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Implications of Elevated Serum Cortisol in the Onset of Postoperative Delirium Following Off-Pump Coronary Artery bypass Grafting: Insights from a bangladesh-based Single Center Experience

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World Journal of Cardiovascular Diseases 2024年第4期14卷 252-267页

作者： Vivek kumar Jha Md Abir Tazim Chowdhury Munama Magdum manoj Tiwari Md Abul bashar Maruf Md Saiful Islam Khan Priyanka Sinha Rajesh Naryan Kapar Md. Rezwanul Hoque Department of Cardiothoracic and Vascular Surgery BP Koirala Institute of Health Sciences Dharan Nepal Department of Cardiothoracic and Vascular Surgery Evercare Hospital Dhaka Dhaka Bangladesh Department of Preventive and Social Medicine National Institute of Preventive and Social Medicine Dhaka Bangladesh Department of Thoracic Surgery BP Koirala Memorial Cancer Hospital Bharatpur Nepal Department of Cardiac Surgery United Hospital Limited Dhaka Bangladesh Department of Cardiothoracic Anesthesia Evercare Hospital Dhaka Dhaka Bangladesh Department of Microbiology Kathmandu Medical College Kathmandu Nepal Department of Nephrology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Cardiac Surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

background: Following coronary artery bypass grafting (CAbG), delirium emerges as a prevalent complication. This study aimed to assess the correlation between elevated serum cortisol levels and the occurrence of postoperative delirium subsequent to off-pump CAbG. Methods: Conducted in the Department of Cardiac Surgery at bSMMU from October 2020 to September 2022, this comparative cross-sectional study included a total of 44 participants. Subjects, meeting specific criteria, were purposefully assigned to two groups based on off-pump CAbG. Group A (n = 22) consisted of patients with normal serum cortisol levels, while Group b (n = 22) comprised individuals with high serum cortisol levels on the first postoperative day. Delirium onset was assessed at the bedside in the ICU on the 1st, 2nd, 3rd, 4th, and 5th postoperative days using standard tools, namely the Richmond Agitation Sedation score (RASS) and The Confusion Assessment Method (CAM-ICU). Data were collected based on the presence or absence of delirium. Statistical analysis utilized SPSS version 26.0, employing an independent Student’s t-test for continuous data and chi-square and Fischer’s exact test for categorical data. A p-value ≤ 0.05 was considered statistically significant. Results: Group-A had a mean age of 54.50 ± 17.97, and Group-b had a mean age of 55.22 ± 15.45, both with a male predominance (81.81% and 86.36% respectively). The mean serum cortisol level was significantly higher in Group b (829.71 ± vs. 389.98 ± 68.77). Postoperative delirium occurred in 27.3% of Group b patients, statistically significant compared to the 4.5% in Group A. However, patients in Group b who developed delirium experienced significantly longer postoperative ICU and hospital stays (79.29 ± 12.27 vs. 11.44 ± 2.85, p ≤ 0.05). There was one mortality in Group b, which was statistically not significant. Conclusion: This study observed a significant association between elevated serum cortisol levels in the postoperative period a

关键词： Coronary Artery bypass Grafting (CAbG) Serum Cortisol Postoperative Delirium bangladesh

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Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes

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Cellular & Molecular Immunology 2019年第12期16卷 946-946页

作者： Ankita Singh Vishal Singh Rajiv L.Tiwari Tulika Chandra Ashutosh kumar Madhu Dikshit manoj K.barthwal Pharmacology Division CSIR-Central Drug Research InstituteB.S.10/1Sector 10Sitapur RoadJankipuram ExtensionLucknow 226031 Uttar PradeshIndia Department of Transfusion Medicine and blood bank King George’s Medical UniversityLucknowUttar PradeshIndia Department of Pathology King George’s Medical UniversityLucknowUttar PradeshIndia

In this article,published online on 31 August 2015,there was an unintended error during image processing of Fig.2b leading to pasting of total ERK andβ-Actin blots not intended for this *** blots have now been replaced with the total ERK andβ-Actin panels that were generated for this *** corrected Fig.2b is shown ***,the conclusion made from the experiment remains unaltered,and this correction has no bearing on the final outcome of the *** inconvenience caused by this error is deeply regretted.

