Daya bay Reactor Neutrino Experiment. We exclude a zero value for sin22θ13 with a significance of 7.7 standard deviations. Electron antineutrinos from six reactors of 2.9 GWm th were detected in six antineutrino detectors deployed in two near （flux-weighted baselines of 470 m and 576 m） and one far （1648 m） underground experimental halls. Using 139 days of data, 28909 （205308） electron antineutrino candidates were detected at the far hall （near halls）. The ratio of the observed to the expected number of antineutrinos assuming no oscillations at the far hall is 0.944± 0.007（stat.） ± 0.003（syst.）. An analysis of the relative rates in six detectors finds sin22θ13=0.089± 0.010（stat.）±0.005（syst.） in a three-neutrino framework.

关键词： neutrino oscillation neutrino mixing reactor Daya bay

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Improved measurement of the reactor antineutrino flux and spectrum at Daya bay

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Chinese Physics C 2017年第1期41卷 11-46页

作者：安丰鹏 A.b.balantekin H.R.band M.bishai S.blyth 曹德文曹国富曹俊岑吴镕陳日朗常劲帆張立楚张昀陈和生陈泉佑陈少敏陈义学陈羽程佳樺程捷程雅苹成兆侃 J.J.Cherwinka 朱明中 A.Chukanov J.P.Cummings J.de Arcos 邓子艳丁雪峰丁雅韵 M.V.Diwan M.Dolgareva J.Dove D.A.Dwyer W.R.Edwards R.Gill M.Gonchar 龚光华宫辉 M.Grassi 顾文强关梦云郭磊郭如盼郭新恒郭子溢 R.W.Hackenburg 韩然 S.Hans 何苗 K.M.Heeger 衡月昆 A.Higuera Y.K.Hor 熊怡胡貝禎胡涛胡维黄恩泉黄翰雄黄性涛 P.Huber 霍文驹 G.Hussain D.E.Jaffe P.Jaffke 任國綸 S.Jetter 季向盼季筱璐焦健斌 R.A.Johnson D.Jones J.Joshi 康丽 S.H.Kettell S.Kohn M.Kramer 關健强郭文伟郭天能 T.J.Langford K.Lau L.Lebanowski J.Lee 李曉菁雷瑞庭 R.Leitner 李超李登杰李飞李高嵩李秋菊黎山峰 S.C.Li 李卫东李小男李玉峰李志兵梁昊林政儒林贵林林盛鑫林士凱林禹丞凌家杰 J.M.Link L.Littenberg b.R.Littlejohn 刘大为刘江来刘金昌 C.W.Loh 陆昌国路浩奇陆稼书陆锦标吕志鹏马秋梅马晓妍马续波马宇倩 Y.Malyshkin D.A.Martinez Caicedo K.T.McDonald R.D.McKeown I.Mitchell M.Mooney Y.Nakajima J.Napolitano D.Naumov E.Naumova 倪浩然宁哲 J.P.Ochoa-Ricoux A.Olshevskiy 潘孝儒 J.Park S.Patton V.Pec 彭仁杰 L.Pinsky 潘振声齐法制祁鸣钱鑫 N.Raper 任杰 R.Rosero b.Roskovec 阮锡超 H.Steiner 孙功星孙吉良唐炜 D.Taychenachev K.TVeskov K.V.Tsang C.E.Tull N.Viaux b.viren V.Vorobei 王正祥王萌王乃彦王瑞光王为王玺王贻芳王喆王铮王志民魏瀚宇温良剑 K.Whisnant C.G.White L.Whitehead T.Wise 黄显诺黄振辉 E.Worcester 吳珈豪吴群吴文杰夏冬梅夏经凯邢志忠徐建一徐吉磊徐晔薛涛杨长根杨海波杨雷阳马生杨梦婷叶梅 Z.Ye 叶铭芳杨炳麟于泽源曾珊占亮张超张宏浩张家文张清民张玄同张一鸣张一心张玉美张志坚张智勇张子平赵洁赵庆旺赵豫斌钟玮丽周莉 N.Zhou 庄红林邹佳恒 Institute of Modern Physics East China University of Science and Technology University of Wisconsin Department of Physics Yale University brookhaven National Laboratory Department of Physics National Taiwan University National United University Nanjing University Institute of High Energy Physics Chinese University of Hong Kong Institute of Physics National Chiao-Tung University Shandong University Department of Engineering Physics Tsinghua University North China Electric Power University Shenzhen University Sun Yat-Sen (Zhongshan) University Joint Institute for Nuclear Research Siena College Department of Physics Illinois Institute of Technology Department of Physics University of Illinois at Urbana-Champaign Lawrence berkeley National Laboratory Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology beijing Normal University Department of Chemistry and Chemical Technology Bronx Community College Department of Physics University of Houston Center for Neutrino Physics Virginia Tech China Institute of Atomic Energy University of Science and Technology of China School of Physics Nankai University Department of Physics University of Cincinnati Department of Physics College of Science and Technology Temple University Dongguan University of Technology Department of Physics University of California Department of Physics The University of Hong Kong Charles University Faculty of Mathematics and Physics Joseph Henry Laboratories Princeton University Department of Nuclear Science and Technology School of Energy and Power Engineering Xi’an Jiaotong University Instituto de F'?sica Pontificia Universidad Católica de Chile California Institute of Technology College of William and Mary Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute China General Nuclear Power Group College of Electronic Science and Engineering National University of Defense Technology Iowa State University Chongqing University

A new measurement of the reactor antineutrino flux and energy spectrum by the Daya bay reactor neutrino experiment is reported. The antineutrinos were generated by six 2.9 GWth nuclear reactors and detected by eight antineutrino detectors deployed in two near（560 m and 600 m flux-weighted baselines） and one far（1640 m flux-weighted baseline） underground experimental halls. With 621 days of data, more than 1.2 million inverse beta decay（IbD） candidates were detected. The IbD yield in the eight detectors was measured, and the ratio of measured to predicted flux was found to be 0.946±0.020（0.992±0.021） for the Huber＋Mueller（ILL＋Vogel） model. A 2.9σ deviation was found in the measured IbD positron energy spectrum compared to the predictions. In particular, an excess of events in the region of 4–6 MeV was found in the measured spectrum, with a local significance of 4.4σ. A reactor antineutrino spectrum weighted by the IbD cross section is extracted for model-independent predictions.

关键词： antineutrino flux energy spectrum reactor Daya bay

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Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第1期8卷 47-59页

作者： Wen-Chi L Chang Shet Masih Anusha Thadi viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai Cancer Prevention and Control Program Fox Chase Cancer Center baruch S.blumberg Institute Department of Pathology Fox Chase Cancer Center R and D Center Synergy Pharmaceuticals Inc.

AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant i

关键词： Guanylate cyclase-C Uroguanylin Plecanatide Inflammation Colorectal cancer

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