关键词： correction intended conclusion

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硅肥对蔗地土壤性状、甘蔗叶片营养及产量的影响(英文)

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南方农业学报 2011年第7期42卷 756-759页

作者：黄海荣徐林 bOKHTIAR S M manoj kumar Srivastav 李杨瑞杨丽涛中国农业科学院甘蔗研究中心广西农业科学院甘蔗研究所甘蔗栽培与育种国家地方联合工程研究中心广西甘蔗遗传改良重点实验室广西作物遗传改良生物技术重点开放实验室南宁530007 广西大学农学院广西亚热带农业生物资源保护与利用国家重点实验室南宁530005

【目的】在大棚条件下进行甘蔗硅肥施用量研究,阐明硅肥对甘蔗生长、营养以及土壤特性等的影响。【方法】以新台糖22号为试验材料,以每桶26gN+1.76gP+20gK为对照,设置T1～T6(20、40、60、80、120and150g/桶)6个不同硅肥用量,研究不同施... 详细信息

【目的】在大棚条件下进行甘蔗硅肥施用量研究,阐明硅肥对甘蔗生长、营养以及土壤特性等的影响。【方法】以新台糖22号为试验材料,以每桶26gN+1.76gP+20gK为对照,设置T1～T6(20、40、60、80、120and150g/桶)6个不同硅肥用量,研究不同施硅水平对甘蔗的影响。【结果】硅肥处理的甘蔗+1叶N、P、Ca、Mg、Si含量较对照有一定提高,其中120g/桶处理的甘蔗+1叶含硅量比对照增加92%。不同施硅水平对甘蔗土壤理化性状具有显著影响,SOM和有效P较对照显著降低,120g/桶处理的有效Si含量较对照增加137%,150g/桶处理的交换性Ca和Mg分别较对照增加117.9%和86.0%,pH均有一定提高。硅肥处理对甘蔗株高和产量增加有显著影响,对甘蔗干物质和产糖量的提高也有促进作用,但不显著。【结论】硅肥对甘蔗生产以及土壤理化性状具有一定正效应,可结合常规施肥进一步推广从而提高甘蔗生产。

关键词：硅肥甘蔗土壤性状营养产量

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Study of the material photon and electron background and the liquid argon detector veto efficiency of the CDEX-10 experiment

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Chinese Physics C 2015年第3期39卷 30-37页

作者：苏健曾志马豪岳骞程建平常建平陈楠陈宁陈庆豪陈云华庄又澄邓智杜强宫辉郝喜庆何庆驹黄瀚雄黄腾锐江灏康克军李浩斌李荐民李金李军李霞李新颖李学潜李玉兰李元景廖恒毅林枫凯林欣德刘书魁吕岚春毛绍基覃建强任杰任婧阮锡超申满斌 SINGH Lakhwinder SINGH manoj kumar SOMA Arun kumar 唐昌建曾昭雄王继敏王力王青王子敬吴世勇吴玉成幸浩洋徐音薛涛杨丽桃杨松纬易难喻纯旭于昊余训臻曾雄辉张岚张蕴华赵明刚赵伟周祖英朱敬军朱维彬朱雪洲朱忠华 Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Beijing 100084 China China Institute of Atomic Energy Beijing 102413 China Nankai University Tianjin 300071 China NUCTECH Company Beijing 100084 China Sichuan University Chengdu 610065 China Yalong River Hydropower Development Company Chengdu 610051 China Department of Physics Banaras Hindu University Varanasi 221005 India

The China Dark Matter Experiment （CDEX） is located at the China Jinping Underground Laboratory （CJPL） and aims to directly detect the weakly interacting massive particles （WIMP） flux with high sensitivity in the low mass region. Here we present a study of tile predicted photon and electron backgrounds including the background contribution of the structure materials of the germanium detector, the passive shielding materials, and the intrinsic radioactivity of the liquid argon that serves as an anti-Compton active shielding detector. A detailed geometry is modeled and the background contribution has been simulated based on the measured radioactivities of all possible components within tile GEANT4 program. Then the photon and electron background level in the energy region of interest （〈10-2events-kg1·day 1·keV-1 （cpkkd）） is predicted based on Monte Carlo simulations. The simulated result is consistent with the design goal of the CDEX-10 experiment, 0.1cpkkd, which shows that the active and passive shield design of CDEX-10 is effective and feasible.

关键词： CDEX-IO material photon and electron background germanium detector liquid argon veto coincidentcut Monte Carlo simulation

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CDEX-1 1 kg point-contact germanium detector for low mass dark matter searches

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Chinese Physics C 2013年第12期37卷 58-64页

作者：康克军岳赛吴呈城程建平李元景白杨毕勇常建平陈楠陈宁陈庆豪陈云华庄又澄邓智杜强宫辉郝喜庆何庆驹胡鑫洄黄瀚雄黄腾锐江灏李浩斌李荐民李金李军李霞李新颖李学潜李玉兰廖恒毅林枫凯林欣德刘书魁吕岚春马豪毛绍基覃建强任杰任婧阮锡超申满斌 Lakhwinder SINGH manoj kumar SINGH Arun kumar SOMA 苏健唐昌建曾昭雄王继敏王力王青王子敬吴世勇吴蔚吴玉成幸浩洋徐音薛涛杨丽桃杨松纬易难喻纯旭于昊余训臻曾雄辉曾志张岚张蕴华赵明刚赵伟钟苏宁周祖英朱敬军朱维彬朱学洲朱忠华 Tsinghua University Nankai University Sichuan University NUCTECH Company YaLong River Hydropower Development Company Institute of Physics AS China Institute of Atomic Energy Department of Physics Banaras Hindu University

The CDEX collaboration has been established for direct detection of light dark matter particles, using ultra-low energy threshold point-contact p-type germanium detectors, in China JinPing underground Laboratory （CJPL）. The first 1 kg point-contact germanium detector with a sub-keV energy threshold has been tested in a passive shielding system located in CJPL. The outputs from both the point-contact P＋ electrode and the outside N＋ electrode make it possible to scan the lower energy range of less than 1 keV and at the same time to detect the higher energy range up to 3 MeV. The outputs from both P＋ and N＋ electrode may also provide a more powerful method for signal discrimination for dark matter experiment. Some key parameters, including energy resolution, dead time, decay times of internal X-rays, and system stability, have been tested and measured. The results show that the 1 kg point-contact germanium detector, together with its shielding system and electronics, can run smoothly with good performances. This detector system will be deployed for dark matter search experiments.

关键词： CDEX point-contact germanium detector dark matter CJPL

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Limits on light WIMPs with a 1 kg-scale germanium detector at 160 eVee physics threshold at the China Jinping Underground Laboratory

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Chinese Physics C 2018年第2期42卷 12-21页

作者：杨丽桃李浩斌岳骞康克军程建平李元景王子敬 M.Agartioglu 安海鹏常建平陈景瀚陈云华邓智杜强宫辉何力胡津纬胡庆东黄瀚雄贾历平江灏李红李荐民李金李霞李学潜李玉兰林枫凯林兴德刘书魁刘仲智马豪马菁露潘辉任杰阮锡超 b.Sevda Vivek Sharma 申满斌 Lakhwinder Singh manoj kumar Singh 唐昌建唐维优田阳王继敏王力王青王轶吴世勇吴玉成幸浩洋徐音薛涛杨松伟易难喻纯旭于海军岳剑峰曾雄辉曾鸣曾志张云华赵明刚赵伟周济芳周祖英朱敬军朱忠华 Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Department of Physics Tsinghua University Institute of Physics Academia Sinica Key Laboratory of Particle and Radiation Imaging vand Department of Engineering Physics Tsinghua University NUCTECH Company YaLong River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Key Laboratory of Particle and Radiation Imaging and Department of Engineering Physics Tsinghua University

We report results of a search for light weakly interacting massive particle（WIMP） dark matter from the CDEX-1 experiment at the China Jinping Underground Laboratory（CJPL）. Constraints on WIMP-nucleon spin-independent（SI） and spin-dependent（SD） couplings are derived with a physics threshold of 160 eVee, from an exposure of 737.1 kg-days. The SI and SD limits extend the lower reach of light WIMPs to 2 GeV and improve over our earlier bounds at WIMP mass less than 6 GeV.

关键词： dark matter WIMPs CDEX pPCGe

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Searching for ^(76)Ge neutrinoless double beta decay with the CDEX-1b experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： bing-Tao Zhang Jun-Zheng Wang Li-Tao Yang Qian Yue Ke-Jun Kang Yuan-Jing Li Hai-Peng An C.Greeshma Jian-Ping Chang Yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong Qiu-Ju Guo Xu-Yuan Guo Li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-bin Li Jian-Min Li Jin Li Qian-Yun Li Ren-Ming-Jie Li Xue-Qian Li Yu-Lan Li Yi-Fan Liang bin Liao Fong-Kay Lin Shin-Ted Lin Jia-Xuan Liu Shu-Kui Liu Yan-Dong Liu Yu Liu Yuan-Yuan Liu Zhong-Zhi Liu Hao Ma Yu-Cai Mao Qi-Yuan Nie Jin-Hua Ning Hui Pan Ning-Chun Qi Jie Ren Xi-Chao Ruan Ze She manoj kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang Yang Tian Guang-Fu Wang Li Wang Qing Wang Yu-Feng Wang Yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu Yu-Cheng Wu Hao-Yang Xing Rui Xu Yin Xu Tao Xue Yu-Lu Yan Nan Yi Chun-Xu Yu Hai-Jun Yu Jian-Feng Yue Ming Zeng Zhi Zeng Feng-Shou Zhang Lei Zhang Zhen-Hua Zhang Zhen-Yu Zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1b,1.008 kg)in the China Jinping Underground Laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of ^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

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膝关节Rosenberg位片上影像学分级与内侧开放楔形胫骨高位截骨术术后临床疗效的关系探讨

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实用骨科杂志 2019年第10期25卷 878-878页

作者： Kyung Wook Nha Seung Min Oh Yoon Won Ha manoj kumar Patel Ji Hyun Seo byung Hoon Lee 黄景星(整理) 王浩浩(整理) 张民(整理) 不详山西医科大学第二医院

目的探讨与内侧开放楔形胫骨高位截骨术(open-wedge high-tibialosteotomy,OWHTO)术后临床疗效最密切相关的影像学分级方法,并找出与OWHTO预后相关的有利和不利因素。方法分析79例膝骨关节炎伴固有胫骨内翻畸形的患者,均接受OWHTO治疗... 详细信息

目的探讨与内侧开放楔形胫骨高位截骨术(open-wedge high-tibialosteotomy,OWHTO)术后临床疗效最密切相关的影像学分级方法,并找出与OWHTO预后相关的有利和不利因素。方法分析79例膝骨关节炎伴固有胫骨内翻畸形的患者,均接受OWHTO治疗。根据改良关节镜下Outerbridge分级以及影像学Kellgren-Lawrence(K-L)分级进行骨关节炎严重程度评估,影像学检查包括站立前后位(anteroposterior,AP)及屈曲45°后前(posteroanterior,PA)负重位(Rosenberg位)。临床疗效采用牛津膝关节评分(Oxford knee score,OKS)进行评估,包括术前和术后2年的随访。采用多元回归分析相关数据。结果随访2年,OKS评分均值由(20±4)分提高到(39±5)分(Pbial angle,MPTA)由(85.6±2.4)°变为(92.9±3.7)°(Pberg位上K-L分级为(2.8±0.9)分(P=0.003),关节镜下改良Outerbridge骨关节炎分级为(3.4±0.7)分。在多元回归分析中,Rosenberg位下K-L分级(P=0.01)、术后MPTA值(P=0.01)与术后2年随访的OKS评分呈显著负相关(P=0.01)。结论采用三种不同的骨关节炎分级方案(分别是改良关节镜下Outerbridge分级、站立前后位的K-L分级、Rosenberg位的K-L分级)来确定HTO手术指证,其中基于Rosenberg位的K-L分级与OWHTO术后OKS评分呈显著负相关,这与Rosenberg位下股骨髁与胫骨髁距离最近有关。说明基于Rosenberg位的K-L分级对HTO手术指证评估以及对晚期膝骨关节炎患者临床疗效的评估具有重要意义。

关键词：胫骨高位截骨术骨关节炎影像学分级牛津膝关节评分

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